Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(116 productos)
- CDK(548 productos)
- Detención del ciclo celular(5 productos)
- Chk(49 productos)
- DYRK(46 productos)
- Dynamin(27 productos)
- Ferroptosis(233 productos)
- HSP(180 productos)
- Integrin(279 productos)
- Kinesina(87 productos)
- LIM quinasa(21 productos)
- Asociado a microtúbulos(275 productos)
- PKC(130 productos)
- PLK(25 productos)
- ROCK(61 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(77 productos)
Mostrar 10 subcategorías más
Se han encontrado 3946 productos de "Ciclo celular / Checkpoint"
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BPKDi
CAS:BPKDi is a potent and selective inhibitor of PKD (protein kinase D).Fórmula:C21H28N6OPureza:98%Forma y color:SolidPeso molecular:380.49Aloisine A
CAS:Aloisine A, a CDK/GSK-3 inhibitor with IC50: Cdk1/B-150nM, Cdk2/A-120nM, Cdk2/E-400nM, Cdk5/25-200nM, Cdk5/35-160nM, GSK-3α-500nM, GSK-3β-650nM, JNK-3-10μM.Fórmula:C16H17N3OPureza:98%Forma y color:SolidPeso molecular:267.33αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)
αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).Fórmula:C28H35F3N6O8SPureza:98%Forma y color:SolidPeso molecular:672.67ProTAME
CAS:ProTAME inhibits APC/CFzr & APC/CCdc20, enhances cell death with doxorubicin/etoposide in primary/MM cells, especially after TOPIIα upregulation.Fórmula:C34H38N4O12SPureza:98%Forma y color:SolidPeso molecular:726.75GSK-3008348
CAS:GSK-3008348 is an antagonist of integrin alpha(v)beta6.Fórmula:C29H37N5O2Pureza:99.547%Forma y color:SolidPeso molecular:487.64TP1287
CAS:TP-1287 is an oral phosphate prodrug of the CDK9 inhibitor, alvocidib.Fórmula:C21H21ClNO8PForma y color:SolidPeso molecular:481.82R-82913
CAS:R-82913 blocks RNA-polymerase, lowers mouse DOI-head-shakes, halts 13 HIV-1 strains with 0.15µM IC50, beats AZT-TP by 20x; ineffective on HIV-2.Fórmula:C16H20ClN3SForma y color:SolidPeso molecular:321.87UCK2 Inhibitor-1
CAS:UCK2 Inhibitor-1 is a non-competitive UCK2 inhibitor with an IC 50 of 4.7 µM .Fórmula:C27H21N3O4SForma y color:SolidPeso molecular:483.54RTC14
CAS:RTC14 induces PTC readthrough, restoring dystrophin and aiding muscle function in Duchenne model mice.Fórmula:C17H18N2O3Forma y color:SolidPeso molecular:298.34Epiroprim
CAS:Epiroprim (Ro11-8958) is a selective dihydrofolate reductase (DHFR) inhibitor with antibacterial activity, inhibiting Staphylococcus and Streptococcus.Fórmula:C19H23N5O2Pureza:99.68% - >99.99%Forma y color:SolidPeso molecular:353.42Braco-19 trihydrochloride
CAS:BRACO19 3HCl inhibits telomerase, blocking its capping function, and prevents HAdV viral replication.Fórmula:C35H46Cl3N7O2Pureza:98.74%Forma y color:SolidPeso molecular:703.1412(S)-HpETE
CAS:12(S)-HpETE activates human blood leukocyte 5-LOE and mediates induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction.Fórmula:C20H32O4Forma y color:SolidPeso molecular:336.47OXA-06 Dihydrochloride
CAS:OXA-06 Dihydrochloride is a PANC-1 cell migration and MYPT1 phosphorylation inhibitor.Fórmula:C21H18FN3Pureza:98%Forma y color:SolidPeso molecular:331.39Bis-Pro-5FU
CAS:Bis-Pro-5FU enhances oral uptake and safety of 5-FU, an anti-cancer drug for colorectal and pancreatic tumors.Fórmula:C10H7FN2O2Forma y color:SolidPeso molecular:206.17Mivobulin Isethionate
CAS:Mivobulin, a tubulin inhibitor (CI-980), may treat glioma, melanoma, prostate, and ovarian cancer, targeting colchicine-binding site.Fórmula:C19H25N5O6SPureza:98%Forma y color:SolidPeso molecular:451.5β-catenin-IN-3
CAS:β-catenin-IN-3 is a selective and potent β-catenin inhibitor (KD: 54.96 nM) that targets a cryptic regulatory site of β-catenin and significantly reduces theFórmula:C19H20Br2N2OSForma y color:SolidPeso molecular:484.25Nitracrine
CAS:Nitracrine: a 1-nitroacridine, hypoxia-selective, anti-tumor agent; inhibits RNA synthesis, binds DNA reversibly and forms covalent adducts.Fórmula:C18H20N4O2Pureza:98%Forma y color:SolidPeso molecular:324.38Synucleozid
CAS:Synucleozid is a potent the SNCA mRNA inhibitor that encodes α-synuclein protein (IC50=1.5 μM), has the potential for the investigation of Parkinson’s disease.Fórmula:C22H20N6Pureza:98%Forma y color:SolidPeso molecular:368.43PF-4950834
CAS:PF-4950834, a ATP-competitive, selective Rho kinase inhibitor, provides therapeutic benefits in chronic inflammatory diseases.Fórmula:C21H19N3O2Pureza:98%Forma y color:SolidPeso molecular:345.39PV-1115
CAS:PV-1115 is an effective and highly selective inhibitor of the Chk2.Fórmula:C20H19N7O3Pureza:98%Forma y color:SolidPeso molecular:405.41CCT245737(S)
CAS:CCT245737(S) is a highly selective oral checkpoint kinase 1 (CHK1) inhibitor.Fórmula:C16H16F3N7OForma y color:SolidPeso molecular:379.34Photoregulin3
CAS:Photoregulin3 is a inhibitor of rod photoreceptor gene expression, potentially though Nr2e3 modulation.Fórmula:C22H23N3O3Forma y color:SolidPeso molecular:377.44Levoleucovorin disodium
CAS:Levoleucovorin disodium is the sodium salt of the enantiomerically active form of Folinic Acid.Fórmula:C20H21N7Na2O7Pureza:98%Forma y color:SolidPeso molecular:517.41HIV-1 inhibitor-43
CAS:HIV-1 Inhibitor-43 suppresses HIV-1, with EC50: 21.3 nM (Y188L), 6.2 nM (K103N-Y181C), <0.7 nM (K103N/Y181C), and lowers HIV RNA/p24 protein.Fórmula:C24H21ClN2O4SForma y color:SolidPeso molecular:468.95Bofumustine
CAS:Bofumustine is a chloroethyl nitrosourea with anti tumor properties.Fórmula:C18H21ClN4O9Forma y color:SolidPeso molecular:472.83(S)-LY3177833 hydrate
CAS:(S)-LY3177833 ((S)-Example 2) hydrate, an orally active CDC7 kinase inhibitor, exhibits extensive in vitro anticancer efficacy.Fórmula:C16H14FN5O2Forma y color:SolidPeso molecular:327.31LY 207702
CAS:LY 207702, a difluorinated purine nucleoside, exhibits antitumor activity in preclinical models.Fórmula:C10H12F2N6O3Pureza:98%Forma y color:SolidPeso molecular:302.24(Rac)-Managlinat dialanetil
CAS:Managlinat dialanetil, an orally available and potent inhibitor of fructose 1,6-bisphosphatase (FBPase) used in research 2 type diabetes.Fórmula:C21H33N4O6PSPureza:98.52%Forma y color:SolidPeso molecular:500.55CDK-IN-10
CAS:CDK-IN-10 is a cell cycle protein-dependent kinase (CDK) inhibitor with potential anticancer activity for cancer research.Fórmula:C18H18N4O2Pureza:97.07%Forma y color:SolidPeso molecular:322.36DHODH-IN-12
CAS:DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.Fórmula:C10H9N3O2Pureza:99.53%Forma y color:SolidPeso molecular:203.2Ref: TM-T11021
1mg73,00€1mL*10mM (DMSO)122,00€5mg149,00€10mg213,00€25mg319,00€50mg447,00€100mg610,00€200mg823,00€CGP 53353
CAS:CGP 53353 (DAPH-7) is a PKC inhibitor with inhibitory effects on PKCβII and PKCβI and can be used to study atherosclerosis.Fórmula:C20H13F2N3O2Pureza:98.11%Forma y color:SolidPeso molecular:365.33CDK2-IN-12
CAS:CDK2-IN-12 (10b), potent CDK2 inhibitor, IC50: 11.6 μM; inhibits hCA I/II/IX/XII, KI: 3534/638.4/44.3/48.8 nM; anti-cancer properties.Fórmula:C20H17N9O2SForma y color:SolidPeso molecular:447.47Codon readthrough inducer 1
CAS:Codon readthrough inducer 1 contains pyrimidine bases and shows good readthrough activity.Fórmula:C15H11N3O5Pureza:98%Forma y color:SolidPeso molecular:313.26JFN05510
CAS:Compound: 3'-O-tert-BDMS-5'-O-DMT-N2-IBG 2'-CE phosphoramidite; has anticancer properties and activates enzymes.Fórmula:C50H68N7O9PSiForma y color:SolidPeso molecular:970.18MS0017509
CAS:MS0017509 is a DNA damage repair inhibitor.Fórmula:C11H10N4Pureza:98%Forma y color:SolidPeso molecular:198.22Picoplatin
CAS:Picoplatin, an anti-cancer agent overcoming platinum resistance, alkylates DNA to block replication, transcription, and induce apoptosis.Fórmula:C6H10Cl2N2PtPureza:98%Forma y color:SolidPeso molecular:376.14CDK2-IN-11
CAS:CDK2-IN-11 inhibits CDK2 (IC50: 6.4 μM) and targets hCA II, IX, XII (Ki: 23.4-56.3 nM); suited for cancer research.Fórmula:C18H14ClN7O2SForma y color:SolidPeso molecular:427.872'-Fluorothymidine
CAS:2'-Fluorothymidine is a selective substrate for TK2, related to thymidine and methyluridine.Fórmula:C10H13FN2O5Pureza:99.98%Forma y color:SolidPeso molecular:260.22Ref: TM-T19101
1mg50,00€1mL*10mM (DMSO)101,00€5mg105,00€10mg161,00€25mg276,00€50mg416,00€100mg625,00€200mg837,00€Erythromycin hydrochloride
CAS:Erythromycin hydrochloride is an inhibitor of protein translation and mammalian mRNA splicing. It inhibits growth of gram negative and gram positiove bacteria.Fórmula:C37H68ClNO13Forma y color:SolidPeso molecular:770.39Fosteabine
CAS:Fosteabine is an oral and prodrug analog of cytarabine. It is resistant to deoxycytidine deaminase.Fórmula:C27H50N3O8PPureza:98%Forma y color:SolidPeso molecular:575.67Piritrexim
CAS:Piritrexim (BW 301U) is an orally available fat-soluble dihydrofolate reductase inhibitor with pulmonary toxicity used in the study of uroepithelial carcinomaFórmula:C17H19N5O2Pureza:98.50% - >99.99%Forma y color:SolidPeso molecular:325.37CBL 0100 free base
CAS:CBL0100 is an inhibitor of viral transcriptional elongation, blocking both HIV-1 replication and reactivation.Fórmula:C24H26N2O2Pureza:98.18% - 98.86%Forma y color:SolidPeso molecular:374.48HHL-6
CAS:HHL-6 is a c-Fos and BDNF protein expression modulator.Fórmula:C19H26N2O3Forma y color:SolidPeso molecular:330.42BMVC
CAS:BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor (IC50: ~0.2 μM) with anticancer activities.Fórmula:C28H25I2N3Forma y color:SolidPeso molecular:657.33APC 366
CAS:APC 366: Mast cell tryptase inhibitor, Ki 7.1 μM. Reduces EAR, LAR, BHR in allergic asthma (sheep model).Fórmula:C22H28N6O4Pureza:99.8%Forma y color:SolidPeso molecular:440.5hDHODH-IN-3
CAS:hDHODH-IN-3 is an inhibitor of human dihydroorotate dehydrogenase with a pMIC50 value of 8.6. hDHODH-IN-3 can inhibit measles virus replication.Fórmula:C18H19BrN4O2Pureza:99.871%Forma y color:SolidPeso molecular:403.27Ref: TM-T11025
500mgA consultar1mg60,00€2mg88,00€5mg133,00€1mL*10mM (DMSO)142,00€10mg203,00€25mg335,00€50mg474,00€100mg623,00€(S)-CR8
CAS:(S)-CR8 is an effective second-generation cyclin-dependent kinase inhibitor.Fórmula:C24H29N7OForma y color:SolidPeso molecular:431.53Aurora Kinases-IN-2
CAS:Aurora Kinases-IN-2 (12Aj) hinders Aurora A/B kinases (IC50: 90/152 nM), used in cancer studies.Fórmula:C22H18ClN5O3Forma y color:SolidPeso molecular:435.86LSN 3213128
CAS:LSN 3213128: a potent oral antifolate targeting AICARFT with IC50s of 16 nM (enzyme) and 19 nM (cells), offers anti-tumor effects.Fórmula:C17H16FN3O4S2Forma y color:SolidPeso molecular:409.45
