Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(114 productos)
- CDK(542 productos)
- Detención del ciclo celular(5 productos)
- Chk(47 productos)
- DYRK(48 productos)
- Dynamin(27 productos)
- Ferroptosis(226 productos)
- HSP(179 productos)
- Integrin(228 productos)
- Kinesina(88 productos)
- LIM quinasa(20 productos)
- Asociado a microtúbulos(274 productos)
- PKC(119 productos)
- PLK(25 productos)
- ROCK(63 productos)
- Rho(5 productos)
- Wee1(14 productos)
- c-Myc(76 productos)
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Se han encontrado 3826 productos de "Ciclo celular / Checkpoint"
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WRN inhibitor 7
CAS:WRN inhibitor 7 (Compound h6), a potent inhibitor of Werner syndrome helicase, demonstrates effective suppression of WRN's helicase and ATPase activities with IC50 values of 9.8 μM and 15.8 μM, respectively. This compound is utilized in the study of microsatellite instable (MSI) cancers [1].Fórmula:C27H23N3O6Forma y color:SolidPeso molecular:485.498-Oxo-dATP
CAS:8-Oxo-dATP can be hydrolyzed to its monophosphate form by the oxidation of purine nucleoside triphosphate MTH1, preventing erroneous incorporation during DNA replication or transcription.Fórmula:C10H12Li4N5O13P3Forma y color:SolidPeso molecular:530.913NSC 641396
CAS:NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC50 value of 1.2 μM. Additionally, it acts as an inhibitor of protein arginine N-methyltransferase 9 (PRMT9) and exhibits antitumor properties.Fórmula:C18H13NO3Forma y color:SolidPeso molecular:291.301DB18
CAS:DB18 serves as a potent, selective inhibitor of CDC2-like kinases (CLKs), exhibiting IC50 values between 10-30 nM for CLK1, CLK2, and CLK4. Additionally, it possesses anti-tumor activity [1].Fórmula:C24H18ClN7O3Forma y color:SolidPeso molecular:487.9PKMYT1-IN-2
CAS:PKMYT1-IN-2 (compound 2) serves as a powerful inhibitor of PKMYT1, exhibiting an IC 50 of 5.7 nM. Additionally, it effectively suppresses the proliferation of HCC1569 cells with an IC 50 of 22 nM [1].Fórmula:C22H19N5O2Forma y color:SolidPeso molecular:385.42ART615
ART615 is a related isomer of ART558. ART615 inhibits Polθ by <10% at 12 μM and is able to act as a control for ART558 (IC50:7.9 nM).Fórmula:C21H21F3N4O2Forma y color:SolidPeso molecular:418.41CDK2-IN-18
CAS:CDK2-IN-18 (compound 8q) serves as a powerful inhibitor of CDK 2/E and CDK 4/D1, showing IC50 values of 8 nM and 46 nM, respectively. It effectively inhibits tumor cell proliferation [1].Fórmula:C21H23N7O2SForma y color:SolidPeso molecular:437.52Uridine 3',5'-diphosphate
CAS:Uridine 3′,5′-diphosphate (3′,5′-UDP; Compound pUp) serves as a competitive RNase inhibitor [1].Fórmula:C9H14N2O12P2Forma y color:SolidPeso molecular:404.16GSK3335103
CAS:GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.Fórmula:C27H36FN3O4Forma y color:SolidPeso molecular:485.59Rhodblock 1a
CAS:Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway, which disrupts the localization and function of proteins within the Rho pathway. This interference hinders the proper formation of the cleavage furrow during cell division, leading to some cells either failing to form the cleavage furrow or forming a ruptured furrow, resulting in binucleated cells. Rhodblock 1a can be utilized for investigating cell division mechanisms and holds potential for research into cardiovascular diseases and cancer.
Fórmula:C20H16N2O2Forma y color:SolidPeso molecular:316.353DHX9-IN-9
CAS:DHX9-IN-9 (509) acts as an inhibitor of the RNA helicase DHX9, demonstrating an EC50 of 0.0177 μM in DHX9 cellular target engagement, primarily utilized in cancer research [1].Fórmula:C21H21ClFN5O3S2Forma y color:SolidPeso molecular:510CDK2/4-IN-2
CAS:CDK2/4-IN-2 (compound 56) serves as a dual inhibitor for CDK2 and CDK4, exhibiting an IC50 of less than 100 nM. It is applicable in cancer research.Fórmula:C18H20F3N7O3S2Forma y color:SolidPeso molecular:503.52Anti-neuroinflammation agent 3
CAS:Compound A.10.3 (Anti-neuroinflammation agent 3) exhibits inhibitory activity against various Ser/Thr kinases or receptor/non-receptor tyrosine kinases.Fórmula:C22H23FN6O2Peso molecular:422.455CDK8-IN-14
CAS:CDK8-IN-14 (compound 12) effectively inhibits CDK8, demonstrating an IC50 of 39.2 nM, and exhibits potent anti-AML cell proliferation effects, with a GC50 value of 0.02±0.01μM in MOLM-13 cells and 0.03±0.01μM in MV4-11 cells [1].Fórmula:C18H13N3O2Forma y color:SolidPeso molecular:303.31Tetrahydrouridine dihydrate
THU dihydrate, a potent CDA inhibitor, outperforms cytidine by blocking the enzyme's active site.Fórmula:C9H20N2O8Forma y color:SolidPeso molecular:284.26KI-CDK9d-32
CAS:KI-CDK9d-32 is a CDK9 PROTAC degrader with a DC50 of 0.89 nM. It facilitates the ubiquitination and degradation of CDK9, inhibits the MYC pathway, and disrupts nucleolar homeostasis. KI-CDK9d-32 demonstrates anticancer activity.Fórmula:C39H45N9O4Forma y color:SolidPeso molecular:703.83BBI-355
CAS:BBI-355 is an oral, potent, and selective small molecule CHK1 inhibitor with an IC50 of 0.3 nM. It exhibits significant antitumor activity, both as a monotherapy and in combination with targeted therapies, across various ecDNA+ oncogene-amplified tumor models.Fórmula:C19H19N7O2Forma y color:SolidPeso molecular:377.40AM-9022
CAS:AM-9022 is a potent and selective KIF18A inhibitor, orally active and suitable for cancer research [1].Fórmula:C27H36F2N6O4SForma y color:SolidPeso molecular:578.67Protein kinase inhibitor 14
CAS:Protein kinase inhibitor 14 (Compound 13) exhibits inhibitory effects on various serine/threonine kinases and receptor/non-receptor tyrosine kinases.Fórmula:C22H22F2N6OForma y color:SolidPeso molecular:424.4472'-F-UMP
CAS:2'-F-UMP is a nucleotide analogue used in the synthesis of oligonucleotides.
Fórmula:C9H12FN2O8PPeso molecular:326.17
