Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(95 productos)
- CDK(501 productos)
- Detención del ciclo celular(4 productos)
- Chk(42 productos)
- DYRK(48 productos)
- Dynamin(23 productos)
- Ferroptosis(215 productos)
- HSP(169 productos)
- Integrin(224 productos)
- Kinesina(66 productos)
- LIM quinasa(19 productos)
- Asociado a microtúbulos(262 productos)
- PKC(102 productos)
- PLK(28 productos)
- ROCK(69 productos)
- Rho(2 productos)
- Wee1(15 productos)
- c-Myc(69 productos)
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Se han encontrado 3485 productos de "Ciclo celular / Checkpoint"
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CBFβ Inhibitor
CAS:<p>CBFβ Inhibitor (5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine) is a cell-permeable CBFβ inhibitor and inhibits its association with Runx1.</p>Fórmula:C12H14N2OSPureza:96.50%Forma y color:SolidPeso molecular:234.32NITD-2
CAS:<p>NITD-2 is a DENV RdRp inhibitor with poor cell membrane penetration; no vaccine or antiviral for DENV exists.</p>Fórmula:C23H19N3O4SPureza:98.03% - 99.46%Forma y color:SolidPeso molecular:433.48Abemaciclib methanesulfonate
CAS:<p>Abemaciclib methanesulfonate (LY2835219) is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM).</p>Fórmula:C27H32F2N8·CH4O3SPureza:98.69% - 99.44%Forma y color:SolidPeso molecular:602.7Sovilnesib
CAS:<p>Sovilnesib is a kinesin-like protein KIF18A inhibitor. Sovilnesib can be used for the cancer research.</p>Fórmula:C26H34F2N6O4SPureza:99.57%Forma y color:SolidPeso molecular:564.65GJ103 sodium salt
CAS:<p>GJ103 sodium salt, a GJ072 analog, lowers surface tension, viscosity, and pH in aqueous solutions, aiding molecular movement.</p>Fórmula:C16H13N4NaO3SPureza:99.70% - 99.91%Forma y color:SolidPeso molecular:364.36Monastrol
CAS:<p>Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.</p>Fórmula:C14H16N2O3SPureza:98.02% - 98.59%Forma y color:SolidPeso molecular:292.35AUZ 454
CAS:<p>AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd of 50/18.6/15.4/9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.</p>Fórmula:C24H26F3N7O2Pureza:99.59%Forma y color:SolidPeso molecular:501.5CX-5461
CAS:<p>CX5461 is an orally rRNA synthesis inhibitor that inhibits Pol I-driven rRNA transcription. CX5461 has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C27H27N7O2SPureza:95.44% - 99.25%Forma y color:SolidPeso molecular:513.61NSC23005 Sodium
CAS:<p>NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.</p>Fórmula:C13H16NNaO4SPureza:99.64%Forma y color:SolidPeso molecular:305.32Spermine tetrahydrochloride
CAS:<p>Spermine tetrahydrochloride, a polyamine in all eukaryotic cells, protects DNA from free radicals.</p>Fórmula:C10H26N4·4HClPureza:99.75% - 99.82%Forma y color:SolidPeso molecular:348.18BVDV-IN-1
CAS:<p>BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM.</p>Fórmula:C20H22N4OPureza:98.43%Forma y color:SolidPeso molecular:334.41PND-1186
CAS:<p>PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).</p>Fórmula:C25H26F3N5O3Pureza:99.14% - 99.75%Forma y color:SolidPeso molecular:501.5OSU-T315
CAS:<p>OSU-T315 (OSU-T315 (1,5-regioisomer)) (1,5-regioisomer) is a ILK inhibitor.</p>Fórmula:C30H30F3N5OPureza:98.69%Forma y color:SolidPeso molecular:533.59HMN-176
CAS:<p>HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).</p>Fórmula:C20H18N2O4SPureza:98.92% - 98.99%Forma y color:SolidPeso molecular:382.43PTC-209
CAS:<p>PTC-209 is a potent and selective BMI-1 inhibitor.</p>Fórmula:C17H13Br2N5OSPureza:99.43% - 99.887%Forma y color:SolidPeso molecular:495.199-Ethylguanine
CAS:<p>9-Ethylguanine is a model nucleobase commonly used in the studies of DNA interactions with organometallic complexes.</p>Fórmula:C7H9N5OPureza:98.6%Forma y color:SolidPeso molecular:179.18BCH001
CAS:<p>BCH001 is a specific small-molecule inhibitor of PAPD5.</p>Fórmula:C20H15F3N2O5Pureza:99.06%Forma y color:SolidPeso molecular:420.34PHA-680632
CAS:<p>PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively.</p>Fórmula:C28H35N7O2Pureza:98.2%Forma y color:SolidPeso molecular:501.62KB-0742 dihydrochloride
CAS:<p>KB-0742 dihydrochloride is a potent, selective and orally inhibitor of CDK9.</p>Fórmula:C16H27Cl2N5Pureza:99.79%Forma y color:SolidPeso molecular:360.33Purvalanol B
CAS:<p>Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively)</p>Fórmula:C20H25ClN6O3Pureza:98.95%Forma y color:SolidPeso molecular:432.9Pipobroman
CAS:<p>Pipobroman (Vercyte) is an alkylating anti-cancer drug effective in PV and ET with low toxicity and thrombosis risk.</p>Fórmula:C10H16Br2N2O2Pureza:97.08%Forma y color:SolidPeso molecular:356.052-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi
CAS:2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine serves as an intermediate.Fórmula:C6H6N4OPureza:99.21% - 99.42%Forma y color:SolidPeso molecular:150.14HALOFUGINONE LACTATE
CAS:<p>HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D.</p>Fórmula:C19H23BrClN3O6Pureza:99.70% - 99.96%Forma y color:SolidPeso molecular:504.8Myoseverin
CAS:<p>Myoseverin triggers myotube fission into single cells, influencing genes for growth, immunity, matrix remodeling, and stress, aiding healing and regeneration.</p>Fórmula:C24H28N6O2Pureza:99.25%Forma y color:SolidPeso molecular:432.52WEE1-IN-3
CAS:<p>WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.</p>Fórmula:C28H31N7O2Pureza:98.33%Forma y color:SolidPeso molecular:497.59Antitumor agent-152
CAS:<p>Organic compound, potential dCK inhibitor, with 2-ethyl-3-methoxyphenyl-1,3-thiazole and pyrimidine units.</p>Fórmula:C17H19N5O2S2Pureza:95.00%Forma y color:SolidPeso molecular:389.5TH588
CAS:<p>TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells.</p>Fórmula:C13H12Cl2N4Pureza:96.05% - 99.82%Forma y color:SolidPeso molecular:295.17ARQ 621
CAS:<p>ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.</p>Fórmula:C28H24Cl2FN5O2Pureza:97.01% - 98.38%Forma y color:SolidPeso molecular:552.43Bredinin aglycone
CAS:<p>Bredinin aglycone (SM-108) is a purine nucleotide analog.</p>Fórmula:C4H5N3O2Pureza:99.06%Forma y color:SolidPeso molecular:127.1Palbociclib monohydrochloride
CAS:<p>Palbociclib monohydrochloride (PD 0332991 hydrochloride) is a selective inhibitor of CDK4/6, with no inhibition against a panel of 36 additional protein kinases</p>Fórmula:C24H29N7O2·HClPureza:99.73% - >99.99%Forma y color:SolidPeso molecular:483.99Nolatrexed
CAS:<p>Nolatrexed is a thymidylate synthase inhibitor with potential anticancer activity.</p>Fórmula:C14H12N4OSPureza:97.53%Forma y color:SolidPeso molecular:284.34Rac1 Inhibitor W56 acetate(1095179-01-3 free base)
<p>Rac1 Inhibitor W56 acetate(1095179-01-3 free base) is a peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activation</p>Fórmula:C76H121N19O25SPureza:98.96%Forma y color:SolidPeso molecular:1732.95TC-E 5003
CAS:<p>TC-E 5003 (NSC-30176) is a selective inhibitor of PRMT1 with IC50 of 1.5 μM.</p>Fórmula:C16H14Cl2N2O4SPureza:97.01%Forma y color:SolidPeso molecular:401.26MK-8745
CAS:<p>MK-8745 is a potent and selective Aurora A inhibitor.</p>Fórmula:C20H19ClFN5OSPureza:99.09% - 99.79%Forma y color:SolidPeso molecular:431.91C/EBPα inducer 1
CAS:<p>C/EBPα inducer 1 (4(3H)-Quinazolinone, 6-fluoro-2-[(1E)-2-(5-nitro-2-furanyl)ethenyl]-3-phenyl-) is a potential inducer of myeloid differentiation via</p>Fórmula:C20H12FN3O4Pureza:98.99%Forma y color:SolidPeso molecular:377.33PTC-209 hydrobromide
CAS:<p>PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in</p>Fórmula:C17H13Br2N5OS·HBrPureza:99.91%Forma y color:SolidPeso molecular:576.1CVT-313
CAS:<p>CVT-313 (NG-26) is a potent, selective, reversible, and ATP-competitive inhibitor.</p>Fórmula:C20H28N6O3Pureza:97.46% - 97.97%Forma y color:SolidPeso molecular:400.47YKL-5-124
CAS:<p>YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displays</p>Fórmula:C28H33N7O3Pureza:99.36%Forma y color:SolidPeso molecular:515.61GW779439X
CAS:<p>GW779439X is an inhibitor of CDK.</p>Fórmula:C22H21F3N8Pureza:97.87%Forma y color:SolidPeso molecular:454.45VPC-80051 racemate
CAS:<p>VPC-80051 is the first small molecule inhibitor of hnRNP A1 splicing activity by using a computer-aided drug discovery approach.</p>Fórmula:C16H13F2N3OPureza:97.36%Forma y color:SolidPeso molecular:301.29LP-935509
CAS:<p>LP-935509 is a selective, brain-permeable, small molecule competitive inhibitor of articulin-2-associated kinase 1 (AAK1).Cost-effective and quality-assured.</p>Fórmula:C20H24N6O3Pureza:98.78% - 99.64%Forma y color:SolidPeso molecular:396.44CB-6644
CAS:<p>CB-6644 is a small molecule inhibitor of the ATPase activity of the RUVBL1/2 complex.Cost-effective and quality-assured.</p>Fórmula:C29H34ClFN4O5Pureza:96.33% - 99.85%Forma y color:SolidPeso molecular:573.062-Chloropyrazine
CAS:<p>2-Chloropyrazine is used in chemical industry.</p>Fórmula:C4H3ClN2Pureza:98.98% - 99.89%Forma y color:Clear Colorless To Yellowish LiquidPeso molecular:114.53Raltitrexed
CAS:<p>Raltitrexed (D1694)(IC50 of 9 nM), a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth.</p>Fórmula:C21H22N4O6SPureza:98.99% - 99.29%Forma y color:Yellow Crystalline PowderPeso molecular:458.49AMG 900
CAS:<p>AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.</p>Fórmula:C28H21N7OSPureza:98.4% - 99.51%Forma y color:SolidPeso molecular:503.58MKC3946
CAS:<p>MKC3946 is an effective and soluble IRE1α inhibitor which triggered modest growth inhibition in multiple myeloma cell lines.</p>Fórmula:C21H20N2O3SPureza:99.65%Forma y color:SolidPeso molecular:380.462′-O-Methylcytidine
CAS:<p>2′-O-Methylcytidine inhibits NS5B-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate.</p>Fórmula:C10H15N3O5Pureza:99.72%Forma y color:SolidPeso molecular:257.24Palbociclib Isethionate
CAS:<p>Palbociclib Isethionate (PD 0332991 isethionate) 是一种高选择性的CDK4/6抑制剂，IC50为11 nM 和16 nM。它对一组 36 种额外的蛋白激酶没有抑制作用。</p>Fórmula:C24H29N7O2·C2H6O4SPureza:99.01% - 99.27%Forma y color:SolidPeso molecular:573.66Arginine-glycine-aspartic acid
CAS:<p>RGD (RGD (Arg-Gly-Asp) Peptides) (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.</p>Fórmula:C12H22N6O6Pureza:99.11%Forma y color:SolidPeso molecular:346.34Eptifibatide acetate (148031-34-9 free base)
CAS:<p>Eptifibatide acetate (148031-34-9), a cyclic heptapeptide GP IIb/IIIa inhibitor antiplatelet drug.</p>Fórmula:C35H49N11O9S2·xC2H4O2Pureza:99.7% - 99.87%Forma y color:SolidPeso molecular:831.96 (free base)
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