Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(116 productos)
- CDK(548 productos)
- Detención del ciclo celular(5 productos)
- Chk(48 productos)
- DYRK(46 productos)
- Dynamin(27 productos)
- Ferroptosis(233 productos)
- HSP(180 productos)
- Integrin(276 productos)
- Kinesina(87 productos)
- LIM quinasa(21 productos)
- Asociado a microtúbulos(273 productos)
- PKC(128 productos)
- PLK(25 productos)
- ROCK(61 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(77 productos)
Mostrar 10 subcategorías más
Se han encontrado 3936 productos de "Ciclo celular / Checkpoint"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
ID-8
CAS:ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.Fórmula:C16H14N2O4Pureza:99.32%Forma y color:SolidPeso molecular:298.29Ganciclovir hydrate
CAS:Ganciclovir hydrate: oral anti-cytomegalovirus; inhibits HSV 1/2, CMV, adenoviruses, FHV-1; brain-penetrating.Fórmula:C9H15N5O5Forma y color:SolidPeso molecular:273.249H-Gly-Arg-Gly-Asp-Asn-Pro-OH
CAS:RGD peptide (GRGDNP) (RGD peptide GRGDNP(2TFA)) is a integrin-ligand interactions inhibitor.Fórmula:C23H38N10O10Pureza:>99.99%Forma y color:SolidPeso molecular:614.61Pyrintegrin
CAS:Pyrintegrin: β1-integrin agonist, boosts embryonic stem cell survival, and podocyte protection, improves cell-matrix adhesion.Fórmula:C23H25N5O3SPureza:99.19%Forma y color:SolidPeso molecular:451.54Ref: TM-T16695
1mg78,00€2mg90,00€5mg150,00€1mL*10mM (DMSO)165,00€10mg215,00€25mg385,00€50mg595,00€100mg858,00€AZ191
CAS:AZ191（IC50 of 17 nM） is an effective and specific DYRK1B inhibitor.Fórmula:C24H27N7OPureza:98.04% - 99.65%Forma y color:SolidPeso molecular:429.52Hexapeptide-10 Acetate
Hexapeptide-10 Acetate (Hexapeptide-10 Acetate) is a synthetic peptide.Fórmula:C30H57N7O10Pureza:98.84%Forma y color:SolidPeso molecular:675.81GNF4877
CAS:GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.Fórmula:C25H27FN6O4Pureza:98.68% - 99.40%Forma y color:SolidPeso molecular:494.52SAR407899
CAS:SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.Fórmula:C14H16N2O2Pureza:99.42%Forma y color:SolidPeso molecular:244.29Ref: TM-T7391
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg75,00€25mg128,00€50mg200,00€100mg319,00€200mg474,00€USP7/USP47 inhibitor
CAS:USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM,Fórmula:C18H11Cl2N3O3S3Pureza:98.5% - 98.71%Forma y color:SolidPeso molecular:484.4Ref: TM-T4338
1mg40,00€1mL*10mM (DMSO)94,00€5mg96,00€10mg152,00€25mg268,00€50mg429,00€100mg703,00€200mg954,00€BSJ-4-116
CAS:BSJ-4-116: potent, selective CDK12 PROTAC, IC50 = 6 nM; downregulates DDR genes, induces premature transcription termination.Fórmula:C40H49ClN8O8SPureza:99.09%Forma y color:SolidPeso molecular:837.38ML364
CAS:ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.Fórmula:C24H18F3N3O3S2Pureza:99.35% - >99.99%Forma y color:SolidPeso molecular:517.54CID 2011756
CAS:CID 2011756 is an ATP-competitive and specific PKD1 inhibitor.Fórmula:C22H21ClN2O3Pureza:98.15% - ≥95%Forma y color:SolidPeso molecular:396.87GAK inhibitor 49
CAS:GAK inhibitor 49 is a highly selective and ATP-competitive cyclin G associated kinase (GAK) inhibitor (IC50: 56 nM; Ki: 0.54 nM ).Fórmula:C20H22N2O5Pureza:98.71%Forma y color:SolidPeso molecular:370.4Ref: TM-T8535
1mg54,00€5mg111,00€1mL*10mM (DMSO)128,00€10mg177,00€25mg299,00€50mg430,00€100mg587,00€200mg792,00€SBC-110736
CAS:SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitorFórmula:C26H27N3O2Pureza:99.44%Forma y color:SolidPeso molecular:413.51LP-935509
CAS:LP-935509 is a selective, brain-permeable, small molecule competitive inhibitor of articulin-2-associated kinase 1 (AAK1).Cost-effective and quality-assured.Fórmula:C20H24N6O3Pureza:98.34% - 99.64%Forma y color:SolidPeso molecular:396.44Ref: TM-T15781
1mg37,00€2mg49,00€5mg79,00€1mL*10mM (DMSO)87,00€10mg124,00€25mg239,00€50mg444,00€100mg647,00€BI-847325
CAS:BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.Fórmula:C29H28N4O2Pureza:97.13% - 97.54%Forma y color:SolidPeso molecular:464.56TH287
CAS:TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.Fórmula:C11H10Cl2N4Pureza:97.73% - 99%Forma y color:SolidPeso molecular:269.13Ref: TM-T2069
1mg37,00€2mg48,00€5mg72,00€1mL*10mM (DMSO)79,00€10mg96,00€25mg188,00€50mg366,00€100mg545,00€GDC0575 monohydrochloride
CAS:GDC0575 (ARRY575), a potent Chk1 inhibitor, IC50 1.2nM, disrupts cell cycle arrest, allowing DNA repair before mitosis.Fórmula:C16H21BrClN5OPureza:97.85%Forma y color:SolidPeso molecular:414.73Ref: TM-T27407
1mg43,00€2mg55,00€5mg80,00€1mL*10mM (DMSO)93,00€10mg103,00€25mg177,00€50mg255,00€100mg356,00€200mg520,00€Aurora kinase inhibitor-2
CAS:Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).Fórmula:C23H20N4O3Pureza:98.66%Forma y color:SolidPeso molecular:400.43Ref: TM-T9040
1mg63,00€5mg138,00€1mL*10mM (DMSO)150,00€10mg200,00€25mg360,00€50mg532,00€100mg788,00€200mg1.063,00€SR18662
SR18662, improved ML264 derivative, inhibits KLF5 at 4.4 nM IC50; curbs colorectal cancer cell growth and triggers apoptosis.Fórmula:C16H19Cl2N3O4SPureza:98.97% - 99.2%Forma y color:SolidPeso molecular:420.31Ref: TM-T22429
1mg46,00€5mg90,00€1mL*10mM (DMSO)100,00€10mg152,00€25mg295,00€50mg475,00€100mg680,00€200mg888,00€500mg1.378,00€BIO-1211
CAS:BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).Fórmula:C36H48N6O9Pureza:99.33%Forma y color:SolidPeso molecular:708.8PKD-IN-1
CAS:CRT0066101 is an inhibitor of PKD.Fórmula:C18H19ClN4OPureza:98%Forma y color:SolidPeso molecular:342.82GNE-6776
CAS:GNE-6776 is a selective USP7 inhibitor.Fórmula:C20H20N4O2Pureza:96.59% - 98.2%Forma y color:SolidPeso molecular:348.4DUB-IN-1
CAS:DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).Fórmula:C20H11N5OPureza:98.33% - 98.96%Forma y color:SolidPeso molecular:337.33Ref: TM-T11110
1mg62,00€5mg110,00€1mL*10mM (DMSO)122,00€10mg173,00€25mg334,00€50mg469,00€100mg618,00€200mg848,00€FOY 251
CAS:FOY 251 is a proteinase inhibitor, and is an anti-proteolytic active metabolite camostate.Fórmula:C17H19N3O7SPureza:97.11% - 99.33%Forma y color:SolidPeso molecular:409.41Ref: TM-T8676
1mg51,00€5mg110,00€1mL*10mM (DMSO)126,00€10mg177,00€25mg300,00€50mg424,00€100mg605,00€500mg1.198,00€α2β1 Integrin Ligand Peptide acetate
α2β1 Integrin Ligand Peptide acetate (α2β1 Integrin Ligand Peptide acetate (134580-64-6)) is a potential antagonist of α2β1 integrin receptor.Fórmula:C16H26N4O11Pureza:98.46%Forma y color:SolidPeso molecular:450.4Hydroxyfasudil Hydrochloride
CAS:Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).Fórmula:C14H18ClN3O3SPureza:98.05%Forma y color:SolidPeso molecular:343.83DUB-IN-2
CAS:Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.Fórmula:C15H9N5OPureza:98.96%Forma y color:SolidPeso molecular:275.26Ref: TM-T11111
1mg54,00€5mg155,00€1mL*10mM (DMSO)169,00€10mg233,00€25mg467,00€50mg682,00€100mg990,00€P18IN011
CAS:P18IN011 (P18IN011 - CAS 77408-67-4 - Calbiochem) is a novel inhibitor of p18(INK4C).
Fórmula:C15H12N2O5SPureza:97.63%Forma y color:SolidPeso molecular:332.33BMH-21
CAS:BMH-21, a small molecule DNA intercalator, binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and not affects phosphorylation of H2AX.Fórmula:C21H20N4O2Pureza:99.47% - 99.84%Forma y color:SolidPeso molecular:360.41BUR1
CAS:BUR1 is a Saccharomyces cerevisiae cyclin-dependent kinase (CDK) and is homologous to mammalian Cdk9, which functions in transcriptional elongation.Fórmula:C16H17N5Pureza:90%Forma y color:SolidPeso molecular:279.34AG-636
CAS:AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.Fórmula:C21H17N3O2Pureza:99.19%Forma y color:SolidPeso molecular:343.38HQ461
CAS:HQ461, a molecular glue, boosts CDK12-DDB1 binding, lowers cyclin K, impedes CDK12 phosphorylation, hinders DNA repair genes, and induces cell death.Fórmula:C15H15N5OS2Pureza:98.11%Forma y color:SolidPeso molecular:345.44Ref: TM-T9849
1mg43,00€2mg56,00€1mL*10mM (DMSO)90,00€5mg93,00€10mg144,00€25mg319,00€50mg537,00€100mg767,00€500mg1.558,00€Hydroxyfasudil
CAS:Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).Fórmula:C14H17N3O3SPureza:98.13%Forma y color:SolidPeso molecular:307.37Pyridostatin TFA
CAS:Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-Fórmula:C37H35F9N8O11Pureza:97.09% - 99.84%Forma y color:SolidPeso molecular:938.71ZCL278
CAS:ZCL278 is a selective Cdc42 GTPase inhibitor.Fórmula:C21H19BrClN5O4S2Pureza:96.29% - 99.72%Forma y color:SolidPeso molecular:584.89Ref: TM-T1855
5mg52,00€10mg74,00€1mL*10mM (DMSO)74,00€25mg129,00€50mg210,00€100mg294,00€200mg470,00€500mg763,00€TAK-960 hydrochloride
CAS:TAK-960 hydrochloride is an oral, potent PLK1 inhibitor with IC50 of 0.8 nM, effective against various tumor cells and xenografts.Fórmula:C27H35ClF3N7O3Forma y color:SolidPeso molecular:598.06Netarsudil free base
CAS:Netarsudil (AR-11324), a ROCK inhibitor, treats glaucoma by increasing eye outflow and lowering IOP, with mild hyperemia as a side effect.Fórmula:C28H27N3O3Forma y color:SolidPeso molecular:453.53T-5224
CAS:T-5224 is a transcription factor c-Fos/AP-1 inhibitor, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcriptionFórmula:C29H27NO8Pureza:97.88% - 99.29%Forma y color:SolidPeso molecular:517.53Ref: TM-T5416
1mg48,00€5mg96,00€1mL*10mM (DMSO)107,00€10mg144,00€25mg254,00€50mg424,00€100mg627,00€200mg998,00€RK33
CAS:"RK33 is a DDX3 inhibitor causing G1 arrest, apoptosis, and radiation sensitization in DDX3-overexpressing cells."Fórmula:C23H20N6O3Pureza:99.04% - 99.72%Forma y color:SolidPeso molecular:428.44AI-10-49
CAS:AI-10-49 is a selective inhibitor of the binding of CBFβ-SMMHC to RUNX1 with IC50 of 260 nM.Fórmula:C30H22F6N6O5Pureza:97.14%Forma y color:SolidPeso molecular:660.52Ref: TM-T6753
2mg38,00€5mg57,00€1mL*10mM (DMSO)84,00€10mg92,00€25mg160,00€50mg231,00€100mg343,00€200mg485,00€BRD9876
CAS:BRD9876 is a selective inhibitor of MM1S growth.Fórmula:C16H14N2Pureza:97.81%Forma y color:SolidPeso molecular:234.3AS2863619
CAS:AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.Fórmula:C16H14Cl2N8OPureza:>99.99%Forma y color:SolidPeso molecular:405.24Ref: TM-T8378
1mg124,00€2mg170,00€5mg260,00€1mL*10mM (DMSO)286,00€10mg409,00€25mg677,00€50mg954,00€100mg1.288,00€IMT1B
CAS:IMT1B (LDC203974) is an oral POLRMT inhibitor that curbs mtDNA expression and has anti-cancer properties.Fórmula:C24H21ClFNO6Pureza:98.26% - 99.83%Forma y color:SolidPeso molecular:473.88Ref: TM-T8842
1mg138,00€5mg295,00€1mL*10mM (DMSO)309,00€10mg505,00€25mg733,00€50mg888,00€100mg1.251,00€HAMNO
CAS:HAMNO (NSC-111847) is a protein interaction inhibitor of replication protein A (RPA).Fórmula:C17H13NO2Pureza:99.96%Forma y color:SolidPeso molecular:263.29TH5427 hydrochloride
CAS:TH5427 HCl inhibits NUDT5 with 29 nM IC50; 690x more selective over MTH1; blocks ATP in breast cancer cells, hindering growth.Fórmula:C20H21Cl3N8O3Forma y color:SolidPeso molecular:527.79RNase L-IN-2
CAS:RNase L-IN-2 activates RNase L at 22 uM, has antiviral effects on various RNA viruses, non-toxic at effective levels.Fórmula:C16H14N2O2SPureza:98.81%Forma y color:SolidPeso molecular:298.36Ref: TM-T8591
1mg120,00€1mL*10mM (DMSO)243,00€5mg264,00€10mg395,00€25mg627,00€50mg890,00€100mg1.198,00€200mg1.603,00€SNS-314
CAS:SNS-314 inhibits Aurora kinases A and B, blocking cell division in AK-overexpressing tumors.Fórmula:C18H15ClN6OS2Pureza:98%Forma y color:SolidPeso molecular:430.93TCID
CAS:TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.Fórmula:C9H2Cl4O2Pureza:99.34%Forma y color:SolidPeso molecular:283.92Ro3280
CAS:Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).Fórmula:C27H35F2N7O3Pureza:97.1% - >99.99%Forma y color:SolidPeso molecular:543.61
