Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(95 productos)
- CDK(501 productos)
- Detención del ciclo celular(4 productos)
- Chk(42 productos)
- DYRK(48 productos)
- Dynamin(23 productos)
- Ferroptosis(215 productos)
- HSP(169 productos)
- Integrin(224 productos)
- Kinesina(66 productos)
- LIM quinasa(19 productos)
- Asociado a microtúbulos(262 productos)
- PKC(102 productos)
- PLK(28 productos)
- ROCK(69 productos)
- Rho(2 productos)
- Wee1(15 productos)
- c-Myc(69 productos)
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Se han encontrado 3485 productos de "Ciclo celular / Checkpoint"
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Ibezapolstat
CAS:<p>Ibezapolstat (ACX-362E) is an antibiotic with antibacterial activity that inhibits Clostridium difficile.</p>Fórmula:C18H20Cl2N6O2Pureza:98% - 99.429%Forma y color:SolidPeso molecular:423.3Y16
CAS:<p>Y16 is a G protein-coupled Rho GEFs inhibitor and also a specific inhibitor of LARG with a Kd of 76 nM.Cost-effective and quality-assured.</p>Fórmula:C24H20N2O3Pureza:98.26% - 99.32%Forma y color:SolidPeso molecular:384.43IMP-1088
CAS:IMP-1088 is a potent inhibitor of human N-myristoyltransferases NMT1 and NMT2 dual.Fórmula:C25H29F2N5OPureza:98.48% - 99.52%Forma y color:SolidPeso molecular:453.53Palbociclib
CAS:<p>Palbociclib is an oral CDK4/6 inhibitor, halts Rb phosphorylation, arrests cell cycle, and curbs tumor growth.</p>Fórmula:C24H29N7O2Pureza:98% - 99.9%Forma y color:SolidPeso molecular:447.535'-Deoxy-5-fluorocytidine
CAS:<p>5'-Deoxy-5-fluorocytidine is an intermediate metabolite of the DNA synthesis inhibitor capecitabine.</p>Fórmula:C9H12FN3O4Pureza:99.67%Forma y color:White SolidPeso molecular:245.21TH5427 hydrochloride
CAS:<p>TH5427 HCl inhibits NUDT5 with 29 nM IC50; 690x more selective over MTH1; blocks ATP in breast cancer cells, hindering growth.</p>Fórmula:C20H21Cl3N8O3Forma y color:SolidPeso molecular:527.79Tirofiban hydrochloride monohydrate
CAS:<p>Tirofiban（MK383） hydrochloride monohydrate is a non-peptide glycoprotein IIb/IIIa antagonist. Cost-effective and quality-assured.</p>Fórmula:C22H39ClN2O6SPureza:98.81% - >99.99%Forma y color:White SolidPeso molecular:495.07RNase L-IN-2
CAS:<p>RNase L-IN-2 activates RNase L at 22 uM, has antiviral effects on various RNA viruses, non-toxic at effective levels.</p>Fórmula:C16H14N2O2SPureza:98.81%Forma y color:SolidPeso molecular:298.36ON-013100
CAS:<p>ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.</p>Fórmula:C19H22O7SPureza:98.27%Forma y color:SolidPeso molecular:394.44IMM-H007
CAS:<p>IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression</p>Fórmula:C22H23N5O8Pureza:97.73%Forma y color:SolidPeso molecular:485.45RI-1
CAS:<p>RI-1 (RAD51 inhibitor 1) is a RAD51 inhibitor (IC50: 5-30 μM).</p>Fórmula:C14H11Cl3N2O3Pureza:99.3% - 99.62%Forma y color:SolidPeso molecular:361.61TMPyP4 tosylate
CAS:<p>TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.</p>Fórmula:C72H66N8O12S4Pureza:98.61% - 99.85%Forma y color:SolidPeso molecular:1363.6STAMBP-IN-1
CAS:<p>STAMBP-IN-1 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release after</p>Fórmula:C27H28N4O4SPureza:99.64%Forma y color:SolidPeso molecular:504.6BMS-1166
CAS:<p>BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor.</p>Fórmula:C36H33ClN2O7Pureza:99.22%Forma y color:SolidPeso molecular:641.112-Aminofluorene
CAS:<p>2-Aminofluorene (2-Fluorenamine) is a biochemical.</p>Fórmula:C13H11NPureza:99.9%Forma y color:Light Yellow CrystallinePeso molecular:181.23SCH900776
CAS:<p>SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.</p>Fórmula:C15H18BrN7Pureza:96.69% - 99.6%Forma y color:SolidPeso molecular:376.25A-286982
CAS:<p>A 286982 blocks the LFA-1 and ICAM-1 integrin-ligand interaction.</p>Fórmula:C24H27N3O4SPureza:97.81%Forma y color:SolidPeso molecular:453.55Pyridostatin
CAS:<p>Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or</p>Fórmula:C31H32N8O5Pureza:98%Forma y color:SolidPeso molecular:596.64PF 477736
CAS:<p>PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (</p>Fórmula:C22H25N7O2Pureza:97.58% - 99.94%Forma y color:SolidPeso molecular:419.48PNU112455A hydrochloride
CAS:<p>PNU112455A hydrochloride is an ATP site competetive inhibitor of CDK2 and CDK5,binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively.</p>Fórmula:C10H12ClN5O2SPureza:98.58% - 99.22%Forma y color:SolidPeso molecular:301.75ML216
CAS:<p>ML216 (CID-49852229) inhibits BLM helicase (IC50: 1.8 μM), 28-fold selective over RECQ1, RECQ5, and UvrD (IC50s > 50 μM).</p>Fórmula:C15H9F4N5OSPureza:98.12%Forma y color:SolidPeso molecular:383.32Fadraciclib
CAS:<p>Fadraciclib (CYC065) is an orally available, second-generation ATP-competitive inhibitor of CDK2/CDK9 kinases (IC50s: 5/26 nM).</p>Fórmula:C21H31N7OPureza:99.75%Forma y color:SolidPeso molecular:397.52Phthalazinone pyrazole
CAS:<p>Phthalazinone pyrazole: a potent, selective oral Aurora-A kinase inhibitor, overexpressed in tumors with oncogenic activity.</p>Fórmula:C18H15N5OPureza:97.03%Forma y color:SolidPeso molecular:317.34Mitonafide
CAS:<p>Mitonafide (NSC-300288) suppresses the activity of M. tuberculosis NAD+ dependent DNA ligase A. Mitonafide is a DNA intercalating agent.</p>Fórmula:C16H15N3O4Pureza:99.89%Forma y color:SolidPeso molecular:313.31Cetraxate hydrochloride
CAS:<p>Cetraxate hydrochloride (DV10062) is an oral gastrointestinal medication. It has a cytoprotective effect.</p>Fórmula:C17H24ClNO4Pureza:99.75%Forma y color:SolidPeso molecular:341.83HMN-214
CAS:<p>HMN-214 (IVX-214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.</p>Fórmula:C22H20N2O5SPureza:98% - >99.99%Forma y color:SolidPeso molecular:424.47TAK-960
CAS:<p>TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.</p>Fórmula:C27H34F3N7O3Pureza:97.06%Forma y color:SolidPeso molecular:561.6Cyclo(-RGDfK) TFA
CAS:<p>Cyclo(-RGDfK) is a selective αvβ3 integrin inhibitor(IC50 : 0.94 nM).</p>Fórmula:C29H42F3N9O9Pureza:98.99% - 99.54%Forma y color:SolidPeso molecular:717.69Ribociclib succinate hydrate
CAS:<p>Ribociclib succinate hydrate is a highly specific CDK4/6 inhibitor (IC50s: 10 nM and 39 nM, respectively).</p>Fórmula:C27H38N8O6Pureza:98%Forma y color:SolidPeso molecular:570.651CHR-6494 TFA
CAS:<p>CHR-6494 TFA: potent haspin inhibitor (IC50=2 nM), blocks H3T3 phosphorylation, triggers apoptosis in cancer cells. Used for cancer research.</p>Fórmula:C18H17F3N6O2Pureza:99.50%Forma y color:SolidPeso molecular:406.3610074-G5
CAS:<p>10074-G5 is an inhibitor of c-Myc-Max dimerization.</p>Fórmula:C18H12N4O3Pureza:99.51% - 99.67%Forma y color:SolidPeso molecular:332.31Adavosertib
CAS:<p>Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.</p>Fórmula:C27H32N8O2Pureza:98.65% - 99.86%Forma y color:SolidPeso molecular:500.6Apcin-A
CAS:<p>Apcin-A is an anaphase-promoting complex (APC) inhibitor.</p>Fórmula:C10H14Cl3N5O2Forma y color:SolidPeso molecular:342.61GSK2850163 hydrochloride
CAS:<p>GSK2850163 hydrochloride is a novel IRE1α inhibitor with IC50 of 20 nM for kinase and 200 nM for RNA enzyme.</p>Fórmula:C24H30Cl3N3OForma y color:SolidPeso molecular:482.87CAN508
CAS:<p>CAN508: potent CDK9/T1 inhibitor; IC50 0.35 μM, Cdk2/E; Ki 13.3 μM, IC50 20 μM; 38x selective; antitumor.</p>Fórmula:C9H10N6OPureza:98.65%Forma y color:SolidPeso molecular:218.22TAK-632
CAS:<p>TAK-632 is a potent pan-Raf inhibitor.</p>Fórmula:C27H18F4N4O3SPureza:98% - 99.5%Forma y color:SolidPeso molecular:554.52SBC-115076
CAS:<p>SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.</p>Fórmula:C31H33N3O5Pureza:97.07% - 99.89%Forma y color:SolidPeso molecular:527.61Tiazofurin
CAS:<p>Tiazofurin, a synthetic nucleoside, has anti-cancer effects and inhibits IMPDH as TAD after metabolism.</p>Fórmula:C9H12N2O5SPureza:99.91%Forma y color:SolidPeso molecular:260.277BIO
CAS:<p>7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.</p>Fórmula:C16H10BrN3O2Pureza:99.67%Forma y color:SolidPeso molecular:356.17Palmatine
CAS:<p>Palmatine, also known as Burasaine, inhibits dopamine production and may treat flavivirus, jaundice, dysentery, hypertension, and liver issues.</p>Fórmula:C21H22NO4Pureza:96.28% - 99.49%Forma y color:SolidPeso molecular:352.4CK7
CAS:<p>CK7, a Cdk2/9 inhibitor, is instrumental in the synthesis of Nek1 inhibitors BSc5231 and BSc5367.</p>Fórmula:C14H12N6O2SPureza:99.54%Forma y color:SolidPeso molecular:328.35Hu7691
CAS:<p>Hu7691 is an Akt inhibitor that inhibits Akt1, Akt2, and Akt3, suppresses neuroblastoma cell proliferation, and induces differentiation of neuroblastoma cells.</p>Fórmula:C22H22ClF3N4OPureza:99.81%Forma y color:SolidPeso molecular:450.88Roniciclib
CAS:<p>Roniciclib (BAY 1000394) is a potent pan-CDK inhibitor and a novel oral cytotoxic agent. Roniciclib inhibits the activity of cell-cycle CDKs CDK1, CDK2, CDK3, CDK4, and of transcriptional CDKs CDK7 and CDK9 with IC(50) values in the range between 5 and 25 nmol/L.</p>Fórmula:C18H21F3N4O3SPureza:98% - 98.63%Forma y color:SolidPeso molecular:430.44GLPG0187
CAS:<p>GLPG0187, a broad spectrum integrin receptor antagonist, inhibits αvβ1-integrin (IC50: 1.3 nM).</p>Fórmula:C29H37N7O5SPureza:99.4% - 99.70%Forma y color:SolidPeso molecular:595.71Indisulam
CAS:<p>Indisulam (E 7070) is a dual-action anticancer drug, blocking G1/S cell cycle transition by degrading cyclin E and activating p53/p21.</p>Fórmula:C14H12ClN3O4S2Pureza:98.68% - 99.77%Forma y color:SolidPeso molecular:385.85SPHINX
CAS:<p>SPHINX is a new generation inhibitor of SPRK1</p>Fórmula:C17H17F3N2O3Pureza:99.29%Forma y color:SolidPeso molecular:354.32BIO-1211
CAS:<p>BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).</p>Fórmula:C36H48N6O9Pureza:99.33%Forma y color:SolidPeso molecular:708.8Palbociclib dihydrochloride
<p>Palbociclib, oral CDK4/6 inhibitor (IC50: 11/16 nM), targets HR+/HER2- breast cancer and hepatocellular carcinoma.</p>Fórmula:C24H31Cl2N7O2Forma y color:SolidPeso molecular:520.45P18IN011
CAS:<p>P18IN011 (P18IN011 - CAS 77408-67-4 - Calbiochem) is a novel inhibitor of p18(INK4C).</p>Fórmula:C15H12N2O5SPureza:97.63%Forma y color:SolidPeso molecular:332.33AT7519 TFA
CAS:<p>AT7519 inhibits CDK1-6 kinases; IC50 ranges 0.018-0.66 μM.</p>Fórmula:C18H18Cl2F3N5O4Forma y color:SolidPeso molecular:496.27
