Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(95 productos)
- CDK(501 productos)
- Detención del ciclo celular(4 productos)
- Chk(42 productos)
- DYRK(48 productos)
- Dynamin(23 productos)
- Ferroptosis(215 productos)
- HSP(169 productos)
- Integrin(224 productos)
- Kinesina(66 productos)
- LIM quinasa(19 productos)
- Asociado a microtúbulos(262 productos)
- PKC(102 productos)
- PLK(28 productos)
- ROCK(69 productos)
- Rho(2 productos)
- Wee1(15 productos)
- c-Myc(69 productos)
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Se han encontrado 3485 productos de "Ciclo celular / Checkpoint"
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roxifiban
CAS:<p>Roxifiban, a prodrug of XV459, is an antiplatelet agent with high affinity and specificity for platelet glycoprotein IIb/IIIa complex(GPIIb/IIIa) receptors.</p>Fórmula:C21H29N5O6Pureza:98%Forma y color:SolidPeso molecular:447.48BMS-265246
CAS:<p>BMS-265246 is a potent and selective CDK1/2 inhibitor.</p>Fórmula:C18H17F2N3O2Pureza:99.25% - 99.57%Forma y color:SolidPeso molecular:345.34ML264
CAS:<p>ML264 (CID-51003603) is a selective kruppel-like factor 5 (KLF5) inhibitor, which potently Inhibits growth of Colorectal Cancer.</p>Fórmula:C17H21ClN2O4SPureza:99.33% - 99.45%Forma y color:SolidPeso molecular:384.88Besifloxacin Hydrochloride
CAS:<p>Besifloxacin Hydrochloride (BOL-303224-A) is a fourth-generation fluoroquinolone antibiotic.</p>Fórmula:C19H21ClFN3O3·HClPureza:99.20%Forma y color:Pale Yellow SolidPeso molecular:430.3Verosudil hydrochloride
CAS:<p>Verosudil (AR-12286) is a selective Rho kinase inhibitor, reducing IOP in XFS & OHT/XFG, offering a new treatment option.</p>Fórmula:C17H18ClN3O2SForma y color:SolidPeso molecular:363.86CCT241736
CAS:<p>CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3</p>Fórmula:C22H23Cl2N7Pureza:96.2% - 99.81%Forma y color:SolidPeso molecular:456.37H-Gly-Arg-Gly-Asp-Asn-Pro-OH
CAS:<p>RGD peptide (GRGDNP) (RGD peptide GRGDNP(2TFA)) is a integrin-ligand interactions inhibitor.</p>Fórmula:C23H38N10O10Pureza:>99.99%Forma y color:SolidPeso molecular:614.61NY2267
CAS:<p>NY2267 (Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethyl</p>Fórmula:C38H43N3O6Pureza:99.16% - 99.27%Forma y color:SolidPeso molecular:637.7610058-F4
CAS:<p>10058-F4 inhibits c-Myc-Max, blocking c-Myc target gene activation, causing cell-cycle arrest & apoptosis.</p>Fórmula:C12H11NOS2Pureza:98% - 99.87%Forma y color:SolidPeso molecular:249.35Alisertib
CAS:<p>Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.</p>Fórmula:C27H20ClFN4O4Pureza:98.31% - >99.99%Forma y color:SolidPeso molecular:518.92CRT0066854
CAS:<p>CRT-0066854 is a PKCι and PKCζ inhibitor. CRT0066854 was able to restore polarized morphogenesis in the dysplastic H-Ras spheroids.</p>Fórmula:C24H25N5SForma y color:SolidPeso molecular:415.55Abemaciclib
CAS:<p>Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity.</p>Fórmula:C27H32F2N8Pureza:99.43% - 99.87%Forma y color:SolidPeso molecular:506.59Natalizumab
CAS:<p>Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.</p>Pureza:98.00%Forma y color:LiquidPeso molecular:N/ASilver sulfadiazine
CAS:<p>Silver sulfadiazine (Dermazin) is a sulfonamide-based topical agent with antibacterial and antifungal activity.</p>Fórmula:C10H9AgN4O2SPureza:99.04% - 99.58%Forma y color:SolidPeso molecular:357.14SNS-314
CAS:<p>SNS-314 inhibits Aurora kinases A and B, blocking cell division in AK-overexpressing tumors.</p>Fórmula:C18H15ClN6OS2Pureza:98%Forma y color:SolidPeso molecular:430.93FUBP1-IN-1
CAS:<p>FUBP1-in-1: Potent FUBP1 inhibitor with 11.0 M IC50, disrupts FUBP1-DNA binding.</p>Fórmula:C19H14F3N3O2SPureza:99.7%Forma y color:SolidPeso molecular:405.39XMD8-92
CAS:<p>XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).</p>Fórmula:C26H30N6O3Pureza:98.21%Forma y color:SolidPeso molecular:474.55Ilorasertib
CAS:<p>Ilorasertib (ABT-348) inhibits Aurora kinases A/B/C & RET, PDGFRβ, Flt1 (IC50: 1-120 nM).</p>Fórmula:C25H21FN6O2SPureza:96.17% - 97.49%Forma y color:SolidPeso molecular:488.54BTB-1
CAS:<p>BTB-1 (NSC156750) is a novel small molecule inhibitor of the mitotic motor protein Kif18A.</p>Fórmula:C12H8ClNO4SPureza:99.71%Forma y color:SolidPeso molecular:297.71JNJ-7706621
CAS:<p>JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.</p>Fórmula:C15H12F2N6O3SPureza:99.1% - 99.85%Forma y color:SolidPeso molecular:394.36KW-2449
CAS:<p>KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.</p>Fórmula:C20H20N4OPureza:98.43% - 99.69%Forma y color:SolidPeso molecular:332.4LDN-192960 hydrochloride
CAS:<p>LDN-192960 hydrochloride is an inhibitor of Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) and Haspin with IC50s of 48 nM and 10 nM, respectively.</p>Fórmula:C18H22Cl2N2O2SPureza:98%Forma y color:SolidPeso molecular:401.35Ara-G
CAS:<p>Ara-G, a deoxyguanosine analog, inhibits DNA synthesis, targeting T cell leukemia by converting to araGTP.</p>Fórmula:C10H13N5O5Pureza:98.74%Forma y color:Slightly Off White To White PowderPeso molecular:283.24Camostat mesylate
CAS:<p>Camostat mesylate (FOY-S980) is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.</p>Fórmula:C21H26N4O8SPureza:99.31% - 99.85%Forma y color:Crystalline SolidPeso molecular:494.521,4-Anthraquinone
CAS:<p>1,4-Anthraquinone: anticancer, hinders nucleoside transport, inhibits synthesis, fragments DNA, curbs L1210 cell growth; aids HPLC analysis of NAC, CAP.</p>Fórmula:C14H8O2Pureza:95.96% - 97.01%Forma y color:Orange Brown SolidPeso molecular:208.21Danusertib
CAS:<p>Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.</p>Fórmula:C26H30N6O3Pureza:97.88% - 98.79%Forma y color:White PowderPeso molecular:474.556-Bromo-2-hydroxy-3-methoxybenzaldehyde
CAS:6-Bromo-2-hydroxy-3-methoxybenzaldehyde (NSC-95682) is an inhibitor of IRE-1α (IC50 : 0.08 μM).Fórmula:C8H7BrO3Pureza:99.82%Forma y color:SolidPeso molecular:231.04CCG-100602
CAS:<p>CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 μM).</p>Fórmula:C21H17ClF6N2O2Pureza:99.58%Forma y color:SolidPeso molecular:478.82Didox
CAS:<p>Didox (NSC-324360), a synthetic RR inhibitor, lowers oxidative injury markers in HIV-related dementia.</p>Fórmula:C7H7NO4Pureza:99.83%Forma y color:SolidPeso molecular:169.13T56-LIMKi
CAS:<p>T56-LIMKi (T5601640) is a selective inhibitor of LIMK2.</p>Fórmula:C19H14F3N3O3Pureza:98.39% - 99.57%Forma y color:SolidPeso molecular:389.33Alovudine
CAS:<p>3'-Fluoro-3'-deoxythymidine (3'-Deoxy-3'-fluorothymidine) is a marker of DNA synthesis,which is less susceptible to inflammatory changes than FDG.</p>Fórmula:C10H13FN2O4Pureza:99.41%Forma y color:Less Solid Colourless SolidPeso molecular:244.22Mycro 3
CAS:<p>Mycro 3 is potent and selective for c-Myc in whole cell assays.</p>Fórmula:C24H17ClF2N6O4Pureza:99.51% - 99.61%Forma y color:SolidPeso molecular:526.88Empesertib
CAS:<p>Empesertib (BAY 1161909) is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.</p>Fórmula:C29H26FN5O4SPureza:97.45% - 99.4%Forma y color:SolidPeso molecular:559.61ZCL278
CAS:<p>ZCL278 is a selective Cdc42 GTPase inhibitor.</p>Fórmula:C21H19BrClN5O4S2Pureza:96.29% - 99.72%Forma y color:SolidPeso molecular:584.89BRD32048
CAS:<p>BRD32048 is a top candidate ETV1 perturbagen. BRD32048 inhibits p300-dependent acetylation of ETV1, thereby promoting its degradation.</p>Fórmula:C16H22N6OPureza:99.87%Forma y color:SolidPeso molecular:314.39Vidofludimus
CAS:<p>Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).</p>Fórmula:C20H18FNO4Pureza:98.33% - 99.58%Forma y color:SolidPeso molecular:355.36IXA4
CAS:<p>IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1.</p>Fórmula:C24H28N4O4Pureza:99.8% - 99.85%Forma y color:SolidPeso molecular:436.5TP-353
CAS:<p>TP-353 (EOS-61973) is a CDK7 inhibitor.</p>Fórmula:C35H30FNO3Pureza:99.12%Forma y color:SolidPeso molecular:531.62Adefovir dipivoxil
CAS:<p>Adefovir dipivoxil (GS 0840) is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against</p>Fórmula:C20H32N5O8PPureza:98% - 99.80%Forma y color:It Has Broad-Spectrum Antiviral ActivityPeso molecular:501.47ENMD-2076
CAS:<p>ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.</p>Fórmula:C21H25N7Pureza:97.63% - ≥95%Forma y color:SolidPeso molecular:375.47STF-083010
CAS:<p>STF-083010 is a selective inhibitor of the IRE1α endonuclease.</p>Fórmula:C15H11NO3S2Pureza:98.09% - 99.45%Forma y color:SolidPeso molecular:317.38Tirapazamine
CAS:<p>Tirapazamine (Win59075) triggers apoptosis in hypoxic cells by damaging DNA and enhances effects of radiation and cisplatin.</p>Fórmula:C7H6N4O2Pureza:96.65% - 99.87%Forma y color:Orange-Red Crystalline PowderPeso molecular:178.155-Fluorocytidine
CAS:<p>5-Fluorocytidine with antiviral activity</p>Fórmula:C9H12FN3O5Pureza:99.23%Forma y color:White PowderPeso molecular:261.214μ8C
CAS:<p>4μ8C (IRE1 Inhibitor III)(IC50=76 nM) is an effective and specific IRE1 Rnase inhibitor.</p>Fórmula:C11H8O4Pureza:97.48% - 98.45%Forma y color:SolidPeso molecular:204.18Longdaysin
CAS:<p>Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).</p>Fórmula:C16H16F3N5Pureza:99.97%Forma y color:SolidPeso molecular:335.33BI-1347
CAS:<p>BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model.</p>Fórmula:C22H20N4OPureza:96.7% - 99.63%Forma y color:SolidPeso molecular:356.42COH29
CAS:<p>COH29 is an oral RNR-blocking thiazole that may reduce DNA synthesis and promote apoptosis, with potential cancer-treating properties.</p>Fórmula:C22H16N2O5SPureza:97.04% - 98.92%Forma y color:SolidPeso molecular:420.44GAK inhibitor 49 hydrochloride
<p>Potent GAK inhibitor 49 hydrochloride: ATP-competitive, highly selective, Ki=0.54 nM, IC50=56 nM, binds to RIPK2.</p>Fórmula:C20H23ClN2O5Forma y color:SolidPeso molecular:406.86Fialuridine
CAS:<p>Fialuridine (DRG-0098), a DNA polymerase inhibitor, shows strong anti-HBV effects both in vitro and in vivo.</p>Fórmula:C9H10FIN2O5Pureza:99.71% - 99.88%Forma y color:Less Crystals Colourless CrystalsPeso molecular:372.09Simeprevir sodium
CAS:<p>Simeprevir is a drug for the treatment and cure of hepatitis C.</p>Fórmula:C38H46N5NaO7S2Pureza:98%Forma y color:SolidPeso molecular:771.92
