Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(94 productos)
- CDK(500 productos)
- Detención del ciclo celular(4 productos)
- Chk(42 productos)
- DYRK(48 productos)
- Dynamin(23 productos)
- Ferroptosis(215 productos)
- HSP(169 productos)
- Integrin(224 productos)
- Kinesina(66 productos)
- LIM quinasa(19 productos)
- Asociado a microtúbulos(261 productos)
- PKC(102 productos)
- PLK(28 productos)
- ROCK(70 productos)
- Rho(2 productos)
- Wee1(15 productos)
- c-Myc(69 productos)
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Se han encontrado 3477 productos de "Ciclo celular / Checkpoint"
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N4-Benzoyl-3'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine
<p>N4-Benzoyl-3'-O-DMT cytidine analog inhibits DNA methyltransferases like Zebularine.</p>Fórmula:C41H43N3O9Forma y color:SolidPeso molecular:721.79HSDVHK-NH2 TFA
<p>HSDVHK-NH2 TFA acts as an antagonist to the αvβ3-vitronectin integrin interaction, displaying an inhibitory concentration (IC 50) of 1.74 pg/mL (2.414 pM) [1] [</p>Fórmula:C32H49F3N12O11Forma y color:SolidPeso molecular:834.85-O-TBDMS-N4-Benzoyl-2-deoxycytidine
CAS:<p>5-O-TBDMS-N4-Benzoyl-2-deoxycytidine is a modified nucleoside utilized in the synthesis of deoxyribonucleic acid (DNA) or nucleic acid.</p>Fórmula:C22H31N3O5SiForma y color:SolidPeso molecular:445.58Erythromycin thiocyanate
CAS:<p>Erythromycin thiocyanate, a macrolide from Streptomyces erythreus, binds 50S ribosomes, halting protein synthesis in bacteria.</p>Fórmula:C38H68N2O13SPureza:98%Forma y color:SolidPeso molecular:793.02Integrin Binding Peptide
CAS:<p>Integrin Binding Peptide, derived from fibronectin, holds the potential as an essential component for preparing PEG hydrogels.</p>Fórmula:C42H63N15O16SForma y color:SolidPeso molecular:1066.12m7GpppUmpG
CAS:<p>m7GpppUmpG, a trinucleotide cap analogue, enables RNA synthesis with cap 0 or 1 structures.</p>Fórmula:C31H42N12O26P4Forma y color:SolidPeso molecular:1122.632'-Deoxy-2'-fluoroguanosine 5'-monophosphate triethyl ammonium
<p>2’-Deoxy-2’-fluoroguanosine 5’-monophosphate triethyl ammonium, a purine nucleoside analog, exhibits broad antitumor activity specifically targeting indolent</p>Fórmula:C22H43FN7O7PForma y color:SolidPeso molecular:567.59LEB-03-146
CAS:<p>LEB-03-146: WEE1 DUBTAC linking AZD1775 to OTUB1 via PEG2; stabilizes WEE1 in HEP3B cells.</p>Fórmula:C46H57N11O8Forma y color:SolidPeso molecular:892.01O-Glycoprotease
<p>O-Glycoprotease is a specific endoprotease for O-glycoproteins, capable of catalyzing the hydrolysis of peptide bonds directly adjacent to O-glycan structures in natural mucin-type O-glycosylated proteins. The sequence of O-Glycoprotease is derived from Akkermansia muciniphila, and it is recombinantly expressed in E. coli with a C-terminal 6×His tag. This enzyme maintains high activity within a pH range of 5.5 to 7.5, is resistant to 1 M NaCl, but is highly sensitive to EDTA (0.5 mM EDTA) and can be inhibited by Zn2+.</p>Forma y color:Odour Solid5'-O-DMT-N2-DMF-dG
CAS:<p>5'-O-DMT-2'-O-TBDMS-rI, a modified nucleoside, finds application in deoxyribonucleic acid (DNA) or nucleic acid synthesis.</p>Fórmula:C34H36N6O6Forma y color:SolidPeso molecular:624.69813-TP
<p>13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.</p>Fórmula:C12H19F2N6O12P3Forma y color:SolidPeso molecular:570.23Nocarnickelamides B
<p>Nocarnickelamides B (Compound 2) is a linear peptide and an inhibitor of ROCK1/2. It exhibits dual inhibitory activity against ROCK1 and ROCK2, with IC50 values of 14.9 μM and 21.9 μM, respectively. This compound binds to the ATP binding site and inhibits ROCK-mediated cytoskeletal contraction markers, such as myosin light chain activation. Nocarnickelamides B can be utilized in glaucoma research.</p>Fórmula:C29H42N6O9Forma y color:Odour SolidPeso molecular:618.68Xylocytidine
CAS:<p>Xylocytidine is a biochemical.</p>Fórmula:C9H13N3O5Forma y color:SolidPeso molecular:243.22GSK270822A
CAS:<p>GSK270822A is a selective ROCK1 inhibitor. GSK270822A exhibits IC50 of 9nM, 1100nM, 1550nM for ROCK1, RSK1, p70S6K, respectively.</p>Fórmula:C24H20N4O2Pureza:98.64% - 99.78%Forma y color:SolidPeso molecular:396.44Endo-1,4-β-xylanase
CAS:<p>Endo-1,4-β-xylanase (CtXyn11A) is a type of xylan hydrolase that hydrolyzes the β-1,4-glycosidic bond of the xylan molecule.</p>Forma y color:SolidCDK12-IN-6
CAS:<p>CDK12-IN-6, a pyrazolotriazine, strongly inhibits CDK12 (IC50 1.19 μM at 2 mM ATP), but not CDK2/Cyclin E or CDK9/Cyclin T1 (both IC50 >20 μM).</p>Fórmula:C20H21F2N9Forma y color:SolidPeso molecular:425.448GSK299423
CAS:<p>GSK299423: Antibiotic possibly effective against bacteria with New Delhi metal-β-lactamase, targeting topoisomerases.</p>Fórmula:C25H27N5O2SPureza:97.34%Forma y color:SolidPeso molecular:461.58Biotin-PEG7-C2-S-Vidarabine
<p>Biotin-PEG7-C2-S-Vidarabine: PEG linker with antiviral adenosine analog effective against herpes and zoster.</p>Fórmula:C36H60N8O12S2Forma y color:SolidPeso molecular:861.04CDK4/6-IN-23
<p>CDK4/6-IN-23 (Compound 42) is a potent and selective inhibitor of CDK4/6, displaying an IC50 of 11 nM for CDK6. This compound significantly activates immune cells and enhances IL-3 production. In mice undergoing 5-FU chemotherapy, CDK4/6-IN-23 demonstrates dual bone marrow protection and immunomodulatory effects.</p>Fórmula:C32H34FN7O4Forma y color:SolidPeso molecular:599.655PP-C8
<p>PP-C8: PROTAC CDK12-Cyclin K degrader with DC50s 416/412 nM; synergizes with PARP inhibitor against TNBC.</p>Fórmula:C43H51FN12O7Forma y color:SolidPeso molecular:866.94Guanosine triphosphate
CAS:<p>Guanosine triphosphate (GTP), a native nucleotide, and its derivatives may serve as specific inhibitors against COVID-19 [1].</p>Fórmula:C10H16N5O14P3Forma y color:SolidPeso molecular:523.18Ceftriaxone
CAS:<p>Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.</p>Fórmula:C18H18N8O7S3Pureza:96.08%Forma y color:SolidPeso molecular:554.58Methylcarbamyl PAF C-8
<p>Methylcarbamyl PAF C-8 is resistant to degradation by PAF-AH and has a half-life of over 100 minutes in platelet-poor plasma, exhibiting platelet aggregation activity. In NRK-49 cells overexpressing PAF receptor, it induces the expression of c-myc, c-fos, and activates mitogen-activated protein kinase (MAPK). Furthermore, Methylcarbamyl PAF C-8 can induce G1 phase cell cycle arrest. This compound shows potential for research in cardiovascular and anti-cancer applications.</p>Forma y color:Odour Solid3'-Deoxy-GTP trisodium
<p>3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) trisodium, an analog of GTP, functions as an RNA chain terminator, thereby inhibiting RNA synthesis. It is capable of suppressing dengue virus DENV NS5 RdRp with an IC50 value of 0.02 μM.</p>Forma y color:Odour SolidCDK9 inhibitor HH1
CAS:<p>CDK9 inhibitor HH1 (8019-9719) is an inhibitor of the human CDK2-cyclin A2 complex with an IC50 value of 2 μM.</p>Fórmula:C13H15N3OSPureza:99.92%Forma y color:SolidPeso molecular:261.34Ficellomycin
CAS:<p>Ficellomycin is an aziridine antibiotic produced by Streptomyces ficellus. Which shows high in vitro activity against Gram-positive bacteria.</p>Fórmula:C13H24N6O3Forma y color:SolidPeso molecular:312.37HSDVHK-NH2
CAS:<p>Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.</p>Fórmula:C30H48N12O9Pureza:98%Forma y color:SolidPeso molecular:720.785'-O-DMTr-2',2'-difluoro-dC(Bz)-methyl phosphonamidite
<p>5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog with extensive antitumor activity against indolent lymphoid malignancies.</p>Fórmula:C44H49F2N4O7PForma y color:SolidPeso molecular:814.85PDI-IN-4
<p>PDI-IN-4 (Compound 14d) is a protein disulfide isomerase inhibitor with an IC50 value of 0.48 μM. It prevents platelet aggregation and thrombosis by reducing the activation of GPIIb/IIIa, without causing significant cytotoxicity. PDI-IN-4 is applicable in thrombosis research.</p>Fórmula:C17H12F3NO2Forma y color:SolidPeso molecular:319.278Brr2-IN-2
<p>Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.</p>Fórmula:C21H25FN4O2Forma y color:SolidPeso molecular:384.45α2β1 Integrin Ligand Peptide
CAS:<p>The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular</p>Fórmula:C14H22N4O9Pureza:98%Forma y color:SolidPeso molecular:390.355'-O-DMT-N4-Bz-2'-F-dC
CAS:<p>5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.</p>Fórmula:C37H34FN3O7Forma y color:SolidPeso molecular:651.68RA-V
<p>RA-V is a natural product that can be used as a reference standard.</p>Fórmula:C160H202N24O41Forma y color:SolidPeso molecular:3117.5N3-[(Pyrid-4-yl)methyl]uridine
<p>N3-[(Pyrid-4-yl)methyl]uridine, a uridine analog, may have antiepileptic properties and aid in researching anticonvulsants and anxiolytics.</p>Fórmula:C15H17N3O6Forma y color:SolidPeso molecular:335.31GK13S
<p>G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.</p>Fórmula:C21H22N6O2Forma y color:SolidPeso molecular:390.44UnyLinker 12 TEA
<p>UnyLinker 12 TEA is a versatile linker used in the synthesis of oligoribonucleotides.</p>Fórmula:C39H35NO10C6H15NForma y color:SolidPeso molecular:778.34655Censavudine
CAS:<p>Censavudine (OBP-601) is an HIV-1/2 treatment and prevention drug, a reverse transcriptase inhibitor with EC50 of 30-890 nM.</p>Fórmula:C12H12N2O4Pureza:98%Forma y color:SolidPeso molecular:248.23CDK7-IN-5
CAS:<p>CDK7-IN-5, a CDK7 inhibitor with an IC 50 value of less than 100 nM, exhibits potent anticancer properties (WO2015154022A1, Compound 104).</p>Fórmula:C34H45N9O2Forma y color:SolidPeso molecular:611.795PD-1/PD-L1-IN-52
<p>PD-1/PD-L1-IN-52 (Compound Ⅲ-5) is an orally active inhibitor of PD-1/PD-L1 interaction, exhibiting an IC50 of 109.9 nM. It demonstrates antitumor activity in a C57BL/6 mouse model of MC38 colon carcinoma cells expressing human PD-1, achieving a tumor growth inhibition (TGI) rate of 49.6%.</p>Forma y color:Odour SolidCDK6/9-IN-1
CAS:<p>CDK6/9-IN-1, an oral dual inhibitor of CDK6/9, has IC50s of 40.5nM (CDK6) and 39.5nM (CDK9).</p>Fórmula:C22H25ClN8OForma y color:SolidPeso molecular:452.95N7-Methyl-2'-O-(2-methoxyethyl) guanosine
<p>N7-Methyl-2’-O-(2-methoxyethyl) guanosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.</p>Fórmula:C14H21N5O6Forma y color:SolidPeso molecular:355.35Ac-dA Phosphoramidite
CAS:<p>Ac-dA Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.</p>Fórmula:C42H50N7O7PForma y color:SolidPeso molecular:795.878Fuzapladib
CAS:<p>Fuzapladib (IS-741) is a PLA2 inhibitor that reduces Mac-1 expression to prevent inflammation and pancreatitis.</p>Fórmula:C15H20F3N3O3SPureza:99.87%Forma y color:SoildPeso molecular:379.4Filanesib TFA
CAS:<p>Filanesib (ARRY-520) inhibits KSP, triggering mitotic arrest and cell death in dividing tumor cells.</p>Fórmula:C22H23F5N4O4SPureza:98%Forma y color:SolidPeso molecular:534.5Dihydro-5-azacytidine
CAS:<p>Dihydro-5-azacytidine (DHAC) is a nucleoside analog that interrupts DNA methylation by integrating into DNA. It also exhibits notable antitumor properties.</p>Fórmula:C8H14N4O5Pureza:>99.99%Forma y color:SolidPeso molecular:246.22Garenoxacin
CAS:<p>Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.</p>Fórmula:C23H20F2N2O4Pureza:98%Forma y color:SolidPeso molecular:426.415'-O-DMT-ibu-dC
CAS:<p>5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.</p>Fórmula:C34H37N3O7Forma y color:SolidPeso molecular:599.67Carboxy-pyridostatin
CAS:<p>Carboxy-pyridostatin, as a fluorescent probe, can target G-quadruplex structures and trap cytoplasmic RNA G-quadruplex structures in cells.</p>Fórmula:C35H34N10O7Forma y color:SolidPeso molecular:706.71CDK12-IN-2
CAS:<p>CDK12-IN-2 selectively inhibits CDK12 (IC50: 52 nM) with minimal effect on CDK2, CDK7, and CDK9, useful for CDK12 research.</p>Fórmula:C32H32N6O2Pureza:99.31%Forma y color:SolidPeso molecular:532.64Py-MAA-Val-Cit-PAB-DX8951
CAS:<p>Py-MAA-Val-Cit-PAB-DX8951, a purine toxin, serves as an intermediate in the synthesis of antibody-drug conjugates [1].</p>Fórmula:C57H66FN11O13SForma y color:SolidPeso molecular:1164.26
