Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(94 productos)
- CDK(500 productos)
- Detención del ciclo celular(4 productos)
- Chk(42 productos)
- DYRK(48 productos)
- Dynamin(23 productos)
- Ferroptosis(215 productos)
- HSP(169 productos)
- Integrin(224 productos)
- Kinesina(66 productos)
- LIM quinasa(19 productos)
- Asociado a microtúbulos(261 productos)
- PKC(102 productos)
- PLK(28 productos)
- ROCK(70 productos)
- Rho(2 productos)
- Wee1(15 productos)
- c-Myc(69 productos)
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Se han encontrado 3477 productos de "Ciclo celular / Checkpoint"
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TC113
<p>TC113, a c(RGDyK)-linked Gemcitabine, targets αvβ3 integrin, entering A549 cells, and inhibits WM266.4 and A549 cell growth.</p>Fórmula:C37H50F2N12O13Forma y color:SolidPeso molecular:908.86CDK2/PIM1-IN-1
<p>CDK2/PIM1-IN-1 is an inhibitor of the kinases CDK2 (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM). It can induce apoptosis (cell death) and reduce the expression of TNF-α, which promotes tumors. CDK2/PIM1-IN-1 exhibits antitumor activity.</p>Forma y color:Odour Solid(+)-Glaucarubinone
<p>(+)-Glaucarubinone is a natural product that can be used as a reference standard.</p>Fórmula:C25H34O10Forma y color:SolidPeso molecular:494.537Rev 2'-O-MOE-A(Bz)-5'-amidite
<p>'Rev 2’-O-MOE-A(Bz)-5’-amidite is a nucleoside analog specifically categorized within the purine subset, renowned for its wide-ranging antitumor efficacy</p>Fórmula:C50H58N7O9PForma y color:SolidPeso molecular:932.013'-β-C-Ethynyl-4-deoxyuridine
<p>3’-Beta-C-Ethynyl-4-deoxyuridine is a purine nucleoside analog.</p>Fórmula:C11H12N2O5Forma y color:SolidPeso molecular:252.22cis-Lomibuvir
CAS:<p>cis-Lomibuvir (cis-VX-222) is a selective HCV NS5B RdRp inhibitor with a Kd of 17 nM and an EC50 of 5.2 nM, targeting thumb pocket 2.</p>Fórmula:C25H35NO4SForma y color:SolidPeso molecular:445.615'-DMTr-3'dA(Bz)-methylphosphonami dite
<p>5’-DMTr-3’dA(Bz)-methylphosphonamidite, a purine nucleoside analog, exhibits wide-ranging antitumor activity, specifically targeting indolent lymphoid</p>Fórmula:C45H51N6O6PForma y color:SolidPeso molecular:802.9NUAK1-IN-2
<p>NUAK1-IN-2 (Compound 24) is an inhibitor of NUAK1 with an IC50 of 3.162 nM, as well as an inhibitor of CDK2/4/6. It is applicable in research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.</p>Fórmula:C24H30N6OForma y color:SolidPeso molecular:418.535IV-361
CAS:<p>IV-361, an orally active and selective CDK7 inhibitor with a Ki value of less than or equal to 50 nM, demonstrates potent anti-cancer activity (US20190256531A1</p>Fórmula:C23H32FN5O2SiForma y color:SolidPeso molecular:457.625Remdesivir nucleoside monophosphate
CAS:<p>Remdesivir metabolite, antiviral nucleoside analog, effective against SARS-CoV and MERS-CoV.</p>Fórmula:C12H14N5O7PForma y color:SolidPeso molecular:371.24Etrolizumab
CAS:<p>MEDI-578 is a CHO-expressed humanized monoclonal antibody targeting NGF/bNGF for the study of neurological and immune system disorders.</p>Pureza:98.9% (SDS-PAGE); 96.6% (SEC-HPLC) - 98.9% (SDS-PAGE); 96.6% (SEC-HPLC)Forma y color:LiquidBIO5192 hydrate
<p>BIO5192 hydrate: potent α4β1 inhibitor, binds selectively (Kd<10 pM, IC50=1.8 nM), boosts murine HSPC mobilization 30x.</p>Forma y color:SolidEmicoron
CAS:<p>Importazole is an inhibitor of the transport receptor importin-β. It specifically inhibits importin-β likely by altering its interaction with RanGTP.</p>Fórmula:C52H58N6O4Pureza:98%Forma y color:SolidPeso molecular:831.056-Mthoxy-9-β-D-(2-C-ethynyl-ribofuranosyl) purine
<p>6-Methoxy-9-β-D-ethynyl-purine: a purine analog with antitumor action, impeding DNA synthesis and inducing apoptosis.</p>Fórmula:C13H14N4O5Forma y color:SolidPeso molecular:306.272'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
CAS:<p>dGMP is a substrate for DNA synthesis, phosphorylated to dGDP and dGTP, and linked to mitochondrial DNA depletion syndrome in humans.</p>Fórmula:C10H14N5Na2O8PForma y color:SolidPeso molecular:409.202Chk1-IN-6
CAS:<p>Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.</p>Fórmula:C16H18F3N7Forma y color:SolidPeso molecular:365.364Clofarabine-5'-triphosphate
CAS:<p>Clofarabine-5'-triphosphate is a metabolite of Clofarabine, produced via phosphorylation by deoxycytidine kinase (dCK). It exhibits cytotoxicity in cancer cells by inhibiting DNA synthesis and DNA repair.</p>Fórmula:C10H14ClFN5O12P3Forma y color:SolidPeso molecular:543.62PD-1/PD-L1-IN-9
CAS:<p>PD-1/PD-L1-IN-9, with an IC50 of 3.8 nM, is a potent and orally active inhibitor of the PD-1/PD-L1 interaction.</p>Fórmula:C22H24N2O2Pureza:99.92%Forma y color:SolidPeso molecular:348.44PROTAC MTP3 degrade-1
<p>PROTACMTP3 degrade-1 is a PROTAC degrader for MYC.</p>Fórmula:C44H38N6O8Forma y color:SolidPeso molecular:778.27511Nitrosofolic acid
CAS:<p>Nitrosofolic acid is a folic acid derivaive.</p>Fórmula:C19H18N8O7Forma y color:SolidPeso molecular:470.40
