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Ciclo celular / Checkpoint

Ciclo celular / Checkpoint

Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.

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Se han encontrado 3477 productos de "Ciclo celular / Checkpoint"

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  • JH-XVI-178
    Targetmol
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    JH-XVI-178

    CAS:
    <p>JH-XVI-178: potent CDK8/19 inhibitor with good pharmacokinetics, low clearance, moderate oral bioavailability.</p>
    Fórmula:C22H22ClN7O
    Forma y color:Solid
    Peso molecular:435.92

    Ref: TM-T40280

  • 3'-Deoxyuridine-5'-triphosphate trisodium
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    3'-Deoxyuridine-5'-triphosphate trisodium

    <p>3'-dUTP trisodium, a nucleotide analogue, inhibits RNA polymerases I/II and UTP integration into RNA (Ki=2.0 μM).</p>
    Fórmula:C9H12N2Na3O14P3
    Forma y color:Soild
    Peso molecular:534.08

    Ref: TM-T35658

  • 5'-O-DMT-PAC-dA
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    5'-O-DMT-PAC-dA

    CAS:
    <p>5’-O-DMT-PAC-dA can be used in the synthesis of oligoribonucleotides[1].</p>
    Fórmula:C39H37N5O7
    Forma y color:Solid
    Peso molecular:687.74

    Ref: TM-T37139

  • m7GpppCmpG
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    m7GpppCmpG

    CAS:
    <p>m7GpppCmpG, a trinucleotide cap analogue, enables RNA manufacturing with cap 0 or cap 1 structures.</p>
    Fórmula:C31H43N13O25P4
    Forma y color:Solid
    Peso molecular:1121.64

    Ref: TM-T74481

  • Phen-DC3 Trifluoromethanesulfonate
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    Phen-DC3 Trifluoromethanesulfonate

    CAS:
    <p>Phen-DC3 Trifluoromethanesulfonate targets G-quadruplexes and inhibits FANCJ/DinG helicases; IC50s: 65±6/50±10 nM.</p>
    Fórmula:C36H26F6N6O8S2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:848.75

    Ref: TM-T13817L

  • Heliquinomycin
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    Heliquinomycin

    CAS:
    <p>Heliquinomycin, a Streptomyces metabolite, inhibits DNA helicase (Ki=6.8 μM) and fights Gram-positive bacteria and various cancer cells.</p>
    Fórmula:C33H30O17
    Forma y color:Solid
    Peso molecular:698.586

    Ref: TM-T36748

  • (1S,3R,5R)-PIM447 dihydrochloride
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    (1S,3R,5R)-PIM447 dihydrochloride

    <p>(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).</p>
    Fórmula:C24H25Cl2F3N4O
    Pureza:98%
    Forma y color:Solid
    Peso molecular:513.38

    Ref: TM-T13425

  • Logo de CymitQuimica
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    UnyLinker 12 TEA

    <p>UnyLinker 12 TEA is a versatile linker used in the synthesis of oligoribonucleotides.</p>
    Fórmula:C39H35NO10C6H15N
    Forma y color:Solid
    Peso molecular:778.34655

    Ref: TM-TSW-00947

  • KWR137
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    KWR137

    <p>KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.</p>
    Fórmula:C33H31ClF3N9O4
    Forma y color:Solid
    Peso molecular:710.105

    Ref: TM-T205674

  • Chrysomycin A
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    Chrysomycin A

    CAS:
    <p>Chrysomycin A is an antibiotic that can be derived from Streptomyces.</p>
    Fórmula:C28H28O9
    Forma y color:Solid
    Peso molecular:508.52

    Ref: TM-T36467

  • MYC-IN-2
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    MYC-IN-2

    CAS:
    <p>MYC-IN-2 is a protein-protein inhibitor targeting the MYC protein, designed for use in cancer research.</p>
    Fórmula:C25H17N3O2S
    Forma y color:Solid
    Peso molecular:423.49

    Ref: TM-T39751

  • Logo de CymitQuimica
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    XT17

    <p>XT17 is an anthrone compound with broad-spectrum antibacterial activity, exerting its effects by disrupting the cell wall and inhibiting DNA synthesis. It demonstrates weak hemolytic activity, low cytotoxicity to mammalian cell lines, and a low rate of resistance development. Additionally, XT17 shows in vivo efficacy in a mouse corneal infection model induced by Staphylococcus aureus or Pseudomonas aeruginosa. Further docking studies confirm that XT17 forms a stable complex with bacterial gyrase. XT17 is suitable for research in the field of anti-infective agents.</p>
    Forma y color:Odour Solid

    Ref: TM-T206517

  • Logo de CymitQuimica
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    5-Aza-xylo-cytidine

    <p>5-Aza-xylo-cytidine, a purine analog with antitumor effects, inhibits DNA synthesis and induces apoptosis in lymphoid cancers.</p>
    Fórmula:C8H12N4O5
    Forma y color:Solid
    Peso molecular:244.2

    Ref: TM-T75220

  • JB300
    Targetmol
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    JB300

    CAS:
    <p>JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.</p>
    Fórmula:C43H45ClFN7O10S
    Forma y color:Solid
    Peso molecular:906.375

    Ref: TM-T204223

  • Gly-Arg-Gly-Asp-Ser
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    Gly-Arg-Gly-Asp-Ser

    CAS:
    <p>Gly-Arg-Gly-Asp-Ser (GRGDS) GRGDS is a cell binding protein domain derived from the cell-binding region of fibronectin.</p>
    Fórmula:C17H30N8O9
    Pureza:98%
    Forma y color:Solid
    Peso molecular:490.47

    Ref: TM-TP1459

  • 5'-O-TBDMS-dA
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    5'-O-TBDMS-dA

    CAS:
    <p>5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.</p>
    Fórmula:C16H27N5O3Si
    Forma y color:Solid
    Peso molecular:365.509

    Ref: TM-T37143

  • WAY-647802
    Targetmol
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    WAY-647802

    CAS:
    <p>WAY-647802 is a CDK inhibitor.</p>
    Fórmula:C11H14N4O3
    Pureza:99.53%
    Forma y color:Solid
    Peso molecular:250.25

    Ref: TM-T9971

  • Anticancer agent 263
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    Anticancer agent 263

    <p>Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.</p>
    Fórmula:C13H20N2O6
    Forma y color:Solid
    Peso molecular:300.308

    Ref: TM-T204102

  • Logo de CymitQuimica
    Targetmol
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    Obtustatin

    <p>Potent α1β1 integrin inhibitor, 0.8 nM IC50 for IV collagen binding. Selective over other integrins. Inhibits FGF2 angiogenesis; antitumor in mouse models.</p>
    Fórmula:C184H284N52O57S8
    Pureza:98%
    Forma y color:Solid
    Peso molecular:4393.07

    Ref: TM-TP1974

  • Fibronectin CS1 Peptide
    Targetmol
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    Fibronectin CS1 Peptide

    CAS:
    <p>Fibronectin CS1 peptide inhibits tumor metastasis, lacking RGD domain; may aid cancer therapy.</p>
    Fórmula:C38H64N8O15
    Pureza:98%
    Forma y color:Solid
    Peso molecular:872.96

    Ref: TM-TP1526