Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(116 productos)
- CDK(548 productos)
- Detención del ciclo celular(5 productos)
- Chk(49 productos)
- DYRK(46 productos)
- Dynamin(27 productos)
- Ferroptosis(233 productos)
- HSP(180 productos)
- Integrin(278 productos)
- Kinesina(87 productos)
- LIM quinasa(21 productos)
- Asociado a microtúbulos(275 productos)
- PKC(128 productos)
- PLK(25 productos)
- ROCK(61 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(77 productos)
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Se han encontrado 3943 productos de "Ciclo celular / Checkpoint"
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ATB107
CAS:ATB107 is a potent and novel inhibitor of indole-3-glycerol phosphate synthase (IGPS, KD: 3 μM).Fórmula:C21H28N8Pureza:98%Forma y color:SolidPeso molecular:392.5Edatrexate
CAS:Edatrexate (CGP 30694), a Methotrexate analog, combats MTX-resistant tumors and researches various cancers.Fórmula:C22H25N7O5Forma y color:SolidPeso molecular:467.48FINDY
CAS:FINDY selectively inhibits DYRK1A at 35 μM IC50, blocking Ser97 autophosphorylation, useful for neurological disorder research.Fórmula:C16H17NO2S2SiForma y color:SolidPeso molecular:347.53HIV-1 inhibitor-43
CAS:HIV-1 Inhibitor-43 suppresses HIV-1, with EC50: 21.3 nM (Y188L), 6.2 nM (K103N-Y181C), <0.7 nM (K103N/Y181C), and lowers HIV RNA/p24 protein.Fórmula:C24H21ClN2O4SForma y color:SolidPeso molecular:468.95Cdc7-IN-17
CAS:Cdc7-IN-17 is a potent inhibitor of CDC7 with an IC 50 of <10 μM that can be used in cancer research [1].Fórmula:C13H15N5OSForma y color:SolidPeso molecular:289.36Y-9738
CAS:Y-9738 is an agent of hypolipidemic.Fórmula:C15H16ClNO4Pureza:98%Forma y color:SolidPeso molecular:309.74Tripolin A
CAS:Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively)Fórmula:C15H11NO3Pureza:98%Forma y color:SolidPeso molecular:253.25Mycro2
CAS:Mycro2 is an inhibitor of the protein-protein interactions between the bHLHZip proteins c-Myc and Max.Fórmula:C17H11F3N4OS2Forma y color:SolidPeso molecular:408.42Nitracrine dihydrochloride
CAS:Nitracrine dihydrochloride is an acridine antineoplastic agent used in mammary and ovarian tumors. It inhibits RNA synthesis.Fórmula:C18H22Cl2N4O2Forma y color:SolidPeso molecular:397.3HBV-IN-21
CAS:HBV-IN-21 inhibits HBV DNA replication (IC50: 2.2 μM) and binds HBV capsid protein well (KD: 60.0 μM).Fórmula:C17H17FN4OS2Forma y color:SolidPeso molecular:376.47AS-136A
CAS:AS-136A is an orally active MV RdRp inhibitor with antiviral activity that inhibits measles virus and blocks viral RNA synthesis.Fórmula:C17H19F3N4O3SPureza:98.52%Forma y color:SolidPeso molecular:416.42Ref: TM-T62160
1mg215,00€5mg537,00€1mL*10mM (DMSO)590,00€10mg802,00€25mg1.369,00€50mg1.783,00€100mg2.395,00€CDK4/6-IN-7
CAS:CDK4/6-IN-7 is an oral, potent CDK4/6 inhibitor with IC50s of 1.58/4.09 nM, crucial for breast cancer studies.Fórmula:C18H18ClN5O3Forma y color:SolidPeso molecular:387.82Crisnatol
CAS:Crisnatol (BWA770U) is an oral anticancer DNA intercalator, toxic to breast cancer cells, not skin fibroblasts.Fórmula:C23H23NO2Forma y color:SolidPeso molecular:345.43UR-3216
CAS:UR-3216 is a prodrug, selectively antagonizing GPIIb/IIIa receptors orally, with its active form, UR-2992, binding tightly to platelets.Fórmula:C27H29N7O7Pureza:98%Forma y color:SolidPeso molecular:563.56Metralindole
CAS:Metralindole is a reversible inhibitor of monoamine oxidase A (RIMA).Fórmula:C15H17N3OForma y color:SolidPeso molecular:255.32SP-471P
CAS:SP-471P inhibits DENV protease; EC50: DENV1-5.9 μM, DENV2-1.4 μM, DENV3-5.1 μM, DENV4-1.7 μM; CC50 >100 μM; lowers viral RNA synthesis.Fórmula:C33H26BrN5O2Forma y color:SolidPeso molecular:604.5CAY10760
CAS:CAY10760 inhibits RAD51-BRCA2 interaction (EC50=19 μM), reduces homologous recombination by 54%, and hinders BxPC-3/Capan-1 cancer cell proliferation.Fórmula:C28H24ClN3O3Forma y color:SolidPeso molecular:485.965-OHdU
CAS:5-OHdU (5-OHdU) is a major oxidation product of 2'-Deoxycytidine and can be incorporated into DNA in vitro.Fórmula:C9H12N2O6Pureza:99.5%Forma y color:SolidPeso molecular:244.2Ref: TM-T19152
1mg35,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg105,00€25mg192,00€50mg289,00€100mg409,00€200mg590,00€AM-5308
CAS:AM-5308 is a kinesin KIF18A inhibitor that can be used to study cancer.Fórmula:C26H35N5O5SPureza:98.06% - 99.58%Forma y color:SolidPeso molecular:529.65DHODH-IN-19
CAS:DHODH-IN-19, a strong DHODH blocker, may help treat cancer and inflammation. (Patent WO2021238881A1)Fórmula:C22H18ClF6N3O3Forma y color:SolidPeso molecular:521.84IACS-4759
CAS:IACS-4759 is a novel potent and selective MTH1 inhibitor with excellent cell permeability and good metabolic stability in microsomes.Fórmula:C10H17N3O2Forma y color:SolidPeso molecular:211.26CDK4/6-IN-12
CAS:CDK4/6-IN-12 inhibits CDK4/6 with IC50s of 592.3 nM & 3090 nM, useful in cancer research.Fórmula:C12H10N6Forma y color:SolidPeso molecular:238.25Cdc7-IN-4
CAS:Cdc7-IN-4 is a potent inhibitor of Cdc7 kinase.Fórmula:C22H24F3N5O4Pureza:98%Forma y color:SolidPeso molecular:479.45Remdesivir maleate
CAS:Remdesivir (GS-5734) is a broad-spectrum antiviral prodrug effective against SARS-CoV-2 and Ebola, used for research, not human treatment.Fórmula:C31H39N6O12PForma y color:SolidPeso molecular:718.656Olomoucine II
CAS:Olomoucine II, a CDK inhibitor effective on Cdk1/2/4/7/9, also inhibits ERK2, ABCB1, and various virus replications, not effective on measles/influenza.Fórmula:C19H26N6O2Pureza:99.94%Forma y color:SolidPeso molecular:370.45CDK9-IN-15
CAS:CDK9-IN-15: potent CDK9 inhibitor, blocks P-TEFb phosphorylation, inhibits transcription, reduces mRNA, induces tumor cell apoptosis.Fórmula:C16H11N3OSPureza:99.32%Forma y color:SolidPeso molecular:293.34Ref: TM-T60619
1mL*10mM (DMSO)44,00€5mg46,00€10mg71,00€25mg126,00€50mg180,00€100mg260,00€200mg364,00€HIPP
CAS:HIPP is a highly selective inhibitor of antineoplastic CtBP.Fórmula:C9H9NO3Forma y color:SolidPeso molecular:179.17TH470
CAS:TH470, a potent and highly selective inhibitor of LIM kinase 1/2 (LIMK1/2), demonstrates specificity with IC50 values of 9.8 nM for LIMK1 and 13 nM for LIMK2,Fórmula:C30H31N5O5S2Forma y color:SolidPeso molecular:605.73MK-0668 Mesylate
CAS:MK-0668 Mesylate is the mesylate form of MK-0668 that is a very potent and orally active very late antigen-4 antagonist.Fórmula:C32H34Cl2N6O9S2Forma y color:SolidPeso molecular:781.6810-Formyl-5,8-dideazafolic acid
CAS:10-Formyl-5,8-dideazafolic acid is a thymidylate synthase inhibitor.Fórmula:C22H21N5O7Pureza:96.04%Forma y color:SolidPeso molecular:467.43cp028
CAS:cp028 inhibits pre-mRNA splicing in vitro.Fórmula:C23H17FN2O4Forma y color:SolidPeso molecular:404.39RSK-IN-1
CAS:RSK-IN-1 (compound 7d) shows anti-tumor activity. RSK-IN-1 is an inhibitor of RSK that inhibits the phosphorylation of YB-1 [1].Fórmula:C22H17NO2Forma y color:SolidPeso molecular:327.38NPD9948
CAS:NPD9948 is a competitive inhibitor of MTH1.Fórmula:C13H14N6Forma y color:SolidPeso molecular:254.29LDN-209929
CAS:LDN-209929 2HCl is a potent and selective inhibitor of haspin kinase.Fórmula:C17H17ClN2OSForma y color:SolidPeso molecular:332.85Aurora kinase inhibitor-10
CAS:Aurora kinase inhibitor-10 is an orally active Aurora B inhibitor (IC50: 8 nM) that exhibits antitumour effects.Fórmula:C21H19F5N6O4SForma y color:SolidPeso molecular:546.47Dyrk1A-IN-5
CAS:Potent DYRK1A inhibitor with IC50s: 6 nM overall, 0.5 μM SF3B1, 2.1 μM tau phosphorylation. Useful for Down syndrome studies.Fórmula:C16H9IN2O2Forma y color:SolidPeso molecular:388.16SLM6
CAS:SLM6, an inhibitor of cyclin-dependent kinase-9 (CDK9), exhibits potent anti-multiple myeloma activity.Fórmula:C12H17N7O4Forma y color:SolidPeso molecular:323.31POLA1 inhibitor 1
CAS:POLA1 inhibitor 1: oral, antitumor, effective on various cancers and Adaroten-resistant cells.Fórmula:C26H27NO4Forma y color:SolidPeso molecular:417.5Crozbaciclib fumarate
CAS:Crozbaciclib fumarate is a CDK4/6 inhibitor with IC 50 s of 3 and 1 nM, respectively.Fórmula:C32H34F2N6O4Forma y color:SolidPeso molecular:604.65CRT-0105446
CAS:CRT-0105446 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.Fórmula:C20H18F3N3O2SPureza:98%Forma y color:SolidPeso molecular:421.44Poloxipan
CAS:Poloxipan inhibits PLK1 (IC50: 3.2µM), PLK2 (1.7µM), PLK3 (3µM); minimal effect on Chk2, STAT1, STAT5b, Lck.Fórmula:C14H10BrN3O3SForma y color:SolidPeso molecular:380.22JA2131
CAS:JA2131: Small PARG inhibitor, IC50 0.4μM, induces DNA damage, stalls replication, kills cancer cells.Fórmula:C13H19N5O2S2Forma y color:SolidPeso molecular:341.45DYRKi
CAS:DYRKi is a nontoxic, DYRK1-selective inhibitor.Fórmula:C20H13F3N4O2SForma y color:SolidPeso molecular:430.4BIPM
CAS:BIPM inhibits ROCK2, alters SH-SY5Y cell migration, actin fibers, neurite length, and reduces cofilin phosphorylation.Fórmula:C23H22N2O3Forma y color:SolidPeso molecular:374.43CDK9/10/GSK3β-IN-1
CAS:CDK9/10/GSK3β-IN-1 is a kinase inhibitor (Flavopiridol analogue) that effectively inhibits HsGSK3β, HsCDK9/CyclinT, HsCDK5/p25 and HsCDK2/CyclinA with IC50Fórmula:C29H24ClN3O4SForma y color:SolidPeso molecular:546.04Alsterpaullone, 2-Cyanoethyl
CAS:Alsterpaullone, 2-Cyanoethyl is a selective dual inhibitor of Cdk1/cyclin B and GSK-3β.Fórmula:C19H14N4O3Forma y color:SolidPeso molecular:346.34CK0106023
CAS:CK0106023, a KSP inhibitor, shows strong antitumor effects in mice, outperforming paclitaxel, and induces monopolar spindles.Fórmula:C30H32BrClN4O2Forma y color:SolidPeso molecular:595.96Balamapimod
CAS:Balamapimod is a reversible inhibitor of Ras/Raf/MEK. It also has a potential anti-tumor activity.Fórmula:C30H32ClN7OSPureza:98%Forma y color:SolidPeso molecular:574.14EMD534085
CAS:EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).Fórmula:C25H31F3N4O2Pureza:98%Forma y color:SolidPeso molecular:476.53Akt1&PKA-IN-1
CAS:Akt1&PKA-IN-1 inhibits Akt/PKA: IC50 = 0.03μM (PKAa), 0.11μM (Akt), 9.8μM (CDK2); selective for CDK2.Fórmula:C20H17Cl2N3OForma y color:SolidPeso molecular:386.27
