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Ciclo celular / Checkpoint

Ciclo celular / Checkpoint

Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.

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Se han encontrado 3477 productos de "Ciclo celular / Checkpoint"

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  • Isocytosine
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    Isocytosine

    CAS:
    <p>Compound PDK0016, with CAS No. 108-53-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0016 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>
    Fórmula:C4H5N3O
    Forma y color:White To Off-White Solid
    Peso molecular:111.1

    Ref: TM-PDK0016

  • Ac-MRGDH-NH2
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    Ac-MRGDH-NH2

    <p>Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.</p>
    Fórmula:C25H41N11O8S
    Forma y color:Solid
    Peso molecular:655.727

    Ref: TM-TP3057

  • Ac-dA Phosphoramidite
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    Ac-dA Phosphoramidite

    CAS:
    <p>Ac-dA Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.</p>
    Fórmula:C42H50N7O7P
    Forma y color:Solid
    Peso molecular:795.878

    Ref: TM-T38425

  • CDK6/9-IN-1
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    CDK6/9-IN-1

    CAS:
    <p>CDK6/9-IN-1, an oral dual inhibitor of CDK6/9, has IC50s of 40.5nM (CDK6) and 39.5nM (CDK9).</p>
    Fórmula:C22H25ClN8O
    Forma y color:Solid
    Peso molecular:452.95

    Ref: TM-T40047

  • 5'-O-DMT-ibu-dC
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    5'-O-DMT-ibu-dC

    CAS:
    <p>5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.</p>
    Fórmula:C34H37N3O7
    Forma y color:Solid
    Peso molecular:599.67

    Ref: TM-T38405

  • Logo de CymitQuimica
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    5-Methylcytidine 5′-triphosphate trisodium

    <p>5-Methylcytidine 5′-triphosphate trisodium (5-Methyl-CTP trisodium), a modified nucleoside triphosphate, enhances translational properties and stability, while</p>
    Fórmula:C10H15N3Na3O14P3
    Forma y color:Solid
    Peso molecular:563.13

    Ref: TM-T74585

  • Logo de CymitQuimica
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    Obtustatin

    <p>Potent α1β1 integrin inhibitor, 0.8 nM IC50 for IV collagen binding. Selective over other integrins. Inhibits FGF2 angiogenesis; antitumor in mouse models.</p>
    Fórmula:C184H284N52O57S8
    Pureza:98%
    Forma y color:Solid
    Peso molecular:4393.07

    Ref: TM-TP1974

  • Logo de CymitQuimica
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    UnyLinker 12 TEA

    <p>UnyLinker 12 TEA is a versatile linker used in the synthesis of oligoribonucleotides.</p>
    Fórmula:C39H35NO10C6H15N
    Forma y color:Solid
    Peso molecular:778.34655

    Ref: TM-TSW-00947

  • WAY-647802
    Targetmol
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    WAY-647802

    CAS:
    <p>WAY-647802 is a CDK inhibitor.</p>
    Fórmula:C11H14N4O3
    Pureza:99.53%
    Forma y color:Solid
    Peso molecular:250.25

    Ref: TM-T9971

  • 3'-Deoxyuridine-5'-triphosphate trisodium
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    3'-Deoxyuridine-5'-triphosphate trisodium

    <p>3'-dUTP trisodium, a nucleotide analogue, inhibits RNA polymerases I/II and UTP integration into RNA (Ki=2.0 μM).</p>
    Fórmula:C9H12N2Na3O14P3
    Forma y color:Soild
    Peso molecular:534.08

    Ref: TM-T35658

  • 5'-O-DMT-N4-Bz-2'-F-dC
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    5'-O-DMT-N4-Bz-2'-F-dC

    CAS:
    <p>5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.</p>
    Fórmula:C37H34FN3O7
    Forma y color:Solid
    Peso molecular:651.68

    Ref: TM-T37137

  • α2β1 Integrin Ligand Peptide
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    α2β1 Integrin Ligand Peptide

    CAS:
    <p>The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular</p>
    Fórmula:C14H22N4O9
    Pureza:98%
    Forma y color:Solid
    Peso molecular:390.35

    Ref: TM-TP1484

  • Logo de CymitQuimica
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    N7-Methyl-2'-O-(2-methoxyethyl) guanosine

    <p>N7-Methyl-2’-O-(2-methoxyethyl) guanosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.</p>
    Fórmula:C14H21N5O6
    Forma y color:Solid
    Peso molecular:355.35

    Ref: TM-T75060

  • Pseudouridimycin
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    Pseudouridimycin

    CAS:
    <p>Pseudouridimycin: a C-nucleoside antibiotic, inhibits bacterial RNAP, targets Gram-negative and Gram-positive bacteria.</p>
    Fórmula:C17H26N8O9
    Pureza:98%
    Forma y color:Solid
    Peso molecular:486.44

    Ref: TM-T16673

  • Logo de CymitQuimica
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    TC113

    <p>TC113, a c(RGDyK)-linked Gemcitabine, targets αvβ3 integrin, entering A549 cells, and inhibits WM266.4 and A549 cell growth.</p>
    Fórmula:C37H50F2N12O13
    Forma y color:Solid
    Peso molecular:908.86

    Ref: TM-T74400

  • Anticancer agent 263
    Targetmol
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    Anticancer agent 263

    <p>Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.</p>
    Fórmula:C13H20N2O6
    Forma y color:Solid
    Peso molecular:300.308

    Ref: TM-T204102

  • CDK7-IN-5
    Targetmol
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    CDK7-IN-5

    CAS:
    <p>CDK7-IN-5, a CDK7 inhibitor with an IC 50 value of less than 100 nM, exhibits potent anticancer properties (WO2015154022A1, Compound 104).</p>
    Fórmula:C34H45N9O2
    Forma y color:Solid
    Peso molecular:611.795

    Ref: TM-T39247

  • PROTAC CDK9 degrader-2
    Targetmol
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    PROTAC CDK9 degrader-2

    CAS:
    <p>PROTAC CDK9 degrader-2, potent, selective, IC50 17 μM in MCF-7, wogonin-derived, targets CRBN.</p>
    Fórmula:C39H36N6O10
    Pureza:98%
    Forma y color:Solid
    Peso molecular:748.74

    Ref: TM-T17728

  • Barasertib
    Targetmol
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    Barasertib

    CAS:
    <p>AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.</p>
    Fórmula:C26H31FN7O6P
    Pureza:99.63% - 99.92%
    Forma y color:Solid
    Peso molecular:587.54

    Ref: TM-T14371

  • Logo de CymitQuimica
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    GK13S

    <p>G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.</p>
    Fórmula:C21H22N6O2
    Forma y color:Solid
    Peso molecular:390.44

    Ref: TM-T75182