Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(114 productos)
- CDK(546 productos)
- Detención del ciclo celular(5 productos)
- Chk(48 productos)
- DYRK(47 productos)
- Dynamin(27 productos)
- Ferroptosis(226 productos)
- HSP(179 productos)
- Integrin(253 productos)
- Kinesina(87 productos)
- LIM quinasa(20 productos)
- Asociado a microtúbulos(274 productos)
- PKC(124 productos)
- PLK(25 productos)
- ROCK(62 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(76 productos)
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Se han encontrado 3872 productos de "Ciclo celular / Checkpoint"
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Ac-MRGDH-NH2
Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.Fórmula:C25H41N11O8SForma y color:SolidPeso molecular:655.7275'-O-DMT-Bz-rC
CAS:5’-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.Fórmula:C37H35N3O8Forma y color:SolidPeso molecular:649.69Cytarabine triphosphate
CAS:Ara-CTP, active Cytarabine metabolite, inhibits DNA synthesis, predicts leukemic chemosensitivity.Fórmula:C9H16N3O14P3Forma y color:SolidPeso molecular:483.16STX-100
PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.Pureza:97.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 97.3% (SDS-PAGE); 97.5% (SEC-HPLC)Forma y color:Odour LiquidPeso molecular:145.12 kDaRifalazil
CAS:Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity, useful for research on chlamydia infections.Fórmula:C51H64N4O13Pureza:98%Forma y color:SolidPeso molecular:941.07Aclacinomycin A
CAS:Aclacinomycin A has a wide range of applications in life science related research.Fórmula:C42H53NO15Pureza:99.43%Forma y color:SolidPeso molecular:811.87Flurocitabine HCl
CAS:Fluorocitabine HCl, a cytarabine analog, hydrolyzes into ara-FC and ara-FU, showing antitumor effects in leukemia and solid cancers.Fórmula:C9H11ClFN3O4Pureza:99.23% - 99.76%Forma y color:SoildPeso molecular:279.655'-O-TBDMS-Bz-dA
CAS:5’-O-TBDMS-Bz-dA is a nucleoside with protective and modification effects.Fórmula:C23H31N5O4SiForma y color:SolidPeso molecular:469.617Chk1-IN-6
CAS:Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.
Fórmula:C16H18F3N7Forma y color:SolidPeso molecular:365.364Ac-dA Phosphoramidite
CAS:Ac-dA Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.Fórmula:C42H50N7O7PForma y color:SolidPeso molecular:795.878Barasertib
CAS:AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Fórmula:C26H31FN7O6PPureza:99.92% - 99.97%Forma y color:SolidPeso molecular:587.543'-β-C-Methyl-2-thiouridine
3’-β-C-Methyl-2-thiouridine, a purine nucleoside analog, exhibits extensive antitumor activity, particularly against indolent lymphoid malignancies.Fórmula:C10H14N2O5SForma y color:SolidPeso molecular:274.29N7-Methyl-2'-O-(2-methoxyethyl) guanosine
N7-Methyl-2’-O-(2-methoxyethyl) guanosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Fórmula:C14H21N5O6Forma y color:SolidPeso molecular:355.35ONX 0801 trisodium
CAS:ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.Fórmula:C32H30N5Na3O10Forma y color:SolidPeso molecular:713.58PROTAC CDK9 degrader-8
PROTAC CDK9 Degrader-8 (Compound 21) is a potent degrader of CDK9 with an IC50 of 0.01 μM, utilized in cancer research [1].Fórmula:C44H52Cl2N10O7Pureza:98%Forma y color:SolidPeso molecular:903.85α2β1 Integrin Ligand Peptide
CAS:The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellularFórmula:C14H22N4O9Pureza:98%Forma y color:SolidPeso molecular:390.35Erythromycin lactobionate
CAS:Erythromycin, a macrolide antibiotic, inhibits bacterial protein synthesis, effective against Streptococcus and Staphylococcus, and affects CYP3A4 metabolism.Fórmula:C49H89NO25Forma y color:SolidPeso molecular:1092.233N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium
CAS:N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].
Fórmula:C21H35N12O17P3Forma y color:SolidPeso molecular:820.498-NH2-ATP
CAS:8-NH2-ATP is an inactive derivative of adenosine triphosphate (ATP), synthesized from 8-NH2-Ado.Fórmula:C10H17N6O13P3Forma y color:SolidPeso molecular:522.205-Caroxy uracil-1-yl acetic acid benzyl ester
5-Caroxy uracil-1-yl acetic acid benzyl ester, a purine analog, inhibits DNA synthesis and induces apoptosis to combat lymphoid cancers.Fórmula:C14H12N2O6Forma y color:SolidPeso molecular:304.256-Amino-4-hydrozino-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine
6-Amino-4-hydrozino-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine is a purine nucleoside analogue with broad antitumor activity, particularly againstFórmula:C10H15N7O4Forma y color:SolidPeso molecular:297.27Rev 2'-O-MOE-C(Bz)-5'-amidite
'Rev 2’-O-MOE-C(Bz)-5’-amidite, a purine nucleoside analog, exhibits broad antitumor activity against indolent lymphoid malignancies.Fórmula:C49H58N5O10PForma y color:SolidPeso molecular:907.99XY028-133
CAS:XY028-133 is a PROTAC-based CDK4/6 degrader for the study of tumors.
Fórmula:C53H67N11O7SPureza:97.11%Forma y color:SolidPeso molecular:1002.237-TFA-ap-7-Deaza-ddA
CAS:Compound 19c is a nucleotide derivative for DNA sequencing dye terminators.Fórmula:C16H16F3N5O3Forma y color:SolidPeso molecular:383.331AURKA against 1
Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.Fórmula:C28H32FN9O2Forma y color:SolidPeso molecular:545.615'-O-DMT-ibu-dC
CAS:5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.Fórmula:C34H37N3O7Forma y color:SolidPeso molecular:599.67N1-Methylpseudouridine-5′-triphosphate tetralithium
N1-Methylpseudouridine-5′-triphosphate tetralithium, also known as 1-Methylpseudouridine-5′-triphosphate tetralithium, is a nucleobase-modified nucleotide.Fórmula:C10H13Li4N2O15P3Forma y color:SolidPeso molecular:521.9N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-deoxycytidine
N4-Acetyl-5’-O-(4,4’-dimethoxytrityl)-5-methyl-2’-deoxycytidine, a purine nucleoside analog, exhibits broad antitumor activity particularly against indolentFórmula:C33H35N3O7Forma y color:SolidPeso molecular:585.65DSPE-PEG2000-iRGD
DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.Forma y color:Odour SolidIRE1α kinase-IN-6
CAS:IRE1α kinase-IN-6 is a potent IRE1α inhibitor with an IC 50 value of 4.4 nM.Fórmula:C25H23Cl2FN6O3S2Forma y color:SolidPeso molecular:609.52Adenosine-2-carboxy methyl amide
Adenosine-2-carboxy methyl amide: a purine analog with antitumor effects, inhibits DNA synthesis and induces apoptosis.Fórmula:C12H16N6O5Forma y color:SolidPeso molecular:324.29LDV
CAS:α4β1 integrin (VLA-4) ligand (Kd ~ 12 nM). Non-fluorescent derivative of LDV FITC.Fórmula:C48H70N10O12Pureza:98%Forma y color:SolidPeso molecular:979.131-(β-D-Xylofuranosyl)-N6-Isopentenyladenine
1-(β-D-Xylofuranosyl)-N6-Isopentenyladenine is an adenosine analog.Fórmula:C15H21N5O4Forma y color:SolidPeso molecular:335.36Psammaplin A
CAS:Psammaplin A: marine-derived, inhibits HDAC/DNA methyltransferases, strong DAC1 blocker (IC50=0.9nM), antimicrobial against Gram-positive bacteria, anticancer.Fórmula:C22H24Br2N4O6S2Forma y color:SolidPeso molecular:664.38NUAK1-IN-1
NUAK1-IN-1 (Compound 9) is an inhibitor of NUAK1 with an IC50 of 5.012 nM, as well as a CDK4 inhibitor. It is suitable for research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.Fórmula:C25H30N6OForma y color:SolidPeso molecular:430.545Nusinersen
CAS:Nusinersen (nusinersen) is a antisense oligonucleotide (ASO) for the treatment of pediatric and adult spinal muscular atrophy (SMA) and increases SMN proteinss.Pureza:98.62%Forma y color:SolidSNX7
CAS:SNX7 (WAY-323879) inhibits CDKI pathway; useful for studying aging and related diseases.Fórmula:C15H14N2OPureza:99.96%Forma y color:SolidPeso molecular:238.282'-Deoxy-2'-fluoro-l-uridine
CAS:2'-Deoxy-2'-fluoro-1-uridine: an L-nucleoside, inhibits RNA viruses by blocking viral RNA polymerase.Fórmula:C9H11FN2O5Forma y color:SolidPeso molecular:246.198-Chloro-2'-O-methyl inosine
8-Chloro-2’-O-methyl inosine, a purine nucleoside analog, exhibits broad antitumor activity against indolent lymphoid malignancies.Fórmula:C11H13ClN4O5Forma y color:SolidPeso molecular:316.72'-Deoxy-2'-fluoro-N3-[3-(tert-butoxycarbonyl) amino]propyluridine
2’-Deoxy-2’-fluoro-N3-[3-(tert-butoxycarbonyl)amino]propyluridine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolentFórmula:C17H26FN3O7Forma y color:SolidPeso molecular:403.4KWR137
KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.Fórmula:C33H31ClF3N9O4Forma y color:SolidPeso molecular:710.105Antibacterial agent 271
Antibacterialagent 271 is an antimicrobial compound that significantly inhibits Escherichia coli, with a minimum inhibitory concentration (MIC) of 2.2 μM. It disrupts bacterial membrane integrity, reducing metabolic activity. By binding to DNA grooves, it inhibits replication and induces reactive oxygen species (ROS) accumulation, leading to bacterial death. Antibacterialagent 271 shows considerable potential in combating bacterial infections.Forma y color:Odour SolidPKMYT1-IN-3
PKMYT1-IN-3 (compound 8ma) is a potent, selective inhibitor of PKMYT1, demonstrating an IC50 of 16.5 nM and exhibiting antitumor activity.Fórmula:C24H26FN5O2Forma y color:SolidPeso molecular:435.492'-O-Acetyl-5'-O-benzoyl-3'-O-(2-methoxyethyl) uridine
2’-O-Acetyl-5’-O-benzoyl-3’-O-(2-methoxyethyl) uridine, an analog of uridine known for its potential antiepileptic properties, is utilized in researchingFórmula:C21H24N2O9Forma y color:SolidPeso molecular:448.42Guanosine 5'-triphosphate trisodium salt hydrate
CAS:5'-GTP trisodium salt hydrate activates G proteins and is a precursor for DNA/RNA synthesis.Fórmula:C10H18N5NaO15P3Pureza:98%Forma y color:SolidPeso molecular:564.185wrwyar-NH2 TFA
wrwyar-NH2 (TFA) serves as the control peptide for wrwycr-NH2.Forma y color:Odour Solid3'Ome-m7GpppAmpG
CAS:3'Ome-m7GpppAmpG is a trinucleotide cap with LNA, boosting translation; useful in mRNA vaccines and gene therapy.Fórmula:C33H45N15O24P4Forma y color:SolidPeso molecular:1159.69TFMU-ADPr triethylamine
TFMU-ADPr triethylamine is a substrate for PARG activity measurement, releasing a fluorophore to indicate PAR hydrolase activity.Fórmula:C25H26F3N5O16P2·5C6H15NForma y color:SolidPeso molecular:1024.42CDK12/13-IN-2
CDK12/13-IN-2 (Compound 24) is a covalent inhibitor of CDK12 and CDK13, exhibiting IC50 values of 15.5 nM and 12.2 nM, respectively. It effectively inhibits the proliferation of breast cancer cells and can be utilized in the research of triple-negative breast cancer.Fórmula:C24H22FN7O2Forma y color:SolidPeso molecular:459.48m7GpppCmpG
CAS:m7GpppCmpG, a trinucleotide cap analogue, enables RNA manufacturing with cap 0 or cap 1 structures.Fórmula:C31H43N13O25P4Forma y color:SolidPeso molecular:1121.64
