Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(120 productos)
- CDK(561 productos)
- Detención del ciclo celular(8 productos)
- Chk(49 productos)
- DYRK(47 productos)
- Dynamin(28 productos)
- Ferroptosis(229 productos)
- HSP(184 productos)
- Integrin(288 productos)
- Kinesina(88 productos)
- LIM quinasa(22 productos)
- Asociado a microtúbulos(286 productos)
- PKC(130 productos)
- PLK(25 productos)
- ROCK(62 productos)
- Rho(7 productos)
- Wee1(19 productos)
- c-Myc(80 productos)
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Se han encontrado 2894 productos para "Ciclo celular / Checkpoint".
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BT173
CAS:BT173 is a novel inhibitor of homeodomain interacting protein kinase 2 (HIPK2 ), attenuating renal fibrosis through suppression of the TGF-ß1/Smad3 pathway.Fórmula:C18H12BrN3O2Pureza:98.24%Forma y color:SolidPeso molecular:382.21IU1-47
CAS:IU1-47 是一种特异性 USP14抑制剂，IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5， IC50为 20 μM。Fórmula:C19H23ClN2OPureza:98.94%Forma y color:White SolidPeso molecular:330.85Ref: TM-T15604
1mg34,00€5mg64,00€1mL*10mM (DMSO)70,00€10mg109,00€25mg222,00€50mg358,00€100mg593,00€200mg830,00€HS-243
CAS:HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.Fórmula:C17H16N4O3Pureza:98.62%Forma y color:SolidPeso molecular:324.33Teplizumab
CAS:Teplizumab (MGA-031) is a humanized monoclonal antibody against CD3 that slows the loss of beta cell function.Teplizumab is used to treat type 1 diabetes.Pureza:SDS-PAGE:95.8%;SEC-HPLC:99.7%Forma y color:LiquidPeso molecular:145.79 kDaHu7691 free base
CAS:Hu7691 free base is an Akt inhibitor that inhibits Akt1, Akt2 and Akt3 and induces differentiation of neuroblastoma cells.Fórmula:C22H21F3N4OPureza:98.89%Forma y color:SolidPeso molecular:414.423Sulfameter
CAS:Sulfameter (Sulfametoxydiazine) is a long-acting sulfonamide antibacterial agent used to treat urinary tract infections and leprosy.Fórmula:C11H12N4O3SPureza:99.46% - 99.90%Forma y color:Crystalline SolidPeso molecular:280.3BMT-124110 Formate
BMT-124110 Formate is a selective AAK1 inhibitor (IC50: 0.9 nM) with anti-injury sensory activity.BMT-124110 Formate inhibits the BMP-2-inducible protein kinaseFórmula:C22H20N2O2Pureza:98.62%Forma y color:White SolidPeso molecular:344.41Ref: TM-T10572L
1mg175,00€5mg388,00€1mL*10mM (DMSO)404,00€10mg572,00€25mg888,00€50mg1.224,00€100mg1.648,00€500mg3.312,00€MYCi975
CAS:MYCi975 (NUCC-0200975) is an orally active inhibitor of MYC.Fórmula:C25H16Cl2F6N2O2Pureza:99.3% - 99.82%Forma y color:SolidPeso molecular:561.3Ref: TM-T12133
10mgA consultar25mgA consultar50mgA consultar1mg118,00€5mg268,00€1mL*10mM (DMSO)344,00€Cinoxacin
CAS:Cinoxacin (Compound 64716), an older synthetic antimicrobial, was related to the quinolone class of antibiotics.Fórmula:C12H10N2O5Pureza:99.62% - 99.98%Forma y color:White SolidPeso molecular:262.22Fuzapladib
CAS:Fuzapladib (IS-741) is a PLA2 inhibitor that reduces Mac-1 expression to prevent inflammation and pancreatitis.Fórmula:C15H20F3N3O3SPureza:99.87%Forma y color:SolidPeso molecular:379.4Ref: TM-T67749
1mg60,00€5mg138,00€1mL*10mM (DMSO)177,00€10mg200,00€25mg424,00€50mg618,00€100mg802,00€Lerociclib dihydrochloride
CAS:Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 2 nM and 1 nM for CDK6/CyclinD3 and CDK4/Fórmula:C26H36Cl2N8OPureza:97.4%Forma y color:SolidPeso molecular:547.52Carmofur
CAS:Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer.Fórmula:C11H16FN3O3Pureza:98.53% - 99.98%Forma y color:SolidPeso molecular:257.26Rifabutin
CAS:Rifabutin (LM-427), a semisynthetic ansamycin, blocks bacterial RNA synthesis by inhibiting RNA polymerase.Fórmula:C46H62N4O11Pureza:98.87% - 99.7%Forma y color:SolidPeso molecular:847.00Foralumab
CAS:Foralumab (NI-0401) is a human anti-CD3 monoclonal antibody for the study of COVID-19 infection.Pureza:96.7% (SDS-PAGE); 96.4% (SEC-HPLC) - 96.7% (SDS-PAGE); 96.4% (SEC-HPLC)Forma y color:Transparent LiquidPeso molecular:146.59 kDaGemifloxacin mesylate
CAS:Gemifloxacin mesylate (Gemifloxacin mesylate) inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventuallyFórmula:C19H24FN5O7SPureza:97.24% - ≥95%Forma y color:Beige SolidPeso molecular:485.49Enrofloxacin
CAS:Enrofloxacin (BAY-Vp2674) is a veterinary antibacterial agent, used in poultry.Fórmula:C19H22FN3O3Pureza:99.43% - >99.99%Forma y color:White SolidPeso molecular:359.39Trilaciclib hydrochloride
CAS:Trilaciclib hydrochloride (G1T28 hydrochloride) is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6).Fórmula:C24H32Cl2N8OPureza:99.69% - 99.89%Forma y color:SolidPeso molecular:519.47TAK-901
CAS:TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among othersFórmula:C28H32N4O3SPureza:99.02% - 99.59%Forma y color:Yellow SolidPeso molecular:504.64Ref: TM-T2709
1mg34,00€5mg66,00€1mL*10mM (DMSO)74,00€10mg99,00€25mg192,00€50mg313,00€100mg497,00€200mg710,00€Abciximab
CAS:Abciximab: chimeric antibody, anti-platelet, blocks glycoprotein IIb/IIIa, vitronectin, Mac-1.Pureza:SDS-PAGE:95.2%;SEC-HPLC:95.9%Forma y color:Transparent LiquidPeso molecular:95.18 kDaCeftriaxone sodium hydrate
CAS:Ceftriaxone sodium hydrate is a broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.Fórmula:C18H16N8Na2O7S3·5H2OPureza:99.77% - 99.78%Forma y color:SolidPeso molecular:661.60Rifaximin
CAS:Rifaximin: an oral semi-synthetic antibiotic from rifamycin SV; targets bacterial RNA polymerase to halt growth.Fórmula:C43H51N3O11Pureza:99.18% - 99.40%Forma y color:SolidPeso molecular:785.88HLM006474
CAS:HLM006474 is a pan inhibitor of E2F. This inhibits E2F4 DNA-binding (IC50: 29.8 μM in A375 cells).Fórmula:C25H25N3O2Pureza:99.20% - 99.38%Forma y color:SolidPeso molecular:399.48CDK8-IN-12
CAS:CDK8-IN-12: selective CDK8 inhibitor (Ki 14 nM), oral anticancer, blocks GSK-3α/β, PCK-θ, halts MV4-11 cell growth.Fórmula:C21H20ClN3O2Pureza:98.55% - 99.22%Forma y color:SoildPeso molecular:381.86Ref: TM-T72048
1mg49,00€5mg96,00€1mL*10mM (DMSO)110,00€10mg142,00€25mg236,00€50mg344,00€100mg482,00€200mg658,00€Otelixizumab
CAS:Otelixizumab (ChAglyCD3) is a chimeric monoclonal antibody targeting CD3, used in research on Type 1 diabetes and autoimmune diseases.Pureza:>95%Forma y color:Transparent LiquidPeso molecular:144.58 kDaATN-161 trifluoroacetate salt
CAS:ATN-161 TFA salt, a new integrin α5β1 inhibitor, curbs angiogenesis, liver metastases growth, enhances survival in mice.Fórmula:C25H36F3N9O10SPureza:98% - 99.98%Forma y color:White SolidPeso molecular:711.67AZ1495
CAS:AZ1495: oral IRAK4 inhibitor (IC50: 5 nM), IRAK1 (23 nM), treats MYD88L265P DLBCL.Fórmula:C21H31N5O2Pureza:98.81%Forma y color:SolidPeso molecular:385.5Ref: TM-T14367
1mg93,00€5mg156,00€1mL*10mM (DMSO)170,00€10mg245,00€25mg349,00€50mg494,00€100mg750,00€200mg1.009,00€CDK2-IN-4
CAS:CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A.Fórmula:C23H18N6O2SPureza:97.24% - 99.10%Forma y color:SolidPeso molecular:442.49Ref: TM-T14916
1mg82,00€5mg192,00€1mL*10mM (DMSO)212,00€10mg304,00€25mg522,00€50mg713,00€100mg1.018,00€MKC8866
CAS:MKC8866, a selective IRE1 RNase inhibitor with an IC50 of 0.29 μM, curbs breast and prostate cancer cell growth.Fórmula:C18H19NO7Pureza:99.28% - 99.85%Forma y color:Yellow SolidPeso molecular:361.35Ref: TM-T15594
1mg84,00€2mg109,00€5mg177,00€1mL*10mM (DMSO)192,00€10mg250,00€25mg423,00€50mg557,00€100mg760,00€200mg1.018,00€AZ-Dyrk1B-33
CAS:AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.Fórmula:C19H16N4Pureza:99.91%Forma y color:SolidPeso molecular:300.36Ref: TM-T14364
1mg44,00€5mg92,00€1mL*10mM (DMSO)100,00€10mg147,00€25mg289,00€50mg419,00€100mg583,00€200mg787,00€HBX 19818
CAS:HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).Fórmula:C25H28ClN3OPureza:97.71%Forma y color:SolidPeso molecular:421.96Ref: TM-T15464
1mg35,00€5mg80,00€1mL*10mM (DMSO)89,00€10mg111,00€25mg177,00€50mg253,00€100mg353,00€200mg502,00€GSK-1520489A
CAS:GSK-1520489A is an active PKMYT1 inhibitor.Fórmula:C21H23N5O3SPureza:99.85%Forma y color:White SolidPeso molecular:425.5Nedaplatin
CAS:Nedaplatin, a cisplatin derivative, induces tumor DNA damage (IC50: 94 μM) through platinum-DNA cross-links, causing apoptosis.Fórmula:C2H8N2O3PtPureza:99.88% - >99.99%Forma y color:SolidPeso molecular:303.17JH-RE-06
CAS:JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POLζ.Fórmula:C20H16Cl3N3O4Pureza:99.29%Forma y color:SolidPeso molecular:468.72Ribociclib succinate
CAS:Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively).Fórmula:C27H36N8O5Pureza:99.90%Forma y color:White SolidPeso molecular:552.63Ref: TM-T15732
2mg34,00€5mg49,00€1mL*10mM (DMSO)60,00€10mg70,00€25mg92,00€50mg109,00€100mg165,00€200mg258,00€500mg459,00€Mps1-IN-3
CAS:Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).Fórmula:C26H31N7O4SPureza:99.25%Forma y color:SolidPeso molecular:537.63Ref: TM-T16130
2mg34,00€5mg54,00€1mL*10mM (DMSO)64,00€10mg87,00€25mg149,00€50mg255,00€100mg384,00€200mg538,00€MF-094
CAS:MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.Fórmula:C30H37N3O4SPureza:99.93%Forma y color:White SolidPeso molecular:535.7Ref: TM-T12024
1mg40,00€5mg93,00€1mL*10mM (DMSO)99,00€10mg137,00€25mg268,00€50mg430,00€100mg620,00€200mg884,00€NU6140
CAS:NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).Fórmula:C23H30N6O2Pureza:98.33%Forma y color:SolidPeso molecular:422.52Ref: TM-T16359
2mg39,00€5mg60,00€1mL*10mM (DMSO)67,00€10mg92,00€25mg177,00€50mg285,00€100mg414,00€200mg580,00€Hycanthone
CAS:Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal.Fórmula:C20H24N2O2SPureza:98.78%Forma y color:Yellow-Orange Powder (Ntp 1992)Peso molecular:356.48R-10015
CAS:R-10015, potent LIMK inhibitor with 38 nM IC50 for LIMK1, targets ATP pocket, and serves as a broad-spectrum HIV antiviral.Fórmula:C20H19ClN6O2Pureza:98.68%Forma y color:SolidPeso molecular:410.86Ref: TM-T12609
1mg50,00€5mg112,00€1mL*10mM (DMSO)124,00€10mg170,00€25mg280,00€50mg371,00€100mg525,00€200mg712,00€Cirtuvivint
CAS:Cirtuvivint (SM08502) is a potent and orally active CDC-like kinase (CLK) inhibitor that can be used to study arthritis.Fórmula:C24H25N7OPureza:99.95% - 99.96%Forma y color:Yellow SolidPeso molecular:427.5Metarrestin
CAS:Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis.Fórmula:C31H30N4OPureza:99.45%Forma y color:White SolidPeso molecular:474.6Ref: TM-T12006
1mg38,00€2mg50,00€5mg84,00€1mL*10mM (DMSO)87,00€10mg137,00€25mg281,00€50mg485,00€100mg700,00€500mg1.459,00€(E/Z)-THZ1 2HCl
CAS:THZ1 2HCl: selective CDK7 allosteric inhibitor, IC50 3.2 nM, hinders cancer cell growth.Fórmula:C31H30Cl3N7O2Pureza:99.51%Forma y color:SolidPeso molecular:638.98Cyclin K degrader 1
Cyclin K degrader 1 is a Cyclin K degrader.Cyclin K degrader 1 is a degrader converted from AT-7519.Cyclin K degrader 1 has weak degrading activity against Cyclin K but does not result in a sustained decrease in degradation affinity.Cyclin K degrader 1 is a degrader converted from AT-7519.Fórmula:C23H17Cl2N5O2Pureza:99.91%Forma y color:SolidPeso molecular:466.32Cibisatamab
CAS:Cibisatamab, a T-cell bispecific antibody, targets CEA on cancer cells and CD3 on T-cells, inducing T-cell-mediated tumor cell killing.Pureza:SDS-PAGE:99.1%;SEC-HPLC:96.5%Forma y color:Transparent LiquidPeso molecular:191.1 kDahSMG-1 inhibitor 11j
CAS:hSMG-1 inhibitor 11j: pyrimidine, IC50=0.11 nM, >455x selective vs. mTOR/PI3Kα/γ/CDK1/CDK2; cancer research use.Fórmula:C27H28ClN7O3SPureza:99.22% - 99.65%Forma y color:Yellow SolidPeso molecular:566.07SU056
CAS:SU056 is a YB-1 inhibitor that induces cell-cycle arrest, apoptosis, and inhibits ovarian cancer cell migration.Fórmula:C20H16FNO5Pureza:99.89%Forma y color:Yellow SolidPeso molecular:369.34TAO Kinase inhibitor 2
CAS:TAO Kinase inhibitor 2 is a TAO kinase inhibitor with an IC50 of 50-500 nM. TAO Kinase inhibitor 2 inhibits KIAA1361 and JIK with IC50s of 50-500 nM.Fórmula:C25H24N2O3Pureza:98.58%Forma y color:SolidPeso molecular:400.47Procaine
CAS:Procaine (Vitamin H3) is a slow-acting ester local anesthetic with a short effect, used for infiltration, nerve, and spinal blocks.Fórmula:C13H20N2O2Pureza:99.57% - 99.82%Forma y color:White SolidPeso molecular:236.31K34c hydrochloride
CAS:K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.Fórmula:C26H30ClN3O4Pureza:99.76% - 99.89%Forma y color:White SolidPeso molecular:483.99Procaine hydrochloride
CAS:Procaine HCl is a benzoic acid derivative used as a local anesthetic, blocking nerve impulses and sensation.Fórmula:C13H20N2O2·HClPureza:99.1% - 99.22%Forma y color:SolidPeso molecular:272.77
