Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(116 productos)
- CDK(547 productos)
- Detención del ciclo celular(5 productos)
- Chk(48 productos)
- DYRK(46 productos)
- Dynamin(27 productos)
- Ferroptosis(233 productos)
- HSP(180 productos)
- Integrin(276 productos)
- Kinesina(87 productos)
- LIM quinasa(21 productos)
- Asociado a microtúbulos(273 productos)
- PKC(128 productos)
- PLK(25 productos)
- ROCK(61 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(77 productos)
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Se han encontrado 3935 productos de "Ciclo celular / Checkpoint"
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TC-E 5003
CAS:TC-E 5003 (NSC-30176) is a selective inhibitor of PRMT1 with IC50 of 1.5 μM.Fórmula:C16H14Cl2N2O4SPureza:97.01%Forma y color:SolidPeso molecular:401.26SL327
CAS:SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.Fórmula:C16H12F3N3SPureza:97.98% - >99.99%Forma y color:SolidPeso molecular:335.35CAN508
CAS:CAN508: potent CDK9/T1 inhibitor; IC50 0.35 μM, Cdk2/E; Ki 13.3 μM, IC50 20 μM; 38x selective; antitumor.Fórmula:C9H10N6OPureza:98.65%Forma y color:SolidPeso molecular:218.226-Thio-2'-Deoxyguanosine
CAS:6-Thio-2'-Deoxyguanosine (β-TGdR) is a nucleoside analog and telomerase substrate.Fórmula:C10H13N5O3SPureza:97.52%Forma y color:SolidPeso molecular:283.31BTYNB
CAS:BTYNB (MDK6620) is an inhibitor of the oncofetal mRNA-binding protein IMP1. MDK6620 downregulates β-TrCP1 mRNA and reduces activation of NF-κB.Fórmula:C12H9BrN2OSPureza:≥95%Forma y color:SolidPeso molecular:309.18IMP-1088
CAS:IMP-1088 is a potent inhibitor of human N-myristoyltransferases NMT1 and NMT2 dual.Fórmula:C25H29F2N5OPureza:98.48% - 99.52%Forma y color:SolidPeso molecular:453.53Ref: TM-T9350
1mg137,00€2mg178,00€5mg268,00€1mL*10mM (DMSO)294,00€10mg444,00€25mg790,00€50mg1.063,00€TAK-632
CAS:TAK-632 is a potent pan-Raf inhibitor.Fórmula:C27H18F4N4O3SPureza:98% - 99.5%Forma y color:SolidPeso molecular:554.52Antitumor agent-152
CAS:Organic compound, potential dCK inhibitor, with 2-ethyl-3-methoxyphenyl-1,3-thiazole and pyrimidine units.Fórmula:C17H19N5O2S2Pureza:95.00%Forma y color:SolidPeso molecular:389.5Ref: TM-T50079
1mg85,00€5mg170,00€1mL*10mM (DMSO)185,00€10mg253,00€25mg414,00€50mg583,00€100mg783,00€200mg1.054,00€CRT0066854
CAS:CRT-0066854 is a PKCι and PKCζ inhibitor. CRT0066854 was able to restore polarized morphogenesis in the dysplastic H-Ras spheroids.Fórmula:C24H25N5SForma y color:SolidPeso molecular:415.55XL228
CAS:XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Fórmula:C22H31N9OPureza:99.07%Forma y color:SolidPeso molecular:437.54Ref: TM-T17267
1mg52,00€2mg73,00€5mg94,00€1mL*10mM (DMSO)104,00€10mg141,00€25mg244,00€50mg371,00€100mg552,00€Irigenin
CAS:Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the ExtraFórmula:C18H16O8Pureza:99.50% - 99.85%Forma y color:SolidPeso molecular:360.31Myoseverin
CAS:Myoseverin triggers myotube fission into single cells, influencing genes for growth, immunity, matrix remodeling, and stress, aiding healing and regeneration.
Fórmula:C24H28N6O2Pureza:99.25%Forma y color:SolidPeso molecular:432.52Palbociclib
CAS:Palbociclib is an oral CDK4/6 inhibitor, halts Rb phosphorylation, arrests cell cycle, and curbs tumor growth.Fórmula:C24H29N7O2Pureza:98% - 99.9%Forma y color:SolidPeso molecular:447.53A-674563 2HCl(552325-73-2(fb-2hcl))
A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.Fórmula:C22H24Cl2N4OPureza:94.66%Forma y color:SolidPeso molecular:431.36Ref: TM-T6139L
1mg81,00€5mg131,00€1mL*10mM (DMSO)161,00€10mg178,00€25mg318,00€50mg479,00€100mg692,00€2-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi
CAS:2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine serves as an intermediate.Fórmula:C6H6N4OPureza:99.21% - 99.42%Forma y color:SolidPeso molecular:150.14GSK-25
CAS:GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K, and a dramatically improved P450 profile.Fórmula:C24H16Cl2F2N6OPureza:98.59%Forma y color:SolidPeso molecular:513.33Ref: TM-T4488
1mg44,00€2mg56,00€5mg87,00€1mL*10mM (DMSO)89,00€10mg111,00€25mg168,00€50mg258,00€100mg430,00€Pipobroman
CAS:Pipobroman (Vercyte) is an alkylating anti-cancer drug effective in PV and ET with low toxicity and thrombosis risk.Fórmula:C10H16Br2N2O2Pureza:97.08%Forma y color:SolidPeso molecular:356.05Palmatine
CAS:Palmatine, also known as Burasaine, inhibits dopamine production and may treat flavivirus, jaundice, dysentery, hypertension, and liver issues.Fórmula:C21H22NO4Pureza:96.28% - 99.49%Forma y color:SolidPeso molecular:352.4ML367
CAS:ML367 inhibits ATAD5 stabilization with low micromolar activity, serving as a probe molecule.Fórmula:C19H12F2N4Pureza:99.39%Forma y color:SolidPeso molecular:334.32SPHINX
CAS:SPHINX is a new generation inhibitor of SPRK1Fórmula:C17H17F3N2O3Pureza:99.29%Forma y color:SolidPeso molecular:354.329-Ethylguanine
CAS:9-Ethylguanine is a model nucleobase commonly used in the studies of DNA interactions with organometallic complexes.Fórmula:C7H9N5OPureza:98.6%Forma y color:SolidPeso molecular:179.18NU6027
CAS:NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-Fórmula:C11H17N5O2Pureza:98.36%Forma y color:SolidPeso molecular:251.29Spermine tetrahydrochloride
CAS:Spermine tetrahydrochloride, a polyamine in all eukaryotic cells, protects DNA from free radicals.Fórmula:C10H26N4·4HClPureza:99.75% - 99.82%Forma y color:SolidPeso molecular:348.18GJ103 sodium salt
CAS:GJ103 sodium salt, a GJ072 analog, lowers surface tension, viscosity, and pH in aqueous solutions, aiding molecular movement.Fórmula:C16H13N4NaO3SPureza:99.70% - 99.91%Forma y color:SolidPeso molecular:364.36Sovilnesib
CAS:Sovilnesib is a kinesin-like protein KIF18A inhibitor. Sovilnesib can be used for the cancer research.Fórmula:C26H34F2N6O4SPureza:99.57%Forma y color:SolidPeso molecular:564.65Ref: TM-T39994
1mg96,00€5mg235,00€1mL*10mM (DMSO)259,00€10mg376,00€25mg630,00€50mg898,00€100mg1.216,00€Gadodiamide
CAS:Gadodiamide is an MRI contrast agent, used in MR imaging procedures to assist in the visualization of blood vessels.Fórmula:C16H26GdN5O8Pureza:99.86% - 99.93%Forma y color:SolidPeso molecular:573.66M2I-1
CAS:M2I-1 inhibits Mad2 binding to Cdc20, disrupting SAC-related PPI and Mad2 dynamics, blocks Mad2-F-Mbp1 in FP assays.Fórmula:C19H24N4O4SPureza:99.02% - >99.99%Forma y color:SolidPeso molecular:404.482,2'-Anhydrouridine
CAS:2,2'-Anhydrouridine (2,2'-Cyclouridine) is a research tool for antiviral and anticancer studies.Fórmula:C9H10N2O5Pureza:98.45%Forma y color:SolidPeso molecular:226.19Poloxin
CAS:Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).Fórmula:C18H19NO3Pureza:99.19%Forma y color:SolidPeso molecular:297.35PRT4165
CAS:PRT4165 (NSC600157) is a potent PRC1-mediated H2A ubiquitylation inhibitor.Fórmula:C15H9NO2Pureza:98.91% - 99.6%Forma y color:SolidPeso molecular:235.24Ref: TM-T3110
5mg43,00€10mg49,00€1mL*10mM (DMSO)50,00€25mg88,00€50mg112,00€100mg182,00€200mg254,00€500mg427,00€KIRA6
CAS:KIRA6 is an effective inhibitor of IRE1α RNase kinase (IC50: 0.6 μM). It can trigger an apoptotic response.
Fórmula:C28H25F3N6OPureza:97.91%Forma y color:SolidPeso molecular:518.53Cdk5 Substrate acetate
Cdk5, a serine/threonine kinase active in neurons, phosphorylates proteins like histone H1; its synthetic substrate has a Km of 5 µM.Fórmula:C55H103N15O14Pureza:96.21%Forma y color:SolidPeso molecular:1198.5N2-Methylguanosine
CAS:N2-methylguanosine is a modified nucleoside of tRNA that occurs at several specific locations in many tRNA's
Fórmula:C11H15N5O5Pureza:97.77%Forma y color:SolidPeso molecular:297.27Preq1-Dihydrochloride
CAS:Preq1-Dihydrochloride, a queuosine pathway intermediate, binds strongly to PreQ1 riboswitch aptamer, suppressing protein expression.Fórmula:C7H11Cl2N5OPureza:99.46%Forma y color:SolidPeso molecular:252.1Triciribine
CAS:Triciribine (NSC-154020) is a DNA synthesis inhibitor, and it also inhibits Akt and HIV-1/2.Fórmula:C13H16N6O4Pureza:99.01% - 99.87%Forma y color:SolidPeso molecular:320.3Ref: TM-T6065
1mg38,00€2mg49,00€5mg80,00€1mL*10mM (DMSO)88,00€10mg116,00€25mg207,00€50mg329,00€100mg512,00€200mg727,00€Rg3039
CAS:Rg3039 (PF-06687859) is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy (SMA). RG3039 improves motor function in SMA mice.Fórmula:C21H23Cl2N5OPureza:98.24% - 99.58%Forma y color:SolidPeso molecular:432.35PF 477736
CAS:PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Fórmula:C22H25N7O2Pureza:97.58% - 99.94%Forma y color:SolidPeso molecular:419.481,7-Diaminoheptane
CAS:1,7-Diaminoheptane, an aliphatic amine, is used in peptide synthesis and as a substrate, ligand, or reagent.Fórmula:C7H18N2Pureza:99.97%Forma y color:White To Light Yellow Crystalline ChunksPeso molecular:130.23BS194
CAS:BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.Fórmula:C20H27N5O3Pureza:99.85%Forma y color:SolidPeso molecular:385.46Fasudil dihydrochloride
CAS:Fasudil dihydrochloride inhibits ROCK1/2, PKA, PKC, PKG, and acts as a Ca²⁺ channel blocker and vasodilator, supporting vascular, cardiovascular, and signaling research.Fórmula:C14H19Cl2N3O2SPureza:99.86%Forma y color:SolidPeso molecular:364.29A-286982
CAS:A 286982 blocks the LFA-1 and ICAM-1 integrin-ligand interaction.Fórmula:C24H27N3O4SPureza:97.81%Forma y color:SolidPeso molecular:453.55Ref: TM-T21781
1mg34,00€2mg48,00€5mg71,00€1mL*10mM (DMSO)77,00€10mg102,00€25mg200,00€50mg333,00€100mg495,00€VX-11e
CAS:VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.Fórmula:C24H20Cl2FN5O2Pureza:98.92% - ≥98%Forma y color:SolidPeso molecular:500.35Didox
CAS:Didox (NSC-324360), a synthetic RR inhibitor, lowers oxidative injury markers in HIV-related dementia.Fórmula:C7H7NO4Pureza:99.83%Forma y color:SolidPeso molecular:169.13CWHM-12
CAS:CWHM-12 is a potent inhibitor of αV integrins (IC50s of 0.2/0.8/1.5/1.8 nM for αvβ8/αvβ3/αvβ6/αvβ1).Fórmula:C26H32BrN5O6Pureza:98.05% - 99.83%Forma y color:SolidPeso molecular:590.47Ref: TM-TQ0250
1mg40,00€2mg52,00€5mg88,00€1mL*10mM (DMSO)96,00€10mg126,00€25mg221,00€50mg369,00€100mg550,00€T56-LIMKi
CAS:T56-LIMKi (T5601640) is a selective inhibitor of LIMK2.Fórmula:C19H14F3N3O3Pureza:98.39% - 99.57%Forma y color:SolidPeso molecular:389.33Tirofiban hydrochloride monohydrate
CAS:Tirofiban（MK383） hydrochloride monohydrate is a non-peptide glycoprotein IIb/IIIa antagonist. Cost-effective and quality-assured.Fórmula:C22H39ClN2O6SPureza:98.81% - >99.99%Forma y color:White SolidPeso molecular:495.07GSK-923295
CAS:GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM).Fórmula:C32H38ClN5O4Pureza:96.22% - 98.02%Forma y color:SolidPeso molecular:592.13Ref: TM-T2039
1mg49,00€5mg97,00€1mL*10mM (DMSO)136,00€10mg168,00€25mg283,00€50mg432,00€100mg605,00€200mg852,00€ON-013100
CAS:ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.Fórmula:C19H22O7SPureza:98.27%Forma y color:SolidPeso molecular:394.44Ref: TM-T16391
1mg48,00€1mL*10mM (DMSO)60,00€5mg71,00€10mg100,00€25mg172,00€50mg268,00€100mg404,00€200mg570,00€Voruciclib
CAS:Voruciclib: oral, selective CDK inhibitor (Ki: 0.626-9.1 nM), reduces MCL-1, targets CDK9 in diffuse large B-cell lymphoma.Fórmula:C22H19ClF3NO5Pureza:99.89% - 99.99%Forma y color:SolidPeso molecular:469.84Hu7691
CAS:Hu7691 is an Akt inhibitor that inhibits Akt1, Akt2, and Akt3, suppresses neuroblastoma cell proliferation, and induces differentiation of neuroblastoma cells.Fórmula:C22H22ClF3N4OPureza:99.81%Forma y color:SolidPeso molecular:450.88
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