Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(116 productos)
- CDK(548 productos)
- Detención del ciclo celular(5 productos)
- Chk(49 productos)
- DYRK(46 productos)
- Dynamin(27 productos)
- Ferroptosis(233 productos)
- HSP(180 productos)
- Integrin(278 productos)
- Kinesina(87 productos)
- LIM quinasa(21 productos)
- Asociado a microtúbulos(274 productos)
- PKC(128 productos)
- PLK(25 productos)
- ROCK(61 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(77 productos)
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Se han encontrado 3939 productos de "Ciclo celular / Checkpoint"
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Locked nucleic acid 1
CAS:Locked nucleic acid 1 is an LNA-type nucleoside derivative.Fórmula:C32H32N2O8Pureza:98%Forma y color:SolidPeso molecular:572.61VVD-214
CAS:VVD-214 (RO7589831) is a WRN deconjugation enzyme lethal-mutagenic inhibitor that can be used to study proliferative diseases.Fórmula:C20H21F2N3O4SPureza:99.24% - 99.93%Forma y color:SoildPeso molecular:437.46Ref: TM-T85309
1mg69,00€5mg147,00€1mL*10mM (DMSO)164,00€10mg224,00€25mg358,00€50mg512,00€100mg707,00€Acapatamab
CAS:Acapatamab (AMG-160) is a Half-Life Extended (HLE) Bispecific T-cell Engager (BiTE) with domains that bind to PSMA and CD3. It exhibits Kd values of 14.8 nM for hPSMA and 22.4 nM for hCD3. This compound is utilized in cancer research.Forma y color:LiquidUbamatamab
CAS:Ubamatamab (REGN4018), a human bispecific antibody targeting Mucin 16 (MUC16) and CD3, exhibits potent antitumor activity [1].Pureza:95%Forma y color:LiquidPOSH-IN-1
CAS:POSH-IN-1 (Compound 108) is an inhibitor of the POSH polypeptide （e3 ligase) and has antiviral, anticancer, and neurodegenerative disease potential.Fórmula:C14H8FNO3SPureza:99.29%Forma y color:SolidPeso molecular:289.28Voxalatamab
CAS:Voxalatamab (JNJ-63898081), an IgG4 bispecific antibody targeting PSMA and CD3, demonstrates anti-cancer efficacy in prostate cancer research [1].Forma y color:LiquidPavurutamab
CAS:Pavurutamab (AMG-701) is a bispecific T cell engager targeting CD3 and BCMA with extended half-life, designed to treat MM.Forma y color:LiquidCaplacizumab
CAS:Caplacizumab (ALX-0681), a humanized anti-von Willebrand factor (vWF) nanobody, serves to impede vWF-mediated platelet adhesion, thereby averting additionalForma y color:LiquidEnlimomab
CAS:Enlimomab (BI-RR 0001), a mouse IgG2a antibody, blocks leukocyte binding to ICAM-1, reducing inflammation and used in stroke research.Forma y color:LiquidPacanalotamab
CAS:Pacanalotamab (AMG 420/BI-836909), a BiTE, directs T-cells to BCMA+ MM cells, causing lysis.Forma y color:LiquidVepsitamab
CAS:Vepsitamab (AMG 199), an anti-MUC17/CD3 BiTE, targets T cells and tumors for cell lysis and T cell activation.Forma y color:LiquidObrindatamab
CAS:Obrindatamab: a humanized bispecific antibody targeting B7-H3/CD3, enhances CTL-mediated cancer cell killing.Forma y color:LiquidIluzanebart
CAS:Iluzanebart, a hTREM2 agonist antibody, enhances microglial survival and function, modeling CSF1R-ALSP and microglial dysfunction in neurodegenerative studies.Pureza:95% - 97.7% (SDS-PAGE); 98.3% (SEC-HPLC)Forma y color:LiquidPeso molecular:144.90 kDaGSK4418959
CAS:GSK4418959 (IDE275) is a selective WRN helicase inhibitor that blocks ATPase and DNA unwinding, serving as a tool in MSI-H cancer research.Fórmula:C31H30F4N4O5SPureza:99.141%Forma y color:SoildPeso molecular:646.65N6-Etheno 2'-deoxyadenosine
CAS:N6-Etheno 2'-deoxyadenosine is used as a biomarker to evaluate chronic inflammation and lipid peroxidation in animal or human tissues.Fórmula:C12H13N5O3Pureza:98%Forma y color:SolidPeso molecular:275.265-Methyl-5,6-dihydrouridine
CAS:5-Methyl-5,6-dihydrouridine is a minor constituent in the chromosomal RNA of the rat ascites tumor. It can be used for nucleic acid modification.Fórmula:C10H16N2O6Pureza:98%Forma y color:SolidPeso molecular:260.24Anti-Mouse TCR γ/δ Antibody (UC7-13D5)
Anti-Mouse TCR gamma/delta Antibody is a host Armenian Hamster-derived IgG class inhibitor targeting the mouse TCR gamma/delta receptor.Forma y color:Odour LiquidMC-1-F2
CAS:MC-1-F2 is a direct FOXC2 inhibitor with anticancer activity and inhibits cancer stem cell (CSC) properties and can be used to study prostate cancer.Fórmula:C37H46N16O2Pureza:97.31% - 98.44%Forma y color:SolidPeso molecular:746.87Tilatamig samrotecan
Tilatamig samrotecan (AZD9592) is an antibody-drug conjugate (ADC) designed to deliver a topoisomerase I inhibitor (TOP1i). It targets epidermal growth factor receptor (EGFR) and c-MET and demonstrates antitumor activity. The compound induces DNA double-strand breaks, elevates pRAD50 and γH2AX expression, and inhibits the growth of non-small cell lung cancer.Forma y color:Odour Solid2'-Azido-2'-deoxyuridine
CAS:2'-Azido-2'-deoxyuridine (N3dUrd) is a ribonucleotide reductase inhibitor with anti-cancer activity.Fórmula:C9H11N5O5Pureza:98%Forma y color:SolidPeso molecular:269.21Mirvetuximab soravtansine
CAS:Mirvetuximab soravtansine (IMGN853) is an antibody-drug coupling that targets FRα, inhibits cell growth, and can be used to study drug-resistant ovarian cancerPureza:6mg/ml - 95.52% (SEC-HPLC)Forma y color:LiquidPeso molecular:145.76 kDaE-982
CAS:E-982 is derived from the reference compound.Fórmula:C25H31NO6SPureza:98%Forma y color:SolidPeso molecular:473.58L-Threonolactone
CAS:L-Threonolactone is a Carbohydrate Derivative.Fórmula:C4H6O4Forma y color:SolidPeso molecular:118.09SB273005
CAS:SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.Fórmula:C22H24F3N3O4Pureza:99.58%Forma y color:SolidPeso molecular:451.44hDHODH-IN-2
CAS:hDHODH-IN-2: Leflunomide metabolite analog, inhibits human dihydroorotate dehydrogenase, anti-inflammatory.Fórmula:C19H16N2O2Pureza:98%Forma y color:SolidPeso molecular:304.349(R)-(+)-O-Demethylbuchenavianine
CAS:(R)-(+)-O-Demethylbuchenavianine is a cyclin-dependent kinase (CDK) inhibitor. It inhibits CDK1, CDK5, glycogen synthase kinase 3 (GSK3), cdc2-like kinase (CLK1), and dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) with IC50 values of 1.1 μM, 0.95 μM, >10 μM, >10 μM, and >10 μM, respectively.Fórmula:C21H21NO4Forma y color:SolidPeso molecular:351.40Adenosine 2'-PEG-Biotin
CAS:Adenosine 2'-PEG-Biotin, a bioreagent derived from adenosine, modulates cellular signaling pathways by mimicking the action of endogenous adenosine and binding to its receptors. This compound is used in research related to bioprobes, biosensors, and diagnostic agents.Fórmula:C26H40N8O8SForma y color:SolidPeso molecular:624.71RI(dl)-2 TFA
CAS:RI(dl)-2 TFA inhibits RAD51 D-loop at 11.1 μM and HR in human cells at 3.0 μM.Fórmula:C19H17N3Forma y color:SolidPeso molecular:287.36GW843682X
CAS:GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).Fórmula:C22H18F3N3O4SPureza:99.92%Forma y color:SolidPeso molecular:477.46XL413
CAS:XL-413 is an oral CDC7 kinase inhibitor, potentially blocking DNA replication, mitosis, and cancer cell growth.Fórmula:C14H12ClN3O2Pureza:98.40% - 99.94%Forma y color:SolidPeso molecular:289.72Tirofiban
CAS:Tirofiban (L700462) (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.Fórmula:C22H36N2O5SPureza:99.83%Forma y color:SolidPeso molecular:440.6BAY1217389
CAS:BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM).Fórmula:C27H24F5N5O3Pureza:98.14% - 99.42%Forma y color:SolidPeso molecular:561.53,4-Dihydroxybenzylamine hydrobromide
CAS:3,4-Dihydroxybenzylamine hydrobromide inhibits DNA polymerase and melanoma growth, varying with tyrosinase activity.Fórmula:C7H10BrNO2Pureza:98.49%Forma y color:Light Beige Crystalline PowderPeso molecular:220.06TAK-285
CAS:TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.Fórmula:C26H25ClF3N5O3Pureza:99.73%Forma y color:SolidPeso molecular:547.96Ref: TM-T6039
1mg38,00€5mg80,00€1mL*10mM (DMSO)96,00€10mg120,00€25mg216,00€50mg354,00€100mg512,00€200mg727,00€Mps1-IN-1
CAS:Mps1-IN-1 is a potent, selective and ATP-competitive inhibitor of Mps1 kinase (IC50 : 367 nM )Fórmula:C28H33N5O4SPureza:99.55%Forma y color:SolidPeso molecular:535.66CDK4/6-IN-12
CAS:CDK4/6-IN-12 inhibits CDK4/6 with IC50s of 592.3 nM & 3090 nM, useful in cancer research.Fórmula:C12H10N6Forma y color:SolidPeso molecular:238.25CDK5 inhibitor 20-223
CAS:CDK5 inhibitor 20-223 is a potent CDK2/CDK5 inhibitor,anti-Colorectal Cancer (CRC), inhibiting cell migration and inducing cell cycle arrest.Fórmula:C19H19N3OForma y color:SolidPeso molecular:305.37IRE1α kinase-IN-8
CAS:IRE1α kinase-IN-8, a benzoheterocyclecarboxaldehyde derivative, serves as a potent inhibitor of IRE-1α.Fórmula:C23H22N2O5Pureza:98%Forma y color:SolidPeso molecular:406.43MSC-1186
CAS:MSC-1186 selectively inhibits SRPKs—IC50: 2.7nM (SRPK1), 81nM (SRPK2), 0.6nM (SRPK3)—for cancer research.Fórmula:C19H17ClFN7O2SForma y color:SolidPeso molecular:461.9Kira8 Hydrochloride
CAS:Kira8 Hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.Fórmula:C31H30Cl2N6O3SPureza:98%Forma y color:SolidPeso molecular:637.58Thiarabine
CAS:Thiarabine displays effective anti-tumor activity. It also inhibition of DNA synthesis.Fórmula:C9H13N3O4SPureza:98%Forma y color:SolidPeso molecular:259.28CDK2-IN-12
CAS:CDK2-IN-12 (10b), potent CDK2 inhibitor, IC50: 11.6 μM; inhibits hCA I/II/IX/XII, KI: 3534/638.4/44.3/48.8 nM; anti-cancer properties.Fórmula:C20H17N9O2SForma y color:SolidPeso molecular:447.47SC-203885
CAS:SC-203885 is a checkpoint kinase 2 inhibitor.Fórmula:C15H13N5O2Pureza:98%Forma y color:SolidPeso molecular:295.3hDHODH-IN-4
CAS:hDHODH-IN-4, a potent DHODH inhibitor, has a pIC50 of 7.8 and blocks measles virus replication with a pMIC50 of 8.8.Fórmula:C21H24N4O2Pureza:99.87%Forma y color:SolidPeso molecular:364.44DAP-81
CAS:DAP-81, a diaminopyrimidine, inhibits Plk1 (IC50: 0.9 nM), disrupts microtubules, causes monopolar spindles; in preclinical studies.Fórmula:C25H20N6O4Forma y color:SolidPeso molecular:468.46REV7/REV3L-IN-1
CAS:REV7/REV3L-IN-1 is a inhibitor of REV7/REV3L interaction(IC50 of 78 μM),Fórmula:C19H21N3O3SPureza:98%Forma y color:SolidPeso molecular:371.45CDK4/6-IN-9
CAS:CDK4/6-IN-9 selectively inhibits CDK4/6 (IC50: 905 nM); potential for MM research.Fórmula:C22H23FN8Forma y color:SolidPeso molecular:418.47NSC47924
CAS:NSC47924 is a laminin receptor (LR) inhibitor.Fórmula:C18H17NO2Pureza:98%Forma y color:SolidPeso molecular:279.33HBV-IN-16
CAS:HBV-IN-16, a quinoline derivative, inhibits HBV cccDNA, key for viral replication (from patent WO2019121357A1).Fórmula:C22H20ClNO4Forma y color:SolidPeso molecular:397.85AnnH31
CAS:AnnH31 is a potent Dyrk1A inhibitor with an IC50 value of 81 nM.AnnH31 inhibits MAO-A with an IC50 of 3.2 μM.AnnH31 can be used as a probe to confirm theFórmula:C15H13N3OPureza:99.99%Forma y color:SolidPeso molecular:251.28
