CymitQuimica logo
Ciclo celular / Checkpoint

Ciclo celular / Checkpoint

Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.

Subcategorías de "Ciclo celular / Checkpoint"

Mostrar 10 subcategorías más

Se han encontrado 3756 productos de "Ciclo celular / Checkpoint"

Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
productos por página.
  • Polθ-IN-5
    Targetmol
    + Info

    Polθ-IN-5

    CAS:
    Polθ-IN-5 (Compound 139) is an inhibitor of DNA polymerase theta (Polθ) that exhibits antitumor activity.
    Fórmula:C23H18ClF2N7O3S
    Forma y color:Solid
    Peso molecular:545.95

    Ref: TM-T200913

  • Dyrk1A-IN-4
    Targetmol
    + Info

    Dyrk1A-IN-4

    CAS:
    Dyrk1A-IN-4, compound 48, is an oral DYRK1A/DYRK2 inhibitor with IC50s: 2 nM (DYRK1A), 6 nM (DYRK2), anticancer properties.
    Fórmula:C14H13F3N6
    Forma y color:Solid
    Peso molecular:322.29

    Ref: TM-T60867

  • p38α inhibitor 9
    Targetmol
    + Info

    p38α inhibitor 9

    CAS:
    p38α inhibitor9 (Compound 2015) is a p38α inhibitor that effectively blocks the enzyme activity of p38α, with an IC50 of less than 20 nM. It inhibits MK2T334 phosphorylation and activates Cdc25b and Cdc25c while inactivating Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy, and DNA damage. Additionally, p38α inhibitor9 can suppress colorectal cancer (CRC) metastasis.
    Fórmula:C27H24FN3O3
    Forma y color:Solid
    Peso molecular:457.496

    Ref: TM-T206722

  • 7-Methylguanosine 5′-monophosphate
    Targetmol
    + Info

    7-Methylguanosine 5′-monophosphate

    CAS:
    7-Methylguanosine 5′-monophosphate (7-Methylguanylic acid) is a component of nucleic acids.
    Fórmula:C11H16N5O8P
    Forma y color:Solid
    Peso molecular:377.25

    Ref: TM-TSW-00951

  • Logo de CymitQuimica
    Targetmol
    + Info

    Antitumor agent-75

    Antitumor agent-75 is a novel and potent antitumor agent.
    Fórmula:C26H23FN6
    Forma y color:Solid
    Peso molecular:438.5

    Ref: TM-T62510

  • 12(S)-HETE
    Targetmol
    + Info

    12(S)-HETE

    CAS:
    <p>Enpatoran hydrochloride (M5049 hydrochloride) is a TLR7/8 inhibitor with antiviral activity that is used in the study of autoimmune diseases.</p>
    Fórmula:C20H32O3
    Forma y color:Solid
    Peso molecular:320.47

    Ref: TM-T37047

  • Valopicitabine dihydrochloride
    Targetmol
    + Info

    Valopicitabine dihydrochloride

    CAS:
    Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.
    Fórmula:C15H25ClN4O6
    Forma y color:Solid
    Peso molecular:392.84

    Ref: TM-T29094

  • EX05
    Targetmol
    + Info

    EX05

    CAS:
    EX05, an effective KIF18A inhibitor, exhibits an IC50 of 8.2 nM and holds potential for cancer research applications.
    Fórmula:C26H30F2N4O5S
    Forma y color:Solid
    Peso molecular:548.60

    Ref: TM-T88621

  • AM-9022
    Targetmol
    + Info

    AM-9022

    CAS:
    AM-9022 is a potent and selective KIF18A inhibitor, orally active and suitable for cancer research [1].
    Fórmula:C27H36F2N6O4S
    Forma y color:Solid
    Peso molecular:578.67

    Ref: TM-T85640

  • PD-L1-IN-7
    Targetmol
    + Info

    PD-L1-IN-7

    CAS:
    PD-L1-IN-7 (compound CB31) serves as a PD-L1 inhibitor, effectuating PD-L1 internalization and retention within cells. It restrains the PD-1/PD-L1 interaction (IC 50: 0.2 nM), alters glycosylation patterns, and facilitates PD-L1 degradation. Additionally, PD-L1-IN-7 enhances T cell infiltration, boosts T cell function, and augments the capacity to destroy tumor cells.
    Fórmula:C46H50N6O7
    Forma y color:Solid
    Peso molecular:798.93

    Ref: TM-T89952

  • Y-99
    Targetmol
    + Info

    Y-99

    CAS:
    Y-99 is a PORCN inhibitor with an IC50 value of 155.4 nM for suppressing the Wnt/β-catenin signaling pathway. Additionally, Y-99 inhibits the expression of p-LRP6, β-catenin, and c-Myc.
    Fórmula:C18H17F2N5O3
    Forma y color:Solid
    Peso molecular:389.36

    Ref: TM-T211259

  • GTSE1-IN-1
    Targetmol
    + Info

    GTSE1-IN-1

    CAS:
    GTSE1-IN-1 (compound Y18), an orally active GTSE1 inhibitor, exhibits notable anticancer properties. It effectively represses the proliferation of cancer cells by downregulating GTSE1 transcription and expression, which leads to DNA damage and promotes persistent cell cycle arrest and cellular senescence. Moreover, GTSE1-IN-1 substantially reduces the adhesion, migration, and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro.
    Fórmula:C21H24FN7
    Forma y color:Solid
    Peso molecular:393.46

    Ref: TM-T200127

  • Logo de CymitQuimica
    Targetmol
    + Info

    MtTMPK-IN-8

    MtTMPK-IN-8 inhibits MtbTMPK, has low cytotoxicity, shows 0.78-9.4 μM activity against Mycobacterium, useful for tuberculosis research.
    Fórmula:C24H24N6O7
    Forma y color:Solid
    Peso molecular:508.48

    Ref: TM-T63491

  • TY-011
    Targetmol
    + Info

    TY-011

    CAS:
    TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.
    Fórmula:C18H16ClN5
    Forma y color:Solid
    Peso molecular:337.81

    Ref: TM-T89833

  • NRTT-IN-1
    Targetmol
    + Info

    NRTT-IN-1

    CAS:
    NRTT-IN-1 (Compound 1) is an inhibitor of the nucleoside reverse transcriptase translocation (NRTT), effectively blocking HIV DNA synthesis and viral replication.
    Fórmula:C28H24FN5O5
    Forma y color:Solid
    Peso molecular:529.519

    Ref: TM-T205482

  • MY05
    Targetmol
    + Info

    MY05

    CAS:
    MY05 selectively targets c-MYC within cells and disrupts the interaction between MYC and MAX. It binds to intracellular c-MYC, modulating its thermal stability, reducing the transcriptional targets of c-MYC, and exhibiting anticancer activity (TNBC, triple-negative breast cancer).
    Fórmula:C19H11ClN4O
    Forma y color:Solid
    Peso molecular:346.77

    Ref: TM-T206537

  • Polθ-IN-7
    Targetmol
    + Info

    Polθ-IN-7

    CAS:
    <p>Polθ-IN-7 (example 12) is an inhibitor of DNA polymerase θ (Polθ) with a Ki of 1.27 nM.</p>
    Fórmula:C28H35F3N6O2
    Forma y color:Solid
    Peso molecular:544.612

    Ref: TM-T204135

  • Dyrk1A-IN-12
    Targetmol
    + Info

    Dyrk1A-IN-12

    CAS:
    <p>Dyrk1A-IN-12 (compound S43) is an inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A). It has an IC50 of 95 nM for inhibiting Dyrk1A. The compound demonstrates antiviral activity against EV-A71 (Enterovirus A71) with an EC50 of 4.4 μM, a CC50 of 12.8 μM, and a selectivity index (SI) of 2.9. Additionally, Dyrk1A-IN-12 exhibits potent inhibitory effects on the herpes simplex virus (HSV).</p>
    Fórmula:C22H16FN3O2S
    Forma y color:Solid
    Peso molecular:405.445

    Ref: TM-T205530

  • Logo de CymitQuimica
    Targetmol
    + Info

    DNA gyrase B-IN-1

    DNA gyrase B-IN-1, a potent inhibitor of P. aeruginosa DNA gyrase B, has IC50 of 2.2 μM with high affinity and stability.
    Fórmula:C23H18ClF3N6O4S
    Forma y color:Solid
    Peso molecular:566.94

    Ref: TM-T64012

  • CDK2 degrader 4
    Targetmol
    + Info

    CDK2 degrader 4

    CAS:
    CDK2 degrader4 (compound 104) is a potent degrader of CDK2, showing promise for cancer research applications.
    Fórmula:C23H26ClN3O5
    Forma y color:Solid
    Peso molecular:459.923

    Ref: TM-T204856