Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(94 productos)
- CDK(500 productos)
- Detención del ciclo celular(4 productos)
- Chk(42 productos)
- DYRK(48 productos)
- Dynamin(23 productos)
- Ferroptosis(215 productos)
- HSP(169 productos)
- Integrin(224 productos)
- Kinesina(66 productos)
- LIM quinasa(19 productos)
- Asociado a microtúbulos(261 productos)
- PKC(102 productos)
- PLK(28 productos)
- ROCK(70 productos)
- Rho(2 productos)
- Wee1(15 productos)
- c-Myc(69 productos)
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Se han encontrado 3477 productos de "Ciclo celular / Checkpoint"
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2'-Deoxy-2'-fluoro-N1-methyl inosine
CAS:<p>Nucleoside Derivatives - 2’-Modified nucleosides, Fluoro-modified nucleosides, N-Methylated /alkylated nucleosides</p>Fórmula:C11H13FN4O4Forma y color:SolidPeso molecular:284.242'-Chloro-2'-deoxyuridine
CAS:<p>2'-Chloro-2'-deoxyuridine is a Halo-nucleoside.</p>Fórmula:C9H11ClN2O5Forma y color:SolidPeso molecular:262.652'-Deoxy-N6,N6-dimethyladenosine
CAS:<p>2'-Deoxy-N6,N6-dimethyladenosine is a Nucleoside Derivative - 6-Modified purine nucleoside.</p>Fórmula:C12H17N5O3Forma y color:SolidPeso molecular:279.31-(b-D-Xylofuranosyl)-5-methylcytosine
CAS:<p>Nucleoside Derivatives –5-Modified pyrimidine nucleosides；Xylo-nucleosides</p>Fórmula:C10H15N3O5Forma y color:SolidPeso molecular:257.243'-O-Methyl-5-methyluridine
CAS:<p>3'-O-Methyl-5-methyluridine is a Nucleoside Derivative - 3'-Modified nucleoside.</p>Fórmula:C11H16N2O6Forma y color:SolidPeso molecular:272.251-Amino-7-cyclopropylmethyl-7,8-dihydro-8-oxo-9-(b-D-xylofuranosyl)guanine
CAS:<p>Nucleoside Derivatives - Xylo-nucleosides; 8-Modified purine nucleosides; Amino nucleosides; N-Methylated alkylated nucleosides</p>Fórmula:C14H20N6O6Forma y color:SolidPeso molecular:368.356-Chloro-9-(2,3,5-tri-O-benzoyl-2-C-methyl-β-D-ribofuranosyl)-9H-purine
CAS:<p>6-Chloro-9-(2,3,5-tri-O-benzoyl-2-C-methyl-β-D-ribofuranosyl)-9H-purine is a 2'-C-Methyl nucleoside; Halo-nucleoside.</p>Fórmula:C32H25ClN4O7Forma y color:SolidPeso molecular:613.021-(b-D-Xylofuranosyl)-5-trifluoromethyluracil
<p>1-(b-D-Xylofuranosyl)-5-trifluoromethyluracil is a Nucleoside Derivative - Xylo-nucleoside, Fluoro-modified nucleoside, 5-Modified pyrimidine nucleoside.</p>Forma y color:Soild2-Cyanoadenosine
CAS:<p>Nucleoside Derivatives - 2’-Modified purine nucleosides</p>Fórmula:C11H12N6O4Forma y color:SolidPeso molecular:292.255-Iodoarabinouridine
CAS:<p>5-Iodoarabinouridine is a Halo-nucleoside; Arabino-nucleoside.</p>Fórmula:C9H11IN2O6Forma y color:SolidPeso molecular:370.1N1-Ethylpseudouridine
CAS:<p>N1-Ethylpseudouridine is a Nucleoside Derivative - C-nucleoside; N-Methylated nucleoside.</p>Fórmula:C11H16N2O6Forma y color:SolidPeso molecular:272.252'-Deoxy-O6-[2-(4-nitrophenylethyl)]guanosine
CAS:<p>2'-Deoxy-O6-[2-(4-nitrophenylethyl)]guanosine is a Nucleoside Derivative - 6-Modified purine nucleoside.</p>Fórmula:C18H20N6O6Forma y color:SolidPeso molecular:416.39KS15
CAS:<p>KS15 is a cryptochrome (CRY) inhibitor that promotes G1 cell cycle arrest, enhances drug sensitivity in MCF-7 cells, antitumour against human breast cancer.</p>Fórmula:C20H22BrNO4Forma y color:SolidPeso molecular:420.33'-O-DMTr-thymidine 5'-CE phosphoramidite
CAS:<p>3'-O-DMTr-thymidine 5'-CE phosphoramidite (2'-OMe-U Phosphoramidite) is a purine nucleoside analog and phosphoramidite derivative .</p>Fórmula:C40H49N4O8PPureza:99.42%Forma y color:SolidPeso molecular:744.81Lifitegrast sodium
CAS:<p>Lifitegrast sodium (SAR-1118-023 sodium) is an integrin antagonist that reduces ocular surface inflammation and can be used to study dry eye.</p>Fórmula:C29H23Cl2N2NaO7SPureza:99.33%Forma y color:SolidPeso molecular:637.46GP-82996
CAS:<p>GP-82996 (CINK4) inhibits CDK4/6; IC50s: 1.5 μM (CDK4/D1), 5.6 μM (CDK6/D1), 25 μM (Cdk5/p35); triggers U2OS cancer cell apoptosis.</p>Fórmula:C27H32N6OPureza:99.94%Forma y color:SolidPeso molecular:456.58HDGFRP2/PSIP1-IN-1
CAS:<p>Compound BPP (HDGFRP2/PSIP1-IN-1) is a dual inhibitor targeting the PWWP domains of Hepatoma-derived Growth Factor Related Protein 2 (HDGFRP2) and its homologue PSIP1. This compound effectively hinders the occurrence and progression of Diffuse Intrinsic Pontine Glioma (DIPG). It demonstrates binding affinity with a Kd value of 7 μM for HDGFRP2, indicative of its efficient ligand efficacy at 0.47. Additionally, Compound BPP exhibits a Kd value of 27 μM when binding to the PSIP1 PWWP domain, and a Kd value of 14 μM against HDGFRP3, confirming its potency as an inhibitor within the HDGFRP2 PWWP subfamily.</p>Fórmula:C8H6BrN3Forma y color:SolidPeso molecular:224.06Napropamide
CAS:<p>Napropamide is an acetamide herbicide that inhibits root growth to control annual grasses and broadleaf weeds.</p>Fórmula:C17H21NO2Pureza:99.14%Forma y color:Colorless Crystals; (Tech Brown Solid) White-Like CrystalPeso molecular:271.35N-6-Furfurylguanosine
CAS:<p>N-6-Furfurylguanosine (kinetin riboside) is a purine nucleoside analog with cytotoxicity, inhibiting the growth of cancer cells.</p>Fórmula:C15H18N6O5Pureza:99.58%Forma y color:SolidPeso molecular:362.345,6-Dihydrothymidine
CAS:<p>2'-Deoxy-N2-methylguanosine is a purine nucleoside analog that can be used as a chemical probe to study DNA-protein interactions.</p>Fórmula:C10H16N2O5Pureza:99.90%Forma y color:SolidPeso molecular:244.24(S)-GNA-T-phosphoramidite
CAS:<p>(S)-GNA-T-phosphoramidite is a nucleoside analog commonly used in the synthesis of other active compounds.</p>Fórmula:C38H47N4O7PPureza:99.35%Forma y color:SolidPeso molecular:702.785-Aza-7-deazaguanine
CAS:<p>5-Aza-7-deazaguanine is a non-natural substituted nucleobase with potential antiviral activity, used in cancer and bacterial infection research.</p>Fórmula:C5H5N5OPureza:98.87%Forma y color:SolidPeso molecular:151.13DTP3
CAS:<p>DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.</p>Fórmula:C26H35N7O5Forma y color:SolidPeso molecular:525.62'-Amino-2'-deoxy-b-D-arabino-5-methyl uridine
CAS:<p>2'-Amino-2'-deoxy-b-D-arabino-5-methyl uridine is a purine nucleoside analog with potential antitumor activity.</p>Fórmula:C10H15N3O5Pureza:96.76%Forma y color:SolidPeso molecular:257.24A-674563
CAS:<p>A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.</p>Fórmula:C22H22N4OPureza:99.21%Forma y color:SolidPeso molecular:358.44GPRP
CAS:<p>GPRP (Gly-Pro-Arg-Pro) is a fibrin polymerization inhibitor.</p>Fórmula:C18H31N7O5Forma y color:White To Off-White PowderPeso molecular:425.48Maleic hydrazide
CAS:<p>Maleic hydrazide is a plant germination inhibitor that participates in nucleic acid metabolism pathways ,inhibiting cell division in the apical meristem.</p>Fórmula:C4H4N2O2Pureza:98.4%Forma y color:Crystals From Water Maleic Hydrazide Is An Odorless White Solid Sinks In Water (Uscg 1999)Peso molecular:112.09N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite
CAS:<p>N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite is an adenine nucleoside analog with potential vasodilator activity and anticancer activity.</p>Fórmula:C47H52N7O7PPureza:98.59%Forma y color:SolidPeso molecular:857.932'-O-Methylinosine
CAS:<p>2'-O-Methylinosine (2'-(o-Methyl)-inosine) is an orally bioavailable purine nucleoside analog with antihypertensive activity.</p>Fórmula:C11H14N4O5Pureza:99.88%Forma y color:SolidPeso molecular:282.252',5-Difluoro-2'-deoxy-1-arabinosyluracil
CAS:<p>2',5-Difluoro-2'-deoxy-1-arabinosyluracil (2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine) is a urinary pyrimidine nucleoside analogue with potential antiepileptic</p>Fórmula:C9H10F2N2O5Pureza:99.94%Forma y color:SolidPeso molecular:264.18NU6102
CAS:<p>NU6102 is a CDK2 inhibitor with antitumor activity against CDK1/cyclinB, CDK1/CDK2, CDK4, DYRK1A , PDK1, and ROCKII, and it can be used to study rectal cancer.</p>Fórmula:C18H22N6O3SPureza:99.76%Forma y color:SolidPeso molecular:402.47LDC4297
CAS:<p>LDC4297 (LDC044297) is a potent and selective CDK7 inhibitor.</p>Fórmula:C23H28N8OPureza:98.25%Forma y color:SolidPeso molecular:432.52GW406108X
CAS:<p>GW406108X is a Kif15 and ULK1 inhibitor; IC50: 0.82 µM (ATPase), pIC50: 6.37; blocks autophagy.</p>Fórmula:C20H11Cl2NO4Pureza:98%Forma y color:SolidPeso molecular:400.21IRES-C11
CAS:<p>IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.</p>Fórmula:C13H11Cl2NO4Pureza:99.89%Forma y color:SolidPeso molecular:316.14Poloxime
CAS:<p>Poloxime is a hydrolysis product of poloxin and is a non-ATP-competitive Plk1 inhibitor. It also has moderate Plk1 inhibitory activity.</p>Fórmula:C10H13NO2Pureza:98%Forma y color:SolidPeso molecular:179.22TAME
CAS:<p>Tosyl-L-Arginine Methyl Ester (TAME (N-4-Tosyl-L-arginine methyl ester)) is an APC inhibitor.</p>Fórmula:C14H22N4O4SPureza:98%Forma y color:SolidPeso molecular:342.41Cilengitide TFA
CAS:<p>Cilengitide, αvβ3/αvβ5 inhibitor, IC50: 4.1/79 nM in vitro. 10x selectivity vs. gpIIbIIIa. Phase 2.</p>Fórmula:C29H41F3N8O9Forma y color:SolidPeso molecular:702.68Nolatrexed dihydrochloride
CAS:<p>Nolatrexed dihydrochloride (Thymitaq) is a soluble, lipophilic cancer drug that inhibits DNA replication, causing cell cycle arrest and apoptosis.</p>Fórmula:C14H14Cl2N4OSPureza:97.02%Forma y color:Tan SolidPeso molecular:357.26CCT244747
CAS:<p>CCT244747 is a potent and selective CHK1 inhibitor oral, ATP-competitive, and cytotoxic, abrogating drug-induced S and G2 blockade and inducing apoptosis .</p>Fórmula:C20H24N8O2Pureza:99.17%Forma y color:SolidPeso molecular:408.46Ribociclib hydrochloride
CAS:<p>Ribociclib hydrochloride is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively).</p>Fórmula:C23H31ClN8OPureza:98%Forma y color:SolidPeso molecular:471sAJM589
CAS:<p>sAJM589 is a Myc inhibitor that dose-dependently disrupts Myc-Max heterodimers, thereby decreasing Myc protein levels and inhibiting the cellular proliferation.</p>Fórmula:C16H10N2OPureza:98%Forma y color:SolidPeso molecular:246.26Synucleozid hydrochloride
CAS:<p>Synucleozid hydrochloride inhibits the translation of the intrinsically disordered protein α-synuclein by targeting its structured mRNA.</p>Fórmula:C22H21ClN6Pureza:98.13%Forma y color:SolidPeso molecular:404.9N,N-Dimethyl-2'-O-methylcytidine
CAS:<p>N,N-Dimethyl-2'-O-methylcytidine (N4, N4, 2'-O-Trimethylcytidine) is a purine nucleoside analogue with anti-cancer activity.</p>Fórmula:C12H19N3O5Pureza:99.62%Forma y color:SolidPeso molecular:285.38-Chloroinosine
CAS:<p>8-Chloroinosine is a purine nucleoside analog and a metabolite of the anticancer compound 8-chloro-adenosine.</p>Fórmula:C10H11ClN4O5Pureza:99.37% - 99.56%Forma y color:SolidPeso molecular:302.67Kinesore
CAS:<p>Kinesore is a cell-permeable modulator that binds to the microtubule motor protein kinesin-1, thereby inhibiting the interaction between KLC2 and SKIP.</p>Fórmula:C20H16Br2N4O4Pureza:97.24%Forma y color:SolidPeso molecular:536.175'-O-DMT-N2-ibu-dG
CAS:<p>5'-O-DMT-N2-ibu-dG is a deoxynucleoside served as a building block in oligonucleotide synthesis, with protecting groups to prevent unwanted reactions.</p>Fórmula:C35H37N5O7Pureza:98.71%Forma y color:SolidPeso molecular:639.78-Bromoadenosine
CAS:<p>8-Bromoadenosine is an adenosine derivative. 8-Br-Adenosine inhibitis mitochondrial membrane potential, cytoplasmic Ca²⁺ levels, and RNA and protein synthesis.</p>Fórmula:C10H12BrN5O4Pureza:99.11%Forma y color:SolidPeso molecular:346.14NSC 23766
CAS:<p>NSC 23766 is a Rac1 GTPase inhibitor by targeting GEFs, inhibiting cell proliferation.NSC23766 competitively inhibits M2 mAChR-induced Rac1 activation.</p>Fórmula:C24H35N7Pureza:99.49%Forma y color:SolidPeso molecular:421.58N2-Isobutyryl-2-deoxyguanosine
CAS:<p>N2-Isobutyryl-2-deoxyguanosine（iBu-dG） is a nucleoside analog that can be used to synthesize oligonucleotides.</p>Fórmula:C14H19N5O5Pureza:97.03%Forma y color:SolidPeso molecular:337.33APE1-IN-1
CAS:<p>APE1-IN-1 is a purine/pyrimidine-free endonuclease 1 inhibitor with potential antitumor activity that enhances the toxicity of alkylating agents on cancer cells</p>Fórmula:C19H21N3OS2Pureza:98.5%Forma y color:SolidPeso molecular:371.52
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