Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(115 productos)
- CDK(546 productos)
- Detención del ciclo celular(5 productos)
- Chk(48 productos)
- DYRK(47 productos)
- Dynamin(27 productos)
- Ferroptosis(227 productos)
- HSP(180 productos)
- Integrin(269 productos)
- Kinesina(87 productos)
- LIM quinasa(20 productos)
- Asociado a microtúbulos(274 productos)
- PKC(126 productos)
- PLK(25 productos)
- ROCK(62 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(76 productos)
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Se han encontrado 3905 productos de "Ciclo celular / Checkpoint"
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AB-3PRGD2
CAS:AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.
Fórmula:C137H215IN30O45SForma y color:SolidPeso molecular:3161.32TLR7 agonist 12
CAS:TLR7 agonist 12, a purine nucleoside analog, inhibits DNA synthesis and induces apoptosis in lymphoid cancers.Fórmula:C14H19N5O8Forma y color:SolidPeso molecular:385.33Py-MAA-Val-Cit-PAB-DX8951
CAS:Py-MAA-Val-Cit-PAB-DX8951, a purine toxin, serves as an intermediate in the synthesis of antibody-drug conjugates [1].Fórmula:C57H66FN11O13SForma y color:SolidPeso molecular:1164.26JB-11 isethionate
CAS:JB-11 isethionate is a bioactive chemical.Fórmula:C21H29N5O7SForma y color:SolidPeso molecular:495.553'-Deoxy-N6-(m-methoxy benzyl)adenosine
3’-Deoxy-N6-(m-methoxy benzyl)adenosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Fórmula:C18H21N5O4Forma y color:SolidPeso molecular:371.39CDK7-IN-1
CAS:CDK7-IN-1, analog of YKL-5-124, inhibits cdk7 with IC50 < 100 nM.Fórmula:C28H35N7O3Forma y color:SolidPeso molecular:517.634αVβ8-IN-1
CAS:αVβ8-IN-1 is an αVβ8 integrin inhibitor that suppresses the growth of multiple tumour cell lines (EMT6, CT26, KPC, TKCC-10).Fórmula:C25H32ClN5O4Forma y color:SolidPeso molecular:502.01STX-100
PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.Pureza:97.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 97.3% (SDS-PAGE); 97.5% (SEC-HPLC)Forma y color:Odour LiquidPeso molecular:145.12 kDaAnti-EMMPRIN/CD147 Antibody
Anti-EMMPRIN/CD147 Antibody is a human-derived antibody expressed in CHO cells, targeting Basigin. For an isotype control, refer to HumanIgG1kappa, Isotype Control.Forma y color:Odour LiquidAc-MRGDH-NH2
Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.Fórmula:C25H41N11O8SForma y color:SolidPeso molecular:655.727Sarecycline hydrochloride
CAS:Sarecycline hydrochloride is a narrow-spectrum tetracycline antibiotic with antimicrobial and anti-inflammatory activity.Fórmula:C24H30ClN3O8Pureza:99.23%Forma y color:SolidPeso molecular:523.965'-ODMT cEt G Phosphoramidite (Amidite)
CAS:5'-ODMT cEt G Amidite is a safe, effective nucleic acid analog with strong antisense activity.Fórmula:C46H56N7O9PForma y color:SolidPeso molecular:881.95Abemaciclib metabolite M18
CAS:Abemaciclib M18 (LSN3106729), a potent CDK inhibitor with antitumor action, used in a PROTAC to degrade CDK4/6.Fórmula:C25H28F2N8OPureza:98%Forma y color:SolidPeso molecular:494.54EFdA-TP
CAS:EFdA-TP: potent HIV-1 RT inhibitor; acts via immediate/delayed chain termination (ICT/DCT) and multiple pathways.Fórmula:C12H15FN5O12P3Forma y color:SolidPeso molecular:533.195MYC-IN-2
CAS:MYC-IN-2 is a protein-protein inhibitor targeting the MYC protein, designed for use in cancer research.Fórmula:C25H17N3O2SForma y color:SolidPeso molecular:423.49N1-Methylsulfonyl pseudouridine
N1-Methylsulfonyl pseudouridine, a purine analog, inhibits DNA synthesis and induces apoptosis in cancer.Fórmula:C10H14N2O8SForma y color:SolidPeso molecular:322.29Heliquinomycin
CAS:Heliquinomycin, a Streptomyces metabolite, inhibits DNA helicase (Ki=6.8 μM) and fights Gram-positive bacteria and various cancer cells.Fórmula:C33H30O17Forma y color:SolidPeso molecular:698.5862'-Deoxy-2'-fluoro-N3-[(pyrid-2-yl)methyl]uridine
2’-Deoxy-2’-fluoro-N3-[(pyrid-2-yl)methyl]uridine, a uridine analogue, exhibits potential for antiepileptic applications.Fórmula:C15H16FN3O5Forma y color:SolidPeso molecular:337.36-Amino-4-methoxy-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine
6-Amino-4-methoxy-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine, a purine nucleoside analogue, exhibits widespread antitumor efficacy, particularly againstFórmula:C11H17N5O5Forma y color:SolidPeso molecular:299.28N1-Methyl-2'-β-C-methyl adenosine
N1-Methyl-2’-beta-C-methyl adenosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Fórmula:C12H17N5O4Forma y color:SolidPeso molecular:295.295'-O-TBDMS-dT
CAS:5’-O-TBDMS-dT is a nucleoside with protective and modification effects.Fórmula:C16H28N2O5SiForma y color:SolidPeso molecular:356.49Rev dC(Bz)-5'-amidite
Rev dC(Bz)-5'-amidite, a purine nucleoside analog with antitumor effects, inhibits DNA synthesis and induces apoptosis in lymphoid cancers.Fórmula:C46H52N5O8PForma y color:SolidPeso molecular:833.915'-O-DMT-2'-O-TBDMS-Ac-rC
CAS:5’-O-DMT-2’-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.Fórmula:C38H47N3O8SiForma y color:SolidPeso molecular:701.892Eesperamicin A1
CAS:Esperamicin A1, a powerful antitumor drug, comes from Actinomadura verrucosospora.Fórmula:C59H80N4O22S4Forma y color:SolidPeso molecular:1325.54Chrysomycin A
CAS:Chrysomycin A is an antibiotic that can be derived from Streptomyces.Fórmula:C28H28O9Forma y color:SolidPeso molecular:508.52m7GpppApG
CAS:M7GpppApG is a trinucleotide mRNA 5' cap analog utilized for in vitro RNA synthesis [1].Fórmula:C31H41N15O24P4Forma y color:SolidPeso molecular:1131.64N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium
CAS:N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].
Fórmula:C21H35N12O17P3Forma y color:SolidPeso molecular:820.49DSPE-PEG2000-iRGD
DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.Forma y color:Odour SolidLB80317
CAS:LB-80317, a DNA polymerase inhibitor, is used potentially for the potential treatment of hepatitis B virus infection.Fórmula:C10H14N5O5PForma y color:SolidPeso molecular:315.222'-β-C-Methyl-3-deazauri dine
CAS:2’-β-C-Methyl-3-deazauridine, a purine nucleoside analogue, exhibits wide antitumor activity specifically against indolent lymphoid malignancies.Fórmula:C11H15NO6Forma y color:SolidPeso molecular:257.24Pyrindamycin A
CAS:Pyrindamycin A is an antibiotic that inhibits DNA synthesis,and shows antitumor activities against murine leukemia.Fórmula:C26H26ClN3O8Pureza:98%Forma y color:SolidPeso molecular:543.95Orbofiban acetate
CAS:Orbofiban Acetate is a compound that serves as an antagonist to the platelet GPIIb/IIIa receptor, effectively inhibiting platelet aggregation when administeredFórmula:C19H27N5O6Forma y color:SolidPeso molecular:421.45JB300
CAS:JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.Fórmula:C43H45ClFN7O10SForma y color:SolidPeso molecular:906.375N4-(3,3,3-Trifluoropropanoyl)cytidine
N4-(3,3,3-Trifluoropropanoyl)cytidine, a cytidine analog, inhibits DNA methyltransferases, possibly anti-metabolic and anti-cancer.Fórmula:C12H14F3N3O6Forma y color:SolidPeso molecular:353.252'-Deoxy-2'-fluoro-N3-(n-dodecyl)uridine
2’-Deoxy-2’-fluoro-N3-(n-dodecyl)uridine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Fórmula:C21H35FN2O5Forma y color:SolidPeso molecular:414.516-Amino-4-hydrozino-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine
6-Amino-4-hydrozino-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine, a pyrimidine nucleoside analog, boasts a broad spectrum of biochemical andFórmula:C10H17N7O3Forma y color:SolidPeso molecular:283.295'-O-TBDMS-dA
CAS:5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.
Fórmula:C16H27N5O3SiForma y color:SolidPeso molecular:365.509RNA splicing modulator 2
CAS:RNA splicing modulator 2 (compound 256) is a RNA splicing modulator [1] .Fórmula:C20H21N5OSForma y color:SolidPeso molecular:379.48THK01
CAS:THK01: ROCK2 inhibitor (IC50=5.7nM), less effective on ROCK1 (923nM). Hinders breast cancer spread via ROCK2-STAT3. For cancer research.Fórmula:C20H13N3O2Forma y color:SolidPeso molecular:327.34ddGTP trisodium
ddGTP trisodium, a ddNTP, inhibits or serves as a substrate for DNA polymerase α, halting DNA chain elongation.Fórmula:C10H13N5Na3O12P3Forma y color:SolidPeso molecular:557.13Anticancer agent 263
Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.Fórmula:C13H20N2O6Forma y color:SolidPeso molecular:300.308Mumefural
CAS:Mumefural, from Prunus mume fruit, hinders platelets, has anti-thrombotic properties, and boosts cognition.
Fórmula:C12H12O9Forma y color:SolidPeso molecular:300.22JH-XVI-178
CAS:JH-XVI-178: potent CDK8/19 inhibitor with good pharmacokinetics, low clearance, moderate oral bioavailability.Fórmula:C22H22ClN7OForma y color:SolidPeso molecular:435.92Xanthosine-5'-Triphosphate
CAS:Xanthosine-5'-Triphosphate (5'-XTP), a nucleotide derived from the deamination of purine bases, plays a crucial role in various biological processes.Fórmula:C10H15N4O15P3Forma y color:SolidPeso molecular:524.164Anticancer agent 84
CAS:Anticancer agent 84 inhibits c-MYC transcription by stabilizing G4 structures, aiding cancer research.Fórmula:C57H67N7O9Forma y color:SolidPeso molecular:994.18PLK1-IN-12
PLK1-IN-12 is a highly selective, orally active PLK1 inhibitor with an IC50 of 20 nM. It demonstrates greater selectivity for PLK1 over PLK2 (IC50: >10000 nM) and PLK3 (IC50: 3953 nM). PLK1-IN-12 exhibits anticancer efficacy across a wide range of cell lines and is applicable to anti-leukemia research.Forma y color:Odour SolidN1-Methylpseudouridine-5′-triphosphate tetralithium
N1-Methylpseudouridine-5′-triphosphate tetralithium, also known as 1-Methylpseudouridine-5′-triphosphate tetralithium, is a nucleobase-modified nucleotide.Fórmula:C10H13Li4N2O15P3Forma y color:SolidPeso molecular:521.9Fostroxacitabine bralpamide
CAS:Fostroxacitabine bralpamide (MIV-818) is an orally active Troxacitabine-based nucleotide prodrug. Fostroxacitabine bralpamide has anticancer effects.Fórmula:C22H30BrN4O8PForma y color:SolidPeso molecular:589.375-Iminodaunorubicin
CAS:5-Iminodaunorubicin: a quinone-altered anthracycline with antitumor effects, causing DNA breaks in cancer.Fórmula:C27H30N2O9Forma y color:SolidPeso molecular:526.5413-TP
13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.Fórmula:C12H19F2N6O12P3Forma y color:SolidPeso molecular:570.23
