Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(120 productos)
- CDK(561 productos)
- Detención del ciclo celular(8 productos)
- Chk(49 productos)
- DYRK(47 productos)
- Dynamin(28 productos)
- Ferroptosis(229 productos)
- HSP(184 productos)
- Integrin(288 productos)
- Kinesina(88 productos)
- LIM quinasa(22 productos)
- Asociado a microtúbulos(286 productos)
- PKC(130 productos)
- PLK(25 productos)
- ROCK(62 productos)
- Rho(7 productos)
- Wee1(19 productos)
- c-Myc(80 productos)
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Se han encontrado 2894 productos para "Ciclo celular / Checkpoint".
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Tenofovir diphosphate TEA
CAS:Tenofovir diphosphate TEA (TFV-DP TEA) is an ATP-competitive DNA polymerase inhibitor that inhibits HIV-1 reverse transcriptase that\has anti-HIV/HBV potential.Fórmula:C9H16N5O10P3·C6H15NPureza:93.45% - 98.51%Forma y color:SolidPeso molecular:548.36Ganciclovir
CAS:Ganciclovir (2'-Nor-2'-deoxyguanosine) is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus.Fórmula:C9H13N5O4Pureza:99.55% - 99.58%Forma y color:White SolidPeso molecular:255.23Valacyclovir hydrochloride
CAS:Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an acyclovir prodrug that inhibits viral DNA replication after metabolization.Fórmula:C13H20N6O4·HClPureza:98.65% - ≥95%Forma y color:White To Off-White Crystalline PowerPeso molecular:360.80DHODH-IN-11
CAS:DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.Fórmula:C15H11N3O2Pureza:98.14%Forma y color:SolidPeso molecular:265.27RWJ 50271
CAS:RWJ 50271 inhibits LFA-1/ICAM-1 interaction with IC50 5.0 μM in HL60 cells.Fórmula:C18H17F3N4O2SPureza:99.09%Forma y color:White SolidPeso molecular:410.41Ref: TM-T12783
1mg120,00€5mg295,00€1mL*10mM (DMSO)326,00€10mg447,00€25mg707,00€50mg964,00€100mg1.243,00€200mg1.693,00€Famciclovir
CAS:Famciclovir (BRL 42810) inhibits Herpes virus DNA polymerase by mimicking nucleosides.Fórmula:C14H19N5O4Pureza:99.85% - 99.99%Forma y color:White SolidPeso molecular:321.33Osalmid
CAS:Osalmid (Oxaphenamide) is a choleretic drug, inhibits ribonucleotide reductase activity by targeting ribonucleotide reductase small subunit M2 (RRM2).Fórmula:C13H11NO3Pureza:99.37% - 99.6%Forma y color:SolidPeso molecular:229.23Procaine hydrochloride
CAS:Procaine HCl is a benzoic acid derivative used as a local anesthetic, blocking nerve impulses and sensation.Fórmula:C13H20N2O2·HClPureza:99.1% - 99.22%Forma y color:SolidPeso molecular:272.77Simurosertib
CAS:Simurosertib (TAK-931) is a selective and ATP-competitive cell division cycle 7 kinase inhibitor (IC50: <0.3 nM).Fórmula:C17H19N5OSPureza:99.93% - 99.98%Forma y color:SolidPeso molecular:341.43Ref: TM-T12642L
1mg62,00€5mg150,00€1mL*10mM (DMSO)157,00€10mg203,00€25mg379,00€50mg533,00€100mg737,00€DNA2 inhibitor C5
CAS:DNA2 inhibitor C5 is a specific cancer sensitizer with an IC50 of 20 μM, targeting multiple DNA2 activities.Fórmula:C10H6N2O5Pureza:99.05%Forma y color:SolidPeso molecular:234.16Ref: TM-T15146
1mg57,00€1mL*10mM (DMSO)112,00€5mg113,00€10mg178,00€25mg334,00€50mg497,00€100mg692,00€MKC9989
CAS:MKC9989 is an inhibitor of Hydroxy aryl aldehydes (HAA). MKC9989 also inhibits IRE1α with an IC50 of 0.23 to 44 μM.Fórmula:C17H20O7Pureza:99.3%Forma y color:Yellow SolidPeso molecular:336.34Ref: TM-T12071
1mg49,00€1mL*10mM (DMSO)133,00€5mg147,00€10mg215,00€25mg356,00€50mg515,00€100mg692,00€Pyrimethamine
CAS:Pyrimethamine (Pirimecidan) is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.Fórmula:C12H13ClN4Pureza:99.67%Forma y color:CrystalsPeso molecular:248.71Ifosfamide
CAS:Ifosfamide (NSC-109724), a prodrug, is a cyclophosphamide analog with antineoplastic action by DNA alkylation and crosslinking.Fórmula:C7H15Cl2N2O2PPureza:99.62% - ≥95%Forma y color:SolidPeso molecular:261.09BOS-172722
CAS:BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint(IC50 of 2 nM).Fórmula:C24H30N8OPureza:99.37%Forma y color:SolidPeso molecular:446.55Enoxacin
CAS:Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.Fórmula:C15H17FN4O3Pureza:99.60% - 99.89%Forma y color:White SolidPeso molecular:320.32CDK4/6-IN-2
CAS:CDK4/6-IN-2 是一种CDK4和CDK6抑制剂，IC50分别为 2.7 和 16 nM。Fórmula:C27H32F2N8Pureza:99.47%Forma y color:SolidPeso molecular:506.59Abrilumab
CAS:Abrilumab (MEDI-7183) is a fully human monoclonal antibody against α4β7 that inhibits the α4β7 integrin.Pureza:98.5% (SDS-PAGE); 99% (SEC-HPLC) - 98.5% (SDS-PAGE); 99% (SEC-HPLC)Forma y color:Transparent LiquidPeso molecular:143.80 kDaBMVC-8C3O
CAS:BMVC-8C3O is a DNA G-quadruplex (G4) ligand.Cost-effective and quality-assured.Fórmula:C42H53I3N4O3Pureza:99.72%Forma y color:Red SolidPeso molecular:1042.61Ref: TM-T13584
1mg101,00€5mg192,00€10mg285,00€1mL*10mM (DMSO)371,00€25mg462,00€50mg623,00€100mg858,00€200mg1.153,00€ZN-c3
CAS:Azenosertib (ZN-c3) is a potent and selective Wee1 inhibitor with balanced potency, ADME, and pharmacokinetic properties. Cost-effective and quality-assured.Fórmula:C29H34N8O2Pureza:99.98%Forma y color:SolidPeso molecular:526.63Ref: TM-T9643
1mg90,00€5mg215,00€1mL*10mM (DMSO)250,00€10mg334,00€25mg620,00€50mg982,00€100mg1.468,00€200mg1.972,00€Carmofur
CAS:Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer.Fórmula:C11H16FN3O3Pureza:98.53% - 99.98%Forma y color:SolidPeso molecular:257.26Hu7691 free base
CAS:Hu7691 free base is an Akt inhibitor that inhibits Akt1, Akt2 and Akt3 and induces differentiation of neuroblastoma cells.Fórmula:C22H21F3N4OPureza:98.89%Forma y color:SolidPeso molecular:414.423ATN-161 trifluoroacetate salt
CAS:ATN-161 TFA salt, a new integrin α5β1 inhibitor, curbs angiogenesis, liver metastases growth, enhances survival in mice.Fórmula:C25H36F3N9O10SPureza:98% - 99.98%Forma y color:White SolidPeso molecular:711.67hSMG-1 inhibitor 11j
CAS:hSMG-1 inhibitor 11j: pyrimidine, IC50=0.11 nM, >455x selective vs. mTOR/PI3Kα/γ/CDK1/CDK2; cancer research use.Fórmula:C27H28ClN7O3SPureza:99.22% - 99.65%Forma y color:Yellow SolidPeso molecular:566.07Trimethoprim
CAS:Trimethoprim (NSC-106568) inhibits dihydrofolate reductase, CYP2C8, and OCT2 - an antibacterial agent.Fórmula:C14H18N4O3Pureza:99.80% - 99.81%Forma y color:SolidPeso molecular:290.32PTBP1-RNA-binding inhibitor P6 TFA
PTBP1-RNA-binding inhibitor P6 TFA is a stapled peptide inhibitor of PTBP1, used to inhibit RNA alternative splicing events regulated by PTBP1.Forma y color:Odour SolidDitercalinium chloride
CAS:Ditercalinium chloride, an anticancer agent, inhibits human DNA polymerase gamma activity and can deplete mitochondrial DNA in both mouse and human cells. Additionally, Ditercalinium chloride is a potential ligand against the COMMD10-AP3S1 fusion protein [1] [2].Fórmula:C46H50Cl2N6O2Forma y color:SolidPeso molecular:789.83Vasoactive intestinal contractor
CAS:Vasoactive intestinal contractor, a novel member of the endothelin family, stimulates a rapid increase in intracellular Ca2+ concentration in fura-2-overexpressed Swiss 3T3 cells [1.Fórmula:C116H161N27O32S4Forma y color:SolidPeso molecular:2573.94RTDLDSLRTYTL
CAS:RTDLDSLRTYTL is a high-affinity and specific inhibitor of Alpha (v) beta (6) integrin (avb6). By binding to the avb6 integrin, this peptide sequence activates T cell cytotoxicity and cytokine production, such as interferon-γ. Through the design of chimeric T cell antigen receptors (CAR), RTDLDSLRTYTL enables T cells to be redirected, allowing them to specifically recognize and attack tumor cells. It is used in research for cancer immunotherapy and the development of targeted drugs.Fórmula:C62H104N18O22Forma y color:SolidPeso molecular:1453.60POLRMT-IN-1
POLRMT-IN-1 (compound S7) is an inhibitor of POLRMT, specifically utilized in cancer-related research.
Forma y color:Odour SolidNuclease S1
CAS:Nuclease S1 breaks down ssDNA and RNA, trims protruding ends of dsDNA.Forma y color:SolidBSJ-5-63
CAS:BSJ-5-63 is an effective degrader of CDK12, CDK7, and CDK9. It reduces the protein expression of CDK12, CDK7, CDK9, RNAPII, and Cyclin K, and also decreases the mRNA expression of BRCA1 and BRCA2. BSJ-5-63 exhibits anticancer activity and holds potential for prostate cancer research.Fórmula:C52H74ClN9O6S2Forma y color:SolidPeso molecular:1020.78HSDVHK-NH2 TFA
HSDVHK-NH2 TFA acts as an antagonist to the αvβ3-vitronectin integrin interaction, displaying an inhibitory concentration (IC 50) of 1.74 pg/mL (2.414 pM) [1] [Fórmula:C32H49F3N12O11Forma y color:SolidPeso molecular:834.8Echistatin TFA
Echistatin TFA: a minimal RGD protein from snake venom; inhibits platelet aggregation and bone resorption; targets αIIbβ3, αvβ3, α5β1.Forma y color:Odour Solid(R)-N-(2,3-Dihydro-1H-indenyl)-2-amino adenosine
(R)-N-(2,3-Dihydro-1H-indenyl)-2-amino adenosine, a purine analog, targets lymphoid cancer via DNA synthesis inhibition and apoptosis.Fórmula:C19H22N6O4Forma y color:SolidPeso molecular:398.42RAD51-IN-3
CAS:RAD51-IN-3 is a Rad51 inhibitor.Fórmula:C31H41N5O5S2Forma y color:SolidPeso molecular:627.823'-β-C-Ethynyl-4-deoxyuridine
3’-Beta-C-Ethynyl-4-deoxyuridine is a purine nucleoside analog.Fórmula:C11H12N2O5Forma y color:SolidPeso molecular:252.22[pThr3]-CDK5 Substrate
CAS:[pThr3]-CDK5 Substrate is an effective Phospho-Thr3CDK5 Substrate.[pThr3]-CDK5 Substrate is phosphorylated by CDK5 with a Km value of 6 µM[1].Fórmula:C53H100N15O15PPureza:98%Forma y color:SolidPeso molecular:1218.438-Chloro-2'-deoxy-2'-fluoro-arabino adenosine
8-Chloro-2’-deoxy-2’-fluoro-arabino adenosine, a purine nucleoside analog, demonstrates broad antitumor activity against indolent lymphoid malignancies.Fórmula:C10H11ClFN5O3Forma y color:SolidPeso molecular:303.68MS7131
MS7131 is a DUBTAC inhibitor that recruits USP1. It effectively reduces histone H3 lysine 27 trimethylation and significantly inhibits the proliferation and colony-forming ability of cancer cells.Forma y color:Odour SolidMS133
MS133 is a human bispecific antibody targeting CD133/PROM1 and CD3E. It is used in the study of colon cancer.Forma y color:Odour Liquid6-Methoxypurine-9-β-D-5'(R)-C-methylriboside
6-Methoxypurine-9-β-D-5’(R)-C-methylriboside, an analog of hypoxanthine—a purine base predominantly found in muscle tissue and a metabolite generated whenFórmula:C12H16N4O5Forma y color:SolidPeso molecular:296.28N6-Methyl-2'-β-C-ethynyl adenosine
N6-Methyl-2’-beta-C-ethynyl adenosine is a purine nucleoside analog.Fórmula:C13H15N5O4Forma y color:SolidPeso molecular:305.29CDK9 degrader-1
CDK9degrader-1 is a selective CDK9 degrader (DC50: 0.4073 µM). It recruits ATG101 to initiate the autophagy-lysosome pathway and forms autophagosomes by recruiting LC3, which then fuse with lysosomes to degrade CDK9 and its partner protein, Cyclin T1 (DC50: 1.215 µM). CDK9degrader-1 induces caspase 3-mediated apoptosis and exhibits antitumor activity in a mouse HCT116 xenograft model.Fórmula:C32H34Cl2N6O4Forma y color:SolidPeso molecular:637.56CDK9/EZH2-IN-1
CAS:CDK9/EZH2-IN-1 is a dual-target inhibitor of CDK9 and EZH2 with IC50 values of 83.9 nM and 108.6 nM, respectively. It induces apoptosis and causes DNA double-strand breaks (DSB). Additionally, CDK9/EZH2-IN-1 inhibits the proliferation of MKN45, MDA-MB-453, and SW620 cancer cells, with respective IC50 values of 136.3 nM, 171.3 nM, and 315.7 nM.Fórmula:C47H59N11O4S2Forma y color:SolidPeso molecular:906.17CDK2-IN-7
CAS:CDK2-IN-7 is a CDK2 inhibitor for treating cancer ( IC 50 < 50 nM).Fórmula:C24H30N6O4SForma y color:SolidPeso molecular:498.6RNA binder 1
RNA binder 1 (Compound 4b) is an RNA-binding agent capable of crossing the blood-brain barrier. It selectively binds to the G-quadruplex structure of the G4C2 repeat sequence RNA of the C9orf72 gene. This compound significantly reduces levels of the toxic polypeptides poly(GA) and poly(GP) in cells derived from amyotrophic lateral sclerosis (ALS) patients, while it has no significant impact on the antisense polypeptide poly(PR), demonstrating selectivity for sense RNA. RNA binder 1 is useful for studying ALS and frontotemporal dementia (FTD).Fórmula:C22H20N10S2Forma y color:SolidPeso molecular:488.13138P8RI acetate
P8RI acetate mimics CD31, activates CDP8RI, and suppresses the immune response by restoring CD31 pathway.Fórmula:C53H81N13O11Pureza:98.39%Forma y color:SolidPeso molecular:1076.29L82-G17
CAS:L82-G17 is an uncompetitive LigI-selective inhibitor in human cells with utility as a probe of the catalytic activity and cellular functions of LigI.Fórmula:C11H9ClN4O2Pureza:99.69%Forma y color:SolidPeso molecular:264.67wrwycr-NH2 TFA
wrwycr-NH2 (TFA) is a peptide that exhibits cytotoxic properties against various cancer cells, inducing DNA damage and cell cycle arrest without causing endoplasmic reticulum stress. It possesses antitumor activity, and its efficacy is enhanced when used in combination with DNA-damaging agents.Forma y color:Odour SolidGRGDSPK TFA
GRGDSPK TFA is an RGD peptide, competitive inhibitor of integrin-fibronectin, used to research integrins in bone dynamics.Fórmula:C30H50F3N11O13Forma y color:SolidPeso molecular:829.78
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