Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(120 productos)
- CDK(561 productos)
- Detención del ciclo celular(8 productos)
- Chk(49 productos)
- DYRK(47 productos)
- Dynamin(28 productos)
- Ferroptosis(229 productos)
- HSP(184 productos)
- Integrin(288 productos)
- Kinesina(88 productos)
- LIM quinasa(22 productos)
- Asociado a microtúbulos(286 productos)
- PKC(130 productos)
- PLK(25 productos)
- ROCK(62 productos)
- Rho(7 productos)
- Wee1(19 productos)
- c-Myc(80 productos)
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Se han encontrado 2894 productos para "Ciclo celular / Checkpoint".
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DG1
DG1 (Compound 8Nc), a Thymidylate Synthase (TS) inhibitor, impedes angiogenesis and alters metabolic reprogramming in NSCLC cells, while effectively suppressingFórmula:C19H17N5O5SForma y color:SolidPeso molecular:427.43xStAx-VHLL
Selective β-catenin degrader, xStAx-VHL peptide, lowers its levels in cells and inhibits tumor growth.Forma y color:SolidCDK2/4-IN-1
CDK2/4-IN-1 (compound B-4a) serves as both a CDK2/4 inhibitor and a microtubule polymerization inhibitor, making it useful in cancer research.Forma y color:Odour SolidSP27
CAS:SP27, a selective PROTAC, degrades PLK4 with a DC50 of 19.5 nM and may be utilized in breast cancer research [1].Fórmula:C40H40F2N12O5Pureza:98%Forma y color:SolidPeso molecular:806.82SK2187
CAS:SK2187 is a selective degrader of AURKAPROTAC with a DC50 of approximately 10 nM. It exhibits growth-inhibitory effects on NGP cells, with an IC50 value of 101.5 nM. SK2187 is utilized in studies of MYCN-amplified neuroblastoma.Fórmula:C45H49ClFN7O11SForma y color:SolidPeso molecular:950.43PRV-IN-1
PRV-IN-1 (compound c14) demonstrates significant antiviral activity against pseudorabies virus (PRV) with an EC50 of 14 pM and a CC50 of 343.7 μM. It effectively inhibits the replication of PRV.Fórmula:C20H28N4O3Forma y color:SolidPeso molecular:372.461Vasoactive intestinal contractor
CAS:Vasoactive intestinal contractor, a novel member of the endothelin family, stimulates a rapid increase in intracellular Ca2+ concentration in fura-2-overexpressed Swiss 3T3 cells [1.Fórmula:C116H161N27O32S4Forma y color:SolidPeso molecular:2573.94BSJ-5-63
CAS:BSJ-5-63 is an effective degrader of CDK12, CDK7, and CDK9. It reduces the protein expression of CDK12, CDK7, CDK9, RNAPII, and Cyclin K, and also decreases the mRNA expression of BRCA1 and BRCA2. BSJ-5-63 exhibits anticancer activity and holds potential for prostate cancer research.Fórmula:C52H74ClN9O6S2Forma y color:SolidPeso molecular:1020.78EC0489
CAS:EC0489, Small molecule-drug conjugate (SMDC) ,a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (Fórmula:C111H156N22O43S2Pureza:98%Forma y color:SolidPeso molecular:2550.7Integrin Binding Peptide
CAS:Integrin Binding Peptide, derived from fibronectin, holds the potential as an essential component for preparing PEG hydrogels.Fórmula:C42H63N15O16SForma y color:SolidPeso molecular:1066.12F3 peptide
CAS:F3 peptide is a fragment of human high mobility group protein 2 (HMGB2) that specifically binds to nucleolin, expressed on the membranes of cancer cells, neovasculature, and endothelial cells. Serving as an effective ligand, F3 peptide enhances the druggability of macromolecular drugs or nanoparticles.Fórmula:C152H263N49O41Forma y color:SolidPeso molecular:3433.02FF-10502
CAS:FF-10502, a pyrimidine analog of Gemcitabine, inhibits DNA polymerases α/β, targeting dormant cancer cells.Fórmula:C9H12FN3O3SForma y color:SolidPeso molecular:261.27PROTAC CDK9 degrader-7
CAS:PROTAC CDK9 degrader-7 is a proteolysis-targeting chimera (PROTAC) specifically designed to target and mediate the degradation of Cyclin-Dependent Kinase 9 (Fórmula:C43H50Cl2N8O9Forma y color:SolidPeso molecular:893.81MUS81-IN-1
MUS81-IN-1 (compound 23) is an MUS81 inhibitor, utilized in cancer research.Fórmula:C23H21N3O5Forma y color:SolidPeso molecular:419.14812TS-002266
CAS:TS-0022666 is a selective TUT4/7 inhibitor, antiproliferative and anti-leukaemic in vivo and in vitro, cancers with FOCAD deficiency.Fórmula:C31H32Cl2N6O5Pureza:98.18%Forma y color:Yellow SolidPeso molecular:639.538-iso Prostaglandin F1β
CAS:8-iso Prostaglandin F1β,inducet vasoconstrictor effects in (PA), (PV) and (MA) through the activation of TXA2R, tyrosine kinase and Rho kinase.Fórmula:C20H36O5Forma y color:SolidPeso molecular:356.5USP7 Ligand-Linker Conjugates 1
USP7Ligand-Linker Conjugates 1 is a Target Protein Ligand-Linker Conjugate comprising a USP7 ligand and a PROTAC linker, capable of recruiting E3 ligase. It is utilized in the synthesis of PROTACUSP7 Degrader-1.Forma y color:Odour SolidCDK9-IN-25
CDK9-IN-25 (compound 4a), an imidazopyrazine derivative, functions as a CDK9 inhibitor with an IC50 of 0.24 μM.Fórmula:C15H16FN5Pureza:98%Forma y color:SolidPeso molecular:285.32TMX-2138
CAS:TMX-2138 is a CDKs PROTAC degrader, with IC50 values of 8.7 nM for CDK1/cyclinB, 10.9 nM for CDK2/cyclinA, 7.0 nM for CDK5/p25, and 25.7 nM for CDK9/cyclinT1. It enhances the ubiquitination and degradation of CDKs and is utilized for ovarian cancer research.Fórmula:C40H43BrFN9O11SForma y color:SolidPeso molecular:956.791Dentonin TFA
Dentonin TFA (AC-100 TFA) is a short peptide fragment derived from MEPE. It enhances osteogenesis by promoting the adhesion of osteoprogenitor cells and supports the survival of immature adherent cells. Dentonin TFA does not have a significant effect on mature osteoblasts and can be utilized in studies of phosphate homeostasis and bone metabolism.Fórmula:C109H161F3N30O44Peso molecular:2651.1235
