Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(94 productos)
- CDK(500 productos)
- Detención del ciclo celular(4 productos)
- Chk(42 productos)
- DYRK(48 productos)
- Dynamin(23 productos)
- Ferroptosis(215 productos)
- HSP(169 productos)
- Integrin(224 productos)
- Kinesina(66 productos)
- LIM quinasa(19 productos)
- Asociado a microtúbulos(261 productos)
- PKC(102 productos)
- PLK(28 productos)
- ROCK(69 productos)
- Rho(2 productos)
- Wee1(15 productos)
- c-Myc(69 productos)
Mostrar 10 subcategorías más
Se han encontrado 3480 productos de "Ciclo celular / Checkpoint"
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PLK1-IN-4
CAS:<p>PLK1-IN-4: strong PLK1 blocker (<0.508 nM IC50), inhibits cancer cell growth, triggers G2/M arrest and apoptosis.</p>Fórmula:C24H25F3N6O4SForma y color:SolidPeso molecular:550.55Solitomab
CAS:<p>Solitomab (AMG 110) is a bispecific antibody targeting CD3 and EpCAM, used in uterine/ovarian carcinosarcoma research.</p>Forma y color:LiquidDHODH-IN-14
CAS:<p>DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.</p>Fórmula:C15H7F4N3O3Pureza:99.81%Forma y color:SolidPeso molecular:353.23DHX9-IN-6
CAS:<p>DHX9-IN-6 is a highly effective ATP-dependent RNA helicase A (DHX9) inhibitor, used in cancer research.</p>Fórmula:C23H18ClFN4O4S2Pureza:99.71%Forma y color:SolidPeso molecular:533Senexin C
CAS:<p>Senexin C is a CDK8/19 inhibitor with anticancer activity.Senexin C inhibits the growth of MV4-11 leukemia cells.</p>Fórmula:C28H27N5OPureza:98.06%Forma y color:SolidPeso molecular:449.55DHX9-IN-4
CAS:<p>DHX9-IN-4 is an ATP-dependent RNA helicase DHX9 inhibitor used in cancer research.</p>Fórmula:C21H22ClN5O4S2Pureza:98.12%Forma y color:SolidPeso molecular:508.01MU-380
CAS:<p>MU-380 is an effective and selective inhibitor of CHK1.</p>Fórmula:C15H15BrF3N7Forma y color:SolidPeso molecular:430.23TAK 029
CAS:<p>TAK 029 is a local glycoprotein IIb/IIIa receptor inhibitor.</p>Fórmula:C19H23N5O7Forma y color:SolidPeso molecular:433.42SB-743921 free base
CAS:<p>SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL).</p>Fórmula:C31H33ClN2O3Pureza:98%Forma y color:SolidPeso molecular:517.06T521
CAS:<p>T521 is a selective inhibitor of the PBD of Plk1 and shows no inhibitory effect on Plk2 and Plk3.</p>Fórmula:C17H14FNO5S2Pureza:99.67%Forma y color:SolidPeso molecular:395.43AVG-233
CAS:<p>AVG-233 is an RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity for the study of respiratory syncytial virus infections.</p>Fórmula:C26H22ClN5O3Pureza:99%Forma y color:SolidPeso molecular:487.94Sapacitabine
CAS:<p>Sapacitabine (CS682) is a nucleoside analog precursor with anticancer activity used in the study of leukemia.</p>Fórmula:C26H42N4O5Pureza:98.82%Forma y color:SolidPeso molecular:490.64CDK/HDAC-IN-3
CAS:<p>CDK/HDAC-IN-3 is an orally active dual inhibitor of HDACs and CDKs, offering potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2, and HDAC3,</p>Fórmula:C24H18Cl2N6O3Pureza:98%Forma y color:SolidPeso molecular:509.34CDK9-IN-8
CAS:<p>CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).</p>Fórmula:C31H32FN7O3Pureza:99.54%Forma y color:SolidPeso molecular:569.63αvβ1 integrin-IN-2
CAS:<p>αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of ανβ1 and α5β1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively.</p>Fórmula:C29H38N4O4Pureza:98%Forma y color:SolidPeso molecular:506.64Teclistamab
CAS:<p>Teclistamab(JNJ-64007957) is a human bispecific monoclonal antibody targeting the CD3 receptor on t-cells and the BCMA for relapsed and refractory multiple myeloma.</p>Pureza:95%Forma y color:LiquidAR-13503
CAS:<p>AR-13503, a Netarsudil metabolite, is a ROCK inhibitor, potentially treating glaucoma and lowering eye pressure.</p>Fórmula:C19H19N3O2Forma y color:SolidPeso molecular:321.37Luvixasertib hydrochloride
CAS:<p>CFI-402257 hydrochloride, a highly selective and orally bioavailable inhibitor targeting TTK/Mps1, demonstrates an in vitro IC50 value of 1.7 nM against TTK. This compound exhibits anti-cancer activity [1].</p>Fórmula:C28H31ClN6O3Forma y color:SolidPeso molecular:535.04Mefenidil
CAS:<p>Mefenidil (McN-2378), a selective cerebral vasodilator, was shown to increase CBF in healthy brains without stimulating O2 uptake in a dog anesthesia model.</p>Fórmula:C12H11N3Pureza:98.27%Forma y color:SolidPeso molecular:197.24USP7-IN-13
CAS:<p>USP7-IN-13 (Compound 101), a USP7 inhibitor, exhibits an IC50 range of 0.2-1 μM and is applicable in researching multiple myeloma [1].</p>Fórmula:C24H28N4O3Forma y color:SolidPeso molecular:420.5WRN inhibitor 2
CAS:<p>WRN Inhibitor 2 (example 118), a potent inhibitor of the WRN (Werner Syndrome ATP-dependent helicase enzyme), exhibits a pIC50 value of 7.0 or greater [1].</p>Fórmula:C15H11F3N2O5S2Pureza:98%Forma y color:SolidPeso molecular:420.38CDK9-IN-23
CAS:<p>CDK9-IN-23 (Example 4) is a potent inhibitor of CDK9, exhibiting an IC50 value of less than 20 nM [1].</p>Fórmula:C22H25ClN4O3Pureza:98%Forma y color:SolidPeso molecular:428.91QR-6401
CAS:<p>QR-6401, a selective macrocyclic CDK2 inhibitor, is orally active with IC50 values of 0.37 nM for CDK2/E1, 10 nM for CDK9/T1, 22 nM for CDK1/A2, 34 nM for CDK6/</p>Fórmula:C19H23N5O3Pureza:98%Forma y color:SolidPeso molecular:369.42Tacaciclib
CAS:<p>Tacaciclib is a cyclin-dependent kinase (CDK) inhibitor with observed antineoplastic activity [1].</p>Fórmula:C30H36N6O3Pureza:98%Forma y color:SolidPeso molecular:528.65Palbociclib orotate
CAS:<p>Palbociclib (PD 0332991) orotate, an orally active selective inhibitor of CDK4 and CDK6, exhibits IC50 values of 11 and 16 nM, respectively.</p>Fórmula:C29H33N9O6Pureza:98%Forma y color:SolidPeso molecular:603.63Butylparaben sodium
CAS:<p>Butylparaben sodium significantly impacts the later phases of spermatogenesis in the testes by impairing hormonal regulation and/or RNA and protein synthesis [1</p>Fórmula:C11H13NaO3Pureza:98%Forma y color:SolidPeso molecular:216.21CDK4-IN-2
CAS:<p>CDK4-IN-2 (A17) is a potent inhibitor of CDK4, exhibiting K i and IC 50 values of less than 10 nM and is utilized in cancer research [1].</p>Fórmula:C22H26F2N6O4SPureza:98%Forma y color:SolidPeso molecular:508.54ROCK-IN-10
CAS:<p>ROCK-IN-10 (compound 50) serves as a powerful inhibitor of ROCK, exhibiting IC50 values of 6 nM for ROCK1 and 4 nM for ROCK2, respectively. It demonstrates over 100-fold selectivity towards ROCK1 and ROCK2 when compared to other kinases [1].</p>Fórmula:C25H25N5O3Forma y color:SolidPeso molecular:443.507Cdk4 Inhibitor
CAS:<p>PD 0332991, an unsymmetrical indolocarbazole compound, is cell-permeable and exhibits antiproliferative effects by functioning as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk4/D1 (IC 50 = 76 nM). Although it can inhibit other Cdks, such as Cdk2/E and Cdk1/B, effectiveness requires higher concentrations (IC 50 = 520 nM and 2.1 µM, respectively) and demonstrates minimal activity against CaMKII, PKA, or GSK-3β (IC 50 ≥ 12.4 µM). PD 0332991 efficiently inhibits tumor cell growth in HCT-116 and NCI-H460 cell lines with an IC 50 < 3.0 µM, primarily through blocking Rb phosphorylation and inducing G1 cell cycle arrest.</p>Fórmula:C20H10BrN3O2Forma y color:SolidPeso molecular:404.2DUB-IN-7
CAS:<p>DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].</p>Fórmula:C17H19N5OForma y color:SolidPeso molecular:309.37Leucettinib-92
CAS:<p>Leucettinib-92 (compound 92) is a kinase inhibitor selective for DYRK/CLK families, displaying IC50 values of 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μM</p>Fórmula:C21H22N4OSPureza:98%Forma y color:SolidPeso molecular:378.49α7β1 integrin modulator-1
CAS:<p>α7β1 Integrin Modulator-1 is a potent modulator with research potential for muscular dystrophy [1].</p>Fórmula:C23H29N3O6SPureza:98%Forma y color:SolidPeso molecular:475.56Votoplam
CAS:<p>Votoplam functions as a gene splicing modulator, employed in the inhibition of Huntington's disease [1].</p>Fórmula:C21H25N9OPureza:98%Forma y color:SolidPeso molecular:419.48EHT 5372
CAS:<p>EHT 5372 inhibits DYRK kinases; IC50: 0.22-221 nM for DYRK1A/B, DYRK2/3, CLK1/2/4, GSK-3α/β.</p>Fórmula:C17H11Cl2N5OSForma y color:SolidPeso molecular:404.27WRN inhibitor 5
CAS:<p>WRN Inhibitor 5 (Example 157), a cyclic vinyl sulfone-based compound, serves as an inhibitor of Werner Syndrome ATP-dependent helicase enzyme (WRN).</p>Fórmula:C23H20N2O6SForma y color:SolidPeso molecular:452.48LDC3140
CAS:<p>LDC3140 is a potent inhibitor of Cyclin-dependent kinase 7 (CDK7).</p>Fórmula:C23H33N7OPureza:98%Forma y color:SolidPeso molecular:423.55BVDU 5′-Triphosphate
CAS:<p>BVDU 5′-Triphosphate is an antiviral agent labeled with 5′-Triphosphate that specifically targets viral DNA polymerase.</p>Fórmula:C11H16BrN2O14P3Pureza:98%Forma y color:SolidPeso molecular:573.08ASC-69
CAS:<p>ASC-69 (APY69) is a promising potent inhibitor of the PD-1/PD-L1 signaling pathway, classified as a small-molecule compound [1].</p>Fórmula:C19H19N7Pureza:98%Forma y color:SolidPeso molecular:345.4m-Se3
CAS:<p>m-Se3 is a potent, selective inhibitor of c-MYC transcription with demonstrated capability to inhibit tumor growth and exhibit anti-cancer activity [1].</p>Fórmula:C29H23IN2SePureza:98%Forma y color:SolidPeso molecular:605.37PLK1/p38γ-IN-1
CAS:<p>PLK1/p38γ-IN-1 (compound 14) serves as a dual inhibitor targeting both PLK1 and p38γ kinases, effectively suppressing the proliferation of human hepatocellular</p>Fórmula:C21H26ClN3O2Pureza:98%Forma y color:SolidPeso molecular:387.9αvβ6 integrin inhibitor 2
CAS:<p>αvβ6 Integrin Inhibitor 2 is a potent inhibitor of αvβ6 integrin, demonstrating an inhibition concentration (IC50) of 96.5 nM.</p>Fórmula:C21H30N4O3Pureza:98%Forma y color:SolidPeso molecular:386.49PVZB1194
CAS:<p>PVZB1194, a biphenyl-type inhibitor of Kinesin spindle protein Eg5 (KIF11), exhibits anticancer potential by inducing cell cycle arrest and apoptosis through</p>Fórmula:C13H9F4NO2SPureza:98%Forma y color:SolidPeso molecular:319.28Synstatin (92-119)
CAS:<p>Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 and</p>Fórmula:C133H207N35O46Pureza:98%Forma y color:SolidPeso molecular:3032.27PD-L1-IN-2
CAS:<p>PD-L1-IN-2, a Naamidine J derivative, serves as a promising antineoplastic immunomodulator by hindering PD-L1 activity.</p>Fórmula:C33H38N4O6Pureza:98%Forma y color:SolidPeso molecular:586.68WRN inhibitor 1
CAS:<p>WRN Inhibitor 1 (example 7) is an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN), selectively targeting its helicase domain.</p>Fórmula:C16H13FN2O4SPureza:98%Forma y color:SolidPeso molecular:348.35COH1
CAS:<p>COH1 is a ribonucleotide reductase (RR) inhibitor utilized in research pertaining to cancer, mitochondrial diseases, and neurodegenerative disorders [1].</p>Fórmula:C11H10N2O3SPureza:98%Forma y color:SolidPeso molecular:250.27MC-Val-Cit-PAB-Ispinesib
CAS:<p>MC-Val-Cit-PAB-Ispinesib (Compound 509) is a potent Eg5 inhibitor and a click chemistry reagent [1].</p>Fórmula:C59H71ClN10O10Forma y color:SolidPeso molecular:1115.71FAICAR
CAS:<p>FAICAR (5-Formamidoimidazole-4-carboxamide ribotide), a purine nucleotide, plays a crucial role in metabolic processes.</p>Fórmula:C10H15N4O9PForma y color:SolidPeso molecular:366.22CDK7-IN-25
CAS:<p>CDK7-IN-25 (CY-16-1) is a potent CDK7 inhibitor with an IC50 value of less than 1nM, utilized in cancer research [1].</p>Fórmula:C33H32N6O3Pureza:98%Forma y color:SolidPeso molecular:560.6512R-LOX-IN-1
CAS:<p>12R-LOX-IN-1 (Compound 4a), with an IC50 of 28.25 µM, is an inhibitor of 12R-LOX.</p>Fórmula:C15H11NO2Forma y color:SolidPeso molecular:237.25
