Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(111 productos)
- CDK(525 productos)
- Detención del ciclo celular(4 productos)
- Chk(46 productos)
- DYRK(49 productos)
- Dynamin(26 productos)
- Ferroptosis(225 productos)
- HSP(180 productos)
- Integrin(256 productos)
- Kinesina(87 productos)
- LIM quinasa(19 productos)
- Asociado a microtúbulos(283 productos)
- PKC(111 productos)
- PLK(25 productos)
- ROCK(66 productos)
- Rho(2 productos)
- Wee1(14 productos)
- c-Myc(75 productos)
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Se han encontrado 3749 productos de "Ciclo celular / Checkpoint"
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Tetrahydrouridine dihydrate
THU dihydrate, a potent CDA inhibitor, outperforms cytidine by blocking the enzyme's active site.Fórmula:C9H20N2O8Forma y color:SolidPeso molecular:284.265-Fluorouridine 5'-phosphate
CAS:5-Fluorouridine 5'-phosphate acts as an ODCase (uridine 5'-monophosphate decarboxylase) inhibitor, exhibiting a Ki value of 98 µM for human ODCase and 645 µM for Methanococcus jannaschii ODCase. This compound also shows inhibitory activity on leukemia and lymphoma cell lines, making it useful for cancer research studies.Fórmula:C9H12FN2O9PForma y color:SolidPeso molecular:342.172Anti-neuroinflammation agent 3
CAS:Compound A.10.3 (Anti-neuroinflammation agent 3) exhibits inhibitory activity against various Ser/Thr kinases or receptor/non-receptor tyrosine kinases.Fórmula:C22H23FN6O2Peso molecular:422.455CDK7-IN-33
CAS:CDK7-IN-33 (Compound 148) is a CDK7 inhibitor with a Ki value of 21.75 nM. It suppresses the proliferation of A549 cells expressing CDK7WT, with a pIC50 of 7.37.Fórmula:C29H36N6O4SForma y color:SolidPeso molecular:564.699Polθ-IN-8
CAS:Polθ-IN-8 (example 77) is a DNA polymerase θ (Polθ) inhibitor with an IC50 for Polθ ATPase activity of less than 100 nM. Polθ-IN-8 is useful for researching diseases related to Polθ activity, such as cancer.Fórmula:C22H22ClN7O3SForma y color:SolidPeso molecular:499.97ART615
ART615 is a related isomer of ART558. ART615 inhibits Polθ by <10% at 12 μM and is able to act as a control for ART558 (IC50:7.9 nM).Fórmula:C21H21F3N4O2Forma y color:SolidPeso molecular:418.415'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine
CAS:5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine is a nucleoside synthesized through oxime ring-opening at the 5' position and methylation at the 2' position. In chemotaxis assays, 5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine demonstrates tissue affinity.Fórmula:C36H39N5O8Forma y color:SolidPeso molecular:669.724Antiviral agent 67
CAS:Antiviralagent 67 (compound PC6) is an inhibitor of DENVNS5 (RNA-dependent RNA polymerase) with a Ki value of 1.12 nM.Fórmula:C19H19N3OForma y color:SolidPeso molecular:305.374PD-1/PD-L1-IN-53
CAS:<p>PD-1/PD-L1-IN-53 (compound B3) serves as an inhibitor targeting both the PD-1/PD-L1 and VISTA signaling pathways. It is utilized in cancer research.</p>Fórmula:C31H37N3O4Forma y color:SolidPeso molecular:515.64CDK2-IN-30
CAS:CDK2-IN-30 (Formula (I)) is a CDK2 inhibitor with an IC50 of ≤20 nM, utilized primarily in tumor research.Fórmula:C18H25N7O3SForma y color:SolidPeso molecular:419.50Ascofuranone
CAS:Ascofuranone is an inhibitor of the ubiquinol oxidase activity of Trypanosoma brucei mitochondrial alternative oxidase (TAO), as well as an inhibitor of HsDHODHFórmula:C23H29ClO5Forma y color:SolidPeso molecular:420.93UM-C162
CAS:UM-C162, a benzimidazole derivative, offers protection to nematodes from Staphylococcus aureus infections. It inhibits biofilm formation without impairing bacterial viability. Additionally, UM-C162 disrupts the production of Staphylococcus aureus hemolysins, proteases, and coagulases. This compound holds potential as an antivirulence agent for managing Staphylococcus aureus infections.Fórmula:C30H25N3O4Peso molecular:491.54CDK8-IN-9
<p>CDK8-IN-9, potent CDK8 inhibitor (IC50: 48.6 nM), curbs tumor growth, useful for colorectal cancer research.</p>Forma y color:Solid2′-OMe-UMP
CAS:2′-OMe-UMP is a nucleotide analog used in the synthesis of oligonucleotides.Fórmula:C10H15N2O9PPeso molecular:338.21LNA-AMP
CAS:LNA-AMP is a nucleotide analog used in the synthesis of oligonucleotides.Fórmula:C11H14N5O7PForma y color:SolidPeso molecular:359.23CHK-IN-1
CAS:CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.Fórmula:C18H19ClFN5OSPureza:>99.99%Forma y color:SolidPeso molecular:407.89L-Tyrosyl-L-glutamic acid
CAS:L-Tyrosyl-L-glutamic acid acts as an inhibitor of the amino acid permease GAP1.Fórmula:C14H18N2O6Forma y color:SolidPeso molecular:310.3Methyl 3-oxodecanoate
CAS:<p>Methyl 3-oxodecanoate exhibits virulence factor activity against human pathogens and shows effects on Synechococcus elongatus (a species of fluorescent algae) as well as on culture supernatant. Additionally, Methyl 3-oxodecanoate inhibits DNA synthesis by suppressing protein synthesis at the translation initiation level.</p>Fórmula:C11H20O3Forma y color:SolidPeso molecular:200.275ROCK/HDAC-IN-1
ROCK/HDAC-IN-1 (Compound 10h) serves as an orally effective inhibitor of ROCK/HDAC. This compound suppresses ROCK1/2 (IC50: 254.9 nM, 58.18 nM) and HDAC1/2/3/6/8 (IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM). It stimulates the activation of DAMPs, notably calreticulin (CRT) exposure and HMGB1 release, suggesting its potential as an inducer of immunogenic cell death (ICD). ROCK/HDAC-IN-1 exhibits antiproliferative effects against breast cancer cells (IC50: 0.37 μM for MDA-MB-231 cells), inhibits tumor growth, activates T cells, and shows no significant toxicity.Fórmula:C19H22N4O3SForma y color:SolidPeso molecular:386.47Tizolemide
CAS:Tizolemide, a sulfonamide diuretic compound with alkaline properties, is cleared through the tubular transport system. It induces changes in the passive transport components across the basolateral membrane of isolated frog skin.Fórmula:C11H14ClN3O3S2Forma y color:SolidPeso molecular:335.832′-F-UDP
CAS:2′-F-UDP is a nucleotide analogue used in the synthesis of oligonucleotides.Fórmula:C9H13FN2O11P2Forma y color:SolidPeso molecular:406.15Bersiporocin
CAS:<p>Bersiporocin is a novel prolyl-tRNA synthetase (PRS) inhibitor that exerts antifibrotic effects through downregulation of collagen synthesis in IPF.</p>Fórmula:C15H19Cl2N3OPureza:98.88% - 99.79%Forma y color:SolidPeso molecular:328.24CYP2C19-IN-1
CYP2C19-IN-1: potent CYP2C19 inhibitor, non-genotoxic, non-hepatotoxic, blocks RdRP (Ki: 6.16 μM), useful for ZIKV research.Fórmula:C26H26N2O6SForma y color:SolidPeso molecular:494.56CDK12/13 ligand 1
CAS:ALK-IN-29 (compound 4c) exhibits notable inhibitory activity against tyrosine kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, showing a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is useful for cancer research.Fórmula:C26H26BrN5OForma y color:SolidPeso molecular:504.42Polθ-IN-6
CAS:Polθ-IN-6 (Compound 89) is an inhibitor of DNA polymerase theta (Polθ) and exhibits antitumor activity.Fórmula:C25H23N3O3SForma y color:SolidPeso molecular:445.53WRN inhibitor 12
CAS:WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.Fórmula:C33H33ClF3N9O5Forma y color:SolidPeso molecular:728.12Lobucavir
CAS:<p>Lobucavir (BMS-180194; SQ 34514) is a nucleoside analogue and an antiviral agent with broad-spectrum activity against various viruses, including HBV, HIV/AIDS, and α, β, and γ herpesviruses (including CMV, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus).</p>Fórmula:C11H15N5O3Forma y color:SolidPeso molecular:265.27DNA Gyrase-IN-13
CAS:<p>DNA Gyrase-IN-13 (compound 1b) is an inhibitor of DNA gyrase with bacteriostatic properties. It exhibits an IC50 of 1.81 μM against Staphylococcus aureus DNA gyrase.</p>Fórmula:C15H21N3O3SForma y color:SolidPeso molecular:323.41WRN inhibitor 11
CAS:WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.Fórmula:C34H35ClF3N9O5Forma y color:SolidPeso molecular:742.15LNA-CTP
CAS:<p>LNA-CTP is a nucleotide analog utilized in the synthesis of oligonucleotides.</p>Fórmula:C10H16N3O14P3Forma y color:SolidPeso molecular:495.17WEE1-IN-11
CAS:WEE1-IN-11 (Compound 13) serves as a potent CDK2 inhibitor with an IC50 of 2.0 nM. It exhibits inhibitory effects on several cell lines, including NCI-H446, A427, OVCAR3, C33A, and WiDr, with respective IC50 values of 93.9, 34.5, 86.7, 23.1, and 85 nM.Fórmula:C26H29FN8OS2Forma y color:SolidPeso molecular:552.69CDK2-IN-31
CAS:CDK2-IN-31 (compound I-125A) is an inhibitor of CDK2 and is utilized in cancer research.Fórmula:C37H52N6O5Forma y color:SolidPeso molecular:660.85BWC0977
CAS:BWC0977 is an effective topoisomerase inhibitor that disrupts bacterial DNA replication by targeting both DNA gyrase and topoisomerase IV. The minimum inhibitory concentration (MIC90) of BWC0977 against MDR (multi-drug resistant) Gram-negative bacteria ranges from 0.03 to 2 µg/mL.Fórmula:C22H21FN6O5Forma y color:SolidPeso molecular:468.44SGC-CLK-1
CAS:SGC-CLK-1 is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. It effectively inhibits the growth of melanoma and glioblastoma cells.Fórmula:C19H15F3N6O2Forma y color:SolidPeso molecular:416.36Polθ-IN-5
CAS:Polθ-IN-5 (Compound 139) is an inhibitor of DNA polymerase theta (Polθ) that exhibits antitumor activity.Fórmula:C23H18ClF2N7O3SForma y color:SolidPeso molecular:545.95Dyrk1A-IN-4
CAS:Dyrk1A-IN-4, compound 48, is an oral DYRK1A/DYRK2 inhibitor with IC50s: 2 nM (DYRK1A), 6 nM (DYRK2), anticancer properties.Fórmula:C14H13F3N6Forma y color:SolidPeso molecular:322.2912(S)-HETE
CAS:<p>Enpatoran hydrochloride (M5049 hydrochloride) is a TLR7/8 inhibitor with antiviral activity that is used in the study of autoimmune diseases.</p>Fórmula:C20H32O3Forma y color:SolidPeso molecular:320.47PD-L1-IN-7
CAS:PD-L1-IN-7 (compound CB31) serves as a PD-L1 inhibitor, effectuating PD-L1 internalization and retention within cells. It restrains the PD-1/PD-L1 interaction (IC 50: 0.2 nM), alters glycosylation patterns, and facilitates PD-L1 degradation. Additionally, PD-L1-IN-7 enhances T cell infiltration, boosts T cell function, and augments the capacity to destroy tumor cells.Fórmula:C46H50N6O7Forma y color:SolidPeso molecular:798.93GTSE1-IN-1
CAS:GTSE1-IN-1 (compound Y18), an orally active GTSE1 inhibitor, exhibits notable anticancer properties. It effectively represses the proliferation of cancer cells by downregulating GTSE1 transcription and expression, which leads to DNA damage and promotes persistent cell cycle arrest and cellular senescence. Moreover, GTSE1-IN-1 substantially reduces the adhesion, migration, and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro.Fórmula:C21H24FN7Forma y color:SolidPeso molecular:393.46TY-011
CAS:TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.Fórmula:C18H16ClN5Forma y color:SolidPeso molecular:337.81Polθ-IN-7
CAS:<p>Polθ-IN-7 (example 12) is an inhibitor of DNA polymerase θ (Polθ) with a Ki of 1.27 nM.</p>Fórmula:C28H35F3N6O2Forma y color:SolidPeso molecular:544.612APE1-IN-3
CAS:APE1-IN-3 (Compound 1), an APE1 inhibitor, is utilized in cancer research.Fórmula:C17H16O4Forma y color:SolidPeso molecular:284.31TASIN-30
CAS:TASIN-30 is an inhibitor of EBP, exhibiting a competitive EC50 value of 0.097 μM, and possesses a competitive EC50 value of 50 μM against DHCR7.Fórmula:C18H30N2O3SForma y color:SolidPeso molecular:354.513'-Deoxy-GTP
CAS:<p>3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) is an analog of GTP and serves as an RNA chain terminator, effectively inhibiting RNA synthesis. It can inhibit dengue virus DENV NS5 RdRp with an IC50 of 0.02 μM.</p>Fórmula:C10H16N5O13P3Forma y color:SolidPeso molecular:507.181GSK_WRN4
CAS:GSK_WRN4 is a WRN helicase inhibitor with anti-cancer activity, inhibiting MSI tumor cell growth by inducing DNA double-strand breaks, useful in cancer researchFórmula:C16H20N2O4SPureza:99.95%Forma y color:SolidPeso molecular:336.41N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine
CAS:N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine is a nucleoside analog that resembles the natural nucleotide adenosine in structure. It acts as an activator of ribonucleotide reductase, facilitating the conversion of ribonucleotides into deoxyribonucleotides.Fórmula:C38H35N5O6Forma y color:SolidPeso molecular:657.714RNAP-σ interaction inhibitor-1
CAS:RNAP-σ interaction inhibitor-1 (compound 5d) acts as an inhibitor of the interaction between RNA polymerase and the sigma factor. It exhibits activity against Streptococci with a minimum inhibitory concentration (MIC) ranging from 1-2 µg/mL.Fórmula:C19H11Cl3N2O6S2Forma y color:SolidPeso molecular:533.79PolQi1
CAS:<p>PolQi1 is a highly efficient and selective Polϴ (DNA polymerase theta) inhibitor with an IC50 of 2 nM, showing potential for cancer therapy.</p>Fórmula:C18H14ClF5N4O2Pureza:98.97%Forma y color:SolidPeso molecular:448.776K465
CAS:6K465 is a potent Aurora A kinase inhibitor that reduces c-MYC and N-MYC oncoproteins, showing antiproliferative effects in SCLC and breast cancer cell lines.Fórmula:C26H33ClFN9OPureza:99.78%Forma y color:SolidPeso molecular:542.05PKMYT1-IN-9
CAS:PKMYT1-IN-9 is a highly selective, orally active inhibitor of PKMYT1 with an IC50 of 4.4 nM. It exhibits greater selectivity for PKMYT1 compared to WEE1, for which the IC50 is 32.4 μM. Additionally, PKMYT1-IN-9 demonstrates antitumor activity.Fórmula:C17H14FN5OForma y color:SolidPeso molecular:323.324CDK9/PARP-IN-1
CAS:CDK9/PARP-IN-1 (compound 37) is an inhibitor of CDK9 and PARP. It demonstrates IC50 values of 118 nM for CDK9 and 107 nM for PARP1. This compound exhibits a broad-spectrum anti-proliferative effect across various cancer cell lines.Fórmula:C38H34F2N8O3Forma y color:SolidPeso molecular:688.725CHK1-IN-4
CAS:<p>CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.</p>Fórmula:C18H18BrN7O2Pureza:98%Forma y color:SolidPeso molecular:444.292′-OMe-ADP
CAS:<p>2′-OMe-ADP is a nucleotide analogue used in oligonucleotide synthesis.</p>Fórmula:C11H17N5O10P2Forma y color:SolidPeso molecular:441.23Werner syndrome RecQ helicase-IN-2
CAS:Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase (WRN) inhibitor, useful in research on colorectal and gastric cancers.Fórmula:C32H34F3N9O5Pureza:99.02%Forma y color:SolidPeso molecular:681.67CDK4-IN-1
CAS:CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50Fórmula:C22H29ClN8Pureza:98%Forma y color:SolidPeso molecular:440.97JY-3-094
CAS:JY-3-094 is a selective Myc inhibitor that targets the hydrophobic domain of Myc and inhibits the formation of the Myc-Max heterodimer, with an IC50 of 33 μM, and can be used for cancer research.Fórmula:C13H8N4O5Pureza:98.72%Forma y color:SolidPeso molecular:300.23CHK1 inhibitor
CAS:CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.Fórmula:C17H21BrN4OPureza:98%Forma y color:SolidPeso molecular:377.28DIDS
CAS:DIDS inhibits anion exchangers reversibly then irreversibly and blocks RAD51.Fórmula:C16H10N2O6S4Pureza:98%Forma y color:SolidPeso molecular:454.52WEE1 degrader 1
WEE1degrader 1 (Compound 10) functions as a Wee1 degrader, exhibiting a DC50 value of 1.5 nM against Wee1. This compound also possesses anticancer properties that inhibit cell proliferation.Fórmula:C30H31N5O3Forma y color:SolidPeso molecular:509.6TMX-3013
CAS:TMX-3013 is a CDK inhibitor that targets multiple cyclin-dependent kinases, specifically suppressing the activity of CDK1, CDK2, CDK4, CDK5, and CDK6 with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM respectively. Additionally, TMX-3013 is utilized in the synthesis of PROTACs, which use polyethylene glycol (PEG) as a linker and Thalidomide as the CRBN-recruiting arm.Fórmula:C17H14BrFN6O3SForma y color:SolidPeso molecular:481.3CDK1-IN-6
CDK1-IN-6 (Ligand 3) is an effective inhibitor of CDK1 and shows potential for use in cancer research.Fórmula:C21H22N4OForma y color:SolidPeso molecular:346.43β-catenin-IN-8
CAS:β-catenin-IN-8 (Compound 25) is an inhibitor of β-catenin. It effectively lowers the levels of both β-catenin and c-Myc proteins and suppresses Wnt target genes (Fgf20 and Sall4). Additionally, β-catenin-IN-8 exhibits anticancer activity against colorectal cancer and possesses metabolic stability.Fórmula:C15H12ClN3O2SForma y color:SolidPeso molecular:333.79IIP0943
CAS:IIP0943 is a selective PLK1 (polo-like kinase 1) inhibitor with an IC50 of 5.1 nM for PLK1. It also exhibits inhibitory activity on the proliferation of HCT116 cells, with an IC50 of 0.22 µM. IIP0943 shows potential for research in the field of oncology.Fórmula:C26H28N6O3SForma y color:SolidPeso molecular:504.604RMS-07
CAS:RMS-07, a covalent MPS1/TTK inhibitor, has an IC50 of 13.1 nM, targeting a kinase hinge cysteine.Fórmula:C35H40N8O2Forma y color:SolidPeso molecular:604.745-Iminodaunorubicin hydrochloride
CAS:5-Iminodaunorubicin HCl: quinone-modified anthracycline with antitumor properties, induces DNA breaks in cancer cells.Fórmula:C27H31ClN2O9Forma y color:SolidPeso molecular:563.00RAD51-IN-7
CAS:RAD51-IN-7 inhibits RAD51 gene, with potential for mitochondrial disorders. (From WO2021164746A1, cmpd 71)Fórmula:C25H31N5O4S2Forma y color:SolidPeso molecular:529.67T-2513 hydrochloride
CAS:T-2513 hydrochloride: selective topoisomerase I inhibitor, binds DNA complex, halts DNA/RNA synthesis, causes cell death.Fórmula:C25H28ClN3O5Forma y color:SolidPeso molecular:485.96Dyrk1A-IN-2
Dyrk1A-IN-2 is a DYRK1A inhibitor (EC50: 37 nM). dyrk1A-IN-2 exhibits efficient promotion of human β-cell replication, as well as low cytotoxicity.Fórmula:C27H32N6O4Forma y color:SolidPeso molecular:504.58Cdc7-IN-10
CAS:Cdc7-IN-10 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in studies of proliferative diseases.Fórmula:C20H22F2N4O2SForma y color:SolidPeso molecular:420.48Glycyl H-1152 hydrochloride
CAS:Glycyl-H-1152 is a potent ROCK-II inhibitor (IC50=11.8 nM) with high selectivity over CaMKII, PKG, Aurora A, PKA, and PKC. Better than Y-27632 and HA-1077.Fórmula:C18H26Cl2N4O3SForma y color:SolidPeso molecular:449.39Haspin-IN-2
CAS:Haspin-IN-2 is a potent haspin inhibitor (IC50: 50 nM) and also inhibits CLK1 (IC50: 445 nM) and DYRK1A (IC50: 917 nM).Fórmula:C12H8N4O3Forma y color:SolidPeso molecular:256.22CDK7-IN-31
CAS:CDK7-IN-31 (compound 13) is an effective and orally active inhibitor of cyclin-dependent kinase 7 (CDK7) with a dissociation constant (Kd) of 0.18 nM. This compound exhibits anticancer activity.Fórmula:C27H32F5N6O2PForma y color:SolidPeso molecular:598.55Aurora/LIM kinase-IN-1
Aurora/LIM kinase-IN-1 (Compound F114) is a dual inhibitor targeting aurora and lim kinases, potentially useful in GBM cancer treatment efforts.Fórmula:C16H20N6OForma y color:SolidPeso molecular:312.37Cdc7-IN-8
CAS:Cdc7-IN-8, inhibits Cdc7 kinase, key in DNA replication, and is promising for cancer research. (WO2021032170A1)Fórmula:C19H21N5O2Forma y color:SolidPeso molecular:351.40L-I-OddU
CAS:L-I-OddU: Selective anti-EBV, halts virus DNA/protein synthesis. EC50: 0.03 µM, low toxicity (CC50: 1000 nM).Fórmula:C8H9IN2O5Forma y color:SolidPeso molecular:340.07DNA Gyrase-IN-1
DNA Gyrase-IN-1: potent, selective promoter inhibitor. IC50: 2.6 μM, inhibits Mtb, MIC: 0.49 μM. Useful for tuberculosis research.Fórmula:C24H24FN7O6Forma y color:SolidPeso molecular:525.49CDK7-IN-17
CAS:CDK7-IN-17, a pyrimidine-based CDK7 inhibitor, shows promise for various cancers, especially with abnormal transcription.Fórmula:C24H26F3N6OPPureza:99.60%Forma y color:SolidPeso molecular:502.47CDK7/12-IN-1
CAS:CDK7/12-IN-1 is a selective CDK7 (IC50: 3 nM) and CDK12 (IC50: 277 nM) inhibitor, effective against tumor growth.Fórmula:C25H34N8OForma y color:SolidPeso molecular:462.59Kolavenic acid analog
CAS:KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.Fórmula:C25H38O4Forma y color:SolidPeso molecular:402.57DS96432529
DS96432529 is a potent and orally active bone anabolic agent through CDK8 inhibition.Fórmula:C18H26N4O3SForma y color:SoildPeso molecular:378.49CDK8-IN-11 hydrochloride
CDK8-IN-11 HCl: potent, selective CDK8 inhibitor (IC50: 46 nM), blocks WNT/β-catenin pathway, used in colon cancer research.Fórmula:C19H16ClF3N4O2Forma y color:SolidPeso molecular:424.8CDK6-IN-1
CAS:CDK6-IN-1 (compound 4i) is an inhibitor of CDK6 that suppresses cell growth and induces cell cycle arrest at the G1 phase.Fórmula:C30H23N5Forma y color:SolidPeso molecular:453.54D-G23
CAS:<p>D-G23 is a selective RAD52 inhibitor. It disrupts RAD52-mediated DNA repair pathways and suppresses the growth of cancer cells deficient in BRCA1 and BRCA2. D-G23 shows promise for research into homologous recombination-related cancers caused by BRCA1/2 mutations, such as hereditary breast and ovarian cancers.</p>Fórmula:C19H22N4O3Forma y color:SolidPeso molecular:354.403Antibacterial agent 110
Compound 4e, an antibacterial against P. aeruginosa, disrupts cell membranes (MIC: 1 μg/ml).Fórmula:C22H21N5O4SForma y color:SolidPeso molecular:451.5LIMK1 inhibitor 2
CAS:LIMK1 inhibitor 2 (compound 41) is a LIMK1 inhibitor with an IC50 value of 9 μM.Fórmula:C10H11N3OSForma y color:SolidPeso molecular:221.279Dencatistat
CAS:<p>Dencatistat is a highly selective and oral cytidine triphosphate synthase 1 CTPS1 inhibitor specific.CTPS1-IN-2 for B-cell, T-cell lymphomas and solid tumors.</p>Fórmula:C24H27N7O5SPureza:98.85%Forma y color:SolidPeso molecular:525.58Cdc7-IN-11
CAS:Cdc7-IN-11 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in the study of proliferative diseases.Fórmula:C20H22F2N4O2SForma y color:SolidPeso molecular:420.48BAY-364
CAS:BAY-364 (BAY-299N) functions as an inhibitor targeting the second bromine domain in TAF1, demonstrating inhibitory effects on TAF1 in Kasumi-1 cells, CD34+Fórmula:C23H19N3O4Forma y color:SolidPeso molecular:401.41MtTMPK-IN-2
CAS:MtTMPK-IN-2 inhibits M. tuberculosis TMPK (IC50: 1.1 μM), Mtb H37Rv (MIC: 12.5 μM), and is cytotoxic in MRC-5 cells (EC50: 6.1 μM).Fórmula:C23H24ClN3O3Forma y color:SolidPeso molecular:425.91MtTMPK-IN-1
MtTMPK-IN-1 inhibits MtTMPK with 2.5 μM IC50, shows moderate anti-tuberculosis activity, and is low in cytotoxicity.Fórmula:C22H24N4O3Forma y color:SolidPeso molecular:392.45ddCTP trisodium
ddCTP trisodium, an HIV reverse transcriptase target, aids AIDS research and DNA sequencing as a ddNTP.Fórmula:C9H13N3Na3O12P3Forma y color:SolidPeso molecular:517.1CLK1/4-IN-1
CLK1/4-IN-1 inhibits Clk1/4 (IC50: 9.7/6.6 nM), curbing T24 cell growth (GI50: 1.1 μM). Potential cancer research tool.Fórmula:C18H14ClNO4SForma y color:SolidPeso molecular:375.83Antitumor agent-74
Antitumor agent-74, a quinazoline derivative, inhibits DNA, arrests cell cycle, and induces apoptosis with agent-75.Fórmula:C26H23FN6Forma y color:SolidPeso molecular:438.5CDK9-IN-13
CDK9-IN-13 is a potent and selective CDK inhibitor (IC50<3 nM). CDK9-IN-13 has a very short half-life in rodents.Fórmula:C27H35N5O2Forma y color:SolidPeso molecular:461.6DYRKs-IN-1 hydrochloride
CAS:DYRKs-IN-1 HCl inhibits DYRK1A (5 nM IC50) & DYRK1B (8 nM IC50) with antitumor properties.Fórmula:C30H31Cl2N7O4Forma y color:SolidPeso molecular:624.524,5'-Dimethylangelicin-NHS
NHS-modified coumarin, 4,5'-Dimethylangelicin-NHS, shows photochemical activity & photosensitivity.Fórmula:C21H19NO7SForma y color:SolidPeso molecular:429.44MtTMPK-IN-9
MtTMPK-IN-9 moderately inhibits MtbTMPK (IC50: 48 μM), has submicromolar Mycobacterium activity, and is non-toxic, aiding tuberculosis research.Fórmula:C25H26N6O7Forma y color:SolidPeso molecular:522.51CB 30900
CAS:CB30900 is a novel and effective thymidylate synthase inhibitor.Fórmula:C31H32FN5O9Forma y color:SolidPeso molecular:637.61Antiangiogenic agent 2
<p>Antiangiogenic agent 2 (compound 3b) is a potent inhibitor of thymidine phosphorylase (IC50: 39.71 μM) and exhibits anti-angiogenic effects.</p>Fórmula:C26H26FN3O4Forma y color:SolidPeso molecular:463.5MtTMPK-IN-8
MtTMPK-IN-8 inhibits MtbTMPK, has low cytotoxicity, shows 0.78-9.4 μM activity against Mycobacterium, useful for tuberculosis research.Fórmula:C24H24N6O7Forma y color:SolidPeso molecular:508.48CDK4/6-IN-3
CAS:CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.Fórmula:C25H31FN8Pureza:98%Forma y color:SolidPeso molecular:462.57LIMK1 inhibitor 1
CAS:LIMK1 inhibitor1 (compound 24) is a LIMK1 inhibitor, potentially useful for cancer research.Fórmula:C12H15N3S2Forma y color:SolidPeso molecular:265.398Aurora A inhibitor 1
CAS:Aurora A inhibitor 1: potent, selective, targets cancer-linked Aurora A overexpression, potential for cancer research. (WO2021147974A1, 49)Fórmula:C25H28ClF2N5O2Forma y color:SolidPeso molecular:503.97CDK1-IN-3
CDK1-IN-3 is a selective inhibitor targeting CDK1 (36.8 nM), CDK2 (305.17 nM), CDK5 (369.37 nM); used in cancer research.Fórmula:C28H25ClF3N5O2Forma y color:SolidPeso molecular:555.98L-2'-Fd4C
CAS:L-2'-Fd4C is an L-nucleoside analogue with both anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity [1].Fórmula:C9H10FN3O3Forma y color:SolidPeso molecular:227.19Pol I-IN-1
Pol I-IN-1 is a powerful inhibitor of RNA polymerase I (Pol I), specifically targeting the large catalytic subunit RPA194, demonstrating an inhibitionFórmula:C23H22N4O2Forma y color:SolidPeso molecular:386.45DENV-IN-6
CAS:DENV-IN-6, a potent anti-DENV (I-IV) and HIV-1 IIIB inhibitor with EC50 ranging 6.8-17.5 μM for DENV and EC50 0.0181 μM for HIV-1.Fórmula:C23H26ClFN4OSForma y color:SolidPeso molecular:461CDK/HDAC-IN-1
CDK/HDAC-IN-1 inhibits CDK2/4/6 & HDAC6 with IC50s: 60.9, 276, 27.2, and 128.6 nM respectively.Fórmula:C20H18N4O4Forma y color:SolidPeso molecular:378.38c-Myc inhibitor 4
Potent oral c-Myc inhibitor 4 reduces the proto-oncogene linked to tumor development.Fórmula:C26H33FN6O3Forma y color:SolidPeso molecular:496.58Dyrk1A/α-synuclein-IN-1
Dyrk1A/α-synuclein-IN-1 (Compound b1) is a dual inhibitor of Dyrk1A (IC50: 177 nM) and α-synuclein aggregation (IC50: 10.5 μM).Fórmula:C20H21N5O3SForma y color:SolidPeso molecular:411.48Adafosbuvir
CAS:Adafosbuvir has antiviral activity.Fórmula:C22H29FN3O10PForma y color:SolidPeso molecular:545.457CDK8-IN-5
CAS:CDK8-IN-5: potent CDK8 inhibitor, IC50=72 nM, boosts IL-10 by 43%, may aid inflammatory bowel disease research.Fórmula:C26H22N2O4Forma y color:SolidPeso molecular:426.46PROTAC CDK12/13 Degrader-1
PROTAC CDK12/13 Degrader-1 (7f) selectively degrades CDK12/13 at nanomolar potency, targeting breast cancer.Forma y color:SolidAurora inhibitor 1
CAS:<p>Aurora inhibitor 1 is a potent Aurora inhibitor (IC50: ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase).</p>Fórmula:C23H25N9SPureza:98%Forma y color:SolidPeso molecular:459.57Zorubicin
CAS:<p>Zorubicin, a Daunorubicin derivative, targets topoisomerase II, inhibits DNA polymerase, and researches acute leukemia, sarcomas.</p>Fórmula:C34H35N3O10Forma y color:SolidPeso molecular:645.66RAD51-IN-5
CAS:RAD51-IN-5 blocks RAD51; may aid mitochondrial disorder research. (WO2021164746A1, cmpd 3)Fórmula:C26H38N4O5S2Forma y color:SolidPeso molecular:550.73MtTMPK-IN-5
MtTMPK-IN-5 inhibits Mtb TMPK with IC50 of 34 μM and fights tuberculosis with MIC of 12.5 μM, aiding TB research.Fórmula:C21H23N5O2Forma y color:SolidPeso molecular:377.44EFdA-TP tetrasodium
CAS:EFdA-TP tetrasodium is a potent HIV-1 inhibitor that blocks DNA synthesis as an ICT or DCT.Fórmula:C12H11FN5Na4O12P3Pureza:98%Forma y color:SolidPeso molecular:621.12CDK7-IN-18
CAS:CDK7-IN-18: potent, pyrimidine-based CDK7 inhibitor with cancer research potential.Fórmula:C22H24F3N7OSPureza:99.28%Forma y color:SolidPeso molecular:491.53ATIC-IN-2
CAS:<p>ATIC-IN-2 (Compound 1) is a competitive inhibitor of the bifunctional enzyme AICAR Tfase/IMPCH (ATIC), binding to inosine monophosphate cyclohydrolase (IMPCH) with a Ki of 0.13 μM.</p>Fórmula:C4H4N4O3SForma y color:SolidPeso molecular:188.165CTX-712
CAS:<p>CTX-712 is a potent inhibitor of cdc2-like kinase ( CLK ). CTX-712 inhibits inhibits cancer survival and cancer cell growth.</p>Fórmula:C19H17FN8O2Forma y color:SolidPeso molecular:408.39GFB-12811
CAS:GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.Fórmula:C22H23F4N5OPureza:98.88%Forma y color:SolidPeso molecular:449.44HRO761
CAS:HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.Fórmula:C31H31ClF3N9O5Pureza:98.74% - 99.62%Forma y color:SolidPeso molecular:702.08Elacytarabine
CAS:Elacytarabine (M7594 0037), a lipid-conjugated derivative of the nucleoside analog cytarabine, is an antineoplastic drug. It has cytotoxicity in solid tumors.Fórmula:C27H45N3O6Pureza:97.69%Forma y color:SolidPeso molecular:507.66VCPIP1-IN-1
CAS:VCPIP1-IN-1 is a VCPIP1 inhibitor used in cancer research.Fórmula:C13H15ClN2O2Pureza:99.3%Forma y color:SolidPeso molecular:266.72CTPS1-IN-1
CAS:CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.Fórmula:C21H22N6O4S2Pureza:99.46%Forma y color:SolidPeso molecular:486.57SR 11302
CAS:SR 11302 is an inhibitor of activator protein-1 (AP-1).Fórmula:C26H32O2Pureza:98.65%Forma y color:SolidPeso molecular:376.53LY3143921 hydrate
CAS:LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].Fórmula:C16H14FN5O2Pureza:98.43%Forma y color:SolidPeso molecular:327.31INCB086550
CAS:INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.Fórmula:C41H39N7O4Pureza:98.49%Forma y color:SolidPeso molecular:693.79Troxacitabine
CAS:Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia (AML). In comparison with gemcitabine, troxacitabine was equally active against MiaPaCa and was more efficacious against Panc-01.Fórmula:C8H11N3O4Pureza:98%Forma y color:SolidPeso molecular:213.19Bicyclomycin benzoate
CAS:Bicyclomycin benzoate (BCM benzoate, FR2054) is a broad-spectrum antibiotic and selective Rho protein inhibitor active against Gram-negative bacteria.Fórmula:C19H22N2O8Forma y color:SolidPeso molecular:406.39NSC639828
CAS:NSC639828 is an efficient inhibitor of DNA polymerase α, exhibiting a remarkable IC50 value of 70 μM. Additionally, NSC639828 demonstrates substantial antitumor activity, making it a promising candidate for cancer research.Fórmula:C18H13BrClN5O3Forma y color:SolidPeso molecular:462.69Tanuxiciclib
CAS:Tanuxiciclib is a cyclin dependent kinase (CDK) inhibitor, specifically designed to interfere with cell cycle progression by inhibiting the activity of CDKs, which are crucial regulators of cell division.Fórmula:C15H13FN6OForma y color:SolidPeso molecular:312.308Ethynylcytidine
CAS:Ethynylcytidine is a nucleoside antimetabolite.Fórmula:C11H13N3O5Pureza:98%Forma y color:SolidPeso molecular:267.242'-Deoxy-2'-fluoro-5-iodouridine
CAS:2'-Deoxy-2'-fluoro-5-iodouridine is a nucleoside, specifically a fluoro-modified and halo-nucleoside.Fórmula:C9H10FIN2O5Forma y color:SolidPeso molecular:372.093BrB-PP1
CAS:3BrB-PP1 is an ATP-competitive analog that exhibits specific inhibitory activity towards protein kinase, particularly effective against protein kinases with mutations in the ATP-binding pocket, such as the Thr97 mutation within Sty1's ATP-binding pocket.Fórmula:C16H18BrN5Forma y color:SolidPeso molecular:360.259N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine
CAS:N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine, catalog number T66118 and CAS number 64325-78-6, is a valuable organic compound for life sciences research.Fórmula:C38H35N5O6Forma y color:SolidPeso molecular:657.727GSK-3/CDK5/CDK2-IN-1
CAS:GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1].Fórmula:C21H22N4O2Forma y color:SolidPeso molecular:362.433PLK1-IN-6
<p>PLK1-IN-6: potent, selective PLK1 inhibitor, IC50 = 0.45 nM, hinders cancer cell growth.</p>Fórmula:C28H37N9O3Forma y color:SolidPeso molecular:547.655'-DMT-3'-TBDMS-ibu-rG
CAS:5'-DMT-3'-TBDMS-ibu-rG is a modified nucleoside employed in deoxyribonucleic acid (DNA) synthesis.Fórmula:C41H51N5O8SiForma y color:SolidPeso molecular:769.96Formycin A
CAS:Formycin A shows antitumor and antiviral activities. Formycin A , a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC50 of 10 μM.Fórmula:C10H13N5O4Pureza:98%Forma y color:SolidPeso molecular:267.245'-O-DMT-N6-ibu-dA
CAS:5'-O-DMT-N6-ibu-dA can be utilized in the synthesis of oligodeoxyribonucleotides.Fórmula:C35H37N5O6Forma y color:SolidPeso molecular:623.71PF-03814735
CAS:PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.Fórmula:C23H25F3N6O2Pureza:98%Forma y color:SolidPeso molecular:474.48Ribocil-C
CAS:Ribocil-C is a selective inhibitor of the bacterial riboflavin riboswitch, a synthetic analogue of flavin mononucleotide (FMN), inhibits bacterial cell growth.Fórmula:C21H21N7OSPureza:98%Forma y color:SolidPeso molecular:419.56-Amino-5-nitropyridin-2-one
CAS:6-Amino-5-nitropyridin-2-one, a pyridine derivative, serves as a nucleobase within hachimoji DNA, where it is specifically paired with 5-aza-7-deazaguanine.Fórmula:C5H5N3O3Pureza:98%Forma y color:SolidPeso molecular:155.11MitoE10
CAS:MitoE10 is an effective mitochondrial targeting antioxidant.Fórmula:C42H55O5PSForma y color:SolidPeso molecular:702.92Tibremciclib
CAS:<p>Tibremciclib is a cyclin-dependent kinase 4 (CDK4) inhibitor that exhibits antineoplastic properties [1].</p>Fórmula:C28H32F2N8Pureza:98%Forma y color:SolidPeso molecular:518.6PHI-101
CAS:<p>PHI-101 is a checkpoint kinase 2 (Chk2) inhibitor that can be used for the study of refractory acute myeloid leukemia (AML) and ovarian cancer.</p>Fórmula:C19H19FN4O2SPureza:99.4%Forma y color:SolidPeso molecular:386.44YK-2168
CAS:<p>YK-2168 is a differentiated selective inhibitor of CDK9.</p>Fórmula:C16H18ClN5Forma y color:SolidPeso molecular:315.80Ref: TM-T200769
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