Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(116 productos)
- CDK(547 productos)
- Detención del ciclo celular(5 productos)
- Chk(48 productos)
- DYRK(46 productos)
- Dynamin(27 productos)
- Ferroptosis(227 productos)
- HSP(180 productos)
- Integrin(276 productos)
- Kinesina(87 productos)
- LIM quinasa(21 productos)
- Asociado a microtúbulos(273 productos)
- PKC(127 productos)
- PLK(25 productos)
- ROCK(61 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(77 productos)
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Se han encontrado 3923 productos de "Ciclo celular / Checkpoint"
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TC113
TC113, a c(RGDyK)-linked Gemcitabine, targets αvβ3 integrin, entering A549 cells, and inhibits WM266.4 and A549 cell growth.Fórmula:C37H50F2N12O13Forma y color:SolidPeso molecular:908.866-Methoxypurine-9-β-D-(3-methoxy riboside)
6-Methoxypurine riboside is a purine analog with anti-lymphoma activity via DNA synthesis inhibition and apoptosis induction.Fórmula:C12H16N4O5Forma y color:SolidPeso molecular:296.28GK13S
G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.Fórmula:C21H22N6O2Forma y color:SolidPeso molecular:390.44LX-7101 hydrochloride
CAS:LX-7101 hydrochloride is a potent LIMK and ROCK2 inhibitor with antihypertensive activity, inhibits LIMK1/2, ROCK, PKA, and can be used to study glaucoma.Fórmula:C23H29N7O3xHClPureza:98.96%Forma y color:SolidPeso molecular:487.99USP8-IN-2
CAS:USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.Fórmula:C19H20ClF3N4OSPureza:99.92%Forma y color:SolidPeso molecular:444.9Ref: TM-T67876
1mg94,00€5mg200,00€1mL*10mM (DMSO)233,00€10mg313,00€25mg520,00€50mg740,00€100mg982,00€12R-LOX-IN-2
CAS:12R-LOX-IN-2 is a 12R-LOX inhibitor that inhibits the hyperproliferation of psoriatic cells and can be used in the study of psoriasis and other skin diseases.Fórmula:C19H13NOPureza:99.92%Forma y color:SolidPeso molecular:271.31CDK2/PIM1-IN-1
CDK2/PIM1-IN-1 is an inhibitor of the kinases CDK2 (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM). It can induce apoptosis (cell death) and reduce the expression of TNF-α, which promotes tumors. CDK2/PIM1-IN-1 exhibits antitumor activity.Forma y color:Odour Solid(+)-Glaucarubinone
(+)-Glaucarubinone is a natural product that can be used as a reference standard.Fórmula:C25H34O10Forma y color:SolidPeso molecular:494.537Volociximab
CAS:Volociximab (M200) is an IgG4 monoclonal antibody targeting the α5β1 integrin , with antiangiogenic, antitumor and anticancer activity, inhibits the growth of rabbit VX2 tumors and is used to study solid tumors.Pureza:95%Forma y color:LiquidPeso molecular:145.4 kDaEciruciclib
CAS:Eciruciclib is an inhibitor of CDK with antitumor properties.Fórmula:C27H33FN8Pureza:99.73%Forma y color:SolidPeso molecular:488.65'-O-DMT-Bz-rC
CAS:5’-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.Fórmula:C37H35N3O8Forma y color:SolidPeso molecular:649.69UnyLinker 12 TEA
UnyLinker 12 TEA is a versatile linker used in the synthesis of oligoribonucleotides.Fórmula:C39H35NO10C6H15NForma y color:SolidPeso molecular:778.34655Carboxy-pyridostatin
CAS:Carboxy-pyridostatin, as a fluorescent probe, can target G-quadruplex structures and trap cytoplasmic RNA G-quadruplex structures in cells.
Fórmula:C35H34N10O7Forma y color:SolidPeso molecular:706.71PROTAC CDK9 degrader-5
CAS:PROTAC CDK9 degrader-5 selectively degrades CDK9 isoforms 42, 55 with DC50 of 0.10μM, 0.14μM via proteasome.Fórmula:C42H48Cl2N8O9Pureza:98%Forma y color:SolidPeso molecular:879.78AV-153
CAS:AV-153, a 1,4-dihydropyridine, reduces DNA damage, stimulates repair, and has anti-cancer properties.Fórmula:C14H19NNaO6Forma y color:SolidPeso molecular:320.297Bimosiamose
CAS:Bimosiamose has anti-inflammatory effects[1].Fórmula:C46H54O16Pureza:98%Forma y color:SolidPeso molecular:862.91Rev 2'-O-MOE-C(Bz)-5'-amidite
'Rev 2’-O-MOE-C(Bz)-5’-amidite, a purine nucleoside analog, exhibits broad antitumor activity against indolent lymphoid malignancies.Fórmula:C49H58N5O10PForma y color:SolidPeso molecular:907.992'-Deoxy-2'-fluoro-l-uridine
CAS:2'-Deoxy-2'-fluoro-1-uridine: an L-nucleoside, inhibits RNA viruses by blocking viral RNA polymerase.Fórmula:C9H11FN2O5Forma y color:SolidPeso molecular:246.19CDK2 degrader 3
CAS:CDK2 degrader3 selectively degrades CDK2 and exhibits antitumor activity.Fórmula:C44H53ClN10O6SForma y color:SolidPeso molecular:885.47PF07104091
CAS:PF07104091 inhibits CDK2, which may lead to cell cycle arrest, induce apoptosis and inhibit tumor cell proliferation. Cost-effective and quality-assured.Fórmula:C19H28N6O4Pureza:99.49% - 99.59%Forma y color:SolidPeso molecular:404.46Ref: TM-T9712
1mg334,00€2mg492,00€5mg780,00€1mL*10mM (DMSO)867,00€10mg1.144,00€25mg1.701,00€50mg2.295,00€100mg3.087,00€PROTAC CDK9 degrader-11
CAS:PROTAC CDK9 degrader-11 (Compound C3) is an orally active PROTAC CDK9 degrader with a DC50 of 1.09 nM. This compound exhibits cytotoxicity in small cell lung cancer (SCLC) cells, with IC50 values in the nanomolar range. It induces cell cycle arrest at the G0/G1 phase and inhibits cell invasion in DMS114 and DMS53 cells. In addition, PROTAC CDK9 degrader-11 shows antitumor activity in an NCI-H446 xenograft mouse model. (Pink: ligand for target protein CDK9 ligand 3; Black: linker; Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56)Fórmula:C39H48Cl2N10O5Forma y color:SolidPeso molecular:807.768m7GpppCpG
CAS:m7GpppCpG, a trinucleotide cap analogue, is used for synthesizing RNA with cap 0 or cap 1 structures.Fórmula:C30H41N13O25P4Forma y color:SolidPeso molecular:1107.61Biotin-PEG7-C2-NH-Vidarabine-S-CH3
Biotin-PEG7-C2-NH-Vidarabine-S-CH3 is a PEG linker with Vidarabine, an anti-herpes/zoster antiviral.Fórmula:C37H62N8O12S2Forma y color:SolidPeso molecular:875.06C16Y
CAS:C16Y, a short peptide, serves as an inhibitor for the integrins αvβ3 and α5β1. It targets the cell membrane and exerts its antitumor activity by inhibiting angiogenesis.Fórmula:C78H115N17O17Forma y color:SolidPeso molecular:1562.853'-β-C-ethynyl-N6-iso-pentenyl adenosine
3’-Beta-C-ethynyl-N6-iso-pentenyl adenosine is an adenosine analog.Fórmula:C17H21N5O4Forma y color:SolidPeso molecular:359.387-TFA-ap-7-Deaza-ddG
CAS:Compound 19d, a nucleotide derivative, is used to make thiotriphosphate dye terminators for DNA sequencing.Fórmula:C16H16F3N5O4Forma y color:SolidPeso molecular:399.33N4-Benzoyl-2'-deoxy-2'-fluoro-β-D-arabinocytidine
N4-Benzoyl-2’-deoxy-2’-fluoro-β-D-arabinocytidine, a purine nucleoside analog, exhibits widespread antitumor activity, particularly against indolent lymphoidFórmula:C16H16FN3O5Forma y color:SolidPeso molecular:349.315'-O-DMT-rU
CAS:5’-O-DMT-rU is a modified nucleoside and can be used to synthesize RNA.Fórmula:C30H30N2O8Forma y color:SolidPeso molecular:546.57CHK1-IN-12
CHK1-IN-12 (Compound example 1-5) is a highly selective and orally active checkpoint kinase 1 (CHK1) inhibitor, demonstrating an in vitro enzyme IC50 of ≤10 nM and a cellular IC50 of ≤50 nM. This compound suppresses the phosphorylation activity of CHK1 kinase, disrupts DNA damage response pathways, and induces tumor cell cycle arrest and apoptosis. CHK1-IN-12 shows promise for cancer research applications.Fórmula:C19H19N7O2Forma y color:SolidPeso molecular:377.16002Olsutamig
CAS:Olsutamig is a bivalent humanized IgG4κ monoclonal antibody inhibitor targeting FOLH1/PSMA and CD3E. It is capable of binding simultaneously to PSMA on tumor cell surfaces and CD3E on T cell surfaces, leading to significant activation of T cells and the specific destruction of prostate cancer cells.Forma y color:LiquidN1-Methyl-2'-deoxy-2'-fluoroarabinoguanosine
Nucleoside Derivatives - Fluoro-modified nucleosides; N-Methylated alkylated nucleosidesForma y color:SoildRef: TM-TNU0546
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultarms2i6A
CAS:ms2i6A is a mitochondrial tRNA-specific modification, which regulates efficient mitochondrial translation and energy metabolism in mammals.Fórmula:C16H23N5O4SForma y color:SolidPeso molecular:381.452',3',5'-Tri-O-benzoyl-5-iodouridine
CAS:Nucleoside Derivatives - Halo-Nucleosides, 5-Modified pyrimidine nucleosidesFórmula:C30H23IN2O9Forma y color:SolidPeso molecular:682.42Ref: TM-TNU0905
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar2,6-Bis(4-morpholinyl)-9-b-D-ribofuranosyl-9H-purine
Nucleoside Derivatives –6-Subtituted nucleosides；2-Substituted nucleosidesForma y color:SoildRef: TM-TNU1411
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar5-Iodo-2'-O-methylcytidine
CAS:5-Iodo-2'-O-methylcytidine is a Halo-nucleoside; 2'-O-Methyl nucleoside.Fórmula:C10H14IN3O5Forma y color:SolidPeso molecular:383.14Ref: TM-TNU0018
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar2-Amino-6-methythio-9-(β-D-ribofuranosyl)-9H-purine
CAS:2-Amino-6-methythio-9-(beta-D-ribofuranosyl)-9H-purine is a Nucleoside Derivative - 6-Modified purine nucleoside; Thio-nucleoside.Fórmula:C11H15N5O4SForma y color:SolidPeso molecular:313.33Ref: TM-TNU0491
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar5-Phenylcytidine
CAS:5-Phenylcytidine is a Nucleoside Derivative - 5-Modified pyrimidine nucleoside.Fórmula:C15H17N3O5Forma y color:SolidPeso molecular:319.31Ref: TM-TNU0150
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar2-Chloro-6-methoxypurine -9-β-D-(2'-deoxy-2'-fluoro)-arabinoriboside
CAS:Fluoro-modified nucleoside; Halo-nucleoside; 2/6/8-Modified purine nucleoside; Arabino-nucleoside;Fórmula:C11H12ClFN4O4Forma y color:SolidPeso molecular:318.69Ref: TM-TNU0104
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar8-Benzyloxy-2'-deoxyguanosine
CAS:8-Benzyloxy-2'-deoxyguanosine is a Nucleoside Derivative - 8-Modified purine nucleoside.Fórmula:C17H19N5O5Forma y color:SolidPeso molecular:373.36Ref: TM-TNU0931
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-[5-(propyn-1-yl)pyridin-3-yl]purine
CAS:9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-[5-(propyn-1-yl)pyridin-3-yl]purine is a Nucleoside Derivative - Fluoro-modified nucleoside, 6-Modified purineFórmula:C18H16FN5O3Forma y color:SolidPeso molecular:369.35Ref: TM-TNU0735
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar5-Methyl-2-thio-xylo-uridine
CAS:Nucleoside Derivatives - Xylo-nucleosides; Thio-nucleosidesFórmula:C10H14N2O5SForma y color:SolidPeso molecular:274.29Ref: TM-TNU0433
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar2'-Deoxy-N4,N4-dimethylcytidine
CAS:2'-Deoxy-N4,N4-dimethylcytidine is a Nucleoside Derivative - N-Methylated nucleoside.Fórmula:C11H17N3O4Forma y color:SolidPeso molecular:255.27Ref: TM-TNU1206
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar2-Chloro-2'-C-methyl-6-N,N-dimethyladenosine
CAS:2’-C-Methyl nucleoside; Halo-nucleoside; 2/6/8-Modified purine nucleosideFórmula:C13H18ClN5O4Forma y color:SolidPeso molecular:343.77Ref: TM-TNU0111
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar5'-O-DMT-dT
CAS:5'-O-DMT-dT (5'-O-(4,4'-Dimethoxytrityl)thymidine) is a nucleoside derivative that finds utility in oligonucleotide synthesis.Fórmula:C31H32N2O7Forma y color:White PowderPeso molecular:544.595'-O-Acetyl-2',3'-dideoxy-2',3'-didehydro-uridine
CAS:Nucleoside Derivatives - Didehydro-nucleosidesFórmula:C11H12N2O5Forma y color:SolidPeso molecular:252.22Ref: TM-TNU0993
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar5'-O-(4,4'-Dimethoxytrityl)-5-methoxyuridine
CAS:Nucleoside Derivatives - 5-Modified pyrimidine nucleosideFórmula:C31H32N2O9Forma y color:SolidPeso molecular:576.59Ref: TM-TNU0852
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar8-Chloro-2'-β-C-methyl inosine
CAS:Nucleoside Derivatives - 2’-Modified nucleosides; 8-Modified purine nucleosides; Halo-nucleosidesFórmula:C11H13ClN4O5Forma y color:SolidPeso molecular:316.7Ref: TM-TNU0553
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar7-Cyclopropylmethyl-7,8-dihydro-8-oxo-9-(b-D-xylofuranosyl) guanine
CAS:Nucleoside Derivatives - Xylo-nucleosides; 8-Modified purine nucleosides; N-Methylated alkylated nucleosidesFórmula:C14H19N5O6Forma y color:SolidPeso molecular:353.33Ref: TM-TNU0388
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar2-Amino-2'-deoxyadenosine
CAS:2-Amino-2'-deoxyadenosine is a deoxyribonucleoside used for the oligonucleotide synthesis.Fórmula:C10H14N6O3Forma y color:SolidPeso molecular:266.265-Hydroxymethyl xylo-uridine
CAS:Nucleoside Derivatives - Xylo-nucleosides; 5-Modified pyrimidine nucleosidesFórmula:C10H14N2O7Forma y color:SolidPeso molecular:274.23Ref: TM-TNU0484
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar
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