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Ciclo celular / Checkpoint

Ciclo celular / Checkpoint

Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.

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Se han encontrado 3485 productos de "Ciclo celular / Checkpoint"

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  • PD-1-IN-17
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    PD-1-IN-17

    CAS:
    <p>PD-1-IN-17 is an inhibitor of programmed cell death-1 (PD-1). PD-1-IN-17 inhibits 92% splenocyte proliferation at 100 nM.</p>
    Fórmula:C13H22N6O7
    Pureza:99.6%
    Forma y color:Solid
    Peso molecular:374.35

    Ref: TM-T12377

  • LNA-GDP
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    LNA-GDP

    CAS:
    <p>LNA-GDP is a nucleotide analog utilized in the synthesis of oligonucleotides.</p>
    Fórmula:C11H15N5O11P2
    Forma y color:Solid
    Peso molecular:455.21

    Ref: TM-TSW-00961

  • Logo de CymitQuimica
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    DNA Gyrase-IN-1

    <p>DNA Gyrase-IN-1: potent, selective promoter inhibitor. IC50: 2.6 μM, inhibits Mtb, MIC: 0.49 μM. Useful for tuberculosis research.</p>
    Fórmula:C24H24FN7O6
    Forma y color:Solid
    Peso molecular:525.49

    Ref: TM-T63681

  • 7-Methylguanosine 5′-monophosphate
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    7-Methylguanosine 5′-monophosphate

    CAS:
    <p>7-Methylguanosine 5′-monophosphate (7-Methylguanylic acid) is a component of nucleic acids.</p>
    Fórmula:C11H16N5O8P
    Forma y color:Solid
    Peso molecular:377.25

    Ref: TM-TSW-00951

  • AB25583
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    AB25583

    CAS:
    <p>AB25583 is a small molecule inhibitor of Polθ helicase (Polθ-hel) with an IC50 of 6 nM. It selectively kills cells deficient in BRCA1/2 and synergizes with Olaparib in cancer cells harboring pathogenic BRCA1/2 mutations. AB25583 can be utilized in tumor research.</p>
    Fórmula:C22H17ClN4O3S
    Forma y color:Solid
    Peso molecular:452.91

    Ref: TM-T200101

  • CDK4/6-IN-3
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    CDK4/6-IN-3

    CAS:
    <p>CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: &lt;0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.</p>
    Fórmula:C25H31FN8
    Pureza:98%
    Forma y color:Solid
    Peso molecular:462.57

    Ref: TM-T10737

  • 5'-DMT-5-F-2'-dU Phosphoramidite
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    5'-DMT-5-F-2'-dU Phosphoramidite

    CAS:
    <p>5'-DMT-5-F-2'-dU Phosphoramidite is a nucleoside phosphoramidite analog employed in oligonucleotide synthesis. It plays a crucial role in developing therapeutic oligonucleotides, which are used in crafting drugs for cancer treatment.</p>
    Fórmula:C39H46FN4O8P
    Forma y color:Solid
    Peso molecular:748.777

    Ref: TM-T206476

  • Logo de CymitQuimica
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    MtTMPK-IN-8

    <p>MtTMPK-IN-8 inhibits MtbTMPK, has low cytotoxicity, shows 0.78-9.4 μM activity against Mycobacterium, useful for tuberculosis research.</p>
    Fórmula:C24H24N6O7
    Forma y color:Solid
    Peso molecular:508.48

    Ref: TM-T63491

  • CDK9 autophagic degrader 1
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    CDK9 autophagic degrader 1

    CAS:
    <p>CDK9 autophagic degrader 1 (Compound 28) is an ATTEC degrader used to target and degrade CDK9, also impacting the levels of its associated Cyclin T1. At a concentration of 100 nM, it exhibits over 80% inhibition of CDK9.</p>
    Fórmula:C34H39N7O4S2
    Forma y color:Solid
    Peso molecular:673.848

    Ref: TM-T204672

  • LIMK1 inhibitor 2
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    LIMK1 inhibitor 2

    CAS:
    <p>LIMK1 inhibitor 2 (compound 41) is a LIMK1 inhibitor with an IC50 value of 9 μM.</p>
    Fórmula:C10H11N3OS
    Forma y color:Solid
    Peso molecular:221.279

    Ref: TM-T204765

  • Metesind Glucuronate
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    Metesind Glucuronate

    CAS:
    <p>Metesind Glucuronate is an antineoplastic. It also is a specific thymidylate synthase inhibitor.</p>
    Fórmula:C29H34N4O10S
    Forma y color:Solid
    Peso molecular:630.67

    Ref: TM-T24454

  • Valopicitabine dihydrochloride
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    Valopicitabine dihydrochloride

    CAS:
    <p>Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>
    Fórmula:C15H25ClN4O6
    Forma y color:Solid
    Peso molecular:392.84

    Ref: TM-T29094

  • Logo de CymitQuimica
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    Antibacterial agent 110

    <p>Compound 4e, an antibacterial against P. aeruginosa, disrupts cell membranes (MIC: 1 μg/ml).</p>
    Fórmula:C22H21N5O4S
    Forma y color:Solid
    Peso molecular:451.5

    Ref: TM-T62740

  • P162-0948
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    P162-0948

    CAS:
    <p>P162-0948 is a selective CDK8 inhibitor with an IC50 value of 50.4 nM. It reduces cell migration and the expression of EMT-related proteins in the A549 human alveolar epithelial cell line. Furthermore, P162-0948 decreases Smad phosphorylation, indicating disruption of the TGF-β/Smad signaling pathway, making it a promising compound for pulmonary fibrosis research.</p>
    Fórmula:C20H15FN4O2
    Forma y color:Solid
    Peso molecular:362.357

    Ref: TM-T205592

  • Logo de CymitQuimica
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    Antiangiogenic agent 2

    <p>Antiangiogenic agent 2 (compound 3b) is a potent inhibitor of thymidine phosphorylase (IC50: 39.71 μM) and exhibits anti-angiogenic effects.</p>
    Fórmula:C26H26FN3O4
    Forma y color:Solid
    Peso molecular:463.5

    Ref: TM-T62931

  • 5-Methylcytosine hydrochloride
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    5-Methylcytosine hydrochloride

    CAS:
    <p>5-Methylcytosine hydrochloride plays a critical role in regulating gene expression, promoting genomic imprinting, and inhibiting transposon factors. It is also closely associated with translation fidelity and tRNA recognition.</p>
    Fórmula:C5H8ClN3O
    Forma y color:Solid
    Peso molecular:161.59

    Ref: TM-T201054

  • JY-3-094
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    JY-3-094

    CAS:
    <p>JY-3-094 is a selective Myc inhibitor that targets the hydrophobic domain of Myc and inhibits the formation of the Myc-Max heterodimer, with an IC50 of 33 μM, and can be used for cancer research.</p>
    Fórmula:C13H8N4O5
    Pureza:98.72%
    Forma y color:Solid
    Peso molecular:300.23

    Ref: TM-T86777

  • IIP0943
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    IIP0943

    CAS:
    <p>IIP0943 is a selective PLK1 (polo-like kinase 1) inhibitor with an IC50 of 5.1 nM for PLK1. It also exhibits inhibitory activity on the proliferation of HCT116 cells, with an IC50 of 0.22 µM. IIP0943 shows potential for research in the field of oncology.</p>
    Fórmula:C26H28N6O3S
    Forma y color:Solid
    Peso molecular:504.604

    Ref: TM-T206115

  • 2'-O-MOE-UTP
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    2'-O-MOE-UTP

    CAS:
    <p>2'-O-MOE-UTP is a nucleotide analog employed in the synthesis of oligonucleotides.</p>
    Fórmula:C12H21N2O16P3
    Forma y color:Solid
    Peso molecular:542.22

    Ref: TM-TSW-00959

  • Logo de CymitQuimica
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    Anticancer agent 30

    <p>Anticancer agent 30 (6f-Z), a 3-arylidene-2-oxindole, selectively inhibits CDK2, showing potent anticancer potential.</p>
    Fórmula:C22H15ClFNO
    Forma y color:Solid
    Peso molecular:363.81

    Ref: TM-T61379