Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(114 productos)
- CDK(545 productos)
- Detención del ciclo celular(5 productos)
- Chk(48 productos)
- DYRK(47 productos)
- Dynamin(27 productos)
- Ferroptosis(226 productos)
- HSP(179 productos)
- Integrin(249 productos)
- Kinesina(87 productos)
- LIM quinasa(20 productos)
- Asociado a microtúbulos(274 productos)
- PKC(124 productos)
- PLK(25 productos)
- ROCK(62 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(76 productos)
Mostrar 10 subcategorías más
Se han encontrado 3859 productos de "Ciclo celular / Checkpoint"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Ceftriaxone sodium hydrate
CAS:Ceftriaxone sodium hydrate is a broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.Fórmula:C18H16N8Na2O7S3·5H2OPureza:99.77% - 99.78%Forma y color:White Or Almost White Crystalline Powder OdorlessPeso molecular:661.6CDK4/6-IN-2
CAS:CDK4/6-IN-2 是一种CDK4和CDK6抑制剂，IC50分别为 2.7 和 16 nM。Fórmula:C27H32F2N8Pureza:99.47%Forma y color:SolidPeso molecular:506.59CHK1-IN-4 hydrochloride
CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1).Fórmula:C18H19BrClN7O2Pureza:99.29%Forma y color:SoildPeso molecular:480.75Kira8
CAS:Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity (IC50: 5.9 nM).Fórmula:C31H29ClN6O3SPureza:98.07%Forma y color:SolidPeso molecular:601.12Ref: TM-T11762L
1mg87,00€5mg202,00€10mg305,00€25mg567,00€50mg810,00€100mg1.111,00€1mL*10mM (DMSO)269,00€MBQ-167
CAS:MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).Fórmula:C22H18N4Pureza:98.07% - 99.52%Forma y color:SolidPeso molecular:338.41Ref: TM-T16021
1mg34,00€2mg49,00€5mg74,00€10mg105,00€25mg197,00€50mg356,00€100mg537,00€1mL*10mM (DMSO)82,00€Danofloxacin mesylate
CAS:Danofloxacin mesylate (CP 76136-27) is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase.
Fórmula:C19H20FN3O3·CH4O3SPureza:99.73%Forma y color:Crystalline SolidPeso molecular:453.48ART558
CAS:ART558 is a potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM).Fórmula:C21H21F3N4O2Pureza:99.18% - 99.67%Forma y color:SolidPeso molecular:418.41Enoxacin
CAS:Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.Fórmula:C15H17FN4O3Pureza:98.68% - 99.89%Forma y color:Off-White To Yellow CrystalsPeso molecular:320.32Ribociclib succinate
CAS:Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively).Fórmula:C27H36N8O5Pureza:99.9%Forma y color:SolidPeso molecular:552.63Ref: TM-T15732
2mg34,00€5mg49,00€10mg70,00€25mg92,00€50mg109,00€100mg165,00€200mg258,00€500mg459,00€1mL*10mM (DMSO)60,00€Elarofiban TFA
CAS:Elarofiban TFA (RWJ-53308 TFA) is a novel and orally active and selective GPIIb/IIIa antagonist for the study of cardiovascular disease.Fórmula:C26H34F6N4O8Pureza:99.08%Forma y color:SoildPeso molecular:644.56JH-RE-06
CAS:JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POLζ.Fórmula:C20H16Cl3N3O4Pureza:99.29%Forma y color:SolidPeso molecular:468.72Ref: TM-T15611
1mg44,00€5mg93,00€10mg152,00€25mg334,00€50mg587,00€100mg1.044,00€1mL*10mM (DMSO)95,00€Enrofloxacin
CAS:Enrofloxacin (BAY-Vp2674) is a veterinary antibacterial agent, used in poultry.
Fórmula:C19H22FN3O3Pureza:99.43% - >99.99%Forma y color:Pale Yellow CrystalsPeso molecular:359.39MALAT1-IN-1
CAS:MALAT1-IN-1 is an effective dose-dependent Malat1 inhibitor, not altering Neat1 expression.Fórmula:C19H21N3O2Pureza:99.58%Forma y color:SolidPeso molecular:323.39Ref: TM-T16007
5mg39,00€10mg63,00€25mg120,00€50mg224,00€100mg432,00€200mg623,00€1mL*10mM (DMSO)44,00€Rifaximin
CAS:Rifaximin: an oral semi-synthetic antibiotic from rifamycin SV; targets bacterial RNA polymerase to halt growth.Fórmula:C43H51N3O11Pureza:99.18% - 99.40%Forma y color:Red-Orange Crystalline PowderPeso molecular:785.88Trimethoprim
CAS:Trimethoprim (NSC-106568) inhibits dihydrofolate reductase, CYP2C8, and OCT2 - an antibacterial agent.Fórmula:C14H18N4O3Pureza:99.80% - 99.81%Forma y color:White To Yellowish PowderPeso molecular:290.32TK216
CAS:TK216 is a potent inhibitor of E26 transformation-specific (ETS) with anticancer activity.Fórmula:C19H15Cl2NO3Pureza:97.22%Forma y color:SolidPeso molecular:376.23MKC8866
CAS:MKC8866, a selective IRE1 RNase inhibitor with an IC50 of 0.29 μM, curbs breast and prostate cancer cell growth.Fórmula:C18H19NO7Pureza:99.28% - 99.854%Forma y color:SolidPeso molecular:361.35Ref: TM-T15594
1mg84,00€2mg109,00€5mg177,00€10mg250,00€25mg423,00€50mg557,00€100mg760,00€200mg1.018,00€1mL*10mM (DMSO)192,00€Orbofiban TFA
CAS:Orbofiban TFA is an orally active GPIIb/IIIa platelet receptor antagonist with inhibitory effects on platelet aggregation for the study of unstable coronaryFórmula:C19H24F3N5O6Pureza:97.21% - 98.72%Forma y color:SolidPeso molecular:475.42Mps1-IN-3
CAS:Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).Fórmula:C26H31N7O4SPureza:99.25%Forma y color:SolidPeso molecular:537.63Ref: TM-T16130
2mg34,00€5mg54,00€10mg87,00€25mg149,00€50mg255,00€100mg384,00€200mg538,00€1mL*10mM (DMSO)64,00€Pseudorabies virus-IN-1
Pseudorabies virus-IN-1 is a potent inhibitor of pseudorabies virus (PRV) with an EC50 of 0.29 nM, acting by targeting PRV deoxyribonucleic acid polymerase (DNA pol) to suppress PRV replication. It effectively inhibits PRV replication even at low concentrations (MIC80: 1.6-8 nM) and is useful for research on PRV infections.Fórmula:C27H23ClF2N4O2Forma y color:SolidPeso molecular:508.947HEMTAC WEE1 degrader-1
CAS:HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC50 of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML). HEMTACWEE1degrader-1 is utilized in AML research.Fórmula:C57H71N15O6Forma y color:SolidPeso molecular:1062.27CW-2
CW-2 is a PARP1 PROTAC degrader known for its potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 μM) and cisplatin-resistant cells (A549/CDDP: IC50 = 3.52 μM). It exhibits synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts its antitumor effects by inducing DNA damage, disrupting DNA repair, and triggering mitochondrial-dependent apoptosis (apoptosis).Fórmula:C43H42Cl2FN11O10PtForma y color:SolidPeso molecular:1156.21251Clofarabine-5'-triphosphate
CAS:Clofarabine-5'-triphosphate is a metabolite of Clofarabine, produced via phosphorylation by deoxycytidine kinase (dCK). It exhibits cytotoxicity in cancer cells by inhibiting DNA synthesis and DNA repair.Fórmula:C10H14ClFN5O12P3Forma y color:SolidPeso molecular:543.62ONX 0801 trisodium
CAS:ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.Fórmula:C32H30N5Na3O10Forma y color:SolidPeso molecular:713.58DNA Gyrase-IN-17
DNA Gyrase-IN-17 (Compound 5C) is an inhibitor of DNA gyrase. It demonstrates significant antimicrobial activity against a range of Gram-positive and Gram-negative strains, including Enterococcus faecium, Escherichia coli, and Pseudomonas aeruginosa, with a MIC value of 62.5 μg/mL. By inhibiting bacterial DNA gyrase, DNA Gyrase-IN-17 disrupts DNA replication. This compound can be useful in the development of antibiotics, particularly for studying resistant strains.Fórmula:C18H15ClFN5OForma y color:SolidPeso molecular:371.09492c-Myc inhibitor 7
CAS:c-Myc inhibitor 7 degrades c-MYC, CK1α, GSPT1, IKZF1/2/3 proteins in tumors, for research on related diseases.Fórmula:C35H30N6O5Forma y color:SoildPeso molecular:614.65WRN inhibitor 17
CAS:WRN inhibitor 17 (Compound 250) is an orally active inhibitor of Werner syndrome ATP-dependent helicase (WRN), specifically targeting the helicase domain activity of WRN. It holds potential for use in cancer research.Fórmula:C33H34F4N4O6SForma y color:SolidPeso molecular:690.71PROTAC MTP3 degrade-1
PROTACMTP3 degrade-1 is a PROTAC degrader for MYC.Fórmula:C44H38N6O8Forma y color:SolidPeso molecular:778.27511Anticancer agent 263
Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.Fórmula:C13H20N2O6Forma y color:SolidPeso molecular:300.30813-TP
13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.Fórmula:C12H19F2N6O12P3Forma y color:SolidPeso molecular:570.23DSPE-PEG2000-iRGD
DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.Forma y color:Odour SolidMumefural
CAS:Mumefural, from Prunus mume fruit, hinders platelets, has anti-thrombotic properties, and boosts cognition.
Fórmula:C12H12O9Forma y color:SolidPeso molecular:300.22JB300
CAS:JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.Fórmula:C43H45ClFN7O10SForma y color:SolidPeso molecular:906.3755-Iminodaunorubicin
CAS:5-Iminodaunorubicin: a quinone-altered anthracycline with antitumor effects, causing DNA breaks in cancer.Fórmula:C27H30N2O9Forma y color:SolidPeso molecular:526.54EFdA-TP
CAS:EFdA-TP: potent HIV-1 RT inhibitor; acts via immediate/delayed chain termination (ICT/DCT) and multiple pathways.Fórmula:C12H15FN5O12P3Forma y color:SolidPeso molecular:533.195Clofarabine-5'-diphosphate trisodium
Clofarabine-5'-diphosphatetrisodium (Clofarabine-DP trisodium) is the sodium salt form of Clofarabine-5'-diphosphate. As a metabolic product of Clofarabine, it results from phosphorylation by deoxycytidine kinase (dCK). Clofarabine-5'-diphosphate trisodium can undergo further phosphorylation to form Clofarabine-5'-triphosphate, demonstrating cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.Fórmula:C10H10ClFN5Na3O9P2Forma y color:SolidPeso molecular:529.58Eesperamicin A1
CAS:Esperamicin A1, a powerful antitumor drug, comes from Actinomadura verrucosospora.Fórmula:C59H80N4O22S4Forma y color:SolidPeso molecular:1325.545'-O-DMTr-2',2'-difluoro-dC(Bz)-methyl phosphonamidite
5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog with extensive antitumor activity against indolent lymphoid malignancies.Fórmula:C44H49F2N4O7PForma y color:SolidPeso molecular:814.855'-O-TBDMS-dA
CAS:5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.
Fórmula:C16H27N5O3SiForma y color:SolidPeso molecular:365.509α-Methyl-DL-aspartic acid
CAS:α-Methyl-DL-aspartic acid specifically inhibits argininosuccinate synthase (ASS), the rate-limiting enzyme in 1-citrulline-to-1-arginine recycling.Fórmula:C5H9NO4Pureza:99.91%Forma y color:SolidPeso molecular:147.13TLR7 agonist 12
CAS:TLR7 agonist 12, a purine nucleoside analog, inhibits DNA synthesis and induces apoptosis in lymphoid cancers.Fórmula:C14H19N5O8Forma y color:SolidPeso molecular:385.33DSPE-PEG3000-iRGD
DSPE-PEG3000-iRGD is a PEG compound comprising DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrin and undergoes proteolytic cleavage within tumors to produce CRGDK/R, interacting with neuropilin-1. This results in tumor targeting and penetration capabilities. DSPE-PEG3000-iRGD is applicable in drug delivery.Forma y color:Odour SolidChrysomycin A
CAS:Chrysomycin A is an antibiotic that can be derived from Streptomyces.Fórmula:C28H28O9Forma y color:SolidPeso molecular:508.52Ac-MRGDH-NH2
Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.Fórmula:C25H41N11O8SForma y color:SolidPeso molecular:655.727Brr2-IN-2
Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.Fórmula:C21H25FN4O2Forma y color:SolidPeso molecular:384.45N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium
CAS:N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].
Fórmula:C21H35N12O17P3Forma y color:SolidPeso molecular:820.49IRE1-IN-2
IRE1-IN-2 (compound G15) functions as a potent inhibitor of IRE1. It effectively suppresses lipid accumulation induced by FFA, exhibiting an IC50 value of 2.06 μM.Fórmula:C16H20O6Forma y color:SolidPeso molecular:308.12599Isocytosine
CAS:Compound PDK0016, with CAS No. 108-53-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0016 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Fórmula:C4H5N3OForma y color:White To Off-White SolidPeso molecular:111.1Clofarabine-5'-diphosphate
CAS:Clofarabine-5'-diphosphate (Clofarabine-DP) is a metabolite resulting from the phosphorylation of Clofarabine by deoxycytidine kinase (dCK). It can undergo further phosphorylation to become Clofarabine-5'-triphosphate, exhibiting cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.Fórmula:C10H13ClFN5O9P2Forma y color:SolidPeso molecular:463.64Echistatin
CAS:Potent αVβ3 integrin blocker, stops osteoclast binding & bone loss, hinders platelet aggregation. Ki=0.27 nM, IC50s: 0.1 nM (bone), 30 nM (platelets).Fórmula:C217H341N71O74S9Pureza:98%Forma y color:SolidPeso molecular:5417.1
