Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(95 productos)
- CDK(501 productos)
- Detención del ciclo celular(4 productos)
- Chk(42 productos)
- DYRK(48 productos)
- Dynamin(23 productos)
- Ferroptosis(215 productos)
- HSP(169 productos)
- Integrin(224 productos)
- Kinesina(66 productos)
- LIM quinasa(19 productos)
- Asociado a microtúbulos(262 productos)
- PKC(102 productos)
- PLK(28 productos)
- ROCK(69 productos)
- Rho(2 productos)
- Wee1(15 productos)
- c-Myc(69 productos)
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Se han encontrado 3485 productos de "Ciclo celular / Checkpoint"
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Aurora kinase inhibitor-9
CAS:<p>Aurora kinase inhibitor-9 (9d) targets AURKA/B with IC50: 0.093 μM for A and 0.09 μM for B, with wide anti-proliferative effects.</p>Fórmula:C19H17Cl2N3O4SForma y color:SolidPeso molecular:454.33ML366
CAS:<p>ML366 is a Vibrio cholerae Quorum Sensing inhibitor Acting via the LuxO response regulator.</p>Fórmula:C17H19N3O4Pureza:98%Forma y color:SolidPeso molecular:329.35PV-1019
CAS:<p>PV-1019 (NSC 744039), a potent Chk2 inhibitor, has an IC50 of 24 nM and blocks Chk2 autophosphorylation and IR-induced apoptosis.</p>Fórmula:C18H17N7O3Forma y color:SolidPeso molecular:379.37D-Xylofuranose, 1,2,3,5-tetraacetate
CAS:<p>1,2,3,5-Tetra-O-acetyl-D-xylofuranose is a starting material for the synthesis of nucleosides.</p>Fórmula:C13H18O9Forma y color:SolidPeso molecular:318.28JTK-101
CAS:<p>JTK-101 is a potent and selective Tat-dependent HIV-1 replication inhibitor.</p>Fórmula:C25H23N3O3Forma y color:SolidPeso molecular:413.47LDN-209929 dihydrochloride
CAS:<p>LDN-209929 dihydrochloride: potent haspin kinase inhibitor, 55 nM IC50, 180x more selective than DYRK2.</p>Fórmula:C17H19Cl3N2OSForma y color:SolidPeso molecular:405.77HBX28258
CAS:<p>HBX28258, a human USP7 inhibitor, binds covalently and selectively deactivates USP7 in colon cancer and kidney cells.</p>Fórmula:C26H30ClN3OPureza:98%Forma y color:SolidPeso molecular:435.99Aurora Kinases-IN-2
CAS:<p>Aurora Kinases-IN-2 (12Aj) hinders Aurora A/B kinases (IC50: 90/152 nM), used in cancer studies.</p>Fórmula:C22H18ClN5O3Forma y color:SolidPeso molecular:435.86JNJ-9676
CAS:<p>JNJ-9676 is an orally active inhibitor of the coronavirus membrane protein, thereby blocking viral assembly and release.coronavirus and SARS-CoV.</p>Fórmula:C28H21F2N5O2Pureza:99.83%Forma y color:SoildPeso molecular:497.5OXA-06 Dihydrochloride
CAS:<p>OXA-06 Dihydrochloride is a PANC-1 cell migration and MYPT1 phosphorylation inhibitor.</p>Fórmula:C21H18FN3Pureza:98%Forma y color:SolidPeso molecular:331.39DHODH-IN-3
CAS:<p>DHODH-IN-3: Human DHODH inhibitor with IC50 of 261 nM, Kiapp 32 nM, potential anti-malaria drug.</p>Fórmula:C17H13ClN2O2Pureza:98%Forma y color:SolidPeso molecular:312.75LSN 3213128
CAS:<p>LSN 3213128: a potent oral antifolate targeting AICARFT with IC50s of 16 nM (enzyme) and 19 nM (cells), offers anti-tumor effects.</p>Fórmula:C17H16FN3O4S2Forma y color:SolidPeso molecular:409.45Lysine-methotrexate
CAS:<p>Lysine-methotrexate is an anticancer drug. It is an inhibitor of dihydrofolate reductase.</p>Fórmula:C21H27N9O3Pureza:98%Forma y color:SolidPeso molecular:453.5LY 207702
CAS:<p>LY 207702, a difluorinated purine nucleoside, exhibits antitumor activity in preclinical models.</p>Fórmula:C10H12F2N6O3Pureza:98%Forma y color:SolidPeso molecular:302.24Codon readthrough inducer 1
CAS:<p>Codon readthrough inducer 1 contains pyrimidine bases and shows good readthrough activity.</p>Fórmula:C15H11N3O5Pureza:98%Forma y color:SolidPeso molecular:313.26MS0017509
CAS:<p>MS0017509 is a DNA damage repair inhibitor.</p>Fórmula:C11H10N4Pureza:98%Forma y color:SolidPeso molecular:198.22Myt1-IN-1
CAS:<p>Myt1-IN-1 has anticancer effects that is a potent inhibitor of Myt1 with an IC 50 of <10 nM [1].</p>Fórmula:C16H15ClN4O2Forma y color:SolidPeso molecular:330.77Type II topoisomerase inhibitor 1
CAS:<p>Potent E. coli DNA gyrase inhibitor (IC50: 1.7 nM), targets Asp73; weak topoisomerase IV inhibitor (IC50: 0.98 μM).</p>Fórmula:C18H15N3O4Forma y color:SolidPeso molecular:337.33BSJ-01-175
CAS:<p>BSJ-01-175: Selective, potent covalent inhibitor of CDK12/13, targets cancer cells, inhibits phosphorylated RNA polymerase II, downregulates CDK12 genes.</p>Fórmula:C30H33ClN6O2Forma y color:SolidPeso molecular:545.08Ulecaciclib
CAS:<p>Ulecaciclib: oral, BBB-permeable CDK inhibitor; favorable pharmacokinetics; ki: 0.62 μM (CDK2/A), 3 nM (CDK6/D3), 0.2 nM (CDK4/D1), 0.63 μM (CDK7/H).</p>Fórmula:C25H33FN8SForma y color:SolidPeso molecular:496.65Cdc7-IN-13
CAS:<p>Cdc7-IN-13 (compound 84) is a highly potent CDC7 inhibitor, exhibiting an IC50 value of <1 nM. This compound holds promise for cancer research [1].</p>Fórmula:C18H20N4O2SForma y color:SolidPeso molecular:356.44Tetrahydrouridine
CAS:<p>Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.</p>Fórmula:C9H16N2O6Pureza:98%Forma y color:SolidPeso molecular:248.23GR 144053 trihydrochloride
CAS:<p>platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist</p>Fórmula:C18H30Cl3N5O2Pureza:98%Forma y color:SolidPeso molecular:454.82AZD7762 HCl
CAS:<p>AZD7762 HCl is a checkpoint kinase inhibitor, driving checkpoint abrogation and enhancing DNA-targeted treatment.</p>Fórmula:C17H20ClFN4O2SPureza:98%Forma y color:SolidPeso molecular:398.88VPC-70619
CAS:<p>VPC-70619: Oral, selective N-Myc inhibitor; blocks cancer growth by hindering N-Myc-Max/DNA binding; well-absorbed.</p>Fórmula:C16H8ClF3N4OForma y color:SolidPeso molecular:364.71DAP-81
CAS:<p>DAP-81, a diaminopyrimidine, inhibits Plk1 (IC50: 0.9 nM), disrupts microtubules, causes monopolar spindles; in preclinical studies.</p>Fórmula:C25H20N6O4Forma y color:SolidPeso molecular:468.46CDK4/6-IN-9
CAS:<p>CDK4/6-IN-9 selectively inhibits CDK4/6 (IC50: 905 nM); potential for MM research.</p>Fórmula:C22H23FN8Forma y color:SolidPeso molecular:418.47Phelorphan
CAS:<p>Phelorphan is an inhibitor of enkephalinase.</p>Fórmula:C20H22N2O4SPureza:98%Forma y color:SolidPeso molecular:386.46HBV-IN-16
CAS:<p>HBV-IN-16, a quinoline derivative, inhibits HBV cccDNA, key for viral replication (from patent WO2019121357A1).</p>Fórmula:C22H20ClNO4Forma y color:SolidPeso molecular:397.85Cdc7-IN-9
CAS:<p>Cdc7-IN-9 can be used for the research of cancer which is a potent inhibitor of Cdc7 [1].</p>Fórmula:C15H17N5OSForma y color:SolidPeso molecular:315.39CDK7-IN-12
CAS:<p>CDK7-IN-12 inhibits CDK7 to control transcription and cell cycle, halting tumor growth in vitro/vivo with cancer research potential.</p>Fórmula:C20H19F3N6Forma y color:SolidPeso molecular:400.4Crisnatol mesylate
CAS:<p>Crisnatol, a potent and selective DNA intercalator, has potential anticancer activity.</p>Fórmula:C24H27NO5SForma y color:SolidPeso molecular:441.54CFM-1
CAS:<p>CFM-1 is an antagonist of the anaphase-promoting complex (APC)-2. It also is a cell cycle and apoptosis regulatory protein (CARP)-1 interaction antagonist.</p>Fórmula:C12H7BrN2O2S2Pureza:98%Forma y color:SolidPeso molecular:355.23CID 5951923
CAS:<p>CID 5951923 is an inhibitor of KLF5 transcription factor with an IC50 of 603 nM.</p>Fórmula:C16H18N2O7SPureza:99.95%Forma y color:SolidPeso molecular:382.39BAY-958
CAS:<p>BAY-958 is a potent and selective inhibitor of PTEFb/CDK9.</p>Fórmula:C17H16FN5O3SPureza:98%Forma y color:SolidPeso molecular:389.4Werner syndrome RecQ helicase-IN-3
CAS:<p>Potent WRN inhibitor, Werner syndrome RecQ helicase-IN-3, is orally active with 0.06 µM IC50; exhibits antiproliferative and anticancer effects.</p>Fórmula:C31H30ClF3N8O5Forma y color:SolidPeso molecular:687.07Mps-BAY2b
CAS:<p>Mps-BAY2b is a novel MPS1 inhibitor.</p>Fórmula:C20H23N5OForma y color:SolidPeso molecular:349.43RUC-1
CAS:<p>RUC-1 is an αIIbβ3-selective ADP-induced platelet aggregation inhibitor.</p>Fórmula:C11H15N5OSPureza:98%Forma y color:SolidPeso molecular:265.33Homocarbonyltopsentin
CAS:<p>Homocarbonyltopsentin: Small molecule, binds TSL2 pentaloops, enhances SMN2 E7 splicing, EC50 16 μM.</p>Fórmula:C21H14N4O3Pureza:98%Forma y color:SolidPeso molecular:370.36Indirubin-5-sulfonate
CAS:<p>Indirubin-5-sulfonate inhibits GSK-3β & CDKs with IC50: 55/35/150/300/65 nM for CDK1/B, 2/A&E, 4/D1, 5/p35.</p>Fórmula:C16H10N2O5SPureza:98%Forma y color:SolidPeso molecular:342.33Guanoctine hydrochloride
CAS:<p>Guanoctine hydrochloride has antihypertensive activity.</p>Fórmula:C9H22ClN3Forma y color:SolidPeso molecular:207.74NSC 109555 ditosylate
CAS:<p>Chk2 inhibitor,ATP-competitive</p>Fórmula:C26H32N10O4SPureza:98%Forma y color:SolidPeso molecular:580.6614α-Demethylase/DNA Gyrase-IN-2
CAS:<p>14α-Demethylase/DNA Gyrase-IN-2 (Compound 6a) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.</p>Fórmula:C24H22N4O4Forma y color:SolidPeso molecular:430.46BDM44768
CAS:<p>BDM44768 is an insulin-degrading enzyme (IDE) inhibitor that acts by inducing glucose intolerance.</p>Fórmula:C24H22FN5O3Forma y color:SolidPeso molecular:447.46IRE1α kinase-IN-3
CAS:<p>IRE1α kinase-IN-3 is a potent, ATP-competitive inhibitor of IRE1α (Ki: 480 nM).</p>Fórmula:C29H32N6O3SForma y color:SolidPeso molecular:544.67Mps1-IN-4
CAS:<p>Mps1-IN-4 is a compound that selectively inhibits Monopolar spindle 1 (Mps1), exhibiting antiproliferative properties useful in cancer research.</p>Fórmula:C26H31F3N6O2Forma y color:SolidPeso molecular:516.56CDK7-IN-8
CAS:<p>CDK7-IN-8 is a potent inhibitor of CDK7 (IC50: 54.29 nM) and exhibits inhibitory activity against several cancer cells and in vivo tumor models.</p>Fórmula:C25H38N8O3Forma y color:SolidPeso molecular:498.622'-Deoxy-L-guanosine
CAS:<p>2'-Deoxy-L-guanosine is a nucleoside that shows antibiotic properties by inhibiting protein synthesis, leading to cell death.</p>Fórmula:C10H13N5O4Forma y color:SolidPeso molecular:267.24Nucleoside-Analog-2
CAS:<p>Nucleoside-Analog-2 is a 4'-Azidocytidine analogue, used to against Hepatitis C virus (HCV) replication.</p>Fórmula:C9H11N5O6Pureza:98%Forma y color:SolidPeso molecular:285.21VE-465
CAS:<p>VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events.</p>Fórmula:C22H28N8OSForma y color:SolidPeso molecular:452.58
