Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(95 productos)
- CDK(501 productos)
- Detención del ciclo celular(4 productos)
- Chk(42 productos)
- DYRK(48 productos)
- Dynamin(23 productos)
- Ferroptosis(215 productos)
- HSP(169 productos)
- Integrin(224 productos)
- Kinesina(67 productos)
- LIM quinasa(19 productos)
- Asociado a microtúbulos(262 productos)
- PKC(102 productos)
- PLK(28 productos)
- ROCK(69 productos)
- Rho(2 productos)
- Wee1(15 productos)
- c-Myc(69 productos)
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Se han encontrado 3486 productos de "Ciclo celular / Checkpoint"
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Akt1&PKA-IN-1
CAS:<p>Akt1&PKA-IN-1 inhibits Akt/PKA: IC50 = 0.03μM (PKAa), 0.11μM (Akt), 9.8μM (CDK2); selective for CDK2.</p>Fórmula:C20H17Cl2N3OForma y color:SolidPeso molecular:386.27WNK1-IN-1
CAS:<p>WNK1-IN-1, a WNK1 inhibitor (IC50: 1.6 μM), also inhibits OSR1 phosphorylation (IC50: 4.3 μM), used in blood pressure and cancer research.</p>Fórmula:C13H15BrCl2N2O4SPureza:98.09%Forma y color:SolidPeso molecular:446.14Type II topoisomerase inhibitor 1
CAS:<p>Potent E. coli DNA gyrase inhibitor (IC50: 1.7 nM), targets Asp73; weak topoisomerase IV inhibitor (IC50: 0.98 μM).</p>Fórmula:C18H15N3O4Forma y color:SolidPeso molecular:337.33Fosteabine
CAS:<p>Fosteabine is an oral and prodrug analog of cytarabine. It is resistant to deoxycytidine deaminase.</p>Fórmula:C27H50N3O8PPureza:98%Forma y color:SolidPeso molecular:575.67Ulecaciclib
CAS:Ulecaciclib: oral, BBB-permeable CDK inhibitor; favorable pharmacokinetics; ki: 0.62 μM (CDK2/A), 3 nM (CDK6/D3), 0.2 nM (CDK4/D1), 0.63 μM (CDK7/H).Fórmula:C25H33FN8SForma y color:SolidPeso molecular:496.65CRT-0105446
CAS:<p>CRT-0105446 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.</p>Fórmula:C20H18F3N3O2SPureza:98%Forma y color:SolidPeso molecular:421.445,10-Dideazaaminopterin
CAS:<p>5,10-Dideazaaminopterin is an antileukemic drug.</p>Fórmula:C21H22N6O5Pureza:98%Forma y color:SolidPeso molecular:438.44Cdc7-IN-13
CAS:<p>Cdc7-IN-13 (compound 84) is a highly potent CDC7 inhibitor, exhibiting an IC50 value of <1 nM. This compound holds promise for cancer research [1].</p>Fórmula:C18H20N4O2SForma y color:SolidPeso molecular:356.44DAP-81
CAS:<p>DAP-81, a diaminopyrimidine, inhibits Plk1 (IC50: 0.9 nM), disrupts microtubules, causes monopolar spindles; in preclinical studies.</p>Fórmula:C25H20N6O4Forma y color:SolidPeso molecular:468.46CDK4/6-IN-9
CAS:<p>CDK4/6-IN-9 selectively inhibits CDK4/6 (IC50: 905 nM); potential for MM research.</p>Fórmula:C22H23FN8Forma y color:SolidPeso molecular:418.47SC-203885
CAS:<p>SC-203885 is a checkpoint kinase 2 inhibitor.</p>Fórmula:C15H13N5O2Pureza:98%Forma y color:SolidPeso molecular:295.3HBV-IN-16
CAS:<p>HBV-IN-16, a quinoline derivative, inhibits HBV cccDNA, key for viral replication (from patent WO2019121357A1).</p>Fórmula:C22H20ClNO4Forma y color:SolidPeso molecular:397.85Crozbaciclib fumarate
CAS:<p>Crozbaciclib fumarate is a CDK4/6 inhibitor with IC 50 s of 3 and 1 nM, respectively.</p>Fórmula:C32H34F2N6O4Forma y color:SolidPeso molecular:604.65Aurora Kinases-IN-2
CAS:<p>Aurora Kinases-IN-2 (12Aj) hinders Aurora A/B kinases (IC50: 90/152 nM), used in cancer studies.</p>Fórmula:C22H18ClN5O3Forma y color:SolidPeso molecular:435.86Dyrk1A-IN-5
CAS:<p>Potent DYRK1A inhibitor with IC50s: 6 nM overall, 0.5 μM SF3B1, 2.1 μM tau phosphorylation. Useful for Down syndrome studies.</p>Fórmula:C16H9IN2O2Forma y color:SolidPeso molecular:388.16CDK7-IN-12
CAS:<p>CDK7-IN-12 inhibits CDK7 to control transcription and cell cycle, halting tumor growth in vitro/vivo with cancer research potential.</p>Fórmula:C20H19F3N6Forma y color:SolidPeso molecular:400.4FAK/aurora kinase-IN-1
CAS:<p>FAK/aurora kinase-IN-1, a dual inhibitor of FAK and aurora kinase, has IC50 values of 6.61 nM and 0.91 nM respectively, and demonstrates anticancer effects (WO2018019252A1; compound 11) [1].</p>Fórmula:C23H24ClN7O3Forma y color:SolidPeso molecular:481.93LSN 3213128
CAS:<p>LSN 3213128: a potent oral antifolate targeting AICARFT with IC50s of 16 nM (enzyme) and 19 nM (cells), offers anti-tumor effects.</p>Fórmula:C17H16FN3O4S2Forma y color:SolidPeso molecular:409.45Myt1-IN-1
CAS:<p>Myt1-IN-1 has anticancer effects that is a potent inhibitor of Myt1 with an IC 50 of <10 nM [1].</p>Fórmula:C16H15ClN4O2Forma y color:SolidPeso molecular:330.77Aurora kinase inhibitor-10
CAS:<p>Aurora kinase inhibitor-10 is an orally active Aurora B inhibitor (IC50: 8 nM) that exhibits antitumour effects.</p>Fórmula:C21H19F5N6O4SForma y color:SolidPeso molecular:546.47Crisnatol mesylate
CAS:<p>Crisnatol, a potent and selective DNA intercalator, has potential anticancer activity.</p>Fórmula:C24H27NO5SForma y color:SolidPeso molecular:441.54P18IN003
CAS:<p>P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion of</p>Fórmula:C17H16N2O3Pureza:98.77%Forma y color:SolidPeso molecular:296.32hDHODH-IN-4
CAS:<p>hDHODH-IN-4, a potent DHODH inhibitor, has a pIC50 of 7.8 and blocks measles virus replication with a pMIC50 of 8.8.</p>Fórmula:C21H24N4O2Pureza:99.87%Forma y color:SolidPeso molecular:364.44AnnH31
CAS:<p>AnnH31 is a potent Dyrk1A inhibitor with an IC50 value of 81 nM.AnnH31 inhibits MAO-A with an IC50 of 3.2 μM.AnnH31 can be used as a probe to confirm the</p>Fórmula:C15H13N3OPureza:99.88%Forma y color:SolidPeso molecular:251.28Werner syndrome RecQ helicase-IN-3
CAS:<p>Potent WRN inhibitor, Werner syndrome RecQ helicase-IN-3, is orally active with 0.06 µM IC50; exhibits antiproliferative and anticancer effects.</p>Fórmula:C31H30ClF3N8O5Forma y color:SolidPeso molecular:687.07Mps-BAY2b
CAS:<p>Mps-BAY2b is a novel MPS1 inhibitor.</p>Fórmula:C20H23N5OForma y color:SolidPeso molecular:349.43(S)-CR8
CAS:<p>(S)-CR8 is an effective second-generation cyclin-dependent kinase inhibitor.</p>Fórmula:C24H29N7OForma y color:SolidPeso molecular:431.53AZD7762 HCl
CAS:<p>AZD7762 HCl is a checkpoint kinase inhibitor, driving checkpoint abrogation and enhancing DNA-targeted treatment.</p>Fórmula:C17H20ClFN4O2SPureza:98%Forma y color:SolidPeso molecular:398.88DHODH-IN-13
CAS:<p>DHODH-IN-13 is an inhibitor of DHODH with IC50 of 4.3 μM for rat liver. DHODH-IN-13 can be used in studies about rheumatoid arthritis.</p>Fórmula:C10H6F3N3O3Pureza:99.66%Forma y color:SolidPeso molecular:273.17Zelpolib
CAS:<p>Zelpolib is a specific inhibitor of DNA polymerase δ (Pol δ), inhibiting DNA replication. antiproliferative.</p>Fórmula:C22H21N3O5S2Pureza:98.79%Forma y color:SolidPeso molecular:471.55Indirubin-5-sulfonate
CAS:<p>Indirubin-5-sulfonate inhibits GSK-3β & CDKs with IC50: 55/35/150/300/65 nM for CDK1/B, 2/A&E, 4/D1, 5/p35.</p>Fórmula:C16H10N2O5SPureza:98%Forma y color:SolidPeso molecular:342.33VPC-70619
CAS:<p>VPC-70619: Oral, selective N-Myc inhibitor; blocks cancer growth by hindering N-Myc-Max/DNA binding; well-absorbed.</p>Fórmula:C16H8ClF3N4OForma y color:SolidPeso molecular:364.71CDK8-IN-10
CAS:<p>CDK8-IN-10 is a selective and potent inhibitor of cell cycle protein-dependent kinase (CDK8) (IC50: 8.25 nM) that can be used to study cancer.</p>Fórmula:C25H15ClF3N5O3Forma y color:SolidPeso molecular:525.87A 65282
CAS:<p>A 65282: antibacterial isothiazoloquinolone, inhibits P4-unknotting, causes DNA breaks via topoisomerase II.</p>Fórmula:C17H16F2N4O2SPureza:98%Forma y color:SolidPeso molecular:378.4SP-471P
CAS:<p>SP-471P inhibits DENV protease; EC50: DENV1-5.9 μM, DENV2-1.4 μM, DENV3-5.1 μM, DENV4-1.7 μM; CC50 >100 μM; lowers viral RNA synthesis.</p>Fórmula:C33H26BrN5O2Forma y color:SolidPeso molecular:604.5RP-106
CAS:<p>RP-106 is an ATP-competitive inhibitor of CDK5/p25, CDK1/cyclin B, and GSK-3.</p>Fórmula:C17H19N3OPureza:98%Forma y color:SolidPeso molecular:281.35Valategrast hydrochloride
CAS:<p>Valategrast hydrochloride (R411), a dual antagonist of integrin α4β1 (VLA-4), is used for the potential treatment of asthma.</p>Fórmula:C30H33Cl4N3O4Pureza:98%Forma y color:SolidPeso molecular:641.41CID 5951923
CAS:<p>CID 5951923 is an inhibitor of KLF5 transcription factor with an IC50 of 603 nM.</p>Fórmula:C16H18N2O7SPureza:99.95%Forma y color:SolidPeso molecular:382.39cp028
CAS:<p>cp028 inhibits pre-mRNA splicing in vitro.</p>Fórmula:C23H17FN2O4Forma y color:SolidPeso molecular:404.39NSC 109555 ditosylate
CAS:<p>Chk2 inhibitor,ATP-competitive</p>Fórmula:C26H32N10O4SPureza:98%Forma y color:SolidPeso molecular:580.6614α-Demethylase/DNA Gyrase-IN-2
CAS:<p>14α-Demethylase/DNA Gyrase-IN-2 (Compound 6a) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.</p>Fórmula:C24H22N4O4Forma y color:SolidPeso molecular:430.46hDHODH-IN-5
CAS:<p>hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH, IC50 = 0.91 μM).</p>Fórmula:C21H21F3N2O2Pureza:99.55%Forma y color:SolidPeso molecular:390.4BAY-958
CAS:<p>BAY-958 is a potent and selective inhibitor of PTEFb/CDK9.</p>Fórmula:C17H16FN5O3SPureza:98%Forma y color:SolidPeso molecular:389.4BDM44768
CAS:<p>BDM44768 is an insulin-degrading enzyme (IDE) inhibitor that acts by inducing glucose intolerance.</p>Fórmula:C24H22FN5O3Forma y color:SolidPeso molecular:447.46Mps1-IN-4
CAS:<p>Mps1-IN-4 is a compound that selectively inhibits Monopolar spindle 1 (Mps1), exhibiting antiproliferative properties useful in cancer research.</p>Fórmula:C26H31F3N6O2Forma y color:SolidPeso molecular:516.56CCT068127
CAS:<p>CCT068127 is a potent CDK2 and CDK9 inhibitor.</p>Fórmula:C19H27N7OForma y color:SolidPeso molecular:369.46PD 130883
CAS:<p>PD 130883 is a potent lipophilic quinazoline antifolate.</p>Fórmula:C18H15N5O3Pureza:98%Forma y color:SolidPeso molecular:349.34CDK7-IN-8
CAS:<p>CDK7-IN-8 is a potent inhibitor of CDK7 (IC50: 54.29 nM) and exhibits inhibitory activity against several cancer cells and in vivo tumor models.</p>Fórmula:C25H38N8O3Forma y color:SolidPeso molecular:498.622'-Deoxy-L-guanosine
CAS:<p>2'-Deoxy-L-guanosine is a nucleoside that shows antibiotic properties by inhibiting protein synthesis, leading to cell death.</p>Fórmula:C10H13N5O4Forma y color:SolidPeso molecular:267.24VE-465
CAS:<p>VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events.</p>Fórmula:C22H28N8OSForma y color:SolidPeso molecular:452.58
