Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(95 productos)
- CDK(501 productos)
- Detención del ciclo celular(4 productos)
- Chk(42 productos)
- DYRK(48 productos)
- Dynamin(23 productos)
- Ferroptosis(215 productos)
- HSP(169 productos)
- Integrin(224 productos)
- Kinesina(66 productos)
- LIM quinasa(19 productos)
- Asociado a microtúbulos(262 productos)
- PKC(102 productos)
- PLK(28 productos)
- ROCK(69 productos)
- Rho(2 productos)
- Wee1(15 productos)
- c-Myc(69 productos)
Mostrar 10 subcategorías más
Se han encontrado 3485 productos de "Ciclo celular / Checkpoint"
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M2N12
CAS:<p>M2N12 selectively inhibits Cdc25C (IC50=0.09μM) and has anti-tumor properties, affecting Cdc25A and B as well.</p>Fórmula:C20H16ClN5O2Pureza:98.01%Forma y color:SolidPeso molecular:393.832'-Fluoro-2'-Deoxyadenosine
CAS:<p>2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP).</p>Fórmula:C10H12FN5O3Pureza:99.95%Forma y color:SolidPeso molecular:269.23IMT1B
CAS:<p>IMT1B (LDC203974) is an oral POLRMT inhibitor that curbs mtDNA expression and has anti-cancer properties.</p>Fórmula:C24H21ClFNO6Pureza:98.26% - 99.83%Forma y color:SolidPeso molecular:473.88Ro5-3335
CAS:<p>Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins.</p>Fórmula:C13H10ClN3OPureza:99.42% - 99.87%Forma y color:SolidPeso molecular:259.69XL228
CAS:<p>XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).</p>Fórmula:C22H31N9OPureza:99.07%Forma y color:SolidPeso molecular:437.54Tozasertib
CAS:<p>Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).</p>Fórmula:C23H28N8OSPureza:99.99%Forma y color:SolidPeso molecular:464.59Ganciclovir hydrate
CAS:<p>Ganciclovir hydrate: oral anti-cytomegalovirus; inhibits HSV 1/2, CMV, adenoviruses, FHV-1; brain-penetrating.</p>Fórmula:C9H15N5O5Forma y color:SolidPeso molecular:273.249SAR-020106
CAS:<p>SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.</p>Fórmula:C19H19ClN6OPureza:97.78%Forma y color:SolidPeso molecular:382.85AS2863619
CAS:<p>AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.</p>Fórmula:C16H14Cl2N8OPureza:>99.99%Forma y color:SolidPeso molecular:405.24Tipiracil hydrochloride
CAS:<p>Tipiracil hydrochloride (MA-1 hydrochloride) is a thymidine phosphorylase inhibitor (TPI).</p>Fórmula:C9H12Cl2N4O2Pureza:98.13% - ≥95%Forma y color:SolidPeso molecular:279.12BRD9876
CAS:<p>BRD9876 is a selective inhibitor of MM1S growth.</p>Fórmula:C16H14N2Pureza:97.81%Forma y color:SolidPeso molecular:234.3THZ2
CAS:<p>THZ2 (CDK7-IN-1), an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC).</p>Fórmula:C31H28ClN7O2Pureza:98.28%Forma y color:SolidPeso molecular:566.05APY29
CAS:<p>APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.</p>Fórmula:C17H16N8Pureza:96.51% - 98.46%Forma y color:SolidPeso molecular:332.36CID-797718
CAS:<p>CID-797718 is a protein kinase D1 (PKD1) inhibitor.</p>Fórmula:C12H11NO3Pureza:98.91% - 99.21%Forma y color:SolidPeso molecular:217.22Voruciclib
CAS:<p>Voruciclib: oral, selective CDK inhibitor (Ki: 0.626-9.1 nM), reduces MCL-1, targets CDK9 in diffuse large B-cell lymphoma.</p>Fórmula:C22H19ClF3NO5Pureza:99.89%Forma y color:SolidPeso molecular:469.84EOAI3402143
CAS:<p>EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis.</p>Fórmula:C25H28Cl2N4O3Pureza:99.6%Forma y color:SolidPeso molecular:503.42R-IMPP
CAS:<p>R-IMPP is an inhibitor of PCSK9 translation.</p>Fórmula:C24H27N3O2Pureza:99.47% - 99.85%Forma y color:SolidPeso molecular:389.49Madrasin
CAS:<p>Madrasin (DDD00107587) is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly.</p>Fórmula:C16H17N5O2Pureza:99.06% - 99.61%Forma y color:SolidPeso molecular:311.34Triazavirin
CAS:<p>Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent.</p>Fórmula:C5H7N6NaO5SPureza:99.55%Forma y color:SolidPeso molecular:286.2Trimethoprim sulfate
CAS:<p>Trimethoprim sulfate, a dihydrofolate reductase inhibitor, treats bacterial infections and sometimes malaria; may depress hematopoiesis.</p>Fórmula:C28H38N8O10SForma y color:SolidPeso molecular:678.72Dimethylenastron
CAS:<p>Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.</p>Fórmula:C16H18N2O2SPureza:98.07%Forma y color:SolidPeso molecular:302.39SCH900776 (S-isomer)
CAS:<p>SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).</p>Fórmula:C15H18BrN7Pureza:99.88%Forma y color:SolidPeso molecular:376.25THZ531
CAS:<p>THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM).</p>Fórmula:C30H32ClN7O2Pureza:97.17% - 99.86%Forma y color:SolidPeso molecular:558.07Pyrintegrin
CAS:<p>Pyrintegrin: β1-integrin agonist, boosts embryonic stem cell survival, and podocyte protection, improves cell-matrix adhesion.</p>Fórmula:C23H25N5O3SPureza:99.19%Forma y color:SolidPeso molecular:451.54GSK-923295
CAS:<p>GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM).</p>Fórmula:C32H38ClN5O4Pureza:96.22% - 98.02%Forma y color:SolidPeso molecular:592.13Senexin B
CAS:<p>Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM).</p>Fórmula:C27H26N6OPureza:99.67%Forma y color:SolidPeso molecular:450.53VX-11e
CAS:VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.Fórmula:C24H20Cl2FN5O2Pureza:98.92% - ≥98%Forma y color:SolidPeso molecular:500.35BS-181 hydrochloride
CAS:<p>BS-181 hydrochloride (BS-181 HCl) is a highly selective CDK7 inhibitor with IC50 of 21 nM.</p>Fórmula:C22H32N6·HClPureza:99.21%Forma y color:SolidPeso molecular:416.99Lurbinectedin
CAS:<p>Lurbinectedin (PM01183) is a DNA minor groove covalent binder. Lurbinectedin also shows effective anti-tumor activity.</p>Fórmula:C41H44N4O10SPureza:98.11%Forma y color:SolidPeso molecular:784.87dGTP
CAS:<p>dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, and</p>Fórmula:C10H16N5O13P3Pureza:99.64%Forma y color:SolidPeso molecular:507.18RK33
CAS:<p>"RK33 is a DDX3 inhibitor causing G1 arrest, apoptosis, and radiation sensitization in DDX3-overexpressing cells."</p>Fórmula:C23H20N6O3Pureza:99.04% - 99.72%Forma y color:SolidPeso molecular:428.44T-5224
CAS:<p>T-5224 is a transcription factor c-Fos/AP-1 inhibitor, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription</p>Fórmula:C29H27NO8Pureza:97.88% - 99.29%Forma y color:SolidPeso molecular:517.53Pyridostatin TFA
CAS:<p>Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-</p>Fórmula:C37H35F9N8O11Pureza:97.09% - 99.84%Forma y color:SolidPeso molecular:938.71Rg3039
CAS:Rg3039 (PF-06687859) is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy (SMA). RG3039 improves motor function in SMA mice.Fórmula:C21H23Cl2N5OPureza:98.24% - 99.58%Forma y color:SolidPeso molecular:432.35Triciribine
CAS:Triciribine (NSC-154020) is a DNA synthesis inhibitor, and it also inhibits Akt and HIV-1/2.Fórmula:C13H16N6O4Pureza:99.01% - 99.87%Forma y color:SolidPeso molecular:320.3GSK180736A
CAS:<p>GSK180736A: GRK2 inhibitor (IC50 0.77µM), >100x selectivity vs GRKs, weak at PKA (IC50 30µM), strong vs ROCK1 (IC50 100nM).</p>Fórmula:C19H16FN5O2Pureza:98.38% - 98.98%Forma y color:SolidPeso molecular:365.36CX-5461 dihydrochloride
<p>CX-5461 dihydrochloride: Oral Pol I inhibitor, HCT-116 (IC50: 142 nM), A375 (IC50: 113 nM), MIA PaCa-2 (IC50: 54 nM), weak on Pol II (IC50 ≥ 25 μM).</p>Fórmula:C27H29Cl2N7O2SForma y color:SolidPeso molecular:586.54N2-Methylguanosine
CAS:<p>N2-methylguanosine is a modified nucleoside of tRNA that occurs at several specific locations in many tRNA's</p>Fórmula:C11H15N5O5Pureza:97.77%Forma y color:SolidPeso molecular:297.27K858 (Racemic)
CAS:<p>K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.</p>Fórmula:C13H15N3O2SPureza:>99.99%Forma y color:SolidPeso molecular:277.34KIRA6
CAS:<p>KIRA6 is an effective inhibitor of IRE1α RNase kinase (IC50: 0.6 μM). It can trigger an apoptotic response.</p>Fórmula:C28H25F3N6OPureza:97.91%Forma y color:SolidPeso molecular:518.53Levofloxacin hydrochloride
CAS:<p>Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.</p>Fórmula:C18H21ClFN3O4Pureza:99.78% - 99.98%Forma y color:SolidPeso molecular:397.85-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE
CAS:<p>5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE targets PLK1.</p>Fórmula:C8H13N3SPureza:99.03%Forma y color:SolidPeso molecular:183.27Folinic acid calcium hydrate
CAS:<p>Folinic acid (Leucovorin) calcium hydrate is a biofolic acid often used as a rescue agent with methotrexate (MTX) to reduce MTX-induced toxicity.</p>Fórmula:C20H23CaN7O8Forma y color:SolidPeso molecular:529.523PRT4165
CAS:<p>PRT4165 (NSC600157) is a potent PRC1-mediated H2A ubiquitylation inhibitor.</p>Fórmula:C15H9NO2Pureza:98.91% - 99.6%Forma y color:SolidPeso molecular:235.24TAK-960 dihydrochloride
<p>TAK-960 dihydrochloride: oral PLK1 inhibitor, IC50 0.8 nM; also Hinders PLK2 and PLK3 (IC50s 16.9/50.2 nM); curbs cancer cell growth.</p>Fórmula:C27H36Cl2F3N7O3Forma y color:SolidPeso molecular:634.52BUR1
CAS:<p>BUR1 is a Saccharomyces cerevisiae cyclin-dependent kinase (CDK) and is homologous to mammalian Cdk9, which functions in transcriptional elongation.</p>Fórmula:C16H17N5Pureza:90%Forma y color:SolidPeso molecular:279.342,2'-Anhydrouridine
CAS:<p>2,2'-Anhydrouridine (2,2'-Cyclouridine) is a research tool for antiviral and anticancer studies.</p>Fórmula:C9H10N2O5Pureza:98.45%Forma y color:SolidPeso molecular:226.19Leukadherin-1
CAS:<p>Leukadherin-1 boosts CD11b/CD18 adhesion, lowers leukocyte movement, cuts inflammation.</p>Fórmula:C22H15NO4S2Pureza:98.49% - 98.93%Forma y color:SolidPeso molecular:421.49RAD51-IN-1
CAS:<p>Rad51-in-1 is a derivative of B02 and an effective inhibitor of Rad51.</p>Fórmula:C22H16ClN3OPureza:99.95%Forma y color:SolidPeso molecular:373.83Gadodiamide
CAS:<p>Gadodiamide is an MRI contrast agent, used in MR imaging procedures to assist in the visualization of blood vessels.</p>Fórmula:C16H26GdN5O8Pureza:99.86%Forma y color:SolidPeso molecular:573.66
![5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT8912.webp&w=3840&q=75)
