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Ciclo celular / Checkpoint

Ciclo celular / Checkpoint

Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.

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Se han encontrado 3730 productos de "Ciclo celular / Checkpoint"

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  • PD-1/PD-L1-IN-53
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    PD-1/PD-L1-IN-53

    CAS:
    <p>PD-1/PD-L1-IN-53 (compound B3) serves as an inhibitor targeting both the PD-1/PD-L1 and VISTA signaling pathways. It is utilized in cancer research.</p>
    Fórmula:C31H37N3O4
    Forma y color:Solid
    Peso molecular:515.64

    Ref: TM-T200774

  • Logo de CymitQuimica
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    2'-F-AMP

    CAS:
    2'-F-AMP is a nucleotide analogue used in the synthesis of oligonucleotides.
    Fórmula:C10H13FN5O6P
    Peso molecular:349.21

    Ref: TM-TSW-00945

  • CHK-IN-1
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    CHK-IN-1

    CAS:
    CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.
    Fórmula:C18H19ClFN5OS
    Pureza:>99.99%
    Forma y color:Solid
    Peso molecular:407.89

    Ref: TM-T13148

  • CDK2-IN-30
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    CDK2-IN-30

    CAS:
    <p>CDK2-IN-30 (Formula (I)) is a CDK2 inhibitor with an IC50 of ≤20 nM, utilized primarily in tumor research.</p>
    Fórmula:C18H25N7O3S
    Forma y color:Solid
    Peso molecular:419.50

    Ref: TM-T200706

  • Polθ-IN-8
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    Polθ-IN-8

    CAS:
    Polθ-IN-8 (example 77) is a DNA polymerase θ (Polθ) inhibitor with an IC50 for Polθ ATPase activity of less than 100 nM. Polθ-IN-8 is useful for researching diseases related to Polθ activity, such as cancer.
    Fórmula:C22H22ClN7O3S
    Forma y color:Solid
    Peso molecular:499.97

    Ref: TM-T207723

  • Aurora B inhibitor 1
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    Aurora B inhibitor 1

    CAS:
    Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor (Ki <0.010 uM) with potential anticancer activity for cancer research.
    Fórmula:C25H26ClF2N7O2
    Pureza:98.37%
    Forma y color:Solid
    Peso molecular:529.97

    Ref: TM-T12010

  • Ascofuranone
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    Ascofuranone

    CAS:
    Ascofuranone is an inhibitor of the ubiquinol oxidase activity of Trypanosoma brucei mitochondrial alternative oxidase (TAO), as well as an inhibitor of HsDHODH
    Fórmula:C23H29ClO5
    Forma y color:Solid
    Peso molecular:420.93

    Ref: TM-T69313

  • CDK7-IN-33
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    CDK7-IN-33

    CAS:
    CDK7-IN-33 (Compound 148) is a CDK7 inhibitor with a Ki value of 21.75 nM. It suppresses the proliferation of A549 cells expressing CDK7WT, with a pIC50 of 7.37.
    Fórmula:C29H36N6O4S
    Forma y color:Solid
    Peso molecular:564.699

    Ref: TM-T206088

  • Logo de CymitQuimica
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    3-deoxy-3-fluoro-β-D-Ribofuranose 25

    CAS:
    Compound 25, β-D-Ribofuranose, 3-deoxy-3-fluoro-, 1,2-diacetate 5-(4-methylbenzoate), exhibits strong activity in inhibiting the growth of tumor cells [1].
    Fórmula:C17H19FO7
    Peso molecular:354.33

    Ref: TM-T87696

  • 5-Fluorouridine 5'-phosphate
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    5-Fluorouridine 5'-phosphate

    CAS:
    5-Fluorouridine 5'-phosphate acts as an ODCase (uridine 5'-monophosphate decarboxylase) inhibitor, exhibiting a Ki value of 98 µM for human ODCase and 645 µM for Methanococcus jannaschii ODCase. This compound also shows inhibitory activity on leukemia and lymphoma cell lines, making it useful for cancer research studies.
    Fórmula:C9H12FN2O9P
    Forma y color:Solid
    Peso molecular:342.172

    Ref: TM-T205644

  • Methyl 3-oxodecanoate
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    Methyl 3-oxodecanoate

    CAS:
    <p>Methyl 3-oxodecanoate exhibits virulence factor activity against human pathogens and shows effects on Synechococcus elongatus (a species of fluorescent algae) as well as on culture supernatant. Additionally, Methyl 3-oxodecanoate inhibits DNA synthesis by suppressing protein synthesis at the translation initiation level.</p>
    Fórmula:C11H20O3
    Forma y color:Solid
    Peso molecular:200.275

    Ref: TM-T206384

  • Norharmine
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    Norharmine

    CAS:
    Norharmine is an analogue of harman and functions as an alkaloid. It serves as an inhibitor of both monoamine oxidase A (MAO-A) and DYRK1A. While it exhibits weak inhibitory activity against MAO-A, it has certain inhibitory effects on DYRK1A.
    Fórmula:C12H10N2O
    Forma y color:Solid
    Peso molecular:198.221

    Ref: TM-T204194

  • WEE1-IN-10
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    WEE1-IN-10

    CAS:
    WEE1-IN-10 is a Wee1 kinase inhibitor that inhibits the growth of LOVO cells, such as pancreatic cancer, malignant melanoma, and malignant glioma.
    Fórmula:C28H30Cl2N8O
    Pureza:98.18%
    Forma y color:Solid
    Peso molecular:565.5

    Ref: TM-T89365

  • Z4P
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    Z4P

    CAS:
    Z4P, an IRE1 inhibitor with blood-brain barrier permeability (BBB), inhibited glioblastoma growth and recurrence in combination with Temozolomide.
    Fórmula:C19H24N2O2
    Pureza:98.99%
    Forma y color:Solid
    Peso molecular:312.41

    Ref: TM-T87658

  • DDO-6079
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    DDO-6079

    CAS:
    DDO-6079 is an efficient CDC37 inhibitor. It suppresses the HSP90-CDC37 and CDC37-CDK4/6 chaperone complexes by binding to an allosteric site on CDC37. Additionally, DDO-6079 reduces the thermal stability of CDK6.
    Fórmula:C18H13ClN2O3
    Forma y color:Solid
    Peso molecular:340.76

    Ref: TM-T204112

  • MY05
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    MY05

    CAS:
    MY05 selectively targets c-MYC within cells and disrupts the interaction between MYC and MAX. It binds to intracellular c-MYC, modulating its thermal stability, reducing the transcriptional targets of c-MYC, and exhibiting anticancer activity (TNBC, triple-negative breast cancer).
    Fórmula:C19H11ClN4O
    Forma y color:Solid
    Peso molecular:346.77

    Ref: TM-T206537

  • 2-CEES
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    2-CEES

    CAS:
    2-CEES is a mustard gas analogue that only forms DNA monoadducts. It induces centromere amplification in both human and mouse cells and can lead to chromosome instability.
    Fórmula:C4H9ClS
    Forma y color:Solid
    Peso molecular:124.632

    Ref: TM-T204286

  • 2-Amino-2'-fluoro-2'-deoxyadenosine
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    2-Amino-2'-fluoro-2'-deoxyadenosine

    CAS:
    <p>2-Amino-2'-fluoro-2'-deoxyadenosine is a component of nucleic acids.</p>
    Fórmula:C10H13FN6O3
    Forma y color:Solid
    Peso molecular:284.25

    Ref: TM-TSW-00955

  • PCNA-IN-1
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    PCNA-IN-1

    CAS:
    PCNA-IN-1 (Compound 11) is an inhibitor of the PCNA/PIP-box interaction, with an IC50 greater than 50 μM. It is applicable in cancer research.
    Fórmula:C19H18I3NO3
    Forma y color:Solid
    Peso molecular:689.065

    Ref: TM-T204170

  • 2′-F-UDP
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    2′-F-UDP

    CAS:
    2′-F-UDP is a nucleotide analogue used in the synthesis of oligonucleotides.
    Fórmula:C9H13FN2O11P2
    Forma y color:Solid
    Peso molecular:406.15

    Ref: TM-TSW-00958