Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(116 productos)
- CDK(548 productos)
- Detención del ciclo celular(5 productos)
- Chk(49 productos)
- DYRK(46 productos)
- Dynamin(27 productos)
- Ferroptosis(233 productos)
- HSP(180 productos)
- Integrin(278 productos)
- Kinesina(87 productos)
- LIM quinasa(21 productos)
- Asociado a microtúbulos(274 productos)
- PKC(128 productos)
- PLK(25 productos)
- ROCK(61 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(77 productos)
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Se han encontrado 3939 productos de "Ciclo celular / Checkpoint"
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Balamapimod
CAS:Balamapimod is a reversible inhibitor of Ras/Raf/MEK. It also has a potential anti-tumor activity.Fórmula:C30H32ClN7OSPureza:98%Forma y color:SolidPeso molecular:574.14AB-182
CAS:AB-182 is an aziridine derivative with antitumor activity.Fórmula:C11H22N3O4PForma y color:SolidPeso molecular:291.28Bis-Pro-5FU
CAS:Bis-Pro-5FU enhances oral uptake and safety of 5-FU, an anti-cancer drug for colorectal and pancreatic tumors.Fórmula:C10H7FN2O2Forma y color:SolidPeso molecular:206.17CDK9-IN-15
CAS:CDK9-IN-15: potent CDK9 inhibitor, blocks P-TEFb phosphorylation, inhibits transcription, reduces mRNA, induces tumor cell apoptosis.Fórmula:C16H11N3OSPureza:99.32%Forma y color:SolidPeso molecular:293.34Ref: TM-T60619
1mL*10mM (DMSO)44,00€5mg46,00€10mg71,00€25mg126,00€50mg180,00€100mg260,00€200mg364,00€Ro 43-5054
CAS:Ro 43-5054 is a small molecular, noncyclic peptidomimetic inhibitor.Fórmula:C24H27N5O7Pureza:98%Forma y color:SolidPeso molecular:497.5ROCK-IN-D1
CAS:ROCK-IN-D1 is an effective and selective inhibitor of ROCK.Fórmula:C22H27N5O2SPureza:98%Forma y color:SolidPeso molecular:425.55CTP Synthetase-IN-1
CAS:CTP Synthetase-IN-1 is a cytidine 5'-triphosphate synthetase (CTPS) inhibitor with antitumor activity for the study of arthritis and rheumatoid arthritis.Fórmula:C20H19F3N6O3S2Pureza:98.11% - 99.18%Forma y color:SolidPeso molecular:512.53Ref: TM-T72505
1mg65,00€5mg141,00€1mL*10mM (DMSO)158,00€10mg230,00€25mg477,00€50mg803,00€100mg1.378,00€IRE1α kinase-IN-9
CAS:IRE1α kinase-IN-9 (compound 2) is a potent inhibitor of IRE-1α, demonstrating an average IC50 value of less than 0.1 μM.Fórmula:C24H24N2O6Pureza:98%Forma y color:SolidPeso molecular:436.463,6-DMAD dihydrochloride
CAS:3,6-DMAD dihydrochloride: Potent IRE1α-XBP1s inhibitor, affects IL-6 secretion and RNase activity, used in cancer research.Fórmula:C22H33Cl2N5Forma y color:SolidPeso molecular:438.44CDK7-IN-12
CAS:CDK7-IN-12 inhibits CDK7 to control transcription and cell cycle, halting tumor growth in vitro/vivo with cancer research potential.Fórmula:C20H19F3N6Forma y color:SolidPeso molecular:400.4Crisnatol mesylate
CAS:Crisnatol, a potent and selective DNA intercalator, has potential anticancer activity.Fórmula:C24H27NO5SForma y color:SolidPeso molecular:441.54CDK8-IN-10
CAS:CDK8-IN-10 is a selective and potent inhibitor of cell cycle protein-dependent kinase (CDK8) (IC50: 8.25 nM) that can be used to study cancer.Fórmula:C25H15ClF3N5O3Forma y color:SolidPeso molecular:525.87A 65282
CAS:A 65282: antibacterial isothiazoloquinolone, inhibits P4-unknotting, causes DNA breaks via topoisomerase II.Fórmula:C17H16F2N4O2SPureza:98%Forma y color:SolidPeso molecular:378.4RP-106
CAS:RP-106 is an ATP-competitive inhibitor of CDK5/p25, CDK1/cyclin B, and GSK-3.Fórmula:C17H19N3OPureza:98%Forma y color:SolidPeso molecular:281.35SNX2-1-108
CAS:SNX2-1-108 is a selective CDK8 and CDK19 inhibitor.Fórmula:C21H16N4Pureza:98%Forma y color:SolidPeso molecular:324.38PD 130883
CAS:PD 130883 is a potent lipophilic quinazoline antifolate.Fórmula:C18H15N5O3Pureza:98%Forma y color:SolidPeso molecular:349.34Werner syndrome RecQ helicase-IN-3
CAS:Potent WRN inhibitor, Werner syndrome RecQ helicase-IN-3, is orally active with 0.06 µM IC50; exhibits antiproliferative and anticancer effects.Fórmula:C31H30ClF3N8O5Forma y color:SolidPeso molecular:687.07FD-IN-1
CAS:FD-IN-1 is an orally active Factor D (FD) inhibitor (IC50=12 nM), inhibits Factor XIa and Tryptase β2 with IC50 values of 7.7 and 6.5 μM, respectively.Fórmula:C23H23NO4Pureza:98.85%Forma y color:SolidPeso molecular:377.43Mps-BAY2b
CAS:Mps-BAY2b is a novel MPS1 inhibitor.Fórmula:C20H23N5OForma y color:SolidPeso molecular:349.43XU1
CAS:XU1（Benzo[c][1,8]naphthyridin-6(5h)-One） is an Aurora protein kinase inhibitor used for the treatment of diseases suitable for inhibition, regulation orFórmula:C12H8N2OPureza:97.81% - 99.59%Forma y color:SolidPeso molecular:196.2Apricitabine
CAS:Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-Fórmula:C8H11N3O3SPureza:99.45%Forma y color:SolidPeso molecular:229.26Ref: TM-T14313
1mg283,00€5mg507,00€1mL*10mM (DMSO)592,00€10mg628,00€25mg962,00€50mg1.601,00€100mg2.682,00€Indirubin-5-sulfonate
CAS:Indirubin-5-sulfonate inhibits GSK-3β & CDKs with IC50: 55/35/150/300/65 nM for CDK1/B, 2/A&E, 4/D1, 5/p35.Fórmula:C16H10N2O5SPureza:98%Forma y color:SolidPeso molecular:342.33D-Xylofuranose, 1,2,3,5-tetraacetate
CAS:1,2,3,5-Tetra-O-acetyl-D-xylofuranose is a starting material for the synthesis of nucleosides.Fórmula:C13H18O9Forma y color:SolidPeso molecular:318.28KIF18A-IN-4
CAS:KIF18A-IN-4: Non-competitive KIF18A inhibitor, IC50 6.16 μM, targets mitotic kinesins/kinases, anti-tumor.Fórmula:C22H27N3O3SForma y color:SolidPeso molecular:413.53ROCK-IN-D2
CAS:ROCK-IN-D2 is an effective and selective inhibitor of ROCK.Fórmula:C22H28N6OPureza:98%Forma y color:SolidPeso molecular:392.5Zelpolib
CAS:Zelpolib is a specific inhibitor of DNA polymerase δ (Pol δ), inhibiting DNA replication. antiproliferative.Fórmula:C22H21N3O5S2Pureza:98.79%Forma y color:SolidPeso molecular:471.55BIPM
CAS:BIPM inhibits ROCK2, alters SH-SY5Y cell migration, actin fibers, neurite length, and reduces cofilin phosphorylation.Fórmula:C23H22N2O3Forma y color:SolidPeso molecular:374.431-Methylcytosine
CAS:1-Methylcytosine (4-amino-1-methylpyrimidin-2(1H)-one) is a methylated form of the cytosine and can be used as the nucleobase of hachimoji DNA paired withFórmula:C5H7N3OPureza:99.88%Forma y color:SolidPeso molecular:125.1310-Methyl-10-deazaaminopterin
CAS:10-Methyl-10-deazaaminopterin is a folate analog that shows antitumor activity.Fórmula:C21H23N7O5Pureza:98%Forma y color:SolidPeso molecular:453.45FN-1501-propionic acid
CAS:FN-1501-propionic acid, a CDK2/9 ligand, in conjunction with a CRBN ligand, has been utilized in the design of a PROTAC CDK2/9 degrader.Fórmula:C25H27N9O4Pureza:98%Forma y color:SolidPeso molecular:517.54Cdc7-IN-3
CAS:Cdc7-IN-3 is a potent inhibitor of Cdc7 kinase.Fórmula:C20H22N4O5Pureza:98%Forma y color:SolidPeso molecular:398.41SB-772077B dihydrochloride
CAS:SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).Fórmula:C15H20Cl2N8O2Pureza:98%Forma y color:SolidPeso molecular:415.28Cyclapolin 9
CAS:Cyclapolin 9: Selective PLK1 inhibitor, IC50 500 nM, ATP-competitive, inactive against other kinases.Fórmula:C9H4F3N3O4SPureza:99.64%Forma y color:SolidPeso molecular:307.21Ref: TM-T22700
1mg96,00€5mg205,00€1mL*10mM (DMSO)227,00€10mg319,00€25mg512,00€50mg707,00€100mg964,00€500mg1.935,00€H-1152
CAS:H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).Fórmula:C16H21N3O2SPureza:98%Forma y color:SolidPeso molecular:319.42Nucleoside-Analog-1
CAS:Nucleoside-Analog-1 is a 4′-Azidocytidine analogue, used to against Hepatitis C virus replication.Fórmula:C9H9N5O5Pureza:98%Forma y color:SolidPeso molecular:267.25-Ethynyluridine
CAS:5-Ethynyluridine marks new RNA for RICK, capturing proteins on various RNAs, even nonpolyadenylated types.Fórmula:C11H12N2O6Pureza:99.77% - 99.78%Forma y color:SolidPeso molecular:268.22Ref: TM-T36971
5mg49,00€1mL*10mM (DMSO)54,00€10mg84,00€25mg138,00€50mg236,00€100mg344,00€200mg515,00€JTK-101
CAS:JTK-101 is a potent and selective Tat-dependent HIV-1 replication inhibitor.Fórmula:C25H23N3O3Forma y color:SolidPeso molecular:413.47CAY10746
CAS:CAY10746 selectively inhibits ROCK I/II with IC50s: 0.014/0.003 μM, useful for diabetic retinopathy research.Fórmula:C26H23N3O5Pureza:99.71%Forma y color:SolidPeso molecular:457.48Ref: TM-T36196
2mg34,00€5mg54,00€1mL*10mM (DMSO)54,00€10mg86,00€25mg172,00€50mg260,00€100mg411,00€200mg552,00€IXA6
CAS:IXA6 is an IRE1/XBP1s agonist with potential vasoprotective activity for the study of neurodegenerative diseases such as Parkinson's disease.Fórmula:C22H20ClN3O3SPureza:98.63%Forma y color:SolidPeso molecular:441.93tBID
CAS:tBID is a selective homeodomain-interacting protein kinase 2 (HIPK2) inhibitor (IC50 of 0.33 μM)Fórmula:C11H3Br4N3O2Pureza:98%Forma y color:SolidPeso molecular:528.78LDN-209929 dihydrochloride
CAS:LDN-209929 dihydrochloride: potent haspin kinase inhibitor, 55 nM IC50, 180x more selective than DYRK2.Fórmula:C17H19Cl3N2OSForma y color:SolidPeso molecular:405.77PF-2771
CAS:PF-2771: potent CENP-E inhibitor, IC50 of 16.1 nM, used in cancer treatment.Fórmula:C29H36ClN5O4Pureza:98%Forma y color:SolidPeso molecular:554.08DHODH-IN-4
CAS:DHODH-IN-4 inhibits human & Plasmodium DHODH; IC50: 4 μM (Pf), 0.18 μM (Hs). It has antimalarial properties.Fórmula:C17H12Cl2N2O2Pureza:99.34%Forma y color:SolidPeso molecular:347.2Ref: TM-T11027
1mg109,00€2mg163,00€5mg243,00€1mL*10mM (DMSO)248,00€10mg355,00€25mg532,00€50mg750,00€100mg1.009,00€500mg2.035,00€BMS-688521
CAS:BMS-688521 is an LFA-1/ICAM interaction inhibitor, a small molecule antagonist of LFA-1 with potential anti-inflammatory activity.Fórmula:C26H19Cl2N5O4Pureza:98.87%Forma y color:SolidPeso molecular:536.37Ref: TM-T14676
1mg108,00€5mg264,00€1mL*10mM (DMSO)311,00€10mg371,00€25mg665,00€50mg874,00€100mg1.063,00€200mg1.423,00€SPC-839
CAS:SPC-839 is an IKK-2 Inhibitor with oral activity.Fórmula:C18H14N4O3SForma y color:SolidPeso molecular:366.39PFM03
CAS:PFM03 is a endonuclease inhibitor that specifically blocks Mre11,reduce MRN endonuclease activity, blocking hMRN-mediated endonucleotomy and nuclear exocytosis.Fórmula:C14H15NO2S2Pureza:99.81% - 99.98%Forma y color:SolidPeso molecular:293.4ARN22089
CAS:ARN22089 is an oral active CDC42 GTPase interaction inhibitor that blocks tumour growth in BRAF mutant mouse melanoma models and PDXs in vivo.Fórmula:C23H27N5Pureza:98.37%Forma y color:SolidPeso molecular:373.49Ref: TM-T85727
1mg109,00€5mg260,00€1mL*10mM (DMSO)286,00€10mg385,00€25mg647,00€50mg964,00€100mg1.431,00€200mg1.963,00€DHODH-IN-3
CAS:DHODH-IN-3: Human DHODH inhibitor with IC50 of 261 nM, Kiapp 32 nM, potential anti-malaria drug.Fórmula:C17H13ClN2O2Pureza:98%Forma y color:SolidPeso molecular:312.75MTH1-IN-2
CAS:MTH1-IN-2 is an inhibitor of MutT homolog 1 (MTH1), with anti-tumor activity.Fórmula:C24H27N3O5SPureza:98%Forma y color:SolidPeso molecular:469.55CLT-28643
CAS:CLT-28643 is a specific α5β1-Integrin inhibitor that prevents fibrosis in GFS, inhibits tumor growth and angiogenesis, suppresses fibrosis and inflammation.Fórmula:C19H17N3O4Pureza:99.89%Forma y color:SolidPeso molecular:351.36
