Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(114 productos)
- CDK(546 productos)
- Detención del ciclo celular(5 productos)
- Chk(48 productos)
- DYRK(47 productos)
- Dynamin(27 productos)
- Ferroptosis(227 productos)
- HSP(180 productos)
- Integrin(269 productos)
- Kinesina(87 productos)
- LIM quinasa(20 productos)
- Asociado a microtúbulos(274 productos)
- PKC(126 productos)
- PLK(25 productos)
- ROCK(62 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(76 productos)
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Se han encontrado 3904 productos de "Ciclo celular / Checkpoint"
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AB-3PRGD2
CAS:AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.
Fórmula:C137H215IN30O45SForma y color:SolidPeso molecular:3161.32TLR7 agonist 12
CAS:TLR7 agonist 12, a purine nucleoside analog, inhibits DNA synthesis and induces apoptosis in lymphoid cancers.Fórmula:C14H19N5O8Forma y color:SolidPeso molecular:385.33Rifalazil
CAS:Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity, useful for research on chlamydia infections.Fórmula:C51H64N4O13Pureza:98%Forma y color:SolidPeso molecular:941.07Xanthosine-5'-Triphosphate
CAS:Xanthosine-5'-Triphosphate (5'-XTP), a nucleotide derived from the deamination of purine bases, plays a crucial role in various biological processes.Fórmula:C10H15N4O15P3Forma y color:SolidPeso molecular:524.164Ascochlorin A
CAS:Ascochlorin A, a compound with a dissociation constant (K D) of 3.29 μM, serves as a novel and potent human dihydroorotate dehydrogenase (hDHODH) inhibitorFórmula:C23H31ClO4Forma y color:SolidPeso molecular:406.95c-Myc inhibitor 10
CAS:c-Myc inhibitor 10 enhances cell potency with improved permeability from methylated morpholine nitrogen.Fórmula:C28H38N6O3Forma y color:SolidPeso molecular:506.64αVβ8-IN-1
CAS:αVβ8-IN-1 is an αVβ8 integrin inhibitor that suppresses the growth of multiple tumour cell lines (EMT6, CT26, KPC, TKCC-10).Fórmula:C25H32ClN5O4Forma y color:SolidPeso molecular:502.015'-O-DMTr-2',2'-difluoro-dC(Bz)-methyl phosphonamidite
5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog with extensive antitumor activity against indolent lymphoid malignancies.Fórmula:C44H49F2N4O7PForma y color:SolidPeso molecular:814.85Ceftriaxone
CAS:Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.Fórmula:C18H18N8O7S3Pureza:96.08%Forma y color:SolidPeso molecular:554.58Ac-MRGDH-NH2
Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.Fórmula:C25H41N11O8SForma y color:SolidPeso molecular:655.727Sarecycline hydrochloride
CAS:Sarecycline hydrochloride is a narrow-spectrum tetracycline antibiotic with antimicrobial and anti-inflammatory activity.Fórmula:C24H30ClN3O8Pureza:99.23%Forma y color:SolidPeso molecular:523.96Nusinersen
CAS:Nusinersen (nusinersen) is a antisense oligonucleotide (ASO) for the treatment of pediatric and adult spinal muscular atrophy (SMA) and increases SMN proteinss.Pureza:98.62%Forma y color:Solid2'-Deoxy-2'-fluoro-N3-[(pyrid-4-yl)methyl]uridine
2’-Deoxy-2’-fluoro-N3-[(pyrid-4-yl)methyl]uridine is a purine nucleoside analog widely known for its antitumor activity, particularly against indolent lymphoidFórmula:C15H16FN3O5Forma y color:SolidPeso molecular:337.3EFdA-TP
CAS:EFdA-TP: potent HIV-1 RT inhibitor; acts via immediate/delayed chain termination (ICT/DCT) and multiple pathways.Fórmula:C12H15FN5O12P3Forma y color:SolidPeso molecular:533.195HDAC-IN-85
HDAC-IN-85 (Compound 1) is an HDAC inhibitor capable of crossing the blood-brain barrier. It exhibits inhibitory effects on brain tumor cell lines and can induce acetylation, resulting in DNA double-strand breaks and promoting RAD51 ubiquitination, which disrupts the DNA repair process. HDAC-IN-85 is applicable in studies of glioblastoma.Fórmula:C24H27FN4O5Forma y color:SolidPeso molecular:470.492'-(2-Nitrobenzyl)-ATP trisodium
2'-(2-Nitrobenzyl)-ATP trisodium is an rATP analogue that acts as a transcription terminator. It inhibits T7 RNA polymerase from continuing RNA chain extension.Fórmula:C17H18N6Na3O15P3Forma y color:SolidPeso molecular:707.97361IV-361
CAS:IV-361, an orally active and selective CDK7 inhibitor with a Ki value of less than or equal to 50 nM, demonstrates potent anti-cancer activity (US20190256531A1Fórmula:C23H32FN5O2SiForma y color:SolidPeso molecular:457.625CBP-501 acetate
CBP-501 acetate is a cell-permeable calmodulin-binding peptide and a candidate G2 phase checkpoint abrogator. It inhibits several Ser216-specific kinases, including MAPKAP-K2, C-Tak1, CHK1, and CHK2, with IC50 values of 0.9 μM, 1.4 μM, 3.4 μM, and 6.5 μM, respectively. CBP-501 acetate is applicable to various cancer research studies.Forma y color:Odour SolidCDK7-IN-1
CAS:CDK7-IN-1, analog of YKL-5-124, inhibits cdk7 with IC50 < 100 nM.Fórmula:C28H35N7O3Forma y color:SolidPeso molecular:517.634TMX-2138
CAS:TMX-2138 is a CDKs PROTAC degrader, with IC50 values of 8.7 nM for CDK1/cyclinB, 10.9 nM for CDK2/cyclinA, 7.0 nM for CDK5/p25, and 25.7 nM for CDK9/cyclinT1. It enhances the ubiquitination and degradation of CDKs and is utilized for ovarian cancer research.Fórmula:C40H43BrFN9O11SForma y color:SolidPeso molecular:956.791
