CymitQuimica logo
Ciclo celular / Checkpoint

Ciclo celular / Checkpoint

Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.

Subcategorías de "Ciclo celular / Checkpoint"

Mostrar 10 subcategorías más

Se han encontrado 3485 productos de "Ciclo celular / Checkpoint"

Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
productos por página.
  • Cdc7-IN-11
    Targetmol
    + Info

    Cdc7-IN-11

    CAS:
    <p>Cdc7-IN-11 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in the study of proliferative diseases.</p>
    Fórmula:C20H22F2N4O2S
    Forma y color:Solid
    Peso molecular:420.48

    Ref: TM-T62231

  • CDK2-IN-39
    Targetmol
    + Info

    CDK2-IN-39

    CAS:
    <p>CDK2-IN-39 (compound 4) is a CDK2 inhibitor.</p>
    Fórmula:C14H15N3O4S
    Forma y color:Solid
    Peso molecular:321.352

    Ref: TM-T204890

  • MKLP2-IN-1
    Targetmol
    + Info

    MKLP2-IN-1

    CAS:
    <p>MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 that demonstrates excellent oral bioactivity. In vitro, MKLP2-IN-1 inhibits the ATPase activity stimulated by recombinant MKLP2 microtubules and, in a mouse Calu-6 lung cancer model, it effectively suppresses tumor growth.</p>
    Fórmula:C23H19BrFN3O2
    Forma y color:Solid
    Peso molecular:468.318

    Ref: TM-T205538

  • CLK1/2-IN-1
    Targetmol
    + Info

    CLK1/2-IN-1

    CAS:
    <p>CLK1/2-IN-1 is a CLK1 and CLK2 inhibitor and it also inhibits SRPK1 and SRPK2.</p>
    Fórmula:C21H20F3N7O
    Pureza:98%
    Forma y color:Solid
    Peso molecular:443.42

    Ref: TM-T23896

  • LN-439A
    Targetmol
    + Info

    LN-439A

    CAS:
    <p>LN-439A (compound LN-439A) is a novel BAP1 inhibitor that suppresses the growth of basal-like breast cancer by degrading KLF5.</p>
    Fórmula:C24H26FN3O4
    Forma y color:Solid
    Peso molecular:439.48

    Ref: TM-T200435

  • p38α inhibitor 9
    Targetmol
    + Info

    p38α inhibitor 9

    CAS:
    <p>p38α inhibitor9 (Compound 2015) is a p38α inhibitor that effectively blocks the enzyme activity of p38α, with an IC50 of less than 20 nM. It inhibits MK2T334 phosphorylation and activates Cdc25b and Cdc25c while inactivating Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy, and DNA damage. Additionally, p38α inhibitor9 can suppress colorectal cancer (CRC) metastasis.</p>
    Fórmula:C27H24FN3O3
    Forma y color:Solid
    Peso molecular:457.496

    Ref: TM-T206722

  • CDK4/9-IN-1
    Targetmol
    + Info

    CDK4/9-IN-1

    CAS:
    <p>CDK4/9-IN-1 (Compound 29) is a selective dual inhibitor of CDK4 and CDK9, exhibiting IC50 values of 23 nM and 12 nM, respectively. It holds potential for use in cancer research.</p>
    Fórmula:C22H34N6O2
    Forma y color:Solid
    Peso molecular:414.544

    Ref: TM-T205312

  • And1 degrader 1
    Targetmol
    + Info

    And1 degrader 1

    CAS:
    <p>And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.</p>
    Fórmula:C26H27Cl2N3O
    Forma y color:Solid
    Peso molecular:468.42

    Ref: TM-T200443

  • FT709
    Targetmol
    + Info

    FT709

    CAS:
    <p>FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.</p>
    Fórmula:C23H22N4O7S
    Forma y color:Solid
    Peso molecular:498.51

    Ref: TM-T63375

  • DNA polymerase-IN-6
    Targetmol
    + Info

    DNA polymerase-IN-6

    CAS:
    <p>DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase, with EC50 values of 0.33 µM for HCMV, 1.9 µM for HSV-1, 0.76 µM for HSV-2, and 0.066 µM for EBV.</p>
    Fórmula:C26H28ClFN8O4
    Forma y color:Solid
    Peso molecular:571.003

    Ref: TM-T204284

  • Logo de CymitQuimica
    Targetmol
    + Info

    CDK1-IN-3

    <p>CDK1-IN-3 is a selective inhibitor targeting CDK1 (36.8 nM), CDK2 (305.17 nM), CDK5 (369.37 nM); used in cancer research.</p>
    Fórmula:C28H25ClF3N5O2
    Forma y color:Solid
    Peso molecular:555.98

    Ref: TM-T63933

  • WRN inhibitor 13
    Targetmol
    + Info

    WRN inhibitor 13

    CAS:
    <p>WRN inhibitor 13 is an inhibitor of the WRN helicase with a pIC50 value ranging from 6 to 7.</p>
    Fórmula:C16H20N2O5S
    Forma y color:Solid
    Peso molecular:352.405

    Ref: TM-T204389

  • GR 83895
    Targetmol
    + Info

    GR 83895

    CAS:
    <p>GR 83895 is an antagonist of prototype fibrinogen receptor.</p>
    Fórmula:C29H39N9O8S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:673.74

    Ref: TM-T25460

  • Logo de CymitQuimica
    Targetmol
    + Info

    CDK8-IN-11 hydrochloride

    <p>CDK8-IN-11 HCl: potent, selective CDK8 inhibitor (IC50: 46 nM), blocks WNT/β-catenin pathway, used in colon cancer research.</p>
    Fórmula:C19H16ClF3N4O2
    Forma y color:Solid
    Peso molecular:424.8

    Ref: TM-T62293

  • 12(S)-HETE
    Targetmol
    + Info

    12(S)-HETE

    CAS:
    <p>Enpatoran hydrochloride (M5049 hydrochloride) is a TLR7/8 inhibitor with antiviral activity that is used in the study of autoimmune diseases.</p>
    Fórmula:C20H32O3
    Forma y color:Solid
    Peso molecular:320.47

    Ref: TM-T37047

  • LIMK1 inhibitor 1
    Targetmol
    + Info

    LIMK1 inhibitor 1

    CAS:
    <p>LIMK1 inhibitor1 (compound 24) is a LIMK1 inhibitor, potentially useful for cancer research.</p>
    Fórmula:C12H15N3S2
    Forma y color:Solid
    Peso molecular:265.398

    Ref: TM-T204784

  • L-I-OddU
    Targetmol
    + Info

    L-I-OddU

    CAS:
    <p>L-I-OddU: Selective anti-EBV, halts virus DNA/protein synthesis. EC50: 0.03 µM, low toxicity (CC50: 1000 nM).</p>
    Fórmula:C8H9IN2O5
    Forma y color:Solid
    Peso molecular:340.07

    Ref: TM-T61080

  • USP7-IN-10
    Targetmol
    + Info

    USP7-IN-10

    CAS:
    <p>USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.</p>
    Fórmula:C26H29ClN4O3S
    Forma y color:Solid
    Peso molecular:513.05

    Ref: TM-T73136

  • SF0166
    Targetmol
    + Info

    SF0166

    CAS:
    <p>SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.</p>
    Fórmula:C23H27F2N5O4
    Forma y color:Solid
    Peso molecular:475.49

    Ref: TM-T70368

  • KL-50
    Targetmol
    + Info

    KL-50

    CAS:
    <p>KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.</p>
    Fórmula:C7H7FN6O2
    Forma y color:Solid
    Peso molecular:226.17

    Ref: TM-T200136