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Ciclo celular / Checkpoint

Ciclo celular / Checkpoint

Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.

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Se han encontrado 3480 productos de "Ciclo celular / Checkpoint"

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  • Dyrk1A-IN-4
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    Dyrk1A-IN-4

    CAS:
    <p>Dyrk1A-IN-4, compound 48, is an oral DYRK1A/DYRK2 inhibitor with IC50s: 2 nM (DYRK1A), 6 nM (DYRK2), anticancer properties.</p>
    Fórmula:C14H13F3N6
    Forma y color:Solid
    Peso molecular:322.29

    Ref: TM-T60867

  • Uridine 3',5'-diphosphate
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    Uridine 3',5'-diphosphate

    CAS:
    <p>Uridine 3′,5′-diphosphate (3′,5′-UDP; Compound pUp) serves as a competitive RNase inhibitor [1].</p>
    Fórmula:C9H14N2O12P2
    Forma y color:Solid
    Peso molecular:404.16

    Ref: TM-T87599

  • β-catenin-IN-8
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    β-catenin-IN-8

    CAS:
    <p>β-catenin-IN-8 (Compound 25) is an inhibitor of β-catenin. It effectively lowers the levels of both β-catenin and c-Myc proteins and suppresses Wnt target genes (Fgf20 and Sall4). Additionally, β-catenin-IN-8 exhibits anticancer activity against colorectal cancer and possesses metabolic stability.</p>
    Fórmula:C15H12ClN3O2S
    Forma y color:Solid
    Peso molecular:333.79

    Ref: TM-T201581

  • ROCK-IN-11
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    ROCK-IN-11

    CAS:
    <p>ROCK-IN-11 (example 94) is an effective inhibitor of ROCK1 and ROCK2, with an IC50 of ≤ 5 μM, and plays a significant role in cancer research.</p>
    Fórmula:C22H20N4O4S
    Forma y color:Solid
    Peso molecular:436.484

    Ref: TM-T204468

  • Logo de CymitQuimica
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    Dyrk1A-IN-2

    <p>Dyrk1A-IN-2 is a DYRK1A inhibitor (EC50: 37 nM). dyrk1A-IN-2 exhibits efficient promotion of human β-cell replication, as well as low cytotoxicity.</p>
    Fórmula:C27H32N6O4
    Forma y color:Solid
    Peso molecular:504.58

    Ref: TM-T63440

  • CDK2-IN-18
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    CDK2-IN-18

    CAS:
    <p>CDK2-IN-18 (compound 8q) serves as a powerful inhibitor of CDK 2/E and CDK 4/D1, showing IC50 values of 8 nM and 46 nM, respectively. It effectively inhibits tumor cell proliferation [1].</p>
    Fórmula:C21H23N7O2S
    Forma y color:Solid
    Peso molecular:437.52

    Ref: TM-T86027

  • 2'-O-MOE-GTP
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    2'-O-MOE-GTP

    CAS:
    <p>2'-O-MOE-GTP is a nucleotide analog utilized in the synthesis of oligonucleotides.</p>
    Fórmula:C13H22N5O15P3
    Forma y color:Solid
    Peso molecular:581.26

    Ref: TM-TSW-00970

  • PKMYT1-IN-7
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    PKMYT1-IN-7

    CAS:
    <p>PKMYT1-IN-7 (compound 7) is an orally active PKMYT1 inhibitor with IC50 values of 1.6 nM for PKMYT1 and 0.06 μM for pCDK1. It inhibits the phosphorylation of CDK1 at T14 and Y15 sites and exhibits anticancer activity both in vitro and in vivo.</p>
    Fórmula:C17H18FN5O3
    Forma y color:Solid
    Peso molecular:359.355

    Ref: TM-T206777

  • PT109
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    PT109

    CAS:
    PT109 is a multikinase inhibitor that targets JNK and other kinases, playing a crucial role in anti-inflammatory, antioxidative, neurogenic, and synaptogenic processes. Specifically, PT109 inhibits JNK isoforms with the following IC50 values: JNK1 at 0.143 μM, JNK2 at 0.831 μM, and JNK3 at 0.285 μM. It also inhibits SGK isoforms (SGK1: IC50=1.34 μM; SGK2: IC50=5.6 μM; SGK3: IC50=26.4 μM) and ROCK2 (IC50=34 μM). Additionally, PT109 reprograms polymorphic glioblastoma multiforme (GBM) into oligodendroglia via the PTBP1/PKM1/2 pathway and alters the metabolic pattern of GBM to exhibit antiglioma activity.
    Fórmula:C23H31N3OS2
    Forma y color:Solid
    Peso molecular:429.64

    Ref: TM-T201273

  • Logo de CymitQuimica
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    FT3967385

    <p>FT3967385: New USP30 inhibitor boosts mitochondrial ubiquitylation via PINK1-PARKIN.</p>
    Fórmula:C21H19N5O2
    Forma y color:Solid
    Peso molecular:373.41

    Ref: TM-T61512

  • LY 254155
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    LY 254155

    CAS:
    <p>LY 254155, an antifolate,binds to mFBP and inhibits hGARFT with Kis of 1.7±0.1 and 2.1±0.2 nM, respectively.</p>
    Fórmula:C19H23N5O6S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:449.48

    Ref: TM-T11922

  • T-2513 hydrochloride
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    T-2513 hydrochloride

    CAS:
    <p>T-2513 hydrochloride: selective topoisomerase I inhibitor, binds DNA complex, halts DNA/RNA synthesis, causes cell death.</p>
    Fórmula:C25H28ClN3O5
    Forma y color:Solid
    Peso molecular:485.96

    Ref: TM-T63225

  • CDK7-IN-31
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    CDK7-IN-31

    CAS:
    <p>CDK7-IN-31 (compound 13) is an effective and orally active inhibitor of cyclin-dependent kinase 7 (CDK7) with a dissociation constant (Kd) of 0.18 nM. This compound exhibits anticancer activity.</p>
    Fórmula:C27H32F5N6O2P
    Forma y color:Solid
    Peso molecular:598.55

    Ref: TM-T201665

  • CDK6-IN-1
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    CDK6-IN-1

    CAS:
    <p>CDK6-IN-1 (compound 4i) is an inhibitor of CDK6 that suppresses cell growth and induces cell cycle arrest at the G1 phase.</p>
    Fórmula:C30H23N5
    Forma y color:Solid
    Peso molecular:453.54

    Ref: TM-T201591

  • PKMYT1-IN-2
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    PKMYT1-IN-2

    CAS:
    <p>PKMYT1-IN-2 (compound 2) serves as a powerful inhibitor of PKMYT1, exhibiting an IC 50 of 5.7 nM. Additionally, it effectively suppresses the proliferation of HCC1569 cells with an IC 50 of 22 nM [1].</p>
    Fórmula:C22H19N5O2
    Forma y color:Solid
    Peso molecular:385.42

    Ref: TM-T87219

  • 2′-F-UDP
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    2′-F-UDP

    CAS:
    <p>2′-F-UDP is a nucleotide analogue used in the synthesis of oligonucleotides.</p>
    Fórmula:C9H13FN2O11P2
    Forma y color:Solid
    Peso molecular:406.15

    Ref: TM-TSW-00958

  • WEE1-IN-11
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    WEE1-IN-11

    CAS:
    WEE1-IN-11 (Compound 13) serves as a potent CDK2 inhibitor with an IC50 of 2.0 nM. It exhibits inhibitory effects on several cell lines, including NCI-H446, A427, OVCAR3, C33A, and WiDr, with respective IC50 values of 93.9, 34.5, 86.7, 23.1, and 85 nM.
    Fórmula:C26H29FN8OS2
    Forma y color:Solid
    Peso molecular:552.69

    Ref: TM-T200924

  • DB18
    Targetmol
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    DB18

    CAS:
    <p>DB18 serves as a potent, selective inhibitor of CDC2-like kinases (CLKs), exhibiting IC50 values between 10-30 nM for CLK1, CLK2, and CLK4. Additionally, it possesses anti-tumor activity [1].</p>
    Fórmula:C24H18ClN7O3
    Forma y color:Solid
    Peso molecular:487.9

    Ref: TM-T86165

  • WRN inhibitor 7
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    WRN inhibitor 7

    CAS:
    <p>WRN inhibitor 7 (Compound h6), a potent inhibitor of Werner syndrome helicase, demonstrates effective suppression of WRN's helicase and ATPase activities with IC50 values of 9.8 μM and 15.8 μM, respectively. This compound is utilized in the study of microsatellite instable (MSI) cancers [1].</p>
    Fórmula:C27H23N3O6
    Forma y color:Solid
    Peso molecular:485.49

    Ref: TM-T87635

  • VPC-80051
    Targetmol
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    VPC-80051

    CAS:
    <p>VPC-80051 is an hnRNP A1 splicing activity inhibitor that directly interacts with the hnRNP A1 RBD and reduces AR-V7 messenger levels in the 22Rv1 CRPC cell line. VPC-80051 is applicable in prostate cancer research.</p>
    Fórmula:C16H13F2N3O
    Forma y color:Solid
    Peso molecular:301.291

    Ref: TM-T204737