Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(115 productos)
- CDK(547 productos)
- Detención del ciclo celular(5 productos)
- Chk(48 productos)
- DYRK(46 productos)
- Dynamin(27 productos)
- Ferroptosis(227 productos)
- HSP(180 productos)
- Integrin(275 productos)
- Kinesina(87 productos)
- LIM quinasa(21 productos)
- Asociado a microtúbulos(273 productos)
- PKC(127 productos)
- PLK(25 productos)
- ROCK(61 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(77 productos)
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Se han encontrado 3920 productos de "Ciclo celular / Checkpoint"
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TLR7 agonist 12
CAS:TLR7 agonist 12, a purine nucleoside analog, inhibits DNA synthesis and induces apoptosis in lymphoid cancers.Fórmula:C14H19N5O8Forma y color:SolidPeso molecular:385.333'-Deoxy-N6-(m-methoxy benzyl)adenosine
3’-Deoxy-N6-(m-methoxy benzyl)adenosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Fórmula:C18H21N5O4Forma y color:SolidPeso molecular:371.39Rifalazil
CAS:Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity, useful for research on chlamydia infections.Fórmula:C51H64N4O13Pureza:98%Forma y color:SolidPeso molecular:941.07Bromochloroacetonitrile
CAS:Bromochloroacetonitrile, a water disinfection by-product, is mutagenic and can break DNA strands.Fórmula:C2HBrClNForma y color:SolidPeso molecular:154.39JB-11 isethionate
CAS:JB-11 isethionate is a bioactive chemical.Fórmula:C21H29N5O7SForma y color:SolidPeso molecular:495.55Cimpuciclib
CAS:Cimpuciclib is a cyclin-dependent kinase(CDK) inhibitor and antineoplastic.Fórmula:C30H35FN8OForma y color:SolidPeso molecular:542.663αVβ8-IN-1
CAS:αVβ8-IN-1 is an αVβ8 integrin inhibitor that suppresses the growth of multiple tumour cell lines (EMT6, CT26, KPC, TKCC-10).Fórmula:C25H32ClN5O4Forma y color:SolidPeso molecular:502.01RNA splicing modulator 3
CAS:RNA Splicing Modulator 3 (Compound 236) is an effective RNA splicing modulator, exhibiting an AC50 value of less than 100 nM [1].Fórmula:C19H20N6OSForma y color:SolidPeso molecular:380.47Ac-MRGDH-NH2
Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.Fórmula:C25H41N11O8SForma y color:SolidPeso molecular:655.7275'-O-DMTr-5-MedC (Ac)-methyl phosphonamidite
5’-O-DMTr-5-MedC (Ac)-methyl phosphonamidite, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignanciesFórmula:C40H51N4O7PForma y color:SolidPeso molecular:730.83Sarecycline hydrochloride
CAS:Sarecycline hydrochloride is a narrow-spectrum tetracycline antibiotic with antimicrobial and anti-inflammatory activity.Fórmula:C24H30ClN3O8Pureza:99.23%Forma y color:SolidPeso molecular:523.96RAD51-IN-3
CAS:RAD51-IN-3 is a Rad51 inhibitor.Fórmula:C31H41N5O5S2Forma y color:SolidPeso molecular:627.82EFdA-TP
CAS:EFdA-TP: potent HIV-1 RT inhibitor; acts via immediate/delayed chain termination (ICT/DCT) and multiple pathways.Fórmula:C12H15FN5O12P3Forma y color:SolidPeso molecular:533.195N1-Methyl-2'-β-C-methyl adenosine
N1-Methyl-2’-beta-C-methyl adenosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Fórmula:C12H17N5O4Forma y color:SolidPeso molecular:295.29PROTAC CDK9 degrader 4
CAS:PROTAC CDK9 degrader 4 is a CDK9 degrader that targets transcriptional regulation and has potential anticancer activity.Fórmula:C43H56N10O5Forma y color:SolidPeso molecular:792.97Demycarosyl-3D-β-D-digitoxosylmithramycin SK
CAS:Demycarosyl-3D-β-D-digitoxosylmithramycin SK, an analog of Mithramycin, exhibits potent anti-tumor activity.Fórmula:C50H72O23Forma y color:SolidPeso molecular:1041.09Heliquinomycin
CAS:Heliquinomycin, a Streptomyces metabolite, inhibits DNA helicase (Ki=6.8 μM) and fights Gram-positive bacteria and various cancer cells.Fórmula:C33H30O17Forma y color:SolidPeso molecular:698.586Confidential-2
Confidential-2: a purine nucleoside analog with antitumor effects on lymphoid cancers, inhibits DNA synthesis, induces apoptosis.Fórmula:C20H25N5O8Forma y color:SolidPeso molecular:463.44LXY3
CAS:LXY3 (LXY2) is a VLA-3 blocking peptide that inhibits the interaction of neutrophil surface integrin α3β1 (VLA-3) with laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is employed to block the neutrophil-mediated release of nanoparticles from the perivascular pool into the tumor stroma and is frequently used for targeted imaging in breast cancer.Fórmula:C32H43N11O15S2Forma y color:SolidPeso molecular:885.88m7GpppApG
CAS:M7GpppApG is a trinucleotide mRNA 5' cap analog utilized for in vitro RNA synthesis [1].Fórmula:C31H41N15O24P4Forma y color:SolidPeso molecular:1131.64Subquinocin
Subquinocin is a CYLD inhibitor that suppresses deubiquitinating enzymes (DUB) of the USP family. By inhibiting CYLD, Subquinocin enhances the activation of the NF-κB and IFN pathways. Additionally, Subquinocin facilitates the activation of IRF3 and/or IRF7 in the RIG-I-mediated interferon pathway.Fórmula:C20H27N3O4SForma y color:SolidPeso molecular:405.17223LB80317
CAS:LB-80317, a DNA polymerase inhibitor, is used potentially for the potential treatment of hepatitis B virus infection.Fórmula:C10H14N5O5PForma y color:SolidPeso molecular:315.2211H-Benzo[a]carbazole
CAS:11H-Benzo[a]carbazole is a kinesin-like protein KIF11 inhibitor that can inhibit the viability of HeLa cells.Fórmula:C16H11NPureza:99.14%Forma y color:SolidPeso molecular:217.27Eesperamicin A1
CAS:Esperamicin A1, a powerful antitumor drug, comes from Actinomadura verrucosospora.Fórmula:C59H80N4O22S4Forma y color:SolidPeso molecular:1325.54Chrysomycin A
CAS:Chrysomycin A is an antibiotic that can be derived from Streptomyces.Fórmula:C28H28O9Forma y color:SolidPeso molecular:508.52N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium
CAS:N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].
Fórmula:C21H35N12O17P3Forma y color:SolidPeso molecular:820.495'-O-DMT-2'-O-TBDMS-Ac-rC
CAS:5’-O-DMT-2’-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.Fórmula:C38H47N3O8SiForma y color:SolidPeso molecular:701.892Rev 2'-O-MOE-5MeC(Bz)-5'-amidite
Rev 2’-O-MOE-5MeC(Bz)-5’-amidite, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Fórmula:C50H60N5O10PForma y color:SolidPeso molecular:922.015'-ODMT cEt G Phosphoramidite (Amidite)
CAS:5'-ODMT cEt G Amidite is a safe, effective nucleic acid analog with strong antisense activity.Fórmula:C46H56N7O9PForma y color:SolidPeso molecular:881.952-Diethoxymethyl adenosine
2-Diethoxymethyl adenosine, an adenosine analog, dilates smooth muscle, inhibits cancer, and leads to drugs like Acadesine.Fórmula:C23H31N5O10Forma y color:SolidPeso molecular:537.52Anti-EMMPRIN/CD147 Antibody
Anti-EMMPRIN/CD147 Antibody is a human-derived antibody expressed in CHO cells, targeting Basigin. For an isotype control, refer to HumanIgG1kappa, Isotype Control.Forma y color:Odour LiquidUridine-5-oxo-acetyl-(9-fluorenylmethyl) ester
Uridine analogue with antitumor effects; inhibits DNA synthesis, induces apoptosis in lymphoid cancers.Fórmula:C24H24N2O9Forma y color:SolidPeso molecular:484.46JB300
CAS:JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.Fórmula:C43H45ClFN7O10SForma y color:SolidPeso molecular:906.3752'-O-Methyladenosine 5'-monophosphate triethyl ammonium
2’-O-Methyladenosine 5’-monophosphate triethyl ammonium is an adenosine analog.Fórmula:C11H14N5O7P2Forma y color:SolidPeso molecular:359.23CDK7-IN-2 hydrochloride hydrate
CAS:CDK7-IN-2 HCl hydrate is a potent, specific CDK7 enzyme inhibitor with significant anti-cancer effects.Fórmula:C26H42ClN7O4Forma y color:SolidPeso molecular:552.125'-O-DMTr-2'-O-MOE inosine 3'-P-methyl phosphonamidite
5’-O-DMTr-2’-O-MOE inosine 3’-P-methyl phosphonamidite, a purine nucleoside analog, exhibits extensive antitumor activity specific to indolent lymphoidFórmula:C41H52N5O8PForma y color:SolidPeso molecular:773.855'-O-TBDMS-dA
CAS:5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.
Fórmula:C16H27N5O3SiForma y color:SolidPeso molecular:365.509ddGTP trisodium
ddGTP trisodium, a ddNTP, inhibits or serves as a substrate for DNA polymerase α, halting DNA chain elongation.Fórmula:C10H13N5Na3O12P3Forma y color:SolidPeso molecular:557.13WAY-647802
CAS:WAY-647802 is a CDK inhibitor.Fórmula:C11H14N4O3Pureza:99.53%Forma y color:SolidPeso molecular:250.25Emicoron
CAS:Importazole is an inhibitor of the transport receptor importin-β. It specifically inhibits importin-β likely by altering its interaction with RanGTP.Fórmula:C52H58N6O4Pureza:98%Forma y color:SolidPeso molecular:831.05Mumefural
CAS:Mumefural, from Prunus mume fruit, hinders platelets, has anti-thrombotic properties, and boosts cognition.
Fórmula:C12H12O9Forma y color:SolidPeso molecular:300.22Anticancer agent 263
Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.Fórmula:C13H20N2O6Forma y color:SolidPeso molecular:300.308JH-XVI-178
CAS:JH-XVI-178: potent CDK8/19 inhibitor with good pharmacokinetics, low clearance, moderate oral bioavailability.Fórmula:C22H22ClN7OForma y color:SolidPeso molecular:435.922'-(2-Nitrobenzyl)-ATP trisodium
2'-(2-Nitrobenzyl)-ATP trisodium is an rATP analogue that acts as a transcription terminator. It inhibits T7 RNA polymerase from continuing RNA chain extension.Fórmula:C17H18N6Na3O15P3Forma y color:SolidPeso molecular:707.97361(R)-N-(2,3-Dihydro-1H-indenyl)-2-amino adenosine
(R)-N-(2,3-Dihydro-1H-indenyl)-2-amino adenosine, a purine analog, targets lymphoid cancer via DNA synthesis inhibition and apoptosis.Fórmula:C19H22N6O4Forma y color:SolidPeso molecular:398.42M7G(3'-OMe-5')pppA(2'-OMe)
M7G(3'-OMe-5')pppA(2'-OMe) is a cap analogue for mRNA synthesis in vitro.Fórmula:C23H33N10O17P3Forma y color:SolidPeso molecular:814.49LL-K8-22
LL-K8-22: potent CDK8/cyclin C degrader; DC50 ~2.5μM; hinders STAT1 phosphorylation; curbs E2F/MYC cancer pathways; for TNBC study.Fórmula:C37H43N5OForma y color:SolidPeso molecular:573.775-Iminodaunorubicin
CAS:5-Iminodaunorubicin: a quinone-altered anthracycline with antitumor effects, causing DNA breaks in cancer.Fórmula:C27H30N2O9Forma y color:SolidPeso molecular:526.54Ceftriaxone
CAS:Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.Fórmula:C18H18N8O7S3Pureza:96.08% - 99.95%Forma y color:SolidPeso molecular:554.58DSPE-PEG1000-iRGD
DSPE-PEG1000-iRGD is a PEG compound made from DSPE and the αv-integrin-targeting peptide (iRGD). The iRGD peptide initially binds to αv-integrins and undergoes proteolytic cleavage within tumors to produce CRGDK/R, which interacts with neuropilin-1, thereby facilitating tumor targeting and penetration. DSPE-PEG1000-iRGD is useful for drug delivery applications.Forma y color:Odour Solid
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