Metabolismo

<p>LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)</p>

<p>Monacolin J (Antibiotic MB 530A) is a cholesterol biosynthesis inhibitor.</p>

<p>KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.</p>

<p>Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.</p>

<p>P 218 is a novel DHFR inhibitor with antimalarial activity and antifolate effects and can be used to study Buruli ulcer.</p>

<p>Meclofenoxate HCl (Lucidril) boosts memory and cognition; it's a DIMETHYLAMINOETHANOL and p-chlorophenoxyacetic acid ester.</p>

<p>L-Tyrosine ((S)-Tyrosine) is a naturally occurring tyrosine and is synthesized in vivo from L-phenylalanine, considered a non-essential amino acid.</p>

<p>XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).</p>

<p>Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes.</p>

<p>Clarithromycin (A-56268), a macrolide antibiotic, inhibits Cytochrome P450 3A4 and P-Glycoprotein.</p>

<p>MM0299 is brain permeable, has anti-glioblastoma activity, inhibits lanosterol synthase (LSS), and induces EPC production in in situ GBM tumors.</p>

<p>GSTO1-IN-1 is a potent glutathione S-transferase omega 1 inhibitor (GSTO1; IC50: 31 nM).</p>

<p>Garadacimab (CSL312) is a human IgG4 antibody against FXIIa, used to research hereditary angioedema.</p>

<p>Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.</p>

<p>Hydralazine hydrochloride, an antihypertensive phthalazine, induces vasodilation and may inhibit tumor DNA methylation.</p>

<p>Nilvadipine (FK235), a calcium channel blocker (CCB), is utilized for treatment of hypertension.</p>

<p>Atovaquone (Atavaquone) is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.</p>

<p>Emicizumab (ACE 910), a humanized antibody, mimics factor VIII, treating and preventing hemophilia A.</p>

<p>Mafenide hydrochloride (4-Aminomethylbenzenesulfonamide hydrochloride) is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-</p>

<p>Arhalofenate (JNJ 39659100) is a selective partial agonist of peroxisome proliferator-activated receptor PPARγ. It is used for the treatment of type 2 diabetes.</p>

<p>OMDM-1 ((Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide) is a selective and metabolically stable anandamide cellular uptake (ACU)</p>

<p>(S)-(+)-N-3-Benzylnirvanol is a cytochrome P450 CYP2C19 inhibitor with a ki value of 82.5μM for CYP2C9 and 0.25μM for CYP2C19.Cost-effective and quality-assured.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Rat PP protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat PP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat PP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Synta66 is a store-operated calcium entry channel Orai inhibitor, and used for the research of neurological disease.</p>

<p>Aldose reductase-IN-1 (AT-001, Caficrestat) is a highly potent inhibitor of aldose reductase.Cost-effective and quality-assured.</p>

<p>Ethylvanillin (Rhodiarome) is a flavorant used in the production of chocolate. It is about three times as potent as vanillin.</p>

<p>PF-06424439 methanesulfonate: oral, potent, selective DGAT2 inhibitor (IC50=14 nM), noncompetitive, slowly reversible.</p>

<p>N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.</p>

<p>MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).</p>

<p>Praziquantel (Droncit) is an anthelmintic that paralyzes worms by increasing calcium in muscle cells, causing tegument damage and immune response.</p>

<p>5-Phenylhydantoin is a Mephenytoin metabolite with anti-epileptic effects, targeting NVSCs.</p>

<p>Hematin (Ferrihemic acid) is an iron-containing porphyrin.</p>

<p>Gabexate mesylate (FOY) inhibits thrombin, plasmin, kallikrein; used for pancreatitis, DIC, hemodialysis anticoagulant.</p>

<p>Otilonium bromide (SP63) , an antimuscarinic, is utilized as a spasmolytic agent.</p>

<p>Debutylbupivacaine is the intermediate of ropivacaine hydrochloride and bupivacaine.</p>

<p>SC-26196 is an orally active inhibitor of Delta6 desaturase (D6D) with IC50 of 0.2 μM in a rat liver microsomal assay, with antiinflammatory properties.</p>

<p>Sodium 2-mercaptoethanesulfonate (Uromitexan) is a sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from antineoplastic.</p>

<p>ML349 is an inhibitor of LYPLA2 (IC50: 144 nM). ML349 is an effective and specific acyl protein thioesterase 2 (APT-2) inhibitor (Ki: 120 nM).</p>

<p>Finasteride (MK-906) is an oral inhibitor of active testosterone 5-alpha-reductase and Ki value is 10 nM.</p>

<p>Mutant IDH1 inhibitor is an effective inhibitor of mutant IDH1 R132H (IC50: &lt; 72 nM).</p>

<p>N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Mouse PP protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse PP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse PP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PL. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PL. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human PL, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human PL in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>DATPT is a 12WLVSKF17 peptide mimetic molecule with anti-inflammatory and antimicrobial activities.DATPT inhibits the production of reactive oxygen species.</p>

<p>HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).</p>

<p>Aspartame (SC-18862), an artificial, non-carbohydrate sweetener, is aspartyl-phenylalanine-1-methyl ester.</p>

<p>2-Methoxy Phenothiazine is light yellow or light gray solid.</p>

<p>Pyrimethamine (Pirimecidan) is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.</p>

<p>Norgestimate metabolite Norelgestromin (17-Deacylnorgestimate), an active metabolites of norgestimate, is a steroidal progestin used in contraceptive patches.</p>

<p>GV-58 agonizes N/P-Q-type Ca2+ channels (EC50: 7.21/8.81 μM) with 20x less inhibition on CDK kinases.</p>