Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(116 productos)
- CDK(548 productos)
- Detención del ciclo celular(5 productos)
- Chk(49 productos)
- DYRK(46 productos)
- Dynamin(27 productos)
- Ferroptosis(233 productos)
- HSP(180 productos)
- Integrin(278 productos)
- Kinesina(87 productos)
- LIM quinasa(21 productos)
- Asociado a microtúbulos(275 productos)
- PKC(128 productos)
- PLK(25 productos)
- ROCK(61 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(77 productos)
Mostrar 10 subcategorías más
Se han encontrado 3944 productos de "Ciclo celular / Checkpoint"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Thiarabine
CAS:Thiarabine displays effective anti-tumor activity. It also inhibition of DNA synthesis.Fórmula:C9H13N3O4SPureza:98%Forma y color:SolidPeso molecular:259.28CK0106023
CAS:CK0106023, a KSP inhibitor, shows strong antitumor effects in mice, outperforming paclitaxel, and induces monopolar spindles.Fórmula:C30H32BrClN4O2Forma y color:SolidPeso molecular:595.96HBV-IN-16
CAS:HBV-IN-16, a quinoline derivative, inhibits HBV cccDNA, key for viral replication (from patent WO2019121357A1).Fórmula:C22H20ClNO4Forma y color:SolidPeso molecular:397.85AS-136A
CAS:AS-136A is an orally active MV RdRp inhibitor with antiviral activity that inhibits measles virus and blocks viral RNA synthesis.Fórmula:C17H19F3N4O3SPureza:98.52%Forma y color:SolidPeso molecular:416.42Ref: TM-T62160
1mg215,00€5mg537,00€1mL*10mM (DMSO)590,00€10mg802,00€25mg1.369,00€50mg1.783,00€100mg2.395,00€IRE1α kinase-IN-8
CAS:IRE1α kinase-IN-8, a benzoheterocyclecarboxaldehyde derivative, serves as a potent inhibitor of IRE-1α.Fórmula:C23H22N2O5Pureza:98%Forma y color:SolidPeso molecular:406.43Dihydro-5-azacytidine acetate
CAS:Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1Fórmula:C10H18N4O7Pureza:98%Forma y color:SolidPeso molecular:306.27DHFR-IN-2
CAS:DHFR-IN-2 (4e) is a potent MtDHFR uncompetitive inhibitor with a 7 μM IC50, promising for TB research.Fórmula:C14H13NO2Forma y color:SolidPeso molecular:227.26SEC inhibitor KL-2
CAS:KL-2: potent SEC inhibitor, selectively disrupts AFF4-CCNT1, dose-dependent, Ki: 1.50 μM.Fórmula:C17H13ClFNO3Pureza:99.86%Forma y color:SolidPeso molecular:333.74CDK4/6-IN-9
CAS:CDK4/6-IN-9 selectively inhibits CDK4/6 (IC50: 905 nM); potential for MM research.Fórmula:C22H23FN8Forma y color:SolidPeso molecular:418.47DAP-81
CAS:DAP-81, a diaminopyrimidine, inhibits Plk1 (IC50: 0.9 nM), disrupts microtubules, causes monopolar spindles; in preclinical studies.Fórmula:C25H20N6O4Forma y color:SolidPeso molecular:468.46Werner syndrome RecQ helicase-IN-4
CAS:Werner syndrome RecQ helicase-IN-4 is a WRN inhibitor with anticancer and anti-proliferative activity, used in colorectal and gastric cancer research.Fórmula:C32H33F3N8O5Pureza:98.27%Forma y color:SolidPeso molecular:666.65Atuveciclib S-Enantiomer
CAS:Atuveciclib S-Enantiomer is a (S)-form of BAY-1143572; a potent, selective CDK9 inhibitor with an IC50 of 16 nM.Fórmula:C18H18FN5O2SPureza:98%Forma y color:SolidPeso molecular:387.43Teloxantrone HCl
CAS:Teloxantrone, a DNA topoisomerase II inhibitor, is used potentially for the treatment of solid tumors.Fórmula:C21H28ClN5O5Forma y color:SolidPeso molecular:465.94Cdc7-IN-13
CAS:Cdc7-IN-13 (compound 84) is a highly potent CDC7 inhibitor, exhibiting an IC50 value of <1 nM. This compound holds promise for cancer research [1].Fórmula:C18H20N4O2SForma y color:SolidPeso molecular:356.44Nexinhib20
CAS:Nexinhib20 is an inhibitor of exosome synthesis and transport with anti-inflammatory activity, inhibits RAB27A and neutral sphingomyelinase 2 (nSMase2) nsMase2.Fórmula:C15H16N4O3Pureza:99.89%Forma y color:SolidPeso molecular:300.31RET-IN-19
CAS:RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.Fórmula:C28H28N6O4SForma y color:SolidPeso molecular:544.62Ulecaciclib
CAS:Ulecaciclib: oral, BBB-permeable CDK inhibitor; favorable pharmacokinetics; ki: 0.62 μM (CDK2/A), 3 nM (CDK6/D3), 0.2 nM (CDK4/D1), 0.63 μM (CDK7/H).Fórmula:C25H33FN8SForma y color:SolidPeso molecular:496.65(R)-Filanesib
CAS:(R)-Filanesib is the R-enantiomer of ARRY-520. (R)-Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor (IC50: 6 nM).Fórmula:C20H22F2N4O2SForma y color:SolidPeso molecular:420.48DHODH-IN-24
CAS:DHODH-IN-24 (compound 16) serves as a powerful inhibitor of human dihydroorotate dehydrogenase (DHODH), exhibiting an IC50 value of 91 nM [1].Fórmula:C26H26N4Forma y color:SolidPeso molecular:394.51Type II topoisomerase inhibitor 1
CAS:Potent E. coli DNA gyrase inhibitor (IC50: 1.7 nM), targets Asp73; weak topoisomerase IV inhibitor (IC50: 0.98 μM).Fórmula:C18H15N3O4Forma y color:SolidPeso molecular:337.33CDK4/6-IN-8
CAS:CDK4/6-IN-8 (Compound 7p) is a selective inhibitor of CDK4 (IC50=5.01 nM) and CDK6 (IC50=3.97 nM).Fórmula:C18H18N6O5Forma y color:SolidPeso molecular:398.37DHODH-IN-3
CAS:DHODH-IN-3: Human DHODH inhibitor with IC50 of 261 nM, Kiapp 32 nM, potential anti-malaria drug.Fórmula:C17H13ClN2O2Pureza:98%Forma y color:SolidPeso molecular:312.75LDN-209929 dihydrochloride
CAS:LDN-209929 dihydrochloride: potent haspin kinase inhibitor, 55 nM IC50, 180x more selective than DYRK2.Fórmula:C17H19Cl3N2OSForma y color:SolidPeso molecular:405.77JTK-101
CAS:JTK-101 is a potent and selective Tat-dependent HIV-1 replication inhibitor.Fórmula:C25H23N3O3Forma y color:SolidPeso molecular:413.47PV-1019
CAS:PV-1019 (NSC 744039), a potent Chk2 inhibitor, has an IC50 of 24 nM and blocks Chk2 autophosphorylation and IR-induced apoptosis.Fórmula:C18H17N7O3Forma y color:SolidPeso molecular:379.37BAY-707
CAS:BAY-707: tolerable in mice, no anticancer efficacy; potent, selective MTH1 inhibitor, IC50 = 2.3 nM; good PK profile.Fórmula:C15H20N4O2Pureza:98%Forma y color:SolidPeso molecular:288.34Aurora kinase inhibitor-9
CAS:Aurora kinase inhibitor-9 (9d) targets AURKA/B with IC50: 0.093 μM for A and 0.09 μM for B, with wide anti-proliferative effects.Fórmula:C19H17Cl2N3O4SForma y color:SolidPeso molecular:454.33Aminopterin sodium
CAS:Aminopterin sodium is an immunosuppressive anticancer drug, blocking folate synthesis by inhibiting dihydrofolate reductase.Fórmula:C19H20N8NaO5Forma y color:SolidPeso molecular:463.41SMAPP1
CAS:SMAPP1 is an activator of protein phosphatase 1 (PP1). SMAPP1 induces PP1 activity in vitro and activates latent HIV-1 provirus in cultured and primary T cells.Fórmula:C27H25N5O5S2Pureza:98%Forma y color:SolidPeso molecular:563.65IMB-10
CAS:IMB-10 is an alphaMbeta2 integrin modulator, inhibiting leukocyte migration and recruitment in vitro and in vivo.Fórmula:C19H15NOS2Forma y color:SolidPeso molecular:337.46Cdc7-IN-14
CAS:Cdc7-IN-14 (compound 82) is a potent CDC7 inhibitor with an IC50 < 1 nM, promising for cancer research.Fórmula:C18H20N4O2SForma y color:SolidPeso molecular:356.44DDD100097
CAS:DDD100097 is a N-myristoyltransferase inhibitor with potential inhibitory effects on Trypanosoma brucei, which can be used to study neurological disorders.Fórmula:C22H30Cl2F2N4O2SPureza:98.89%Forma y color:SolidPeso molecular:523.472-Keto-D-galactose
CAS:2-Keto-D-galactose inhibits DNA synthesis and inhibits the proliferation of in vitro grown Ehrlich ascites tumor cells.Fórmula:C6H10O6Pureza:98%Forma y color:SolidPeso molecular:178.14(R)-DRF053 dihydrochloride
CAS:cdk/CK1 inhibitor,potent and ATP-competitiveFórmula:C23H29Cl2N7OPureza:98%Forma y color:SolidPeso molecular:490.43BI-831266
CAS:BI-831266 is a potent and selective Aurora kinase B inhibitor.Fórmula:C27H38ClN7O2Forma y color:SolidPeso molecular:528.09MK-0668
CAS:MK-0668 is a very potent and orally active very late antigen-4 antagonist.Fórmula:C31H30Cl2N6O6SForma y color:SolidPeso molecular:685.58Eg5 Inhibitor V, trans-24
CAS:Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.Fórmula:C26H21N3O3Pureza:99.75%Forma y color:SolidPeso molecular:423.46Ref: TM-T11155
1mg96,00€5mg193,00€1mL*10mM (DMSO)215,00€10mg289,00€25mg469,00€50mg642,00€100mg858,00€200mg1.153,00€Yoshi-864
CAS:Yoshi-864, an alkyl sulfonate, alkylates DNA to hinder replication; potential anti-cancer agent.Fórmula:C8H20ClNO6S2Forma y color:SolidPeso molecular:325.83AM-TS23
CAS:AM-TS23 is used as a DNA polymerase lambda and beta inhibitor.Fórmula:C17H12N2O3S3Pureza:98%Forma y color:SolidPeso molecular:388.48BPIC
CAS:BPIC is an agent of anti-tumor that acts by inhibiting inflammation and scavenging free radicals.Fórmula:C27H20N2O5Forma y color:SolidPeso molecular:452.46ML366
CAS:ML366 is a Vibrio cholerae Quorum Sensing inhibitor Acting via the LuxO response regulator.Fórmula:C17H19N3O4Pureza:98%Forma y color:SolidPeso molecular:329.35CLK1-IN-2
CLK1-IN-2: Metabolically stable, Clk1-selective inhibitor; IC50=1.7nM; useful in tumor, Duchenne MD, HIV-1, influenza research.Fórmula:C16H12Cl2N2O2SForma y color:SolidPeso molecular:367.25TDRL-X80
CAS:TDRL-X80 inhibits XPA DNA binding; effective on single, double, and cisplatin-damaged DNA; IC50: 18-29 μM (FP), 21-39 μM (ELISA).Fórmula:C23H15ClN2O6Forma y color:SolidPeso molecular:450.83SLK/STK10-IN-1
CAS:SLK/STK10-IN-1 is a selective and potent inhibitor of SLK and STK10 with potential antitumor activity.Fórmula:C17H13ClN2O3Pureza:99.34%Forma y color:SolidPeso molecular:328.75BMH-23
CAS:BMH-23 is an RNA polymerase I inhibitor that acts by causing nucleolar stress and showing potent anticancer activity across many tumor types.Fórmula:C15H15N3Pureza:98%Forma y color:SolidPeso molecular:237.3HBX28258
CAS:HBX28258, a human USP7 inhibitor, binds covalently and selectively deactivates USP7 in colon cancer and kidney cells.Fórmula:C26H30ClN3OPureza:98%Forma y color:SolidPeso molecular:435.99JNJ-9676
CAS:JNJ-9676 is an orally active inhibitor of the coronavirus membrane protein, thereby blocking viral assembly and release.coronavirus and SARS-CoV.Fórmula:C28H21F2N5O2Pureza:99.83%Forma y color:SoildPeso molecular:497.5Ref: TM-T205924
1mg137,00€5mg330,00€1mL*10mM (DMSO)354,00€10mg532,00€25mg1.108,00€50mg1.738,00€100mg2.592,00€BPKDi
CAS:BPKDi is a potent and selective inhibitor of PKD (protein kinase D).Fórmula:C21H28N6OPureza:98%Forma y color:SolidPeso molecular:380.49Aloisine A
CAS:Aloisine A, a CDK/GSK-3 inhibitor with IC50: Cdk1/B-150nM, Cdk2/A-120nM, Cdk2/E-400nM, Cdk5/25-200nM, Cdk5/35-160nM, GSK-3α-500nM, GSK-3β-650nM, JNK-3-10μM.Fórmula:C16H17N3OPureza:98%Forma y color:SolidPeso molecular:267.33ProTAME
CAS:ProTAME inhibits APC/CFzr & APC/CCdc20, enhances cell death with doxorubicin/etoposide in primary/MM cells, especially after TOPIIα upregulation.Fórmula:C34H38N4O12SPureza:98%Forma y color:SolidPeso molecular:726.75
