Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(94 productos)
- CDK(500 productos)
- Detención del ciclo celular(4 productos)
- Chk(42 productos)
- DYRK(48 productos)
- Dynamin(23 productos)
- Ferroptosis(215 productos)
- HSP(169 productos)
- Integrin(224 productos)
- Kinesina(66 productos)
- LIM quinasa(19 productos)
- Asociado a microtúbulos(261 productos)
- PKC(102 productos)
- PLK(28 productos)
- ROCK(69 productos)
- Rho(2 productos)
- Wee1(15 productos)
- c-Myc(69 productos)
Mostrar 10 subcategorías más
Se han encontrado 3480 productos de "Ciclo celular / Checkpoint"
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H3B-968
CAS:<p>H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, effectively targeting its helicase, ATPase, and exonuclease</p>Fórmula:C22H18F6N4O4SPureza:98%Forma y color:SolidPeso molecular:548.46BIO-7662
CAS:<p>BIO-7662 is an effective and highly selective antagonist of α4β1 integrin.</p>Fórmula:C38H48N6O8SPureza:98%Forma y color:SolidPeso molecular:748.89CDK9-IN-19
CAS:<p>CDK9-IN-19: Potent CDK9 inhibitor, anti-cancer, moderate pharmacokinetics, low hERG impact, effective in AML research.</p>Fórmula:C26H22F2N4O5Forma y color:SolidPeso molecular:508.47hDHODH-IN-1
CAS:<p>hDHODH-IN-1 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an anti-inflammatory effect.</p>Fórmula:C17H14N2O2Pureza:99.97%Forma y color:SolidPeso molecular:278.31BMT-090605 hydrochloride
CAS:<p>BMT-090605 HCl: AAK1 inhibitor (IC50=0.6 nM), also targets BIKE (IC50=45 nM) & GAK (IC50=60 nM), with potential in neuropathic pain research.</p>Fórmula:C21H25ClN4O2Forma y color:SolidPeso molecular:400.915'-ODMT cEt m5U Phosphoramidite (Amidite)
CAS:<p>5'-ODMT cEt m5U Phosphoramidite Amidite, a locked nucleic acid (LNA) analog, demonstrates exceptional safety and antisense activity [1] [2].</p>Fórmula:C42H51N4O9PForma y color:SolidPeso molecular:786.85Zaurategrast
CAS:<p>Zaurategrast is an effective and oral-effective inhibitor of the α4-integrin.</p>Fórmula:C26H25BrN4O3Pureza:98%Forma y color:SolidPeso molecular:521.41DNA Gyrase-IN-8
CAS:<p>DNA Gyrase-IN-8 is a potent inhibitor of DNA gyrase, demonstrating antimicrobial activity with an IC50 of 8.45 µM [1].</p>Fórmula:C19H14BrN5OPureza:98%Forma y color:SolidPeso molecular:408.25KSP-IA
CAS:<p>KSP-IA is a potent, specific, allosteric, and cell-active KSP inhibitor.</p>Fórmula:C21H22F2N2OPureza:98%Forma y color:SolidPeso molecular:356.41Lotrafiban
CAS:<p>Lotrafiban: Oral GP IIb/IIIa inhibitor for treating coronary and cerebrovascular disease.</p>Fórmula:C23H32N4O4Forma y color:SolidPeso molecular:428.52Balapiravir hydrochloride
CAS:<p>Balapiravir HCl, an NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>Fórmula:C21H31ClN6O8Forma y color:SolidPeso molecular:530.96CCT251455
CAS:<p>CCT251455, the mitotic kinase monopolar spindle 1 (MPS1/TTK) inhibitor, is a potent (IC50=3 nM) and specific chemical tool.</p>Fórmula:C26H26ClN7O2Pureza:99.1% - 99.1%Forma y color:SolidPeso molecular:503.98DAM-IN-1
CAS:<p>DMA-IN-1 is a DNA adenine methyltransferase (DAM) inhibitor with an IC50 value of 48 μM.</p>Fórmula:C16H17NO4Pureza:98%Forma y color:SolidPeso molecular:287.31ON 108600
CAS:<p>ON 108600 is a chemical inhibitor targeting CK2 (Casein Kinase 2), TNIK, and DYRK1, demonstrating IC50 values of 0.016 μM and 0.007 μM for DYRK1A and DYRK1B, 0.</p>Fórmula:C22H14Cl2N2O6S2Pureza:98%Forma y color:SolidPeso molecular:537.39GSK2163632A
CAS:<p>GSK2163632A is an insulin-like growth factor 1 receptor inhibitor that acts by binding to a novel region of the GRK active site cleft.</p>Fórmula:C27H32N8O3SForma y color:SolidPeso molecular:548.665,6,7,8-Tetrahydro-8-deazahomofolic acid
CAS:<p>5,6,7,8-Tetrahydro-8-deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor and other folate related enzymes inhibitor.</p>Fórmula:C21H26N6O6Forma y color:SolidPeso molecular:458.47KM05382
CAS:<p>KM05382 inhibits CDK9 and the transcription of GAPDH.</p>Fórmula:C20H19ClN2O3S2Forma y color:SolidPeso molecular:434.96Methotrexate-γ-aspartate
CAS:<p>Methotrexate-gamma-aspartate has growth inhibitory effects. It is used in antibody-targeted liposomes.</p>Fórmula:C24H27N9O8Pureza:98%Forma y color:SolidPeso molecular:569.53Antifolate C1
CAS:<p>Antifolate C1 blocks purine creation, favors uptake via folate receptors/PCFT over RFC.</p>Fórmula:C19H21N5O6SForma y color:SolidPeso molecular:447.46CDK7-IN-14
CAS:<p>CDK7-IN-14, a potent CDK7 inhibitor from pyrimidines, may treat transcriptionally dysregulated cancers (CN114249712A).</p>Fórmula:C22H24F3N6OPForma y color:SolidPeso molecular:476.43Lotrafiban hydrochloride
CAS:<p>Lotrafiban hydrochloride is an platelet glycoprotein IIb/IIIa blocker with oral activity.</p>Fórmula:C23H33ClN4O4Forma y color:SolidPeso molecular:464.995-DACTHF
CAS:<p>5,11-methenyltetrahydrohomofolate blocks GAR & AIR transformylase; used as an anti-purine drug.</p>Fórmula:C19H24N6O6Pureza:98%Forma y color:SolidPeso molecular:432.43Diazoketone methotrexate
CAS:<p>Diazoketone methotrexate is an analog of methotrexate with potential antitumor activity.</p>Fórmula:C21H22N10O4Forma y color:SolidPeso molecular:478.46IIIM-290
CAS:<p>IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).</p>Fórmula:C23H21Cl2NO5Pureza:98%Forma y color:SolidPeso molecular:462.32PLK1-IN-7
CAS:<p>PLK1-IN-7 (compound 30e) is a potent inhibitor exhibiting an IC50 value of 0.66 nM and demonstrates significant antiproliferative and antitumor activities [1].</p>Fórmula:C24H24F4N8O2Forma y color:SolidPeso molecular:532.49TAS-114
CAS:<p>TAS-114 is a dUTPase and DPD inhibitor that modulates catabolic pathways to improve systemic availability of 5-FU.</p>Fórmula:C21H29N3O6SPureza:99.76%Forma y color:SolidPeso molecular:451.54Spirofylline
CAS:<p>Spirofylline is an agent of bronchodilator, has the potential for asthma and bronchitis and emphysema treatment.</p>Fórmula:C24H28N6O5Pureza:98%Forma y color:SolidPeso molecular:480.52CCT-251921
CAS:<p>CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).</p>Fórmula:C21H23ClN6OPureza:99.07%Forma y color:SolidPeso molecular:410.93-Cyanovinylcarbazole phosphoramidite
CAS:<p>3-Cyanovinylcarbazole phosphoramidite: an antiviral, hinders viral DNA synthesis, modifies ribonucleotides.</p>Fórmula:C50H53N4O6PForma y color:SolidPeso molecular:836.95AAPK-25
CAS:<p>AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.</p>Fórmula:C21H13Cl2N3O2SPureza:97.05%Forma y color:SolidPeso molecular:442.325'-ODMT cEt N-Bz A Phosphoramidite (Amidite)
CAS:<p>5'-ODMT cEt N-Bz A Phosphoramidite Amidite, a locked nucleic acid (LNA) analogue, exhibits hybridization and mismatch discrimination capabilities similar to LNA, and shows resistance to exonuclease digestion [1].</p>Fórmula:C49H54N7O8PForma y color:SolidPeso molecular:899.97JNJ-26076713
CAS:<p>JNJ-26076713, an oral alpha V integrin blocker, may treat macular edema, AMD, and diabetic retinopathy.</p>Fórmula:C29H38N4O3Pureza:98%Forma y color:SolidPeso molecular:490.64Raluridine
CAS:<p>Raluridine is an HIV treatment inhibiting RNA-directed DNA polymerase with IC50 of 1.8 microM, compared to FLT, AZT, ddI, and ddC.</p>Fórmula:C9H10ClFN2O4Pureza:98%Forma y color:SolidPeso molecular:264.64XL413 hydrochloride
CAS:<p>XL413 hydrochloride (BMS-863233 Hydrochloride) is a potent, selective and ATP competitive inhibitor of Cdc7. XL413 hydrochloride also inhibits CK2 and PIM1.</p>Fórmula:C14H13Cl2N3O2Pureza:98.81% - 99.8%Forma y color:SolidPeso molecular:326.18Pelitrexol
CAS:<p>Pelitrexol (AG2037) is a GARFT inhibitor, which can inhibit the activity of mTORC1, block the cell cycle in the s-phase, with antiproliferative activity,NSCLC .</p>Fórmula:C20H25N5O6SPureza:98.03%Forma y color:SolidPeso molecular:463.51DNA polymerase-IN-3
CAS:<p>DNA polymerase-IN-3 (Compd 5b), a coumarin derivative, demonstrates inhibitory activity against Taq DNA polymerase and has potential applications in</p>Fórmula:C13H12O4Pureza:98%Forma y color:SolidPeso molecular:232.23SHP2/CDK4-IN-1
CAS:<p>SHP2/CDK4-IN-1: dual inhibitor, oral, potent (IC50: SHP2 4.3 nM, CDK4 18.2 nM), hinders TNBC growth, strong antitumor effects in mice.</p>Fórmula:C33H35ClF2N10OSForma y color:SolidPeso molecular:693.21PF-6808472
CAS:<p>PF-6808472 is a cell-permeable covalent kinase probe, reacts with conserved lysine residues within the ATP-binding site of kinases.</p>Fórmula:C25H27FN8O3SPureza:99.02%Forma y color:SolidPeso molecular:538.6N-desmethyl Netupitant
CAS:<p>N-desmethyl Netupitant is a metabolite of Netupitant and a potential Substance-P receptor agonist.</p>Fórmula:C29H30F6N4OPureza:98%Forma y color:SolidPeso molecular:564.57CDK9-IN-9
CAS:<p>CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).</p>Fórmula:C22H23F2N5O2SPureza:98%Forma y color:SolidPeso molecular:459.51Lamifiban
CAS:<p>Lamifiban is a nonpeptide glycoprotein IIb/IIIa antagonist. It prevents platelet loss during experimental cardiopulmonary bypass.</p>Fórmula:C24H28N4O6Pureza:98%Forma y color:SolidPeso molecular:468.55-Iodo-indirubin-3'-monoxime
CAS:<p>5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s</p>Fórmula:C16H10IN3O2Forma y color:SolidPeso molecular:403.17CDK7-IN-22
CAS:<p>CDK7-IN-22 (compound 101) is a selective CDK7 inhibitor that exhibits antitumor activity, demonstrating specificity for CDK7 [1].</p>Fórmula:C22H25F3N6Pureza:98%Forma y color:SolidPeso molecular:430.47PD-1/PD-L1-IN-33
CAS:<p>PD-1/PD-L1-IN-33 (Compound N11), a PD-1/PD-L1 inhibitor, effectively impedes the interaction between PD-1 and PD-L1 with an IC50 of 6.3 nM.</p>Fórmula:C26H27N5OPureza:98%Forma y color:SolidPeso molecular:425.53DNA gyrase B-IN-3
CAS:<p>DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against Gram</p>Fórmula:C14H9Cl2N3O4SPureza:98%Forma y color:SolidPeso molecular:386.21RNA polymerase II-IN-1
CAS:<p>RNA polymerase II-IN-1 (19iv), an amatoxin, inhibits Pol II at 36.66 nM IC50, is more toxic to cancer cells, less to normal cells than α-Amanitin.</p>Fórmula:C38H53N11O12SPureza:98%Forma y color:SolidPeso molecular:887.962'-Deoxypseudoisocytidine
CAS:<p>2'-Deoxypseudoisocytidine is a nucleoside analogue.</p>Fórmula:C9H13N3O4Pureza:98%Forma y color:SolidPeso molecular:227.22PD-1/PD-L1-IN-34
CAS:<p>PD-1/PD-L1-IN-34 (Compound (1S,2S)-A25) effectively inhibits the PD-1/PD-L1 interaction (IC 50 = 0.029 μM) and demonstrates selective binding affinity to PD-L1</p>Fórmula:C35H33ClN2O3Pureza:98%Forma y color:SolidPeso molecular:565.1Aurora Kinases-IN-4
CAS:<p>Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM.</p>Fórmula:C26H28N8OPureza:98%Forma y color:SolidPeso molecular:468.55PD-1/PD-L1-IN-26
CAS:<p>PD-1/PD-L1-IN-26 is a strong inhibitor with IC50 of 0.0380 μM that may boost immune response in cancer by aiding CD4+ T cell entry to tumors.</p>Fórmula:C43H52N4O8Pureza:98%Forma y color:SolidPeso molecular:752.89
