Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(94 productos)
- CDK(500 productos)
- Detención del ciclo celular(4 productos)
- Chk(42 productos)
- DYRK(48 productos)
- Dynamin(23 productos)
- Ferroptosis(215 productos)
- HSP(169 productos)
- Integrin(224 productos)
- Kinesina(66 productos)
- LIM quinasa(19 productos)
- Asociado a microtúbulos(261 productos)
- PKC(102 productos)
- PLK(28 productos)
- ROCK(69 productos)
- Rho(2 productos)
- Wee1(15 productos)
- c-Myc(69 productos)
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Se han encontrado 3480 productos de "Ciclo celular / Checkpoint"
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hSMG-1 inhibitor 11e
CAS:<p>hSMG-1 inhibitor 11e is an effective and selective inhibitor of hSMG-1 (IC50 <0.05 nM) and can be used in studies about cancer treatment.</p>Fórmula:C26H27N7O3SPureza:99.89%Forma y color:SolidPeso molecular:517.6RP-6685
CAS:<p>RP-6685 is a potent, selective DNA Polθ inhibitor with strong oral efficacy, an IC50 of 5.8 nM, and marked antitumor effects in mice.</p>Fórmula:C22H14F7N5OPureza:99.65%Forma y color:SoildPeso molecular:497.3710-Formylfolic acid
CAS:<p>10-Formylfolic acid is a novel and potent inhibitor of dihydrofolate reductase, which can be used in leukemia research.</p>Fórmula:C20H19N7O7Pureza:98.42%Forma y color:SolidPeso molecular:469.41116-9e
CAS:<p>116-9e (MAL2-11B) is an Hsp70 chaperone DNAJA1 inhibitor with antiviral properties, inhibits SV40 replication, and can be used to study cancer drug resistance.</p>Fórmula:C31H32N2O5Pureza:99.55%Forma y color:SolidPeso molecular:512.6TTP-8307
CAS:<p>TTP-8307 is an antiviral compound that inhibits the replication of rhinoviruses and enteroviruses and is used in the study of viral infections.</p>Fórmula:C27H21FN4OPureza:98.95%Forma y color:SolidPeso molecular:436.48BML-259
CAS:<p>BML-259 inhibits CDK5/CDK2 (IC50: 64/98 nM) for cancer and neurodegeneration research.</p>Fórmula:C14H16N2OSPureza:99.84%Forma y color:SolidPeso molecular:260.35Eprociclovir
CAS:<p>Eprociclovir (A-5021) is a novel acyclovir analog that is a potent inhibitor of EHV1 replication and may be used for the treatment and/or prevention of</p>Fórmula:C11H15N5O3Pureza:98.50% - 99.86%Forma y color:SolidPeso molecular:265.27Peldesine
CAS:<p>Peldesine (BCX 34), an oral purine nucleoside phosphorylase blocker, halts T-cell growth; used in CTCL, psoriasis, HIV research. IC50: 800 nM.</p>Fórmula:C12H11N5OPureza:99.27% - 99.9%Forma y color:SolidPeso molecular:241.25Chiauranib
CAS:<p>Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.</p>Fórmula:C27H21N3O3Pureza:99.22%Forma y color:SolidPeso molecular:435.47GRK6-IN-1
CAS:<p>GRK6-IN-1 (compound 18) is a potent GRK6 blocker, with an IC50 of 120 nM, showing promise for multiple myeloma research.</p>Fórmula:C22H23ClN6O2Pureza:99.37%Forma y color:SolidPeso molecular:438.91D-I03
CAS:<p>D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM.</p>Fórmula:C23H36N6SPureza:99.65%Forma y color:SolidPeso molecular:428.64PS423
CAS:<p>PS423 is a substrate-selective protein kinase PDK1 inhibitor that acts by binding to the PIF-pocket allosteric docking site.</p>Fórmula:C25H23F3O9Pureza:98.81% - 99.26%Forma y color:SolidPeso molecular:524.44UMK57
CAS:<p>UMK57 is a CENP-Ei and MCAK enhancer, selectively promoting k-MT attachment error correction to inhibit chromosome missegregation of small molecule compounds,</p>Fórmula:C17H17N3SPureza:99.81%Forma y color:SolidPeso molecular:295.4BioE-1115
CAS:<p>BioE-1115 is a selective and potent inhibitor of serine-threonine protein kinase (PASK, IC50 = 4 nM). BioE-1115 is a potent inhibitor of CK2α (IC50 = 10 μM).</p>Fórmula:C19H18FN3O2Pureza:97.54%Forma y color:SolidPeso molecular:339.36Poloxin-2
CAS:<p>Poloxin-2 is a potent and selective Plk1 PBD inhibitor with anti-tumour activity that reduces the protein level of Plk1 in HeLa cells.</p>Fórmula:C16H15NO3Pureza:99.67%Forma y color:SolidPeso molecular:269.3Cdk2 Inhibitor II
CAS:<p>Cdk2 Inhibitor II is a selective and potent CDK2 inhibitor50 at 60 nM.</p>Fórmula:C14H11BrN4O3SPureza:97.07%Forma y color:SolidPeso molecular:395.23CDK-IN-2
CAS:<p>CDK-IN-2 (CDK inhibitor II) is a potent and specific CDK9 inhibitor (IC50: <8 nM).</p>Fórmula:C18H19ClFN3O2Pureza:99.67%Forma y color:SolidPeso molecular:363.81SB 328437
CAS:<p>SB 328437 ((S)-methyl 2-(1-naphthamido)-3-(4-nitrophenyl)propanoate) is an effective and selective antagonist of CCR3 (IC50 = 4.5 nM).</p>Fórmula:C21H18N2O5Pureza:99.54%Forma y color:SolidPeso molecular:378.38CHK1-IN-3
CAS:<p>CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).</p>Fórmula:C20H23N9OPureza:98.78%Forma y color:SolidPeso molecular:405.46GS-6620 PM
CAS:<p>GS-6620 PM, oral Hep C polymerase inhibitor prodrug, is a potent GS-6620 derivative with limited activity against other viruses.</p>Fórmula:C13H15N5O4Pureza:98.52% - 98.7%Forma y color:SolidPeso molecular:305.29SB-747651A Dihydrochloride
CAS:<p>SB-747651A dihydrochloride, an MSK1 inhibitor (IC50=11 nM), also targets PRK2, RSK1, p70S6K, ROCK-II; potential in inflammation study.</p>Fórmula:C16H24Cl2N8OPureza:98.05%Forma y color:SolidPeso molecular:415.32(S)-Enitociclib
CAS:<p>(S)-Enitociclib (VIP152) is a selective CDK9 inhibitor that inhibits the transcription of anti-apoptotic and pro-survival proteins.</p>Fórmula:C19H18F2N4O2SPureza:98.98%Forma y color:SolidPeso molecular:404.43CHD1Li 6.11
CAS:<p>CHD1Li 6.11 inhibits CHD1L protein (IC50: 3.3 µM), shrinks CRC tumors in vivo, and is orally active.</p>Fórmula:C21H22BrN5OSPureza:99.04%Forma y color:SolidPeso molecular:472.4Galocitabine
CAS:<p>Galocitabine (Neofrutulon), a thymidylate synthase inhibitor, is used potentially for the treatment of cancer.</p>Fórmula:C19H22FN3O8Pureza:99.89%Forma y color:SolidPeso molecular:439.39DENV-IN-5
CAS:<p>Denv-in-5 is an effective and selective dengue virus (DENV) inhibitor with EC50 values of 1.47, 9.23, 7.08, 8.91 μM for denV-I-IV and 0.1512 μM for HIV-1IIIB.</p>Fórmula:C23H25ClF2N4OSPureza:99.06%Forma y color:SolidPeso molecular:478.999-Isopropylolomoucine
CAS:<p>9-Isopropylolomoucine (N9-Isopropylolomoucine), a cell cycle protein-dependent kinase inhibitor, is a thiopurine.</p>Fórmula:C17H22N6OPureza:99.82%Forma y color:SolidPeso molecular:326.4PCSK9-IN-10
CAS:<p>PCSK9-IN-10: potent oral PCSK9 inhibitor (IC50 = 6.4 µM), upregulates LDLR, curbs atherosclerosis, for hyperlipidemia research.</p>Fórmula:C18H23N5O4Pureza:99.06%Forma y color:SoildPeso molecular:373.41Haspin-IN-3
CAS:<p>Haspin-IN-3 is a potent haspin inhibitor with an IC50 of 14 nM.Haspin-IN-3 has anticancer activity.</p>Fórmula:C16H10N2O3Pureza:98.78%Forma y color:SolidPeso molecular:278.26AGX51
CAS:<p>AGX51 is an antagonist of inhibitor of DNA binding (ID) proteins. AGX51 treatment lead to pan-Id degradation, cell cycle arrest, and cell death.</p>Fórmula:C27H29NO4Pureza:97.65%Forma y color:OilPeso molecular:431.52Cytembena
CAS:<p>Cytembena is a cytostatic and a carcinogenic compound that may increase the incidence of fibroadenomas.Cytembena broadly inhibits DNA biosynthesis.</p>Fórmula:C11H8BrNaO4Pureza:99.35%Forma y color:White PowderPeso molecular:307.07(S)-PF-06873600
CAS:<p>(S)-PF-06873600 is the S enantiomer of PF-06873600 which is an inhibitor of CDK.</p>Fórmula:C20H27F2N5O4SPureza:98.59%Forma y color:SolidPeso molecular:471.52dCeMM2
CAS:<p>dCeMM2 degrades glue by promoting CDK12-cyclin K ubiquitination and degradation via CRL4B ligase interaction.</p>Fórmula:C16H11ClN6OSPureza:99.68%Forma y color:SolidPeso molecular:370.82SEL120-34A
CAS:<p>SEL120-34A inhibits CDK8 (IC50: 4.4 nM) & CDK19 (10.4 nM), less on CDK9 (1070 nM), has antitumor properties.</p>Fórmula:C15H18Br2N4Pureza:99.764% - 99.84%Forma y color:SolidPeso molecular:414.14ERCC1-XPF-IN-2
CAS:<p>ERCC1-XPF-IN-2: Nucleotide repair active, boosts cisplatin, inhibits ERCC1-XPF (IC50: 0.6 μM).</p>Fórmula:C15H13Cl2NO3Pureza:98.21%Forma y color:SolidPeso molecular:326.17Talviraline
CAS:<p>Talviraline (Bay 10-8979) is an RNA-induced DNA polymerase inhibitor.Talviraline is a potent inhibitor of HIV-1-induced cell killing and HIV-1 replication in a</p>Fórmula:C15H20N2O3S2Pureza:99.82%Forma y color:SolidPeso molecular:340.46Talotrexin ammonium
CAS:<p>Talotrexin ammonium, a non-polyglutamic antifolate, inhibits cancer by targeting DHFR.</p>Fórmula:C27H30N10O6Pureza:97.49%Forma y color:SolidPeso molecular:590.59NR2F6 modulator-1
CAS:<p>NR2F6 modulator-1, a potent agent for NR2F6, affects immune response and tumor stem cell activity.</p>Fórmula:C23H17NO5SPureza:98.31%Forma y color:SolidPeso molecular:419.45DDRI-18
CAS:<p>DDRI-18 is an inhibitor that regulates the DNA damage response, has anticancer activity, and inhibits non-homologous end-joining (NHEJ) DNA repair.</p>Fórmula:C26H20N6Pureza:98%Forma y color:SolidPeso molecular:416.48AzddMeC
CAS:<p>AzddMeC (Az-Dcme) is an HIV-1 reverse transcriptase and HIV-1 replication inhibitor with antiretroviral activity.AzddMeC is used in the study of HIV-1 infection</p>Fórmula:C10H14N6O3Pureza:97.14% - 99.62%Forma y color:SolidPeso molecular:266.26NSC16168
CAS:<p>NSC16168 is a selective ERCC1-XPF inhibitor that inhibits DNA repair and potentiates the antitumor activity of cisplatin.</p>Fórmula:C17H15NO9S3Pureza:99.88%Forma y color:SolidPeso molecular:473.5COH34
CAS:<p>COH34 (1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol) is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM.</p>Fórmula:C18H15NOSPureza:99.57%Forma y color:SolidPeso molecular:293.38CRT-0105950
CAS:<p>CRT-0105950 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.</p>Fórmula:C21H16ClN3OSPureza:99.78% - 99.86%Forma y color:SolidPeso molecular:393.89ZIM
CAS:<p>ZIM, from 4-Aminoantipyrine, induces DNA and chromosomal damage, cell death, and phagocytosis, with potential in cancer therapy.</p>Fórmula:C20H19N3O3Pureza:99.85%Forma y color:SolidPeso molecular:349.38ITX3
CAS:<p>ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM.</p>Fórmula:C22H17N3OSPureza:99.02%Forma y color:SolidPeso molecular:371.45Netivudine
CAS:<p>Netivudine, a potent NRTI with anti-varicella activity, treats HIV by inhibiting reverse transcriptase, reducing viral load.</p>Fórmula:C12H14N2O6Pureza:99.78%Forma y color:SolidPeso molecular:282.25HA-1004
CAS:<p>HA-1004 is a inhibitor of PKG, PKA, PKC and MLC.</p>Fórmula:C12H15N5O2SPureza:99.56% - 99.63%Forma y color:SolidPeso molecular:293.34Cdc7-IN-7c
CAS:<p>Cdc7-IN-7c (Cdc7 inhibitor-7c) has antitumor activity and has inhibitory effect on liver cancer, lung cancer, kidney cancer, brain cancer and cervical cancer.</p>Fórmula:C15H17N5OSPureza:98.19% - 99.22%Forma y color:SolidPeso molecular:315.39AS-0141
CAS:<p>AS-0141 (Cdc7-IN-6) 是一种有效的 Cdc7 激酶抑制剂 (IC50=4 nM)，具有抗肿瘤活性。Cdc7 是一种丝氨酸苏氨酸蛋白激酶酶，在细胞周期中对 DNA 复制的启动至关重要。</p>Fórmula:C21H22F3N5O4Pureza:99.97%Forma y color:SolidPeso molecular:465.43Elarofiban
CAS:<p>Elarofiban(RWJ-53308) is a novel and orally active GPIIb/IIIa antagonist.</p>Fórmula:C22H32N4O4Pureza:98.76%Forma y color:SolidPeso molecular:416.51GSK2850163
CAS:<p>GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).</p>Fórmula:C24H29Cl2N3OPureza:99.04%Forma y color:SolidPeso molecular:446.41
