Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(94 productos)
- CDK(500 productos)
- Detención del ciclo celular(4 productos)
- Chk(42 productos)
- DYRK(48 productos)
- Dynamin(23 productos)
- Ferroptosis(215 productos)
- HSP(169 productos)
- Integrin(224 productos)
- Kinesina(66 productos)
- LIM quinasa(19 productos)
- Asociado a microtúbulos(261 productos)
- PKC(102 productos)
- PLK(28 productos)
- ROCK(69 productos)
- Rho(2 productos)
- Wee1(15 productos)
- c-Myc(69 productos)
Mostrar 10 subcategorías más
Se han encontrado 3480 productos de "Ciclo celular / Checkpoint"
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Briciclib
CAS:<p>Briciclib (ON 014185) is a small molecule that suppresses cyclin D1 accumulation in Y cells.</p>Fórmula:C19H23O10PSPureza:98% - 99.84%Forma y color:SolidPeso molecular:474.42CCT245737
CAS:<p>CCT245737 is an orally active, selective Chk1 inhibitor, and is >1,000-fold selective over CHK2 and CDK1.Cost-effective and quality-assured.</p>Fórmula:C16H16F3N7OPureza:98.06% - 99.69%Forma y color:SolidPeso molecular:379.34Dalpiciclib hydrochloride
<p>Dalpiciclib (SHR-6390) HCl is an oral CDK4/6 inhibitor with IC50s of 12.4/9.9 nM, an antitumor for breast and esophageal cancers.</p>Fórmula:C25H31ClN6O2Forma y color:SolidPeso molecular:483.01Cucurbitacin B
CAS:<p>Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells.</p>Fórmula:C32H46O8Pureza:97.1% - 99.33%Forma y color:SolidPeso molecular:558.7Y16
CAS:<p>Y16 is a G protein-coupled Rho GEFs inhibitor and also a specific inhibitor of LARG with a Kd of 76 nM.Cost-effective and quality-assured.</p>Fórmula:C24H20N2O3Pureza:98.26% - 99.32%Forma y color:SolidPeso molecular:384.436-Mercaptopurine hydrate
CAS:<p>6-Mercaptopurine hydrate is a leukemia treatment; it blocks purine metabolism, affecting DNA synthesis.</p>Fórmula:C5H6N4OSPureza:97.54% - 99.14%Forma y color:Light Yellow Crystalline PowderPeso molecular:170.19LIMK-IN-22j
CAS:<p>LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.</p>Fórmula:C20H21BrN8Pureza:99.165%Forma y color:SolidPeso molecular:453.34MC180295
CAS:<p>MC180295 ((rel)-MC180295) is a novel potent, highly selective CDK9 inhibitor (IC50: 5 nM), displays >22-fold selectivity over other CDKs.</p>Fórmula:C17H18N4O3SPureza:99.84%Forma y color:SolidPeso molecular:358.41Cyclo(-RGDfK)
CAS:<p>Cyclo(-RGDfK) is a selective and potent inhibitor of integrin αvβ3 with an IC50 value of 0.94 nM.Cost-effective and quality-assured.</p>Fórmula:C27H41N9O7Pureza:95.29% - >99.99%Forma y color:SolidPeso molecular:603.67CID44216842
CAS:<p>CID44216842 is a potent Cdc42-selective inhibitor with EC50: 1.0μM (WT), 1.2μM (Q61L) in GTP assay; 0.3μM (WT), 0.5μM (Q61L) in GDP assay. Use as a probe.</p>Fórmula:C22H20BrN3O3SPureza:99.66%Forma y color:SolidPeso molecular:486.38M2N12
CAS:<p>M2N12 selectively inhibits Cdc25C (IC50=0.09μM) and has anti-tumor properties, affecting Cdc25A and B as well.</p>Fórmula:C20H16ClN5O2Pureza:98.01%Forma y color:SolidPeso molecular:393.836-AZATHYMINE
CAS:<p>6-azathymine inhibits D-3-aminoisobutyrate-pyruvate aminotransferase; 6-azauracil competes with beta-alanine, uncompetitive with pyruvic acid, Ki ~8.9 mM.</p>Fórmula:C4H5N3O2Pureza:99.47%Forma y color:SolidPeso molecular:127.13-Methylcytidine
CAS:<p>3-Methylcytidine as biomarkers of four different types of cancer: lung cancer, gastric cancer, colon cancer, and breast cancer.</p>Fórmula:C10H15N3O5Pureza:99.52%Forma y color:SolidPeso molecular:257.24(1E)-CFI-400437 dihydrochloride
CAS:<p>(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) is a selective and potent polo-like kinase 4 (PLK4) inhibitor.</p>Fórmula:C29H30Cl2N6O2Pureza:97.08%Forma y color:SolidPeso molecular:565.5TH-257
CAS:<p>TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).</p>Fórmula:C24H26N2O3SPureza:98.23%Forma y color:SolidPeso molecular:422.54CRT0044876
CAS:<p>CRT0044876 (7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.</p>Fórmula:C9H6N2O4Pureza:98.27% - 98.98%Forma y color:Brown PowderPeso molecular:206.155-Fluoroorotic acid
CAS:<p>5-Fluoroorotic acid is an inhibitor of thymidylate synthase.</p>Fórmula:C5H3FN2O4Pureza:99.7% - >99.99%Forma y color:White To Pale Yellow PowderPeso molecular:174.09RI-2
CAS:<p>RI-2, a potent RAD51 inhibitor, has a 44.17 μM IC50 and selectively blocks human HR repair.</p>Fórmula:C21H18Cl2N2O4Pureza:99.63% - 99.86%Forma y color:SolidPeso molecular:433.28Quarfloxin
CAS:<p>Quarfloxin (CX-3543), a fluoroquinolone, inhibits neuroblastoma with nanomolar IC50, disrupting nucleolin and G-quadruplex DNA.</p>Fórmula:C35H33FN6O3Pureza:99.77%Forma y color:SolidPeso molecular:604.672'-Fluoro-2'-Deoxyadenosine
CAS:<p>2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP).</p>Fórmula:C10H12FN5O3Pureza:99.95%Forma y color:SolidPeso molecular:269.23Ro5-3335
CAS:<p>Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins.</p>Fórmula:C13H10ClN3OPureza:99.42% - 99.87%Forma y color:SolidPeso molecular:259.69XL228
CAS:<p>XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).</p>Fórmula:C22H31N9OPureza:99.07%Forma y color:SolidPeso molecular:437.54Tozasertib
CAS:<p>Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).</p>Fórmula:C23H28N8OSPureza:99.99%Forma y color:SolidPeso molecular:464.59SAR-020106
CAS:<p>SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.</p>Fórmula:C19H19ClN6OPureza:97.78%Forma y color:SolidPeso molecular:382.85Tipiracil hydrochloride
CAS:<p>Tipiracil hydrochloride (MA-1 hydrochloride) is a thymidine phosphorylase inhibitor (TPI).</p>Fórmula:C9H12Cl2N4O2Pureza:98.13% - ≥95%Forma y color:SolidPeso molecular:279.12Lurbinectedin
CAS:<p>Lurbinectedin (PM01183) is a DNA minor groove covalent binder. Lurbinectedin also shows effective anti-tumor activity.</p>Fórmula:C41H44N4O10SPureza:98.11%Forma y color:SolidPeso molecular:784.87THZ2
CAS:<p>THZ2 (CDK7-IN-1), an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC).</p>Fórmula:C31H28ClN7O2Pureza:98.28%Forma y color:SolidPeso molecular:566.05Madrasin
CAS:<p>Madrasin (DDD00107587) is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly.</p>Fórmula:C16H17N5O2Pureza:99.06% - 99.61%Forma y color:SolidPeso molecular:311.34Trimethoprim sulfate
CAS:<p>Trimethoprim sulfate, a dihydrofolate reductase inhibitor, treats bacterial infections and sometimes malaria; may depress hematopoiesis.</p>Fórmula:C28H38N8O10SForma y color:SolidPeso molecular:678.72Dimethylenastron
CAS:<p>Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.</p>Fórmula:C16H18N2O2SPureza:98.07%Forma y color:SolidPeso molecular:302.39SCH900776 (S-isomer)
CAS:<p>SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).</p>Fórmula:C15H18BrN7Pureza:99.88%Forma y color:SolidPeso molecular:376.25THZ531
CAS:<p>THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM).</p>Fórmula:C30H32ClN7O2Pureza:97.17% - 99.86%Forma y color:SolidPeso molecular:558.07Levofloxacin hydrochloride
CAS:<p>Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.</p>Fórmula:C18H21ClFN3O4Pureza:99.78% - 99.98%Forma y color:SolidPeso molecular:397.8dGTP
CAS:<p>dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, and</p>Fórmula:C10H16N5O13P3Pureza:99.64%Forma y color:SolidPeso molecular:507.18CX-5461 dihydrochloride
<p>CX-5461 dihydrochloride: Oral Pol I inhibitor, HCT-116 (IC50: 142 nM), A375 (IC50: 113 nM), MIA PaCa-2 (IC50: 54 nM), weak on Pol II (IC50 ≥ 25 μM).</p>Fórmula:C27H29Cl2N7O2SForma y color:SolidPeso molecular:586.54Folinic acid calcium hydrate
CAS:<p>Folinic acid (Leucovorin) calcium hydrate is a biofolic acid often used as a rescue agent with methotrexate (MTX) to reduce MTX-induced toxicity.</p>Fórmula:C20H23CaN7O8Forma y color:SolidPeso molecular:529.523RAD51-IN-1
CAS:<p>Rad51-in-1 is a derivative of B02 and an effective inhibitor of Rad51.</p>Fórmula:C22H16ClN3OPureza:99.95%Forma y color:SolidPeso molecular:373.83CBFβ Inhibitor
CAS:<p>CBFβ Inhibitor (5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine) is a cell-permeable CBFβ inhibitor and inhibits its association with Runx1.</p>Fórmula:C12H14N2OSPureza:96.50%Forma y color:SolidPeso molecular:234.32NITD-2
CAS:<p>NITD-2 is a DENV RdRp inhibitor with poor cell membrane penetration; no vaccine or antiviral for DENV exists.</p>Fórmula:C23H19N3O4SPureza:98.03% - 99.46%Forma y color:SolidPeso molecular:433.48Monastrol
CAS:<p>Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.</p>Fórmula:C14H16N2O3SPureza:98.02% - 98.59%Forma y color:SolidPeso molecular:292.35AUZ 454
CAS:<p>AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd of 50/18.6/15.4/9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.</p>Fórmula:C24H26F3N7O2Pureza:99.59%Forma y color:SolidPeso molecular:501.5CX-5461
CAS:<p>CX5461 is an orally rRNA synthesis inhibitor that inhibits Pol I-driven rRNA transcription. CX5461 has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C27H27N7O2SPureza:95.44% - 99.25%Forma y color:SolidPeso molecular:513.61BVDV-IN-1
CAS:<p>BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM.</p>Fórmula:C20H22N4OPureza:98.43%Forma y color:SolidPeso molecular:334.41PND-1186
CAS:<p>PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).</p>Fórmula:C25H26F3N5O3Pureza:99.14% - 99.75%Forma y color:SolidPeso molecular:501.5OSU-T315
CAS:<p>OSU-T315 (OSU-T315 (1,5-regioisomer)) (1,5-regioisomer) is a ILK inhibitor.</p>Fórmula:C30H30F3N5OPureza:98.69%Forma y color:SolidPeso molecular:533.59HMN-176
CAS:<p>HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).</p>Fórmula:C20H18N2O4SPureza:98.92% - 98.99%Forma y color:SolidPeso molecular:382.43PTC-209
CAS:<p>PTC-209 is a potent and selective BMI-1 inhibitor.</p>Fórmula:C17H13Br2N5OSPureza:99.43% - 99.887%Forma y color:SolidPeso molecular:495.19PHA-680632
CAS:<p>PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively.</p>Fórmula:C28H35N7O2Pureza:98.2%Forma y color:SolidPeso molecular:501.62Purvalanol B
CAS:<p>Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively)</p>Fórmula:C20H25ClN6O3Pureza:98.95%Forma y color:SolidPeso molecular:432.9HALOFUGINONE LACTATE
CAS:<p>HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D.</p>Fórmula:C19H23BrClN3O6Pureza:99.70% - 99.96%Forma y color:SolidPeso molecular:504.8
