Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(116 productos)
- CDK(547 productos)
- Detención del ciclo celular(5 productos)
- Chk(48 productos)
- DYRK(46 productos)
- Dynamin(27 productos)
- Ferroptosis(233 productos)
- HSP(180 productos)
- Integrin(276 productos)
- Kinesina(87 productos)
- LIM quinasa(21 productos)
- Asociado a microtúbulos(273 productos)
- PKC(128 productos)
- PLK(25 productos)
- ROCK(61 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(77 productos)
Mostrar 10 subcategorías más
Se han encontrado 3935 productos de "Ciclo celular / Checkpoint"
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COH29
CAS:COH29 is an oral RNR-blocking thiazole that may reduce DNA synthesis and promote apoptosis, with potential cancer-treating properties.Fórmula:C22H16N2O5SPureza:97.04% - 98.92%Forma y color:SolidPeso molecular:420.44Ref: TM-T3157
1mg34,00€2mg49,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg113,00€25mg178,00€50mg334,00€100mg557,00€200mg790,00€Fialuridine
CAS:Fialuridine (DRG-0098), a DNA polymerase inhibitor, shows strong anti-HBV effects both in vitro and in vivo.Fórmula:C9H10FIN2O5Pureza:99.71% - 99.88%Forma y color:Less Crystals Colourless CrystalsPeso molecular:372.09Tipiracil hydrochloride
CAS:Tipiracil hydrochloride (MA-1 hydrochloride) is a thymidine phosphorylase inhibitor (TPI).Fórmula:C9H12Cl2N4O2Pureza:98.13% - ≥95%Forma y color:SolidPeso molecular:279.12CHR-6494 TFA
CAS:CHR-6494 TFA: potent haspin inhibitor (IC50=2 nM), blocks H3T3 phosphorylation, triggers apoptosis in cancer cells. Used for cancer research.Fórmula:C18H17F3N6O2Pureza:99.50%Forma y color:SolidPeso molecular:406.36Ref: TM-T9521
1mg60,00€5mg122,00€1mL*10mM (DMSO)142,00€10mg190,00€25mg318,00€50mg452,00€100mg627,00€200mg845,00€SRI-29329
CAS:SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).Fórmula:C20H26ClN7Pureza:99.18%Forma y color:SolidPeso molecular:399.92THZ2
CAS:THZ2 (CDK7-IN-1), an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC).Fórmula:C31H28ClN7O2Pureza:98.28%Forma y color:SolidPeso molecular:566.05NSC23005
CAS:NSC23005 sodium is a p18INK inhibitor with potently promoted hematopoietic stem cell (HSC) expansion (ED50: 5.21 nM).Fórmula:C13H17NO4SPureza:>99.99%Forma y color:SolidPeso molecular:283.34E7820
CAS:E7820 (ER68203-00) is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells).Fórmula:C17H12N4O2SPureza:98.31% - 99.11%Forma y color:SolidPeso molecular:336.37Ref: TM-T4435
1mg34,00€2mg49,00€5mg65,00€1mL*10mM (DMSO)80,00€10mg84,00€25mg137,00€50mg200,00€100mg321,00€200mg477,00€Lifitegrast
CAS:Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.
Fórmula:C29H24Cl2N2O7SPureza:99.39% - 99.66%Forma y color:SolidPeso molecular:615.48Mitonafide
CAS:Mitonafide (NSC-300288) suppresses the activity of M. tuberculosis NAD+ dependent DNA ligase A. Mitonafide is a DNA intercalating agent.Fórmula:C16H15N3O4Pureza:99.89%Forma y color:SolidPeso molecular:313.31Ref: TM-T25817
1mg34,00€2mg46,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg90,00€25mg178,00€50mg295,00€100mg484,00€200mg690,00€500mg1.035,00€TH287 hydrochloride
CAS:TH287 inhibits MTH1 (IC50: 0.8 nM), causing DNA damage in cancer cells through oxidized dNTP incorporation, leading to cytotoxicity in mouse xenografts.Fórmula:C11H11Cl3N4Pureza:>99.99%Forma y color:SolidPeso molecular:305.59ILK-IN-3
CAS:ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.Fórmula:C10H12N6OPureza:99.69%Forma y color:SolidPeso molecular:232.24CCG-203971
CAS:CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.Fórmula:C23H21ClN2O3Pureza:98.82% - 99.50%Forma y color:SolidPeso molecular:408.88Cyclo(RADfK)
CAS:Cyclo(RADfK) is a selective α(v)β(3) integrin ligand used in neoangiogenesis research, therapy, and diagnostics; it's a control for RGD peptides.Fórmula:C28H43N9O7Pureza:>99.99%Forma y color:SolidPeso molecular:617.7RI-1
CAS:RI-1 (RAD51 inhibitor 1) is a RAD51 inhibitor (IC50: 5-30 μM).Fórmula:C14H11Cl3N2O3Pureza:99.3% - 99.62%Forma y color:SolidPeso molecular:361.61CCG-222740
CAS:CCG-222740 is an inhibitor of Rho/MRTF pathwayFórmula:C23H19ClF2N2O3Pureza:98.76%Forma y color:SolidPeso molecular:444.86Ref: TM-T7764
2mg39,00€5mg62,00€1mL*10mM (DMSO)66,00€10mg94,00€25mg172,00€50mg260,00€100mg371,00€200mg530,00€TMPyP4 tosylate
CAS:TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.Fórmula:C72H66N8O12S4Pureza:98.61% - 99.85%Forma y color:SolidPeso molecular:1363.6PHA-767491
CAS:PHA-767491 (CAY10572) is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively.Fórmula:C12H11N3OPureza:99.49% - >99.99%Forma y color:SolidPeso molecular:213.24Ref: TM-T6206
2mg34,00€5mg49,00€1mL*10mM (DMSO)50,00€10mg64,00€25mg92,00€50mg138,00€100mg197,00€200mg295,00€STF-083010
CAS:STF-083010 is a selective inhibitor of the IRE1α endonuclease.Fórmula:C15H11NO3S2Pureza:98.09% - 99.45%Forma y color:SolidPeso molecular:317.38Ref: TM-T6681
5mg49,00€1mL*10mM (DMSO)55,00€10mg75,00€25mg114,00€50mg193,00€100mg349,00€200mg527,00€500mg767,00€Trilaciclib
CAS:Trilaciclib is a short-acting, orally effective CDK4/6 inhibitor with IC₅₀ values of 1 nM and 4 nM respectively. enhances antitumour immunity.Fórmula:C24H30N8OPureza:99.624%Forma y color:SolidPeso molecular:446.55Madrasin
CAS:Madrasin (DDD00107587) is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly.Fórmula:C16H17N5O2Pureza:99.06% - 99.61%Forma y color:SolidPeso molecular:311.34JSH-150
CAS:JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM).Fórmula:C24H33ClN6O2SPureza:99.96% - 99.96%Forma y color:SolidPeso molecular:505.08Dimethylenastron
CAS:Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.Fórmula:C16H18N2O2SPureza:98.07%Forma y color:SolidPeso molecular:302.39Ref: TM-T3118
1mg34,00€2mg46,00€5mg58,00€1mL*10mM (DMSO)64,00€10mg93,00€25mg147,00€50mg222,00€100mg334,00€SCH900776 (S-isomer)
CAS:SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).Fórmula:C15H18BrN7Pureza:99.88%Forma y color:SolidPeso molecular:376.25Ref: TM-T3700
1mg50,00€2mg66,00€5mg90,00€1mL*10mM (DMSO)108,00€10mg146,00€25mg250,00€50mg403,00€100mg593,00€Cilengitide
CAS:Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.Fórmula:C27H40N8O7Pureza:98% - 99.8%Forma y color:SolidPeso molecular:588.66iRGD peptide
CAS:iRGD peptide: 9-amino acid cyclic compound (CRGDKGPDC), found through phage display in mice with tumors.Fórmula:C35H57N13O14S2Pureza:98.77%Forma y color:SolidPeso molecular:948.04THZ531
CAS:THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM).Fórmula:C30H32ClN7O2Pureza:97.17% - 99.86%Forma y color:SolidPeso molecular:558.07Ref: TM-T4293
1mg59,00€2mg86,00€5mg105,00€1mL*10mM (DMSO)130,00€10mg144,00€25mg313,00€50mg447,00€100mg650,00€500mg1.341,00€IXA4
CAS:IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1.Fórmula:C24H28N4O4Pureza:99.8% - 99.85%Forma y color:SolidPeso molecular:436.5BRD32048
CAS:BRD32048 is a top candidate ETV1 perturbagen. BRD32048 inhibits p300-dependent acetylation of ETV1, thereby promoting its degradation.Fórmula:C16H22N6OPureza:99.87%Forma y color:SolidPeso molecular:314.39Ref: TM-T23820
1mL*10mM (DMSO)44,00€2mg50,00€5mg105,00€10mg172,00€25mg304,00€50mg485,00€100mg782,00€200mg1.054,00€SBC-115076
CAS:SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.Fórmula:C31H33N3O5Pureza:97.07% - 99.89%Forma y color:SolidPeso molecular:527.61Ref: TM-T2626
1mg38,00€2mg50,00€5mg80,00€1mL*10mM (DMSO)87,00€10mg94,00€25mg172,00€50mg309,00€100mg477,00€500mg1.063,00€Pyridostatin
CAS:Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome orFórmula:C31H32N8O5Pureza:98%Forma y color:SolidPeso molecular:596.64LY2880070
CAS:LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy.Fórmula:C19H23N7O2Pureza:99.77%Forma y color:SolidPeso molecular:381.43Phthalazinone pyrazole
CAS:Phthalazinone pyrazole: a potent, selective oral Aurora-A kinase inhibitor, overexpressed in tumors with oncogenic activity.Fórmula:C18H15N5OPureza:97.03%Forma y color:SolidPeso molecular:317.34Sarecycline free base
CAS:Sarecycline free base (P005672) is a tetracycline-derived, narrow-spectrum antibiotic.Fórmula:C24H29N3O8Pureza:98%Forma y color:SolidPeso molecular:487.5WEE1-IN-3
CAS:WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.Fórmula:C28H31N7O2Pureza:98.33%Forma y color:SolidPeso molecular:497.59Ref: TM-T8916
1mg66,00€5mg147,00€1mL*10mM (DMSO)161,00€10mg225,00€25mg398,00€50mg532,00€100mg767,00€200mg1.018,00€Alisertib
CAS:Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.Fórmula:C27H20ClFN4O4Pureza:98.31% - >99.99%Forma y color:SolidPeso molecular:518.92Ref: TM-T2241
5mg52,00€1mL*10mM (DMSO)59,00€10mg92,00€25mg146,00€50mg215,00€100mg334,00€200mg430,00€500mg705,00€IMM-H007
CAS:IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expressionFórmula:C22H23N5O8Pureza:97.73%Forma y color:SolidPeso molecular:485.45Ref: TM-T9010
1mg38,00€5mg92,00€1mL*10mM (DMSO)124,00€10mg128,00€25mg215,00€50mg304,00€100mg411,00€200mg570,00€BMS-265246
CAS:BMS-265246 is a potent and selective CDK1/2 inhibitor.Fórmula:C18H17F2N3O2Pureza:99.25% - 99.57%Forma y color:SolidPeso molecular:345.34Ref: TM-T2679
1mg34,00€5mg71,00€1mL*10mM (DMSO)78,00€10mg110,00€25mg210,00€50mg318,00€100mg455,00€200mg617,00€Bredinin aglycone
CAS:Bredinin aglycone (SM-108) is a purine nucleotide analog.Fórmula:C4H5N3O2Pureza:99.06%Forma y color:SolidPeso molecular:127.1LIMK-IN-22j
CAS:LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.Fórmula:C20H21BrN8Pureza:99.165%Forma y color:SolidPeso molecular:453.34KB-0742 dihydrochloride
CAS:KB-0742 dihydrochloride is a potent, selective and orally inhibitor of CDK9.Fórmula:C16H27Cl2N5Pureza:99.79%Forma y color:SolidPeso molecular:360.33Ref: TM-T9446
1mg90,00€2mg136,00€5mg222,00€1mL*10mM (DMSO)235,00€10mg358,00€25mg597,00€50mg850,00€100mg1.153,00€Atuveciclib
CAS:Atuveciclib Racemate is an oral CDK9 inhibitor with a 13 nM IC50, targeting P-TEFb/CDK9 selectively.Fórmula:C18H18FN5O2SPureza:98.8%Forma y color:SolidPeso molecular:387.43Ref: TM-T10464L
1mg84,00€2mg114,00€5mg192,00€1mL*10mM (DMSO)212,00€10mg313,00€25mg580,00€50mg773,00€100mg1.063,00€PTC-209 hydrobromide
CAS:PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in
Fórmula:C17H13Br2N5OS·HBrPureza:99.91%Forma y color:SolidPeso molecular:576.1Ref: TM-T6178
1mg37,00€5mg78,00€1mL*10mM (DMSO)89,00€10mg124,00€25mg265,00€50mg465,00€100mg753,00€200mg1.035,00€Afuresertib hydrochloride
CAS:Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)Fórmula:C18H18Cl3FN4OSPureza:99.96%Forma y color:SolidPeso molecular:463.8Ref: TM-T7885
2mg49,00€5mg71,00€1mL*10mM (DMSO)81,00€10mg89,00€25mg155,00€50mg240,00€100mg414,00€200mg538,00€Abemaciclib methanesulfonate
CAS:Abemaciclib methanesulfonate (LY2835219) is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM).
Fórmula:C27H32F2N8·CH4O3SPureza:98.69% - 99.44%Forma y color:SolidPeso molecular:602.7Carotegrast methyl
CAS:Carotegrast methyl (AJM300), an orally-active small molecule, can antagonize the α4 integrin receptor. It is a specific and dual α4β1/α4β7 integrin antagonist.Fórmula:C28H26Cl2N4O5Pureza:99.26% - 99.72%Forma y color:SolidPeso molecular:569.44Rabusertib
CAS:Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.
Fórmula:C18H22BrN5O3Pureza:98.86% - 99.87%Forma y color:SolidPeso molecular:436.3YKL-5-124
CAS:YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displaysFórmula:C28H33N7O3Pureza:99.36%Forma y color:SolidPeso molecular:515.61Ref: TM-T22461
1mg82,00€5mg152,00€1mL*10mM (DMSO)167,00€10mg222,00€25mg385,00€50mg560,00€100mg790,00€MC180295
CAS:MC180295 ((rel)-MC180295) is a novel potent, highly selective CDK9 inhibitor (IC50: 5 nM), displays >22-fold selectivity over other CDKs.Fórmula:C17H18N4O3SPureza:99.84%Forma y color:SolidPeso molecular:358.41Ref: TM-T5533
1mg52,00€5mg124,00€1mL*10mM (DMSO)136,00€10mg177,00€25mg301,00€50mg424,00€100mg605,00€200mg797,00€RAD51-IN-1
CAS:Rad51-in-1 is a derivative of B02 and an effective inhibitor of Rad51.Fórmula:C22H16ClN3OPureza:99.95%Forma y color:SolidPeso molecular:373.83
