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Ciclo celular / Checkpoint

Ciclo celular / Checkpoint

Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.

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Se han encontrado 3482 productos de "Ciclo celular / Checkpoint"

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  • 8-Oxo-dATP
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    8-Oxo-dATP

    CAS:
    <p>8-Oxo-dATP can be hydrolyzed to its monophosphate form by the oxidation of purine nucleoside triphosphate MTH1, preventing erroneous incorporation during DNA replication or transcription.</p>
    Fórmula:C10H12Li4N5O13P3
    Forma y color:Solid
    Peso molecular:530.913

    Ref: TM-T206632

  • CDK12/13 ligand 1
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    CDK12/13 ligand 1

    CAS:
    <p>ALK-IN-29 (compound 4c) exhibits notable inhibitory activity against tyrosine kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, showing a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is useful for cancer research.</p>
    Fórmula:C26H26BrN5O
    Forma y color:Solid
    Peso molecular:504.42

    Ref: TM-T201159

  • Logo de CymitQuimica
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    Sovesudil hydrochloride

    <p>Sovesudil (PHP-201) HCl: potent local ROCK inhibitor; targets ROCK I/II (IC50: 3.7/2.3 nM); lowers IOP, non-congesting.</p>
    Fórmula:C23H23ClFN3O3
    Forma y color:Solid
    Peso molecular:443.9

    Ref: TM-T62608

  • Polθ-IN-6
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    Polθ-IN-6

    CAS:
    <p>Polθ-IN-6 (Compound 89) is an inhibitor of DNA polymerase theta (Polθ) and exhibits antitumor activity.</p>
    Fórmula:C25H23N3O3S
    Forma y color:Solid
    Peso molecular:445.53

    Ref: TM-T200918

  • NSC 641396
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    NSC 641396

    CAS:
    <p>NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC50 value of 1.2 μM. Additionally, it acts as an inhibitor of protein arginine N-methyltransferase 9 (PRMT9) and exhibits antitumor properties.</p>
    Fórmula:C18H13NO3
    Forma y color:Solid
    Peso molecular:291.301

    Ref: TM-T204449

  • NRTT-IN-1
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    NRTT-IN-1

    CAS:
    <p>NRTT-IN-1 (Compound 1) is an inhibitor of the nucleoside reverse transcriptase translocation (NRTT), effectively blocking HIV DNA synthesis and viral replication.</p>
    Fórmula:C28H24FN5O5
    Forma y color:Solid
    Peso molecular:529.519

    Ref: TM-T205482

  • Logo de CymitQuimica
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    Dyrk1A/B-IN-1

    <p>Dyrk1A/B-IN-1 (3n) is a potent DYRK1A/B inhibitor, cell-permeable, with Ki values of 67.8 nM (1A) and 237.9 nM (1B), IC50s of 1.1 and 0.8 μM.</p>
    Fórmula:C21H17N3O2S2
    Forma y color:Solid
    Peso molecular:407.51

    Ref: TM-T62043

  • WRN inhibitor 12
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    WRN inhibitor 12

    CAS:
    WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.
    Fórmula:C33H33ClF3N9O5
    Forma y color:Solid
    Peso molecular:728.12

    Ref: TM-T201316

  • Lobucavir
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    Lobucavir

    CAS:
    <p>Lobucavir (BMS-180194; SQ 34514) is a nucleoside analogue and an antiviral agent with broad-spectrum activity against various viruses, including HBV, HIV/AIDS, and α, β, and γ herpesviruses (including CMV, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus).</p>
    Fórmula:C11H15N5O3
    Forma y color:Solid
    Peso molecular:265.27

    Ref: TM-T200820

  • D-G23
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    D-G23

    CAS:
    <p>D-G23 is a selective RAD52 inhibitor. It disrupts RAD52-mediated DNA repair pathways and suppresses the growth of cancer cells deficient in BRCA1 and BRCA2. D-G23 shows promise for research into homologous recombination-related cancers caused by BRCA1/2 mutations, such as hereditary breast and ovarian cancers.</p>
    Fórmula:C19H22N4O3
    Forma y color:Solid
    Peso molecular:354.403

    Ref: TM-T206763

  • DNA Gyrase-IN-13
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    DNA Gyrase-IN-13

    CAS:
    <p>DNA Gyrase-IN-13 (compound 1b) is an inhibitor of DNA gyrase with bacteriostatic properties. It exhibits an IC50 of 1.81 μM against Staphylococcus aureus DNA gyrase.</p>
    Fórmula:C15H21N3O3S
    Forma y color:Solid
    Peso molecular:323.41

    Ref: TM-T201341

  • Dyrk1A-IN-12
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    Dyrk1A-IN-12

    CAS:
    <p>Dyrk1A-IN-12 (compound S43) is an inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A). It has an IC50 of 95 nM for inhibiting Dyrk1A. The compound demonstrates antiviral activity against EV-A71 (Enterovirus A71) with an EC50 of 4.4 μM, a CC50 of 12.8 μM, and a selectivity index (SI) of 2.9. Additionally, Dyrk1A-IN-12 exhibits potent inhibitory effects on the herpes simplex virus (HSV).</p>
    Fórmula:C22H16FN3O2S
    Forma y color:Solid
    Peso molecular:405.445

    Ref: TM-T205530

  • BRD-7880
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    BRD-7880

    CAS:
    <p>BRD-7880 is a potent and highly specific inhibitor of aurora kinases B and C.</p>
    Fórmula:C32H38N4O7
    Forma y color:Solid
    Peso molecular:590.67

    Ref: TM-T70600

  • CDK2 degrader 4
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    CDK2 degrader 4

    CAS:
    <p>CDK2 degrader4 (compound 104) is a potent degrader of CDK2, showing promise for cancer research applications.</p>
    Fórmula:C23H26ClN3O5
    Forma y color:Solid
    Peso molecular:459.923

    Ref: TM-T204856

  • RMS-07
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    RMS-07

    CAS:
    <p>RMS-07, a covalent MPS1/TTK inhibitor, has an IC50 of 13.1 nM, targeting a kinase hinge cysteine.</p>
    Fórmula:C35H40N8O2
    Forma y color:Solid
    Peso molecular:604.74

    Ref: TM-T73483

  • GSK3335103
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    GSK3335103

    CAS:
    <p>GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.</p>
    Fórmula:C27H36FN3O4
    Forma y color:Solid
    Peso molecular:485.59

    Ref: TM-T200463

  • CDK7/12-IN-1
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    CDK7/12-IN-1

    CAS:
    <p>CDK7/12-IN-1 is a selective CDK7 (IC50: 3 nM) and CDK12 (IC50: 277 nM) inhibitor, effective against tumor growth.</p>
    Fórmula:C25H34N8O
    Forma y color:Solid
    Peso molecular:462.59

    Ref: TM-T62926

  • Rhodblock 1a
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    Rhodblock 1a

    CAS:
    <p>Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway, which disrupts the localization and function of proteins within the Rho pathway. This interference hinders the proper formation of the cleavage furrow during cell division, leading to some cells either failing to form the cleavage furrow or forming a ruptured furrow, resulting in binucleated cells. Rhodblock 1a can be utilized for investigating cell division mechanisms and holds potential for research into cardiovascular diseases and cancer.</p>
    Fórmula:C20H16N2O2
    Forma y color:Solid
    Peso molecular:316.353

    Ref: TM-T206882

  • LZ9
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    LZ9

    CAS:
    <p>LZ9 is an ATP-competitive inhibitor of CDK1 and CDK2, with potential applications in colorectal cancer (CRC) research.</p>
    Fórmula:C17H11F3N4O2
    Forma y color:Solid
    Peso molecular:360.29

    Ref: TM-T204957

  • (R)-CSN5i-3
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    (R)-CSN5i-3

    CAS:
    <p>(R)-CSN5i-3 is CSN5i-3 of the R configuration.</p>
    Fórmula:C28H29F2N5O2
    Pureza:99.76% - 99.97%
    Forma y color:Solid
    Peso molecular:505.56

    Ref: TM-T12620