Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(94 productos)
- CDK(500 productos)
- Detención del ciclo celular(4 productos)
- Chk(42 productos)
- DYRK(48 productos)
- Dynamin(23 productos)
- Ferroptosis(215 productos)
- HSP(169 productos)
- Integrin(224 productos)
- Kinesina(66 productos)
- LIM quinasa(19 productos)
- Asociado a microtúbulos(261 productos)
- PKC(102 productos)
- PLK(28 productos)
- ROCK(70 productos)
- Rho(2 productos)
- Wee1(15 productos)
- c-Myc(69 productos)
Mostrar 10 subcategorías más
Se han encontrado 3477 productos de "Ciclo celular / Checkpoint"
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LY3295668
CAS:<p>LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.</p>Fórmula:C24H26ClF2N5O2Pureza:99.68%Forma y color:SolidPeso molecular:489.95DHX9-IN-2
CAS:<p>DHX9-IN-2 is an inhibitor targeting ATP-dependent RNA de-helicase A (DHX9) with anticancer and antitumor activity for cancer research.</p>Fórmula:C18H16ClN3O3S2Pureza:98%Forma y color:SolidPeso molecular:421.92BDP9066
CAS:<p>BDP9066 is a potent and selective MRCK inhibitor, inhibits MRCKβ and MRCKα/β, and can be used for the prevention and treatment of skin cancer.</p>Fórmula:C20H24N6Pureza:98.18%Forma y color:SolidPeso molecular:348.44Cdk1/2 Inhibitor III
CAS:<p>Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor with an IC50 value of 2.1 μM against CDK1/cyclin B.</p>Fórmula:C15H13F2N7O2S2Pureza:99.07%Forma y color:SolidPeso molecular:425.44αvβ1 integrin-IN-1
CAS:<p>αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.</p>Fórmula:C26H34N6O6SPureza:99.74% - >99.99%Forma y color:SolidPeso molecular:558.65Roxifiban acetate
CAS:<p>Roxifiban acetate（DMP 754 acetate） is a potent GP IIb / IIIa antagonist that exhibits antiplatelet aggregation activity via immune mediation and can be used in</p>Fórmula:C23H33N5O8Pureza:97.91% - 98.36%Forma y color:SolidPeso molecular:507.54CFI-402257
CAS:<p>CFI-402257 is a selective inhibitor of Mps1/TTK kinase (Mps1 Ki = 0.09 nM; EC50 = 6.5 nM)and can be used in studies about hepatocellular carcinoma diseases.</p>Fórmula:C28H30N6O3Pureza:96.66% - 99.51%Forma y color:SolidPeso molecular:498.58Debio-0123
CAS:<p>Debio-0123: potent, specific oral WEE1 inhibitor; IC50 in low nanomolar; boosts DNA damage & Carboplatin's anti-cancer effects.</p>Fórmula:C26H28Cl2N6OPureza:99.93%Forma y color:SolidPeso molecular:511.45Plogosertib
CAS:<p>Plogosertib (CYC140) is a PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib is antiproliferative and can be used to study solid and hematologic tumors.</p>Fórmula:C34H48N8O3Pureza:99.22% - 99.85%Forma y color:SolidPeso molecular:616.797PD-L1-IN-3
CAS:<p>PD-L1-IN-3 is a PD-1/PD-L1 inhibitor for the study of tumors and immune diseases.</p>Fórmula:C19H15ClFN2OSPureza:99.47%Forma y color:SoildPeso molecular:373.85CCT129202
CAS:<p>CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.</p>Fórmula:C23H25ClN8OSPureza:98.14%Forma y color:SolidPeso molecular:497.02B I09
CAS:<p>B I09, an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells.</p>Fórmula:C16H17NO5Pureza:98.80%Forma y color:SolidPeso molecular:303.31(R)-Simurosertib
CAS:<p>(R)-Simurosertib ((R)-TAK-931) is an inhibitor of the ATP-competitive cell division cycle 7 (CDC7) kinase.</p>Fórmula:C17H19N5OSPureza:99.89%Forma y color:SolidPeso molecular:341.43Sorivudine
CAS:<p>Sorivudine (BV-araU) is an antiviral blocking DNA synthesis in viruses like varicella, HSV-1, and Epstein-Barr.</p>Fórmula:C11H13BrN2O6Pureza:99.74%Forma y color:SolidPeso molecular:349.13Lomibuvir
CAS:<p>Lomibuvir (VCH-222, VX-222) is an allosteric inhibitor of HCV NS5B with Kd 17 nM, blocks RNA elongation, EC50 5.2 nM for 1b/Con1.</p>Fórmula:C25H35NO4SPureza:99.83%Forma y color:SolidPeso molecular:445.61CLK1/4-IN-1
<p>CLK1/4-IN-1 inhibits Clk1/4 (IC50: 9.7/6.6 nM), curbing T24 cell growth (GI50: 1.1 μM). Potential cancer research tool.</p>Fórmula:C18H14ClNO4SForma y color:SolidPeso molecular:375.83PAIR2
CAS:<p>PAIR2 is a selective IRE1α RNase partial antagonist, blocking its ATP site and preventing KIRA from hindering XBP1 splicing.</p>Fórmula:C27H26F4N6O3SForma y color:SolidPeso molecular:590.592-Amino-2'-fluoro-2'-deoxyadenosine
CAS:<p>2-Amino-2'-fluoro-2'-deoxyadenosine is a component of nucleic acids.</p>Fórmula:C10H13FN6O3Forma y color:SolidPeso molecular:284.25CTX-712
CAS:<p>CTX-712 is a potent inhibitor of cdc2-like kinase ( CLK ). CTX-712 inhibits inhibits cancer survival and cancer cell growth.</p>Fórmula:C19H17FN8O2Forma y color:SolidPeso molecular:408.392'-Deoxycytidine hydrate
CAS:<p>2'-Deoxycytidine (Deoxycytidine) hydrate is a component of nucleic acids.</p>Fórmula:C9H15N3O5Forma y color:SolidPeso molecular:245.23KWR095
CAS:<p>KWR095 is an orally active inhibitor of WRN, demonstrating an IC50 of 0.032 μM against WRN ATPase. It disrupts the double-stranded helicase activity of WRN and inhibits tumor cell proliferation, exhibiting antitumor properties.</p>Fórmula:C33H31ClF3N9O4Forma y color:SolidPeso molecular:710.105Terpendole E
CAS:<p>Terpendole E is an atypical L5 site inhibitor.</p>Fórmula:C28H39NO3Forma y color:SolidPeso molecular:437.61ATIC-IN-2
CAS:<p>ATIC-IN-2 (Compound 1) is a competitive inhibitor of the bifunctional enzyme AICAR Tfase/IMPCH (ATIC), binding to inosine monophosphate cyclohydrolase (IMPCH) with a Ki of 0.13 μM.</p>Fórmula:C4H4N4O3SForma y color:SolidPeso molecular:188.165DENV-IN-6
CAS:<p>DENV-IN-6, a potent anti-DENV (I-IV) and HIV-1 IIIB inhibitor with EC50 ranging 6.8-17.5 μM for DENV and EC50 0.0181 μM for HIV-1.</p>Fórmula:C23H26ClFN4OSForma y color:SolidPeso molecular:461MtTMPK-IN-3
CAS:<p>MtTMPK-IN-3 inhibits Mycobacterium tuberculosis kinase with IC50 0.12μM, MIC 12.5μM on Mtb, cytotoxic EC50 12.5μM on MRC-5 cells.</p>Fórmula:C23H23Cl2N3O3Forma y color:SolidPeso molecular:460.35MtTMPK-IN-1
<p>MtTMPK-IN-1 inhibits MtTMPK with 2.5 μM IC50, shows moderate anti-tuberculosis activity, and is low in cytotoxicity.</p>Fórmula:C22H24N4O3Forma y color:SolidPeso molecular:392.45CDK7-IN-18
CAS:<p>CDK7-IN-18: potent, pyrimidine-based CDK7 inhibitor with cancer research potential.</p>Fórmula:C22H24F3N7OSForma y color:SolidPeso molecular:491.53LY309887
CAS:<p>LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.</p>Fórmula:C19H23N5O6SForma y color:SolidPeso molecular:449.48IRE1α kinase-IN-4
CAS:<p>IRE1α kinase-IN-4 (compound 6) is a potent inhibitor of IRE1α, exhibiting a Ki value of 140 nM. It acts as an ATP-competitive ligand for IRE1α [1].</p>Fórmula:C29H31N7O2Forma y color:SolidPeso molecular:509.6Polθ-IN-5
CAS:<p>Polθ-IN-5 (Compound 139) is an inhibitor of DNA polymerase theta (Polθ) that exhibits antitumor activity.</p>Fórmula:C23H18ClF2N7O3SForma y color:SolidPeso molecular:545.95GSK_WRN4
CAS:<p>GSK_WRN4 is a WRN helicase inhibitor with anti-cancer activity, inhibiting MSI tumor cell growth by inducing DNA double-strand breaks, useful in cancer research</p>Fórmula:C16H20N2O4SPureza:99.95%Forma y color:SolidPeso molecular:336.41GHP-88309
CAS:<p>GHP-88309 is an orally active, broad-spectrum anti-paramyxovirus agent that targets viral polymerase, interrupting viral RNA synthesis. It effectively inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with an EC50 of 0.06-1.2 μM. In mouse models, GHP-88309 demonstrates significant anti-infective activity.</p>Fórmula:C16H11FN2OForma y color:SolidPeso molecular:266.27CDK4/6-IN-24
CAS:<p>CDK4/6-IN-24 (Compound A) is an inhibitor of CDK4/6 with broad-spectrum antitumor activity. It can effectively inhibit various cancer cells, exhibiting an IC50 in the submicromolar range.</p>Fórmula:C32H41N7O3Forma y color:SolidPeso molecular:571.713Valopicitabine
CAS:<p>Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic</p>Fórmula:C15H24N4O6Pureza:98%Forma y color:SolidPeso molecular:356.37Pol I-IN-1
<p>Pol I-IN-1 is a powerful inhibitor of RNA polymerase I (Pol I), specifically targeting the large catalytic subunit RPA194, demonstrating an inhibition</p>Fórmula:C23H22N4O2Forma y color:SolidPeso molecular:386.45L-2'-Fd4C
CAS:<p>L-2'-Fd4C is an L-nucleoside analogue with both anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity [1].</p>Fórmula:C9H10FN3O3Forma y color:SolidPeso molecular:227.196K465
CAS:<p>6K465 is a potent Aurora A kinase inhibitor that reduces c-MYC and N-MYC oncoproteins, showing antiproliferative effects in SCLC and breast cancer cell lines.</p>Fórmula:C26H33ClFN9OPureza:99.78%Forma y color:SolidPeso molecular:542.05EFdA-TP tetrasodium
CAS:<p>EFdA-TP tetrasodium is a potent HIV-1 inhibitor that blocks DNA synthesis as an ICT or DCT.</p>Fórmula:C12H11FN5Na4O12P3Pureza:98%Forma y color:SolidPeso molecular:621.1214α-Demethylase/DNA Gyrase-IN-1
<p>14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.</p>Fórmula:C26H22N4O4Forma y color:SolidPeso molecular:454.48PKMYT1-IN-9
CAS:<p>PKMYT1-IN-9 is a highly selective, orally active inhibitor of PKMYT1 with an IC50 of 4.4 nM. It exhibits greater selectivity for PKMYT1 compared to WEE1, for which the IC50 is 32.4 μM. Additionally, PKMYT1-IN-9 demonstrates antitumor activity.</p>Fórmula:C17H14FN5OForma y color:SolidPeso molecular:323.324MtTMPK-IN-5
<p>MtTMPK-IN-5 inhibits Mtb TMPK with IC50 of 34 μM and fights tuberculosis with MIC of 12.5 μM, aiding TB research.</p>Fórmula:C21H23N5O2Forma y color:SolidPeso molecular:377.44CHK1-IN-2
CAS:<p>CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).</p>Fórmula:C20H22N4OSPureza:98%Forma y color:SolidPeso molecular:366.48CDK9/PARP-IN-1
CAS:<p>CDK9/PARP-IN-1 (compound 37) is an inhibitor of CDK9 and PARP. It demonstrates IC50 values of 118 nM for CDK9 and 107 nM for PARP1. This compound exhibits a broad-spectrum anti-proliferative effect across various cancer cell lines.</p>Fórmula:C38H34F2N8O3Forma y color:SolidPeso molecular:688.725Aurora A inhibitor 1
CAS:<p>Aurora A inhibitor 1: potent, selective, targets cancer-linked Aurora A overexpression, potential for cancer research. (WO2021147974A1, 49)</p>Fórmula:C25H28ClF2N5O2Forma y color:SolidPeso molecular:503.97Werner syndrome RecQ helicase-IN-2
CAS:<p>Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase (WRN) inhibitor, useful in research on colorectal and gastric cancers.</p>Fórmula:C32H34F3N9O5Pureza:99.02%Forma y color:SolidPeso molecular:681.67RAD51-IN-5
CAS:<p>RAD51-IN-5 blocks RAD51; may aid mitochondrial disorder research. (WO2021164746A1, cmpd 3)</p>Fórmula:C26H38N4O5S2Forma y color:SolidPeso molecular:550.73Mazethramycin
CAS:<p>Mazethramycin is an antitumor antibiotic that exerts its effects by disrupting DNA replication and RNA synthesis within cells. It is utilized in cancer research.</p>Fórmula:C17H19N3O4Peso molecular:329.35Zorubicin
CAS:<p>Zorubicin, a Daunorubicin derivative, targets topoisomerase II, inhibits DNA polymerase, and researches acute leukemia, sarcomas.</p>Fórmula:C34H35N3O10Forma y color:SolidPeso molecular:645.66TASIN-30
CAS:<p>TASIN-30 is an inhibitor of EBP, exhibiting a competitive EC50 value of 0.097 μM, and possesses a competitive EC50 value of 50 μM against DHCR7.</p>Fórmula:C18H30N2O3SForma y color:SolidPeso molecular:354.512′-OMe-ADP
CAS:<p>2′-OMe-ADP is a nucleotide analogue used in oligonucleotide synthesis.</p>Fórmula:C11H17N5O10P2Forma y color:SolidPeso molecular:441.23
