Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(116 productos)
- CDK(547 productos)
- Detención del ciclo celular(5 productos)
- Chk(48 productos)
- DYRK(46 productos)
- Dynamin(27 productos)
- Ferroptosis(233 productos)
- HSP(180 productos)
- Integrin(276 productos)
- Kinesina(87 productos)
- LIM quinasa(21 productos)
- Asociado a microtúbulos(273 productos)
- PKC(128 productos)
- PLK(25 productos)
- ROCK(61 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(77 productos)
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Se han encontrado 3934 productos de "Ciclo celular / Checkpoint"
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PROTAC CDK9 degrader-11
CAS:PROTAC CDK9 degrader-11 (Compound C3) is an orally active PROTAC CDK9 degrader with a DC50 of 1.09 nM. This compound exhibits cytotoxicity in small cell lung cancer (SCLC) cells, with IC50 values in the nanomolar range. It induces cell cycle arrest at the G0/G1 phase and inhibits cell invasion in DMS114 and DMS53 cells. In addition, PROTAC CDK9 degrader-11 shows antitumor activity in an NCI-H446 xenograft mouse model. (Pink: ligand for target protein CDK9 ligand 3; Black: linker; Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56)Fórmula:C39H48Cl2N10O5Forma y color:SolidPeso molecular:807.7682'-Deoxy-2'-fluoro-N3-(n-dodecyl)uridine
2’-Deoxy-2’-fluoro-N3-(n-dodecyl)uridine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Fórmula:C21H35FN2O5Forma y color:SolidPeso molecular:414.51ROCK-IN-32
CAS:ROCK-IN-32 is an effective Rho-kinase inhibitor.Fórmula:C20H17Cl2N3O2Pureza:98%Forma y color:SolidPeso molecular:402.27DSPE-PEG5000-cRGD
DSPE-PEG5000-cRGD is a PEG compound composed of DSPE and an αvβ3 targeting peptide (cRGD). The cRGD peptide has the ability to specifically bind to the αvβ3 present on the surfaces of numerous cancer cells and new vascular cells. DSPE-PEG5000-cRGD is useful for drug delivery applications.Forma y color:Odour Solid8β,9α-Dihydroxylindan-4(5),7(11)-dien-8α,12-olide
CAS:8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, exhibits anti-LIMK1 activity and inhibits cell motility [1].Fórmula:C15H18O4Forma y color:SolidPeso molecular:262.38-Chloro-2'-O-methyl inosine
8-Chloro-2’-O-methyl inosine, a purine nucleoside analog, exhibits broad antitumor activity against indolent lymphoid malignancies.Fórmula:C11H13ClN4O5Forma y color:SolidPeso molecular:316.7N1-Methylxylo-guanosine
N1-Methylxylo-guanosine, a purine analog, targets lymphoid cancer via DNA synthesis inhibition and apoptosis.Fórmula:C11H15N5O5Forma y color:SolidPeso molecular:297.275'-O-DMT-rU
CAS:5’-O-DMT-rU is a modified nucleoside and can be used to synthesize RNA.Fórmula:C30H30N2O8Forma y color:SolidPeso molecular:546.57m7GpppCmpG
CAS:m7GpppCmpG, a trinucleotide cap analogue, enables RNA manufacturing with cap 0 or cap 1 structures.Fórmula:C31H43N13O25P4Forma y color:SolidPeso molecular:1121.64GS-443902
CAS:Remdesivir triphosphate (GS-443902) inhibits RSV/HCV RdRp with IC50s: 1.1/5 µM.Fórmula:C12H16N5O13P3Pureza:98%Forma y color:SolidPeso molecular:531.2Clofarabine-5'-diphosphate trisodium
Clofarabine-5'-diphosphatetrisodium (Clofarabine-DP trisodium) is the sodium salt form of Clofarabine-5'-diphosphate. As a metabolic product of Clofarabine, it results from phosphorylation by deoxycytidine kinase (dCK). Clofarabine-5'-diphosphate trisodium can undergo further phosphorylation to form Clofarabine-5'-triphosphate, demonstrating cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.Fórmula:C10H10ClFN5Na3O9P2Forma y color:SolidPeso molecular:529.58C16Y
CAS:C16Y, a short peptide, serves as an inhibitor for the integrins αvβ3 and α5β1. It targets the cell membrane and exerts its antitumor activity by inhibiting angiogenesis.Fórmula:C78H115N17O17Forma y color:SolidPeso molecular:1562.853-Cyanovinyl-9-(5'-O-DMT-2'-deoxyribofuranosyl)carbazole
3-Cyanovinyl-9-(5'-O-DMT-2'-deoxyribofuranosyl)carbazole, a purine nucleoside analog, demonstrates extensive antitumor activity, particularly against indolentFórmula:C41H36N2O5Forma y color:SolidPeso molecular:636.73m7GpppGmpG
CAS:m7GpppGmpG, a trinucleotide 5′ cap analog, exhibits capping efficiencies of 86% for the RNAs obtained [1].Fórmula:C32H43N15O25P4Forma y color:SolidPeso molecular:1161.665'-O-DMTr-2'-O-MOE inosine 3'-P-methyl phosphonamidite
5’-O-DMTr-2’-O-MOE inosine 3’-P-methyl phosphonamidite, a purine nucleoside analog, exhibits extensive antitumor activity specific to indolent lymphoidFórmula:C41H52N5O8PForma y color:SolidPeso molecular:773.85FF-10502
CAS:FF-10502, a pyrimidine analog of Gemcitabine, inhibits DNA polymerases α/β, targeting dormant cancer cells.Fórmula:C9H12FN3O3SForma y color:SolidPeso molecular:261.27NUAK1-IN-2
NUAK1-IN-2 (Compound 24) is an inhibitor of NUAK1 with an IC50 of 3.162 nM, as well as an inhibitor of CDK2/4/6. It is applicable in research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.Fórmula:C24H30N6OForma y color:SolidPeso molecular:418.535RNA splicing modulator 1
CAS:RNA Splicing Modulator 1 (Compound 233) is a modulator of RNA splicing, exhibiting an AC50 value of less than 100 nM [1].Fórmula:C19H20N6OSForma y color:SolidPeso molecular:380.47CHK1-IN-12
CHK1-IN-12 (Compound example 1-5) is a highly selective and orally active checkpoint kinase 1 (CHK1) inhibitor, demonstrating an in vitro enzyme IC50 of ≤10 nM and a cellular IC50 of ≤50 nM. This compound suppresses the phosphorylation activity of CHK1 kinase, disrupts DNA damage response pathways, and induces tumor cell cycle arrest and apoptosis. CHK1-IN-12 shows promise for cancer research applications.Fórmula:C19H19N7O2Forma y color:SolidPeso molecular:377.160025-Azacytidine 5′-triphosphate sodium
5-Azacytidine 5'-triphosphate sodium, a cytidine analog, selectively inhibits the incorporation of [3 H]CTP into RNA by DNA-dependent RNA polymerase, withoutForma y color:Odour Solid
