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Ciclo celular / Checkpoint

Ciclo celular / Checkpoint

Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.

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Se han encontrado 3756 productos de "Ciclo celular / Checkpoint"

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  • 2'-(2-Nitrobenzyl)-ATP
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    2'-(2-Nitrobenzyl)-ATP

    CAS:
    2'-(2-Nitrobenzyl)-ATP is an analog of rATP. It acts as a transcription terminator by inhibiting the elongation of RNA chains by T7 RNA polymerase.
    Fórmula:C17H21N6O15P3
    Forma y color:Solid
    Peso molecular:642.30

    Ref: TM-T207643

  • Ladirubicin
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    Ladirubicin

    CAS:
    Ladirubicin, as an anthracyclines analog is the leading compound of alkylcyclines.
    Fórmula:C29H31NO11S
    Forma y color:Solid
    Peso molecular:601.62

    Ref: TM-T32534

  • CDK9-IN-11
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    CDK9-IN-11

    CAS:
    CDK9-IN-11 is a potent CDK9 inhibitor that is the ligand for the PROTAC CDK9 Degrader-1 [1].
    Fórmula:C20H25N3O4
    Pureza:98%
    Forma y color:Solid
    Peso molecular:371.43

    Ref: TM-T10743

  • PT109
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    PT109

    CAS:
    PT109 is a multikinase inhibitor that targets JNK and other kinases, playing a crucial role in anti-inflammatory, antioxidative, neurogenic, and synaptogenic processes. Specifically, PT109 inhibits JNK isoforms with the following IC50 values: JNK1 at 0.143 μM, JNK2 at 0.831 μM, and JNK3 at 0.285 μM. It also inhibits SGK isoforms (SGK1: IC50=1.34 μM; SGK2: IC50=5.6 μM; SGK3: IC50=26.4 μM) and ROCK2 (IC50=34 μM). Additionally, PT109 reprograms polymorphic glioblastoma multiforme (GBM) into oligodendroglia via the PTBP1/PKM1/2 pathway and alters the metabolic pattern of GBM to exhibit antiglioma activity.
    Fórmula:C23H31N3OS2
    Forma y color:Solid
    Peso molecular:429.64

    Ref: TM-T201273

  • Logo de CymitQuimica
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    CDK1-IN-4

    CDK1-IN-4 inhibits CDK1 (IC50: 44.52 nM), CDK2/CDK5 less potently, impacts cell cycle, used in cancer studies.
    Fórmula:C26H24ClN5S
    Forma y color:Solid
    Peso molecular:474.02

    Ref: TM-T63080

  • UMPK ligand 1
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    UMPK ligand 1

    CAS:
    <p>UMPK ligand 1 (ZINC07785412) serves as a ligand for uridine monophosphate kinase (UMPK).</p>
    Fórmula:C15H22N4O5S
    Forma y color:Solid
    Peso molecular:370.424

    Ref: TM-T204579

  • NSC 641396
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    NSC 641396

    CAS:
    NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC50 value of 1.2 μM. Additionally, it acts as an inhibitor of protein arginine N-methyltransferase 9 (PRMT9) and exhibits antitumor properties.
    Fórmula:C18H13NO3
    Forma y color:Solid
    Peso molecular:291.301

    Ref: TM-T204449

  • 8-Oxo-dATP
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    8-Oxo-dATP

    CAS:
    8-Oxo-dATP can be hydrolyzed to its monophosphate form by the oxidation of purine nucleoside triphosphate MTH1, preventing erroneous incorporation during DNA replication or transcription.
    Fórmula:C10H12Li4N5O13P3
    Forma y color:Solid
    Peso molecular:530.913

    Ref: TM-T206632

  • AR-13324 M1 metabolite
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    AR-13324 M1 metabolite

    CAS:
    <p>AR-13324 M1 metabolite is a hydrolysis metabolite of AR-13324 mesylate.</p>
    Fórmula:C19H19N3O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:321.37

    Ref: TM-T10358L

  • Logo de CymitQuimica
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    CDK8-IN-11 hydrochloride

    CDK8-IN-11 HCl: potent, selective CDK8 inhibitor (IC50: 46 nM), blocks WNT/β-catenin pathway, used in colon cancer research.
    Fórmula:C19H16ClF3N4O2
    Forma y color:Solid
    Peso molecular:424.8

    Ref: TM-T62293

  • Xanthosine-5'-Triphosphate trisodium
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    Xanthosine-5'-Triphosphate trisodium

    CAS:
    <p>Xanthosine-5'-Triphosphate (5'-XTP) trisodium is a nucleotide formed through the deamination of purine bases. It serves as a substrate for inosine triphosphate pyrophosphatase (ITPase).</p>
    Fórmula:C10H12N4Na3O15P3
    Forma y color:Solid
    Peso molecular:590.111

    Ref: TM-TXB-00592

  • Cimpuciclib tosylate
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    Cimpuciclib tosylate

    CAS:
    Cimpuciclib tosylate, a selective CDK4 inhibitor (IC50: 0.49 nM), exhibits anti-tumor activity.
    Fórmula:C37H43FN8O4S
    Forma y color:Solid
    Peso molecular:714.85

    Ref: TM-T72433

  • Logo de CymitQuimica
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    14α-Demethylase/DNA Gyrase-IN-1

    14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.
    Fórmula:C26H22N4O4
    Forma y color:Solid
    Peso molecular:454.48

    Ref: TM-T62792

  • (R)-CSN5i-3
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    (R)-CSN5i-3

    CAS:
    (R)-CSN5i-3 is CSN5i-3 of the R configuration.
    Fórmula:C28H29F2N5O2
    Pureza:99.76% - 99.97%
    Forma y color:Solid
    Peso molecular:505.56

    Ref: TM-T12620

  • Valopicitabine
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    Valopicitabine

    CAS:
    <p>Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic</p>
    Fórmula:C15H24N4O6
    Pureza:98%
    Forma y color:Solid
    Peso molecular:356.37

    Ref: TM-T13281

  • GHP-88309
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    GHP-88309

    CAS:
    <p>GHP-88309 is an orally active, broad-spectrum anti-paramyxovirus agent that targets viral polymerase, interrupting viral RNA synthesis. It effectively inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with an EC50 of 0.06-1.2 μM. In mouse models, GHP-88309 demonstrates significant anti-infective activity.</p>
    Fórmula:C16H11FN2O
    Forma y color:Solid
    Peso molecular:266.27

    Ref: TM-T204819

  • Mps1-IN-8
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    Mps1-IN-8

    CAS:
    Mps1-IN-8, a Mps1 inhibitor, can be utilized in the study of various tumors [1].
    Fórmula:C35H47N8O6P
    Forma y color:Solid
    Peso molecular:706.77

    Ref: TM-T86927

  • Metesind Glucuronate
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    Metesind Glucuronate

    CAS:
    Metesind Glucuronate is an antineoplastic. It also is a specific thymidylate synthase inhibitor.
    Fórmula:C29H34N4O10S
    Forma y color:Solid
    Peso molecular:630.67

    Ref: TM-T24454

  • Aurora inhibitor 1
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    Aurora inhibitor 1

    CAS:
    Aurora inhibitor 1 is a potent Aurora inhibitor (IC50: ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase).
    Fórmula:C23H25N9S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:459.57

    Ref: TM-T10412

  • PAIR2
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    PAIR2

    CAS:
    PAIR2 is a selective IRE1α RNase partial antagonist, blocking its ATP site and preventing KIRA from hindering XBP1 splicing.
    Fórmula:C27H26F4N6O3S
    Forma y color:Solid
    Peso molecular:590.59

    Ref: TM-T64183