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Ciclo celular / Checkpoint

Ciclo celular / Checkpoint

Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.

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Se han encontrado 3477 productos de "Ciclo celular / Checkpoint"

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  • CHK1-IN-11
    Targetmol
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    CHK1-IN-11

    CAS:
    <p>CHK1-IN-11 (Compound 1) is an orally active inhibitor of checkpoint kinase 1 (CHK1). It is utilized in research focused on cancers with oncogene amplification.</p>
    Fórmula:C20H22N8O2
    Forma y color:Solid
    Peso molecular:406.44

    Ref: TM-T207353

  • CDK2 degrader 6
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    CDK2 degrader 6

    CAS:
    <p>CDK2 degrader6 (compound 6) is an orally active CDK2 degrader with a DC50 of 46.5 nM, and is applicable in breast cancer research.</p>
    Fórmula:C23H22F5N5O3
    Forma y color:Solid
    Peso molecular:511.44

    Ref: TM-T207287

  • LNA-CTP
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    LNA-CTP

    CAS:
    <p>LNA-CTP is a nucleotide analog utilized in the synthesis of oligonucleotides.</p>
    Fórmula:C10H16N3O14P3
    Forma y color:Solid
    Peso molecular:495.17

    Ref: TM-TSW-00954

  • RNAP-σ interaction inhibitor-2
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    RNAP-σ interaction inhibitor-2

    CAS:
    <p>RNAP-σ interaction inhibitor-2 (compound 7d) is an inhibitor targeting the interaction between RNA polymerase and the sigma factor. It demonstrates inhibitory activity against S. aureus with a minimum inhibitory concentration (MIC) of 2 µg/mL.</p>
    Fórmula:C27H19Cl3N2O6S2
    Forma y color:Solid
    Peso molecular:637.939

    Ref: TM-T206884

  • Antiviral agent 67
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    Antiviral agent 67

    CAS:
    <p>Antiviralagent 67 (compound PC6) is an inhibitor of DENVNS5 (RNA-dependent RNA polymerase) with a Ki value of 1.12 nM.</p>
    Fórmula:C19H19N3O
    Forma y color:Solid
    Peso molecular:305.374

    Ref: TM-T206310

  • CD 10899
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    CD 10899

    CAS:
    <p>CD 10899, a hydroxylated metabolite of Volasertib, is pharmacologically active against Polo-like kinase 1 (PLK1) with an IC50 of 6 nM. Volasertib is an orally active, highly potent, and ATP-competitive PLK1 inhibitor. CD 10899 can be used for cancer research [1].</p>
    Fórmula:C34H50N8O4
    Forma y color:Solid
    Peso molecular:634.81

    Ref: TM-T86023

  • iPAF1C
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    iPAF1C

    CAS:
    <p>iPAF1C is a powerful inhibitor of the polymerase-associated factor 1 complex (PAF1C) and exhibits anti-HIV activity [1].</p>
    Fórmula:C27H26BrFN4O
    Forma y color:Solid
    Peso molecular:521.42

    Ref: TM-T86731

  • CDK1-IN-6
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    CDK1-IN-6

    <p>CDK1-IN-6 (Ligand 3) is an effective inhibitor of CDK1 and shows potential for use in cancer research.</p>
    Fórmula:C21H22N4O
    Forma y color:Solid
    Peso molecular:346.43

    Ref: TM-T201825

  • 2,5-Di-tert-butyl-1,4-benzoquinone
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    2,5-Di-tert-butyl-1,4-benzoquinone

    CAS:
    <p>2,5-Di-tert-butyl-1,4-benzoquinone is a potent antibacterial agent found primarily in marine Streptomyces sp. VITVSK1, effective against emerging antibiotic resistance. Additionally, it serves as a powerful inhibitor of RNA polymerase.</p>
    Fórmula:C14H20O2
    Forma y color:Solid
    Peso molecular:220.31

    Ref: TM-T201504

  • Mps1-IN-8
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    Mps1-IN-8

    CAS:
    <p>Mps1-IN-8, a Mps1 inhibitor, can be utilized in the study of various tumors [1].</p>
    Fórmula:C35H47N8O6P
    Forma y color:Solid
    Peso molecular:706.77

    Ref: TM-T86927

  • WRN inhibitor 7
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    WRN inhibitor 7

    CAS:
    <p>WRN inhibitor 7 (Compound h6), a potent inhibitor of Werner syndrome helicase, demonstrates effective suppression of WRN's helicase and ATPase activities with IC50 values of 9.8 μM and 15.8 μM, respectively. This compound is utilized in the study of microsatellite instable (MSI) cancers [1].</p>
    Fórmula:C27H23N3O6
    Forma y color:Solid
    Peso molecular:485.49

    Ref: TM-T87635

  • N-Nitrosonornicotine
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    N-Nitrosonornicotine

    CAS:
    <p>N-Nitrosonornicotine, a tobacco-specific nitrosamine, exhibits carcinogenic and mutagenic properties, and is capable of inducing micronuclei in C3A cells. Additionally, N-Nitrosonornicotine can form DNA adducts.</p>
    Fórmula:C9H11N3O
    Forma y color:Solid
    Peso molecular:177.2

    Ref: TM-T201694

  • DB18
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    DB18

    CAS:
    <p>DB18 serves as a potent, selective inhibitor of CDC2-like kinases (CLKs), exhibiting IC50 values between 10-30 nM for CLK1, CLK2, and CLK4. Additionally, it possesses anti-tumor activity [1].</p>
    Fórmula:C24H18ClN7O3
    Forma y color:Solid
    Peso molecular:487.9

    Ref: TM-T86165

  • VPC-80051
    Targetmol
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    VPC-80051

    CAS:
    <p>VPC-80051 is an hnRNP A1 splicing activity inhibitor that directly interacts with the hnRNP A1 RBD and reduces AR-V7 messenger levels in the 22Rv1 CRPC cell line. VPC-80051 is applicable in prostate cancer research.</p>
    Fórmula:C16H13F2N3O
    Forma y color:Solid
    Peso molecular:301.291

    Ref: TM-T204737

  • LIMK-IN-2
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    LIMK-IN-2

    CAS:
    <p>LIMK-IN-2 (Compound 52), an LIMK inhibitor, has demonstrated potential anti-angiogenic activity by suppressing the cell migration of osteosarcoma and cervical cancer cells [1].</p>
    Fórmula:C28H27N5O2
    Forma y color:Solid
    Peso molecular:465.55

    Ref: TM-T86811

  • 5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine
    Targetmol
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    5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine

    CAS:
    <p>5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine is a nucleoside synthesized through oxime ring-opening at the 5' position and methylation at the 2' position. In chemotaxis assays, 5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine demonstrates tissue affinity.</p>
    Fórmula:C36H39N5O8
    Forma y color:Solid
    Peso molecular:669.724

    Ref: TM-T206273

  • TMX-3013
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    TMX-3013

    CAS:
    <p>TMX-3013 is a CDK inhibitor that targets multiple cyclin-dependent kinases, specifically suppressing the activity of CDK1, CDK2, CDK4, CDK5, and CDK6 with IC50 values of 0.9 nM, &lt;0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM respectively. Additionally, TMX-3013 is utilized in the synthesis of PROTACs, which use polyethylene glycol (PEG) as a linker and Thalidomide as the CRBN-recruiting arm.</p>
    Fórmula:C17H14BrFN6O3S
    Forma y color:Solid
    Peso molecular:481.3

    Ref: TM-T201425

  • PKMYT1-IN-2
    Targetmol
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    PKMYT1-IN-2

    CAS:
    <p>PKMYT1-IN-2 (compound 2) serves as a powerful inhibitor of PKMYT1, exhibiting an IC 50 of 5.7 nM. Additionally, it effectively suppresses the proliferation of HCC1569 cells with an IC 50 of 22 nM [1].</p>
    Fórmula:C22H19N5O2
    Forma y color:Solid
    Peso molecular:385.42

    Ref: TM-T87219

  • PLK1-IN-11
    Targetmol
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    PLK1-IN-11

    CAS:
    <p>PLK1-IN-11 (Cluster 4, 16953209) is a PLK1 inhibitor with an IC50 of 1 μM. It is applicable in research on various cancers such as pancreatic, ovarian, breast, and non-small cell lung cancer.</p>
    Fórmula:C12H11N5O
    Forma y color:Solid
    Peso molecular:241.249

    Ref: TM-T205548

  • 2'-O-MOE-GTP
    Targetmol
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    2'-O-MOE-GTP

    CAS:
    <p>2'-O-MOE-GTP is a nucleotide analog utilized in the synthesis of oligonucleotides.</p>
    Fórmula:C13H22N5O15P3
    Forma y color:Solid
    Peso molecular:581.26

    Ref: TM-TSW-00970