Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(115 productos)
- CDK(547 productos)
- Detención del ciclo celular(5 productos)
- Chk(48 productos)
- DYRK(47 productos)
- Dynamin(27 productos)
- Ferroptosis(227 productos)
- HSP(180 productos)
- Integrin(269 productos)
- Kinesina(87 productos)
- LIM quinasa(20 productos)
- Asociado a microtúbulos(273 productos)
- PKC(126 productos)
- PLK(25 productos)
- ROCK(62 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(76 productos)
Mostrar 10 subcategorías más
Se han encontrado 3909 productos de "Ciclo celular / Checkpoint"
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IMT1B
CAS:IMT1B (LDC203974) is an oral POLRMT inhibitor that curbs mtDNA expression and has anti-cancer properties.Fórmula:C24H21ClFNO6Pureza:98.26% - 99.83%Forma y color:SolidPeso molecular:473.88Ref: TM-T8842
1mg138,00€5mg295,00€1mL*10mM (DMSO)309,00€10mg505,00€25mg733,00€50mg888,00€100mg1.251,00€AS2863619
CAS:AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.Fórmula:C16H14Cl2N8OPureza:>99.99%Forma y color:SolidPeso molecular:405.24Ref: TM-T8378
1mg124,00€2mg170,00€5mg260,00€1mL*10mM (DMSO)286,00€10mg409,00€25mg677,00€50mg954,00€100mg1.288,00€BRD9876
CAS:BRD9876 is a selective inhibitor of MM1S growth.Fórmula:C16H14N2Pureza:97.81%Forma y color:SolidPeso molecular:234.3RK33
CAS:"RK33 is a DDX3 inhibitor causing G1 arrest, apoptosis, and radiation sensitization in DDX3-overexpressing cells."Fórmula:C23H20N6O3Pureza:99.04% - 99.72%Forma y color:SolidPeso molecular:428.44T-5224
CAS:T-5224 is a transcription factor c-Fos/AP-1 inhibitor, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcriptionFórmula:C29H27NO8Pureza:97.88% - 99.29%Forma y color:SolidPeso molecular:517.53Ref: TM-T5416
1mg48,00€5mg96,00€1mL*10mM (DMSO)107,00€10mg144,00€25mg254,00€50mg424,00€100mg627,00€200mg998,00€Pyridostatin TFA
CAS:Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-Fórmula:C37H35F9N8O11Pureza:97.09% - 99.84%Forma y color:SolidPeso molecular:938.71BUR1
CAS:BUR1 is a Saccharomyces cerevisiae cyclin-dependent kinase (CDK) and is homologous to mammalian Cdk9, which functions in transcriptional elongation.Fórmula:C16H17N5Pureza:90%Forma y color:SolidPeso molecular:279.34LP-935509
CAS:LP-935509 is a selective, brain-permeable, small molecule competitive inhibitor of articulin-2-associated kinase 1 (AAK1).Cost-effective and quality-assured.Fórmula:C20H24N6O3Pureza:98.34% - 99.64%Forma y color:SolidPeso molecular:396.44Ref: TM-T15781
1mg37,00€2mg49,00€5mg79,00€1mL*10mM (DMSO)87,00€10mg124,00€25mg239,00€50mg444,00€100mg647,00€H-Gly-Arg-Gly-Asp-Asn-Pro-OH
CAS:RGD peptide (GRGDNP) (RGD peptide GRGDNP(2TFA)) is a integrin-ligand interactions inhibitor.Fórmula:C23H38N10O10Pureza:>99.99%Forma y color:SolidPeso molecular:614.61Alovudine
CAS:3'-Fluoro-3'-deoxythymidine (3'-Deoxy-3'-fluorothymidine) is a marker of DNA synthesis,which is less susceptible to inflammatory changes than FDG.Fórmula:C10H13FN2O4Pureza:99.41%Forma y color:Less Solid Colourless SolidPeso molecular:244.22Dasabuvir
CAS:Dasabuvir (ABT-333) blocks HCV replication by inhibiting the essential NS5B RNA polymerase.Fórmula:C26H27N3O5SPureza:99.54% - 99.62%Forma y color:SolidPeso molecular:493.57Peldesine dihydrochloride
CAS:Peldesine (BCX 34) dihydrochloride is an inhibitor of PNP in humans, rats, and mice, also hindering T-cell proliferation, used in lymphoma and HIV research.Fórmula:C12H13Cl2N5OForma y color:SolidPeso molecular:314.176-Chloropurine riboside
CAS:6-Chloropurine riboside (6-CPR): purine analog with antitumor, anti-inflammatory, antiviral, antifungal effects, and neuroprotective properties.Fórmula:C10H11ClN4O4Pureza:96.84%Forma y color:SoildPeso molecular:286.6700CKI-7 free base
CAS:CKI-7 free base is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.Fórmula:C11H12ClN3O2SForma y color:SolidPeso molecular:285.75Orbofiban
CAS:Orbofiban, an orally administered antagonist of the platelet GPIIb/IIIa receptor, effectively inhibits platelet aggregation.Fórmula:C17H23N5O4Forma y color:SolidPeso molecular:361.4Apcin
CAS:Apcin: potent APC/C(Cdc20) E3 ligase inhibitor, blocks substrate recognition & mitosis, synergizes with Ts-Arg-OMe.Fórmula:C13H14Cl3N7O4Pureza:96.74%Forma y color:SolidPeso molecular:438.65Ref: TM-T8561
1mg46,00€2mg59,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg133,00€25mg259,00€50mg447,00€100mg673,00€CHR-6494
CAS:CHR-6494 is a haspin inhibitor that inhibits histone H3T3 phosphorylation (IC50: 2 nM).Fórmula:C16H16N6Pureza:98.78%Forma y color:SolidPeso molecular:292.34Ref: TM-T14959
5mg54,00€1mL*10mM (DMSO)60,00€10mg82,00€25mg145,00€50mg259,00€100mg442,00€200mg643,00€Brr2-IN-3
CAS:Brr2-IN-3 (Brr2 Inhibitor C9) is an allosteric inhibitor of the spliceosomal RNA helicase Brr2. Brr2 is implicated in autosomal-dominant retinitis pigmentosa.Fórmula:C24H20N4O3SPureza:99.26%Forma y color:SolidPeso molecular:444.51Ref: TM-T22282
1mg52,00€2mg65,00€5mg92,00€1mL*10mM (DMSO)110,00€10mg161,00€25mg290,00€50mg420,00€100mg587,00€200mg792,00€Brequinar
CAS:Brequinar (NSC-368390) is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.Fórmula:C23H15F2NO2Pureza:99.1% - 99.57%Forma y color:SolidPeso molecular:375.37Bonafton
CAS:Bonafton (Bonaphthone) is an antiviral agent.Fórmula:C10H5BrO2Pureza:97.16%Forma y color:SolidPeso molecular:237.05Ref: TM-T8877
1mg56,00€1mL*10mM (DMSO)92,00€5mg118,00€10mg167,00€25mg281,00€50mg421,00€100mg605,00€200mg845,00€3-Deazauridine
CAS:3-Deazauridine (NSC-126849), a uridine analog, blocks CTP synthesis by competing with CTP synthetase.Fórmula:C10H13NO6Pureza:99.86%Forma y color:SolidPeso molecular:243.21kb-NB77-78
CAS:kb-NB77-78 is an analog of CID797718, which is a by-product of the synthesis of the parental compound, CID755673(PKD1 inhibitor).Fórmula:C18H25NO3SiPureza:99.54%Forma y color:SolidPeso molecular:331.48EHT 1864 2HCl
CAS:EHT 1864 (EHT 1864 2HCl) is a Rac family GTPase inhibitor that blocks activation by direct binding to Rac1, Rac1b, Rac2, and Rac3. Cost effective and quality assured.Fórmula:C25H29Cl2F3N2O4SPureza:98.39% - 99.42%Forma y color:SolidPeso molecular:581.47Fanotaprim
CAS:Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor.Fórmula:C19H22N8OPureza:98.1%Forma y color:SolidPeso molecular:378.43Ref: TM-T36692
1mg50,00€2mg71,00€5mg110,00€1mL*10mM (DMSO)122,00€10mg170,00€25mg318,00€50mg442,00€100mg627,00€200mg845,00€HA-100
CAS:HA-100 is an inhibitor of protein kinaseFórmula:C13H15N3O2SPureza:99.44%Forma y color:Pale Yellow Crystalline SolidPeso molecular:277.34PNU112455A hydrochloride
CAS:PNU112455A hydrochloride is an ATP site competetive inhibitor of CDK2 and CDK5,binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively.Fórmula:C10H12ClN5O2SPureza:98.58% - 99.22%Forma y color:SolidPeso molecular:301.75Ref: TM-T8230
2mg44,00€5mg71,00€1mL*10mM (DMSO)79,00€10mg100,00€25mg172,00€50mg266,00€100mg434,00€500mg964,00€Ribociclib succinate hydrate
CAS:Ribociclib succinate hydrate is a highly specific CDK4/6 inhibitor (IC50s: 10 nM and 39 nM, respectively).Fórmula:C27H38N8O6Pureza:98%Forma y color:SolidPeso molecular:570.651CAN508
CAS:CAN508: potent CDK9/T1 inhibitor; IC50 0.35 μM, Cdk2/E; Ki 13.3 μM, IC50 20 μM; 38x selective; antitumor.Fórmula:C9H10N6OPureza:98.65%Forma y color:SolidPeso molecular:218.22TAK-632
CAS:TAK-632 is a potent pan-Raf inhibitor.Fórmula:C27H18F4N4O3SPureza:98% - 99.5%Forma y color:SolidPeso molecular:554.52Palmatine
CAS:Palmatine, also known as Burasaine, inhibits dopamine production and may treat flavivirus, jaundice, dysentery, hypertension, and liver issues.Fórmula:C21H22NO4Pureza:96.28% - 99.49%Forma y color:SolidPeso molecular:352.4SPHINX
CAS:SPHINX is a new generation inhibitor of SPRK1Fórmula:C17H17F3N2O3Pureza:99.29%Forma y color:SolidPeso molecular:354.32Hu7691
CAS:Hu7691 is an Akt inhibitor that inhibits Akt1, Akt2, and Akt3, suppresses neuroblastoma cell proliferation, and induces differentiation of neuroblastoma cells.Fórmula:C22H22ClF3N4OPureza:99.81%Forma y color:SolidPeso molecular:450.887BIO
CAS:7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.
Fórmula:C16H10BrN3O2Pureza:99.67%Forma y color:SolidPeso molecular:356.17SBC-115337
CAS:SBC-115337 is a PCSK9 inhibitor.Fórmula:C29H19N3O4Pureza:99.41%Forma y color:SolidPeso molecular:473.48Simeprevir
CAS:Simeprevir (TMC435) is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM.Fórmula:C38H47N5O7S2Pureza:99.45% - 99.92%Forma y color:SolidPeso molecular:749.94WR99210 hydrochloride(47326-86-3 free base)
CAS:WR99210 hydrochloride is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (pfDHFR), which is a major malarial drug target.Fórmula:C14H19Cl4N5O2Pureza:97.77% - 99.8%Forma y color:SolidPeso molecular:431.14Ref: TM-T17257L
1mg62,00€5mg132,00€1mL*10mM (DMSO)157,00€10mg200,00€25mg338,00€50mg497,00€100mg708,00€200mg954,00€WNK-IN-11
CAS:WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM)Fórmula:C21H21Cl2N5OSPureza:98.32%Forma y color:SolidPeso molecular:462.4Ref: TM-T5456
1mg87,00€5mg172,00€1mL*10mM (DMSO)188,00€10mg280,00€25mg474,00€50mg683,00€100mg964,00€500mg1.918,00€3'-Deoxyguanosine
CAS:3'-Deoxyguanosine is a ligand that can be complexed with enzymes, such as purine nucleoside phosphorylase, and receptors.Fórmula:C10H13N5O4Pureza:98.85% - 98.96%Forma y color:SolidPeso molecular:267.24Phosphonoformic acid trisodium salt hexa
CAS:Phosphonoformic acid trisodium salt hexa (Sodium phosphonatoformate hexahydrate) is an antiviral drug for the treatment of CMV retinitis.Fórmula:CH12Na3O11PPureza:98%Forma y color:SolidPeso molecular:300.03Cyclo(RGDyK) trifluoroacetate
CAS:Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.Fórmula:C31H43F6N9O12Pureza:95.28% - ≥95%Forma y color:SolidPeso molecular:847.72PfDHODH-IN-1
CAS:PfDHODH-IN-1 is an inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase(PfDHODH) which catalyzes the rate-limiting step for DNA and RNA biosynthesis.Fórmula:C14H11F3N2O2Pureza:99.87%Forma y color:SolidPeso molecular:296.24Ref: TM-T12438
1mg52,00€1mL*10mM (DMSO)92,00€5mg101,00€10mg152,00€25mg295,00€50mg447,00€100mg658,00€200mg888,00€GAK inhibitor 49 hydrochloride
Potent GAK inhibitor 49 hydrochloride: ATP-competitive, highly selective, Ki=0.54 nM, IC50=56 nM, binds to RIPK2.Fórmula:C20H23ClN2O5Forma y color:SolidPeso molecular:406.86Tirapazamine
CAS:Tirapazamine (Win59075) triggers apoptosis in hypoxic cells by damaging DNA and enhances effects of radiation and cisplatin.Fórmula:C7H6N4O2Pureza:96.65% - 99.87%Forma y color:Orange-Red Crystalline PowderPeso molecular:178.15LDN-192960 hydrochloride
CAS:LDN-192960 hydrochloride is an inhibitor of Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) and Haspin with IC50s of 48 nM and 10 nM, respectively.Fórmula:C18H22Cl2N2O2SPureza:98%Forma y color:SolidPeso molecular:401.35Levofloxacin hydrochloride
CAS:Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.Fórmula:C18H21ClFN3O4Pureza:99.78% - 99.98%Forma y color:SolidPeso molecular:397.8Lurbinectedin
CAS:Lurbinectedin (PM01183) is a DNA minor groove covalent binder. Lurbinectedin also shows effective anti-tumor activity.Fórmula:C41H44N4O10SPureza:98.11%Forma y color:SolidPeso molecular:784.87M2N12
CAS:M2N12 selectively inhibits Cdc25C (IC50=0.09μM) and has anti-tumor properties, affecting Cdc25A and B as well.Fórmula:C20H16ClN5O2Pureza:98.01%Forma y color:SolidPeso molecular:393.83Ref: TM-T11929
1mg84,00€5mg152,00€1mL*10mM (DMSO)167,00€10mg236,00€25mg447,00€50mg670,00€100mg982,00€CRT0066854
CAS:CRT-0066854 is a PKCι and PKCζ inhibitor. CRT0066854 was able to restore polarized morphogenesis in the dysplastic H-Ras spheroids.Fórmula:C24H25N5SForma y color:SolidPeso molecular:415.55Mps1-IN-3 hydrochloride
Mps1-IN-3 HCl: potent Mps1 inhibitor (IC50: 50 nM), hampers glioblastoma growth, enhances vincristine efficacy in vivo.Fórmula:C26H32ClN7O4SForma y color:SolidPeso molecular:574.09Tipiracil
CAS:Tipiracil inhibits thymidine phosphorylase, enhancing trifluridine bioavailability, and is studied in colorectal and gastric cancer treatment.Fórmula:C9H11ClN4O2Pureza:99.815%Forma y color:SolidPeso molecular:242.66
