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Ciclo celular / Checkpoint

Ciclo celular / Checkpoint

Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.

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Se han encontrado 3477 productos de "Ciclo celular / Checkpoint"

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  • Logo de CymitQuimica
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    N4-Benzoyl-3'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine

    <p>N4-Benzoyl-3'-O-DMT cytidine analog inhibits DNA methyltransferases like Zebularine.</p>
    Fórmula:C41H43N3O9
    Forma y color:Solid
    Peso molecular:721.79

    Ref: TM-T75224

  • Lys-Gln-Ala-Gly-Asp-Val
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    Lys-Gln-Ala-Gly-Asp-Val

    CAS:
    <p>KQAGDV is a fibrinogen γ-chain cell adhesion peptide, targeting α2bβ3 integrin, and binds SMCs.</p>
    Fórmula:C25H44N8O10
    Forma y color:Solid
    Peso molecular:616.66

    Ref: TM-T76376

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    DHFR-IN-11

    <p>DHFR-IN-11 (compound 6b) is a DHFR inhibitor with demonstrated inhibitory efficacy against the M.</p>
    Forma y color:Odour Solid

    Ref: TM-T82570

  • Erythromycin thiocyanate
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    Erythromycin thiocyanate

    CAS:
    <p>Erythromycin thiocyanate, a macrolide from Streptomyces erythreus, binds 50S ribosomes, halting protein synthesis in bacteria.</p>
    Fórmula:C38H68N2O13S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:793.02

    Ref: TM-T11233

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    Zimistobart

    CAS:
    <p>Zimistobart (BMS-986315) is a fully human IgG1 antibody that targets and binds to NKG2A. It is applicable in research for non-small cell lung cancer (NSCLC). For an isotype control, refer to HumanIgG1kappa, Isotype Control.</p>
    Forma y color:Liquid

    Ref: TM-T9901A-767

  • Lysidine
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    Lysidine

    CAS:
    <p>Lysidine (2-Methyl-2-iMidazoline) is a nucleoside rarely seen outside of tRNA. Lysidine has better translation fidelity.</p>
    Fórmula:C4H8N2
    Pureza:98%
    Forma y color:Light Yellow To Off-White Crystalline
    Peso molecular:84.12

    Ref: TM-T21052

  • Fuzapladib
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    Fuzapladib

    CAS:
    <p>Fuzapladib (IS-741) is a PLA2 inhibitor that reduces Mac-1 expression to prevent inflammation and pancreatitis.</p>
    Fórmula:C15H20F3N3O3S
    Pureza:99.87%
    Forma y color:Soild
    Peso molecular:379.4

    Ref: TM-T67749

  • PROTAC CDK9 degrader-2
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    PROTAC CDK9 degrader-2

    CAS:
    <p>PROTAC CDK9 degrader-2, potent, selective, IC50 17 μM in MCF-7, wogonin-derived, targets CRBN.</p>
    Fórmula:C39H36N6O10
    Pureza:98%
    Forma y color:Solid
    Peso molecular:748.74

    Ref: TM-T17728

  • NUAK1-IN-1
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    NUAK1-IN-1

    <p>NUAK1-IN-1 (Compound 9) is an inhibitor of NUAK1 with an IC50 of 5.012 nM, as well as a CDK4 inhibitor. It is suitable for research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.</p>
    Fórmula:C25H30N6O
    Forma y color:Solid
    Peso molecular:430.545

    Ref: TM-T205625

  • CGP-74514
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    CGP-74514

    CAS:
    <p>CGP-74514,CDK1 inhibitor (IC50=25 nM). Induces G2/M arrest, apoptosis. Used in bladder cancer research.</p>
    Fórmula:C19H24ClN7
    Pureza:98.54%
    Forma y color:Soild
    Peso molecular:385.89

    Ref: TM-T206046

  • EC0488
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    EC0488

    CAS:
    <p>EC0488 was used to synthesize EC0531, which has folic acid receptor specificity and anti-tumor activity.</p>
    Fórmula:C65H98N16O34S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:1679.63

    Ref: TM-T11144

  • Logo de CymitQuimica
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    Nocarnickelamides B

    <p>Nocarnickelamides B (Compound 2) is a linear peptide and an inhibitor of ROCK1/2. It exhibits dual inhibitory activity against ROCK1 and ROCK2, with IC50 values of 14.9 μM and 21.9 μM, respectively. This compound binds to the ATP binding site and inhibits ROCK-mediated cytoskeletal contraction markers, such as myosin light chain activation. Nocarnickelamides B can be utilized in glaucoma research.</p>
    Fórmula:C29H42N6O9
    Forma y color:Odour Solid
    Peso molecular:618.68

    Ref: TM-TN9153

  • Bz-rC Phosphoramidite
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    Bz-rC Phosphoramidite

    CAS:
    <p>Bz-rC Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.</p>
    Fórmula:C52H66N5O9PSi
    Forma y color:Solid
    Peso molecular:964.185

    Ref: TM-T38566

  • m7GpppCpG
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    m7GpppCpG

    CAS:
    <p>m7GpppCpG, a trinucleotide cap analogue, is used for synthesizing RNA with cap 0 or cap 1 structures.</p>
    Fórmula:C30H41N13O25P4
    Forma y color:Solid
    Peso molecular:1107.61

    Ref: TM-T74480

  • Rachelmycin
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    Rachelmycin

    CAS:
    <p>Rachelmycin, a potent antibiotic and antitumor agent from Streptomyces zelensis, binds to DNA's minor groove.</p>
    Fórmula:C37H33N7O8
    Forma y color:Solid
    Peso molecular:703.712

    Ref: TM-T40810

  • Logo de CymitQuimica
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    XT17

    <p>XT17 is an anthrone compound with broad-spectrum antibacterial activity, exerting its effects by disrupting the cell wall and inhibiting DNA synthesis. It demonstrates weak hemolytic activity, low cytotoxicity to mammalian cell lines, and a low rate of resistance development. Additionally, XT17 shows in vivo efficacy in a mouse corneal infection model induced by Staphylococcus aureus or Pseudomonas aeruginosa. Further docking studies confirm that XT17 forms a stable complex with bacterial gyrase. XT17 is suitable for research in the field of anti-infective agents.</p>
    Forma y color:Odour Solid

    Ref: TM-T206517

  • Nitrosofolic acid
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    Nitrosofolic acid

    CAS:
    <p>Nitrosofolic acid is a folic acid derivaive.</p>
    Fórmula:C19H18N8O7
    Forma y color:Solid
    Peso molecular:470.40

    Ref: TM-T33691

  • CDK12-IN-2
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    CDK12-IN-2

    CAS:
    <p>CDK12-IN-2 selectively inhibits CDK12 (IC50: 52 nM) with minimal effect on CDK2, CDK7, and CDK9, useful for CDK12 research.</p>
    Fórmula:C32H32N6O2
    Pureza:99.31%
    Forma y color:Solid
    Peso molecular:532.64

    Ref: TM-T39752

  • Carboxy-pyridostatin
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    Carboxy-pyridostatin

    CAS:
    <p>Carboxy-pyridostatin, as a fluorescent probe, can target G-quadruplex structures and trap cytoplasmic RNA G-quadruplex structures in cells.</p>
    Fórmula:C35H34N10O7
    Forma y color:Solid
    Peso molecular:706.71

    Ref: TM-T30745

  • Psammaplin A
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    Psammaplin A

    CAS:
    <p>Psammaplin A: marine-derived, inhibits HDAC/DNA methyltransferases, strong DAC1 blocker (IC50=0.9nM), antimicrobial against Gram-positive bacteria, anticancer.</p>
    Fórmula:C22H24Br2N4O6S2
    Forma y color:Solid
    Peso molecular:664.38

    Ref: TM-T36303