Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(94 productos)
- CDK(500 productos)
- Detención del ciclo celular(4 productos)
- Chk(42 productos)
- DYRK(48 productos)
- Dynamin(23 productos)
- Ferroptosis(215 productos)
- HSP(169 productos)
- Integrin(224 productos)
- Kinesina(66 productos)
- LIM quinasa(19 productos)
- Asociado a microtúbulos(261 productos)
- PKC(102 productos)
- PLK(28 productos)
- ROCK(69 productos)
- Rho(2 productos)
- Wee1(15 productos)
- c-Myc(69 productos)
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Se han encontrado 3480 productos de "Ciclo celular / Checkpoint"
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NVS-SM2
CAS:<p>NVS-SM2 boosts SMN2 splicing, enhances exon 7 inclusion, and raises SMN protein levels orally.</p>Fórmula:C23H30N6OForma y color:SolidPeso molecular:406.52Homouridine
CAS:<p>Homouridine, an analogue of uridine, functions as an intermediate in the synthesis of MMP-2 inhibitor (compound I, IC50 = 150 μM).</p>Fórmula:C10H14N2O6Pureza:98%Forma y color:SolidPeso molecular:258.23CDK4/6-IN-17
CAS:<p>CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells.</p>Fórmula:C27H28F4N8Pureza:98%Forma y color:SolidPeso molecular:540.563-Hydroxyxanthone
CAS:<p>3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical vein</p>Fórmula:C13H8O3Pureza:98%Forma y color:SolidPeso molecular:212.2CDK9-IN-2
CAS:<p>CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.</p>Fórmula:C23H25ClFN5Pureza:99%Forma y color:SolidPeso molecular:425.93G-5758
CAS:<p>G-5758 is an orally active IRE1α inhibitor with an IC50 of 38 nM for XBP1s. It is used in studies involving multiple myeloma models [KMS-11], demonstrating good tolerance in rats at oral doses up to 500 mg/kg. G-5758 exhibits pharmacodynamic effects comparable to those induced by IRE1 knockdown.</p>Fórmula:C27H24F4N6O3SForma y color:SolidPeso molecular:588.58ATN-161
CAS:<p>ATN-161 is an integrin α5β1 binding peptide and antagonist that inhibits VEGF-induced hCECs migration and angiogenesis.</p>Fórmula:C23H35N9O8SPureza:98%Forma y color:SolidPeso molecular:597.64Netropsin dihydrochloride
CAS:<p>Netropsin dihydrochloride, a small MGB, blocks topoisomerase I/II, hindering cleavable complex stabilization.</p>Fórmula:C18H28Cl2N10O3Pureza:98%Forma y color:SolidPeso molecular:503.39USP1-IN-3
CAS:<p>USP1-IN-3 is a selective inhibitor of USPI that inhibits USPI-UAFI (IC50<30 nM). USP1-IN-3 can be used to study cancer.</p>Fórmula:C27H24F3N7OForma y color:SolidPeso molecular:519.52Emzadirib
CAS:<p>Emzadirib (RAD51-IN-2) is a potent RAD51 inhibitor with potential anticancer activity for the study of DNA damage repair.</p>Fórmula:C27H40N4O6S2Pureza:99.79% - 99.9%Forma y color:SolidPeso molecular:580.76Senexin A hydrochloride
CAS:<p>Senexin A hydrochloride functions as a selective inhibitor of CDK8/19, with an IC 50 of 280 nM for CDK8, and specifically inhibits p21-induced transcription without affecting other biological effects of p21. Additionally, it suppresses CMV-GFP induction and the stimulatory activity of the consensus NF-κB-dependent promoters [1] [2].</p>Fórmula:C17H15ClN4Forma y color:SolidPeso molecular:310.78CDK9-IN-29
CAS:<p>CDK9-IN-29 (compound Z11) is a potent inhibitor of CDK9, exhibiting high kinase selectivity and an IC50 value of 3.20 nM.</p>Fórmula:C29H33F2N5O4Pureza:98%Forma y color:SolidPeso molecular:553.6CDK-IN-11
CAS:<p>CDK-IN-11, a heterocyclic compound, promotes cardiomyocyte maturation [1].</p>Fórmula:C25H21BrN4O2Forma y color:SolidPeso molecular:489.36WRN inhibitor 3
CAS:<p>WRN Inhibitor 3 (example 110), a cyclic vinyl sulfone-based compound, serves as an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN).</p>Fórmula:C20H20N2O5SForma y color:SolidPeso molecular:400.45WRN inhibitor 4
CAS:<p>WRN Inhibitor 4 (Example 107), a cyclic vinyl sulfone-based compound, serves as an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN).</p>Fórmula:C16H14N2O5SForma y color:SolidPeso molecular:346.36Nε-(1-Carboxyethyl)-L-lysine
CAS:<p>Nε-(1-Carboxyethyl)-L-lysine (CEL) is an advanced glycation end-product (AGE). Exposure to CEL reduces glutamate uptake and S100B secretion in the hippocampus.</p>Fórmula:C9H18N2O4Forma y color:SolidPeso molecular:218.25c-Myc inhibitor 8
CAS:<p>c-Myc inhibitor 8 suppresses cell growth in various cancers and is used in research.</p>Fórmula:C19H12BrClF3NO3S2Forma y color:SolidPeso molecular:538.79CT1113
CAS:<p>CT1113, a potent inhibitor of both USP28 and USP25, effectively reduces MYC levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer CDX</p>Fórmula:C25H29N5O2SForma y color:SolidPeso molecular:463.69-Deazaguanine
CAS:<p>9-Deazaguanine is a nucleoside analogue exhibiting inhibitory activity against bovine purine nucleoside phosphorylase (PNP).</p>Fórmula:C6H6N4OPureza:98%Forma y color:SolidPeso molecular:150.14GGTI 2147
CAS:<p>GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.</p>Fórmula:C28H30N4O3Pureza:98.69%Forma y color:SolidPeso molecular:470.56(2S,3R)-Voruciclib
CAS:<p>(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. It is an orally active CDK inhibitor.</p>Fórmula:C22H19ClF3NO5Pureza:98%Forma y color:SolidPeso molecular:469.84UNC2170 maleate
CAS:<p>53BP1-binding protein 1 (53BP1) engages with dimethylated lysine 20 on histone 4 (H4K20me2) through its tandem tudor domains within a homodimer configuration, crucial for the DNA damage response. UNC2170, a micromolar 53BP1 ligand, selectively interacts with this site, demonstrating at least 17-fold preference for 53BP1 over similar proteins. This interaction occurs in a pocket formed by the 53BP1's tudor domains. Moreover, UNC2170 acts as an antagonist to 53BP1 in cellular lysates, effectively inhibiting class switch recombination, a process dependent on the functional 53BP1 tudor domain, thus confirming its cellular activity.</p>Fórmula:C14H21BrN2OC4H4O4Forma y color:SolidPeso molecular:429.31L-739758
CAS:<p>L-739758 is a glycoprotein IIb/IIIa inhibitor.</p>Fórmula:C22H26N4O5S3Forma y color:SolidPeso molecular:522.66CCT-271850
CAS:<p>CCT-271850 is an inhibitor of the spindle checkpoint function of Monospindle 1.</p>Fórmula:C24H29N7OPureza:98%Forma y color:SolidPeso molecular:431.53CCG-232964
CAS:<p>CCG-232964 is an orally active Rho/MRTF/SRF inhibitor that suppresses LPA-induced CTGF gene expression [1].</p>Fórmula:C15H15ClN2O3SPureza:98%Forma y color:SolidPeso molecular:338.81ROCK-IN-9
CAS:<p>ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM.</p>Fórmula:C20H20FN5O2Pureza:98%Forma y color:SolidPeso molecular:381.45'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)
CAS:<p>5'-ODMT cEt N-Bzm5 C Phosphoramidite is a strong modified nucleic acid analog for antisense oligos.</p>Fórmula:C49H56N5O9PForma y color:SolidPeso molecular:889.97Sovesudil
CAS:<p>Sovesudil (PHP-201) is a potent ROCK inhibitor with IC50 of 3.7 nM/2.3 nM for ROCK-I/II; lowers IOP without hyperemia.</p>Fórmula:C23H22FN3O3Forma y color:SolidPeso molecular:407.44DDD85646
CAS:<p>DDD85646 is an inhibitor of T. brucei N-myristoyltransferase with a Ki of 1.44 nM, an IC50 of 2 nM and an EC50 of 2 nM. The IC50 of hNMT is 4 nM.</p>Fórmula:C21H24Cl2N6O2SPureza:97.8% - 99.76%Forma y color:SolidPeso molecular:495.43Phototrexate
CAS:<p>Phototrexate, a photochromic Methotrexate analog, is a UVA-activated, reversible DHFR inhibitor with antifolate properties (IC50: 6 nM cis vs. 34 μM trans).</p>Fórmula:C20H19N7O5Forma y color:SolidPeso molecular:437.41SB-267268
CAS:<p>SB-267268: αvβ3 inhibitor (IC50: 0.68 nM human, 0.29 nM mouse), blocks αvβ3/αvβ5 integrins (Ki: 0.9 nM human, 0.5 nM monkey αvβ3, 0.7 nM human αvβ5).</p>Fórmula:C22H24F3N3O4Pureza:98%Forma y color:SolidPeso molecular:451.44TNP-351
CAS:<p>Tnp 351 is a novel antifolate drug being assessed for chemotherapy of lung cancer.</p>Fórmula:C21H24N6O5Forma y color:SolidPeso molecular:440.45USP7-IN-12
CAS:<p>USP7-IN-12 (compound 1) is a potent, orally active inhibitor of Usp7, exhibiting an IC50 of 3.67 nM and demonstrating antiproliferative activity [1].</p>Fórmula:C29H28ClFN4O2SForma y color:SolidPeso molecular:551.07Gly-Arg-Gly-Asp-Ser TFA
CAS:<p>Gly-Arg-Gly-Asp-Ser (TFA), osteopontin domain, binds αvβ3 and αvβ5 integrins; IC50s: ~5 μM, ~6.5 μM.</p>Fórmula:C19H31F3N8O11Forma y color:SolidPeso molecular:604.49CCT241533
CAS:<p>CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).</p>Fórmula:C23H27FN4O4Pureza:98%Forma y color:SolidPeso molecular:442.48Integrin Antagonists 27
CAS:<p>Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist. It has a binding affinity of 18 nM and as a novel anticancer agent.</p>Fórmula:C24H20N4O5Forma y color:SolidPeso molecular:444.44ML 315 hydrochloride
CAS:<p>ML 315, a selective dual inhibitor targeting CDK (Cyclin-Dependent Kinase) and DYRK (Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase) with IC50 values of 68 nM and 282 nM, respectively, is utilized in research pertaining to cancer and neurological diseases [1].</p>Fórmula:C18H14Cl3N3O2Forma y color:SolidPeso molecular:410.682OXA-06 hydrochloride
CAS:<p>OXA-06 hydrochloride, an ATP-competitive ROCK inhibitor, impedes anchorage-dependent growth and invasion in non-small cell lung cancer cell lines. It effectively inhibits cofilin phosphorylation without inducing apoptosis [1].</p>Fórmula:C21H20Cl2FN3Forma y color:SolidPeso molecular:404.31Kif15-IN-2
CAS:<p>Kif15-IN-2 is a kinesin Kif15 inhibitor with potential anticancer activity and can be used in prostate cancer research.</p>Fórmula:C20H20N6O4SPureza:98.17%Forma y color:SolidPeso molecular:440.48Lerociclib
CAS:<p>Lerociclib (G1T38) is a CDK4/6 inhibitor with anticancer and antitumor activities, inhibiting CDK4/CyclinD1 and CDK6/CyclinD3.</p>Fórmula:C26H34N8OPureza:99%Forma y color:SolidPeso molecular:474.6Galidesivir hydrochloride
CAS:<p>Galidesivir hydrochloride is an inhibitor of viral RNA-dependent RNA polymerase (RdRp). It inhibits SARS-CoV-2 by tightly binding to its RdRp.</p>Fórmula:C11H16ClN5O3Pureza:98%Forma y color:SolidPeso molecular:301.73Riviciclib
CAS:<p>Riviciclib, a CDK inhibitor (CDK9/T1, CDK4/D1, CDK1/B), has IC50s: 20, 63, 79 nM respectively, and fights cisplatin-resistant tumors.</p>Fórmula:C21H20ClNO5Pureza:98%Forma y color:SolidPeso molecular:401.84(S)-Cdc7-IN-18
CAS:<p>'(S)-Cdc7-IN-18 from patent WO2020239107A1 inhibits CDC7, curbing MCM2 and tumor growth.'</p>Fórmula:C19H21N5OSForma y color:SolidPeso molecular:367.47TC-I 15
CAS:<p>α2β1 integrin inhibitor</p>Fórmula:C23H28N4O6S2Pureza:98%Forma y color:SolidPeso molecular:520.62GSK2646264
CAS:<p>GSK2646264 (Compound 44) inhibits SYK (pIC50=7.1) and kinases like LCK, LRRK2; penetrates skin.</p>Fórmula:C24H26N2O2Forma y color:SolidPeso molecular:374.48Carotegrast
CAS:<p>Carotegrast, an orally available α4 integrin receptor inhibitor, has anti-inflammatories activities.</p>Fórmula:C27H24Cl2N4O5Forma y color:SolidPeso molecular:555.41USP1-IN-6
CAS:<p>USP1-IN-6 (Compound 11) functions as a potent USP1 inhibitor, exhibiting an IC50 value of less than 50 nM.</p>Fórmula:C29H27F3N8OForma y color:SolidPeso molecular:560.57CDK8-IN-3
CAS:<p>CDK8-IN-3 is an inhibitor of CDK8.</p>Fórmula:C22H23N5O2Pureza:98%Forma y color:SolidPeso molecular:389.45Bisindolylmaleimide X hydrochloride
CAS:<p>Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).</p>Fórmula:C26H25ClN4O2Pureza:99.23%Forma y color:SolidPeso molecular:460.96FT206
CAS:<p>FT206 is a carboxamide inhibitor of ubiquitin-specific protease[1].</p>Fórmula:C25H29N5OSForma y color:SolidPeso molecular:447.6
