Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(116 productos)
- CDK(548 productos)
- Detención del ciclo celular(5 productos)
- Chk(49 productos)
- DYRK(46 productos)
- Dynamin(27 productos)
- Ferroptosis(233 productos)
- HSP(180 productos)
- Integrin(278 productos)
- Kinesina(87 productos)
- LIM quinasa(21 productos)
- Asociado a microtúbulos(275 productos)
- PKC(128 productos)
- PLK(25 productos)
- ROCK(61 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(77 productos)
Mostrar 10 subcategorías más
Se han encontrado 3943 productos de "Ciclo celular / Checkpoint"
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BA-1049
CAS:BA-1049 is a selective ROCK2 inhibitor.Fórmula:C16H21N3O2SForma y color:SolidPeso molecular:319.42XIE18-6
CAS:XIE18-6 is a novel INK4C inhibitor that blocks p18 activity and promotes ex vivo expansion of human and murine hematopoietic stem cells.Fórmula:C18H15NO6SPureza:99.712%Forma y color:SolidPeso molecular:373.38Beaucage reagent
CAS:Beaucage reagent, which is found to be effective in causing DNA cleavage.Fórmula:C7H4O3S2Pureza:98.50%Forma y color:White To Off-White PowderPeso molecular:200.23GSK-3008348
CAS:GSK-3008348 is an antagonist of integrin alpha(v)beta6.Fórmula:C29H37N5O2Pureza:99.547%Forma y color:SolidPeso molecular:487.64CI-898 HCl
CAS:CI-898 HCl: lipophilic antifolate, DHFR inhibitor, effective on methotrexate-resistant cancers, synergizes with other drugs in advanced P338 leukemia.Fórmula:C19H26Cl3N5O3Forma y color:SolidPeso molecular:478.8CDK4/6-IN-14
CAS:CDK4/6-IN-14: potent CDK4/6 inhibitor, IC50s 10/16 nM, >60-fold selectivity over CDKs 1/2/7/9, selective across 205 kinases.Fórmula:C24H27ClFN7OForma y color:SolidPeso molecular:483.97Trimetrexate glucuronate
CAS:Trimetrexate glucuronate, a folic acid foe, blocks DNA/RNA synthesis by inhibiting purine and thymidylic acid production, may fight tumors.Fórmula:C25H33N5O10Forma y color:SolidPeso molecular:563.564CDK7-IN-15
CAS:CDK7-IN-15 (Compound 8) is an effective CDK7 inhibitor for studying cancers associated with transcriptional dysregulation.Fórmula:C21H24F4N6OSPureza:99.27%Forma y color:SolidPeso molecular:484.51TCS 2314
CAS:TCS 2314, Selective VLA-4 antagonist (IC50=4.4 nM), high clearance/low oral bioavailability, for asthma research.Fórmula:C28H34N4O6Pureza:99.86%Forma y color:SolidPeso molecular:522.59ROCK-IN-4
CAS:ROCK-IN-4: Inhibits ROCK, sustains NO release, disrupts F-actin, hinders HTM cell respiration, aids glaucoma research.Fórmula:C20H26ClFN4O7SForma y color:SolidPeso molecular:520.96USP28-IN-2
CAS:USP28-IN-2 selectively inhibits USP28 (IC50=0.3 μM), degrades c-Myc, kills cancer cells, lowers ankyrin-1/2, and enhances Regorafenib effects.Fórmula:C23H20Cl2N2O3SForma y color:SolidPeso molecular:475.39CCG-257081
CAS:CCG-257081 blocks Rho/MRTF/SRF pathway; prevents fibrosis in mice; useful in cancer and fibrosis research.Fórmula:C24H19ClF3N3O2Pureza:99.60% - 99.94%Forma y color:SolidPeso molecular:473.87DNA Gyrase-IN-2
CAS:DNA Gyrase-IN-2 inhibits E. coli (IC50: 3.29-10.49 μM) and M. tuberculosis (IC50: 4.41-5.61 μM) COX, has antibacterial properties.Fórmula:C24H24N8OS2Forma y color:SolidPeso molecular:504.63ERCC1-XPF-IN-1
CAS:ERCC1-XPF-IN-1: potent ERCC1-XPF inhibitor (IC50: 0.49 μM), hampers CPD removal, boosts UV toxicity, hinders DNA repair.Fórmula:C28H32ClN5O2Forma y color:SolidPeso molecular:506.04CP681301
CAS:CP681301 is a potent CDK5 inhibitor with anti-tumor effects in Drosophila and reduces Glioma stem cells' growth and renewal.Fórmula:C17H22N4OForma y color:SolidPeso molecular:298.38Cdc7-IN-15
CAS:Cdc7-IN-15 (Example 108) is an inhibitor of cdc7 kinase that has potential to be used for cancer research [1].Fórmula:C12H14N4OSForma y color:SolidPeso molecular:262.33Mivobulin Isethionate
CAS:Mivobulin, a tubulin inhibitor (CI-980), may treat glioma, melanoma, prostate, and ovarian cancer, targeting colchicine-binding site.Fórmula:C19H25N5O6SPureza:98%Forma y color:SolidPeso molecular:451.5MLAF50
CAS:MLAF50 is an inhibitor of the REV1 UBM2-Ubiquitin interaction.Fórmula:C15H12I2O4Forma y color:SolidPeso molecular:510.06FD-IN-1
CAS:FD-IN-1 is an orally active Factor D (FD) inhibitor (IC50=12 nM), inhibits Factor XIa and Tryptase β2 with IC50 values of 7.7 and 6.5 μM, respectively.Fórmula:C23H23NO4Pureza:98.85%Forma y color:SolidPeso molecular:377.43JH-XIV-68-3
CAS:JH-XIV-68-3: Selective DYRK1A/B inhibitor; effective in HNSCC cell lines.Fórmula:C21H17F3N8OForma y color:SolidPeso molecular:454.41XU1
CAS:XU1（Benzo[c][1,8]naphthyridin-6(5h)-One） is an Aurora protein kinase inhibitor used for the treatment of diseases suitable for inhibition, regulation orFórmula:C12H8N2OPureza:97.81% - 99.59%Forma y color:SolidPeso molecular:196.2Akt1&PKA-IN-2
CAS:Akt1&PKA-IN-2 ((R)-29) inhibits AKT1, PKAα, CDK2 with IC50s: 0.007, 0.01, 0.69 µM respectively.Fórmula:C20H17Cl2N3OForma y color:SolidPeso molecular:386.27HBV-IN-4
CAS:HBV-IN-4, a phthalazinone, inhibits HBV DNA replication orally (IC50: 14 nM), encouraging genome-free capsids with strong anti-HBV effects.Fórmula:C24H19ClFN5O3Forma y color:SolidPeso molecular:479.89CDK1-IN-1
CAS:CDK1-IN-7 inhibits CDK1 at 161.2 nM, triggers p53-dependent apoptosis, and selectively targets tumor growth.Fórmula:C27H23N5O3Forma y color:SolidPeso molecular:465.5AZD7762 HCl
CAS:AZD7762 HCl is a checkpoint kinase inhibitor, driving checkpoint abrogation and enhancing DNA-targeted treatment.Fórmula:C17H20ClFN4O2SPureza:98%Forma y color:SolidPeso molecular:398.88KIF18A-IN-4
CAS:KIF18A-IN-4: Non-competitive KIF18A inhibitor, IC50 6.16 μM, targets mitotic kinesins/kinases, anti-tumor.Fórmula:C22H27N3O3SForma y color:SolidPeso molecular:413.53FLDP-5
CAS:FLDP-5: BBB-penetrant curcuminoid, induces ROS, DNA damage, S phase arrest, suppresses tumors in LN-18 cells.Fórmula:C21H21NO5Forma y color:SolidPeso molecular:367.4Picoplatin
CAS:Picoplatin, an anti-cancer agent overcoming platinum resistance, alkylates DNA to block replication, transcription, and induce apoptosis.Fórmula:C6H10Cl2N2PtPureza:98%Forma y color:SolidPeso molecular:376.14HHL-6
CAS:HHL-6 is a c-Fos and BDNF protein expression modulator.Fórmula:C19H26N2O3Forma y color:SolidPeso molecular:330.42Antitumor agent-84
Antitumor agent-84 stabilizes G-quadruplex DNA, exhibits potent anti-tumor effects.Fórmula:C24H31N7Forma y color:SolidPeso molecular:417.55TDRL-551
CAS:TDRL-551 is a novel and potent replication protein A (RPA) inhibitor (IC50=18 µM) with potential anticancer activity.TDRL-551 inhibits RPA-DNA interaction andFórmula:C25H23ClIN3O4Pureza:98.09%Forma y color:SolidPeso molecular:591.83Ref: TM-T28935
1mg73,00€5mg160,00€1mL*10mM (DMSO)202,00€10mg250,00€25mg505,00€50mg803,00€100mg1.288,00€Metralindole HCl
CAS:Metralindole is a reversible monoamine oxidase A (RIMA) inhibitor, it was investigated as a potential antidepressant.Fórmula:C15H18ClN3OPureza:98%Forma y color:SolidPeso molecular:291.78Cdc7-IN-5
CAS:Cdc7-IN-5: potent Cdc7 serine-threonine kinase inhibitor, critical for starting DNA replication.Fórmula:C25H23N3O5Pureza:98.4%Forma y color:SolidPeso molecular:445.47Ref: TM-T10727
1mg90,00€5mg215,00€1mL*10mM (DMSO)236,00€10mg356,00€25mg587,00€50mg802,00€100mg1.108,00€H-1152
CAS:H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).Fórmula:C16H21N3O2SPureza:98%Forma y color:SolidPeso molecular:319.42HR22C16
CAS:HR22C16 is an effective, selective, and cell-permeable mitotic kinesin Eg5 inhibitor.Fórmula:C23H23N3O3Forma y color:SolidPeso molecular:389.45MtTMPK-IN-6
CAS:MtTMPK-IN-6 inhibits M. tuberculosis thymidylate kinase with IC50 of 29 μM, promising for TB research.Fórmula:C23H25N3O3Forma y color:SolidPeso molecular:391.46CDK7-IN-2
CAS:CDK7-IN-2 inhibits CDK7, essential for RNA polymerase II activation and cell cycle control, with cancer research potential.Fórmula:C26H39N7O3Forma y color:SolidPeso molecular:497.63Zaurategrast ethyl ester sulfate
CAS:Zaurategrast ethyl ester sulfate is a α4β1/α4β7 integrin antagonist, and used for the treatment of inflammatory and autoimmune disorders.Fórmula:C56H60Br2N8O10SPureza:98%Forma y color:SolidPeso molecular:1197.01Piposulfan
CAS:Piposulfan, a water-insoluble alkylating agent, is used as an antineoplastic and anti-tumor agent.Fórmula:C12H22N2O8S2Forma y color:SolidPeso molecular:386.44XVA143
CAS:XVA143 is an integrin α/β I-like allosteric antagonist, inhibits LFA-1 (αLβ2 integrin)-dependent firm adhesion, induces extended conformations of integrins.Fórmula:C25H21Cl2N3O8Pureza:99.94%Forma y color:SolidPeso molecular:562.36CM03
CAS:CM03 is a cell-selective G-quadruplex ligand with anti-cancer activity, stabilizing G4 genes, useful in pancreatic cancer research.Fórmula:C34H44N6O6Pureza:98.65%Forma y color:SolidPeso molecular:632.75CDK8-IN-7
CAS:CDK8-IN-7 is a potent CDK8 inhibitor with a Kd of 3.5 nM, showing promise for AML research.Fórmula:C30H40N2Forma y color:SolidPeso molecular:428.65Werner syndrome RecQ helicase-IN-4
CAS:Werner syndrome RecQ helicase-IN-4 is a WRN inhibitor with anticancer and anti-proliferative activity, used in colorectal and gastric cancer research.Fórmula:C32H33F3N8O5Pureza:98.27%Forma y color:SolidPeso molecular:666.65Valomaciclovir
CAS:Valomaciclovir is a DNA polymerase inhibitor potentially for treatment of acute herpes zoster and EB virus infection.Fórmula:C15H24N6O4Forma y color:SolidPeso molecular:352.39Valategrast
CAS:Valategrast: potent, oral dual α4β1/α4β7 integrin antagonist, may treat COPD and asthma.Fórmula:C30H32Cl3N3O4Pureza:98%Forma y color:SolidPeso molecular:604.953'-Deoxyuridine-5'-triphosphate
CAS:3'-dUTP, a nucleotide analogue, competitively inhibits RNA polymerases I & II, with a Ki of 2.0 µM.Fórmula:C9H15N2O14P3Forma y color:SolidPeso molecular:468.14CB10-277
CAS:CB10-277 is a synthetic anti-cancer drug related to dacarbazine that alkylates DNA, inhibits DNA replication and repair, and may block DNA synthesis.Fórmula:C9H11N3O2Forma y color:SolidPeso molecular:193.2CAY10746
CAS:CAY10746 selectively inhibits ROCK I/II with IC50s: 0.014/0.003 μM, useful for diabetic retinopathy research.Fórmula:C26H23N3O5Pureza:99.71%Forma y color:SolidPeso molecular:457.48Ref: TM-T36196
2mg34,00€5mg54,00€1mL*10mM (DMSO)54,00€10mg86,00€25mg172,00€50mg260,00€100mg411,00€200mg552,00€5-Aminouridine
CAS:5-Aminouridine (4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)) modifies nucleobases and is incorporated into the target DNA.Fórmula:C9H13N3O6Pureza:99.53%Forma y color:SolidPeso molecular:259.22NSC 693868
CAS:CDKs and GSK-3 inhibitorFórmula:C9H7N5Pureza:98%Forma y color:SolidPeso molecular:185.19
