GPCR / proteína G
Los inhibidores de GPCR/proteínas G son compuestos que se dirigen a los receptores acoplados a proteínas G (GPCR) y a las proteínas G asociadas, que desempeñan roles cruciales en la transmisión de señales desde el exterior hacia el interior de las células. Estos inhibidores son esenciales para estudiar las vías de señalización mediadas por los GPCR, que están involucradas en numerosos procesos fisiológicos, incluyendo la percepción sensorial, la respuesta inmunitaria y la neurotransmisión. Los inhibidores de GPCR también son importantes en el desarrollo de fármacos, ya que muchos agentes terapéuticos tienen como objetivo estos receptores. En CymitQuimica, ofrecemos una amplia gama de inhibidores de GPCR/proteínas G de alta calidad para apoyar su investigación en farmacología, biología celular y campos relacionados.
Subcategorías de "GPCR / proteína G"
- Receptor 5-HT(1.025 productos)
- Receptor de adenosina(251 productos)
- Receptor adrenérgico(3.027 productos)
- Receptor de bombesina(35 productos)
- Receptor de bradicinina(61 productos)
- CXCR(158 productos)
- CaSR(34 productos)
- Receptor de cannabinoides(218 productos)
- Colecistoquinina(1 productos)
- Receptor de dopamina(445 productos)
- Receptor de endotelina(86 productos)
- Receptor GNRH(84 productos)
- GPCR19(36 productos)
- GRK(33 productos)
- GTPasa(23 productos)
- Receptor de glucagón(195 productos)
- Hedgehog / Smoothened(49 productos)
- Receptor de histamina(385 productos)
- Receptor LPA(21 productos)
- Receptor de melatonina(26 productos)
- Receptor de OX(41 productos)
- Receptor de opioides(327 productos)
- PAFR(14 productos)
- PKA(60 productos)
- Receptor S1P(18 productos)
- SGLT(31 productos)
- Receptor sigma(46 productos)
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Se han encontrado 6011 productos de "GPCR / proteína G"
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Ro4368554
CAS:Ro4368554 is a selective 5-HT6 antagonist capable of crossing the blood-brain barrier. It can reverse memory deficits caused by scopolamine and tryptophan depletion. Ro4368554 is applicable for research related to memory impairments.Fórmula:C19H21N3O2SForma y color:SolidPeso molecular:355.454SB 258741 hydrochloride
SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1].Fórmula:C19H31ClN2O2SForma y color:SolidPeso molecular:386.98H1R ligand-1
CAS:H1R ligand-1 (Compound fragment 1) is a high-affinity ligand for the human histamine H1 receptor (H1R). It can serve as a scaffold for synthesizing a series of derivatives to investigate H1R binding kinetics.Fórmula:C19H23NOForma y color:SolidPeso molecular:281.3925-IAI hydrochloride
CAS:5-IAI hydrochloride is a psychoactive analog of para-iodoamphetamine. 5-IAI hydrochloride significantly reduces serotonin uptake sites and hippocampal serotonin levels in rats.Fórmula:C9H11ClINForma y color:SolidPeso molecular:295.548SGLT1/2-IN-8
CAS:SGLT1/2-IN-8 (compound 8) is a potent and orally active dual inhibitor of SGLT1/2, exhibiting IC50 values of 4 nM and 1 nM, respectively. It shows antihyperglycemic properties, making it suitable for related research.Fórmula:C22H26O6Forma y color:SolidPeso molecular:386.438SGLT1/2-IN-1
CAS:SGLT1/2-IN-1 is a dual SGLT1/SGLT2 inhibitor.Fórmula:C25H28O8Forma y color:SolidPeso molecular:456.48Lisuride
CAS:Lisuride: an oral D2 dopamine agonist, ergot derivative, used in Parkinson's, migraine, and high prolactin research.Fórmula:C20H26N4OForma y color:SolidPeso molecular:338.45MRS2279 diammonium
CAS:MRS2279 diammonium, a P2Y1 antagonist with K i 2.5 nM, IC 50 51.6 nM, blocks ADP-induced platelet aggregation, pK b 8.05.Fórmula:C13H24ClN7O8P2Forma y color:SolidPeso molecular:503.77AL 6598
CAS:AL 6598, a prodrug of PGD2 agonist AL 6556, reduces IOP by 53% at 1μg twice daily in monkeys; binds DP receptors with Ki of 3.2μM.Fórmula:C23H39ClO5Forma y color:SolidPeso molecular:431.01Dopamine D3 receptor antagonist-2
Dopamine D3 receptor antagonist-2 is a dopamine D3 receptor selective (Ki=2.16 nM) or multi-targeting dual ligand that shows potential effects in CNS disorders.Fórmula:C23H27Cl2N3O3Forma y color:SolidPeso molecular:464.38CS-003 Free base
CAS:CS-003: Triple neurokinin receptor antagonist; Ki=2.3 nM (NK1), 0.54 nM (NK2), 0.74 nM (NK3); treats respiratory diseases.Fórmula:C34H38Cl2N2O6SPureza:98%Forma y color:SolidPeso molecular:673.65L-796778 acetate
CAS:L-796778 acetate is a selective sst3 receptor agonist. In CHO-K1 cells expressing hsst3 receptors, it acts as a partial agonist that inhibits Forskolin-induced cAMP production, with an IC50 value of 18 nM. Additionally, L-796778 acetate exhibits anticonvulsant properties.Fórmula:C31H44N6O9Forma y color:SolidPeso molecular:644.716GRPR antagonist-1
GRPR antagonist-1 targets GRPR, kills specific cancer cells (e.g., PC3, Pan02, HGC-27), and promotes apoptosis by modulating Bcl-2 and Bax.Fórmula:C29H33F3N4O4Forma y color:SolidPeso molecular:558.59BER-5
CAS:BER-5 is a potent MrgX2 antagonist, demonstrating broad-spectrum antagonistic activity against various MrgX2 agonists. It can inhibit Substance P(SP)-induced degranulation in LAD2 cells and alleviate SP-induced allergic reactions in mice. BER-5 is useful for researching mechanisms related to allergic reactions.Fórmula:C20H16O4Forma y color:SolidPeso molecular:320.3416(R)-Iloprost
CAS:Iloprost, a potent prostacyclin analog, binds IP & EP1 receptors (Ki 11 nM), contains 16(S/R) isomers, and inhibits platelets (IC50 65 nM).Fórmula:C22H32O4Forma y color:SolidPeso molecular:360.49MRS2279
CAS:Selective, high affinity competitive antagonist of the P2Y1 receptorFórmula:C13H18ClN5O8P2Pureza:98%Forma y color:SolidPeso molecular:469.71CCG258208
CAS:GRKs-IN-1 has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).Fórmula:C24H25FN4O4Pureza:98%Forma y color:SolidPeso molecular:452.48OP-2507
CAS:OP-2507, a prostacyclin agonist, is used potentially for the treatment of hepatic insufficiency and hypertension.Fórmula:C25H41NO4Pureza:98%Forma y color:SolidPeso molecular:419.6(S)-AL-8810
CAS:(S)-AL 8810 is an 11β-fluoro analog of PGF2α, serving as a potent and selective antagonist for FP receptors. It is the C-15 diastereomer of AL 8810, with an inverted (S) configuration at C-15 compared to AL 8810, where the "natural" configuration is 15-(R).Fórmula:C24H31FO4Peso molecular:402.50Lactic acid sodium (60% w/w in water)
CAS:Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is an activator of hydroxycarboxylic acid receptor 1 (HCAR1) and an epigenetic regulator that induces lysine residue lactylation. As the end product of glycolysis, it bridges the gap between glycolysis and oxidative phosphorylation. This compound is a tumor metabolite, offering immunoprotective effects of lactate in antitumor immunity. Additionally, it possesses antimicrobial properties and can be used as a food preservative.Fórmula:C3H5NaO3Forma y color:SolidPeso molecular:112.06
