GPCR / proteína G
Los inhibidores de GPCR/proteínas G son compuestos que se dirigen a los receptores acoplados a proteínas G (GPCR) y a las proteínas G asociadas, que desempeñan roles cruciales en la transmisión de señales desde el exterior hacia el interior de las células. Estos inhibidores son esenciales para estudiar las vías de señalización mediadas por los GPCR, que están involucradas en numerosos procesos fisiológicos, incluyendo la percepción sensorial, la respuesta inmunitaria y la neurotransmisión. Los inhibidores de GPCR también son importantes en el desarrollo de fármacos, ya que muchos agentes terapéuticos tienen como objetivo estos receptores. En CymitQuimica, ofrecemos una amplia gama de inhibidores de GPCR/proteínas G de alta calidad para apoyar su investigación en farmacología, biología celular y campos relacionados.
Subcategorías de "GPCR / proteína G"
- Receptor 5-HT(1.025 productos)
- Receptor de adenosina(251 productos)
- Receptor adrenérgico(3.027 productos)
- Receptor de bombesina(35 productos)
- Receptor de bradicinina(61 productos)
- CXCR(158 productos)
- CaSR(34 productos)
- Receptor de cannabinoides(218 productos)
- Colecistoquinina(1 productos)
- Receptor de dopamina(445 productos)
- Receptor de endotelina(86 productos)
- Receptor GNRH(84 productos)
- GPCR19(36 productos)
- GRK(33 productos)
- GTPasa(23 productos)
- Receptor de glucagón(195 productos)
- Hedgehog / Smoothened(49 productos)
- Receptor de histamina(385 productos)
- Receptor LPA(21 productos)
- Receptor de melatonina(26 productos)
- Receptor de OX(41 productos)
- Receptor de opioides(327 productos)
- PAFR(14 productos)
- PKA(60 productos)
- Receptor S1P(18 productos)
- SGLT(31 productos)
- Receptor sigma(46 productos)
Mostrar 19 subcategorías más
Se han encontrado 6011 productos de "GPCR / proteína G"
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(S)-Bucindolol
CAS:(S)-Bucindolol is an enantiomer of bucindolol, specifically a β1-adrenergic receptor antagonist. It is primarily utilized in research related to heart failure.Fórmula:C22H25N3O2Forma y color:SolidPeso molecular:363.45Nolpitantium besilate
CAS:Nolpitantium besilate is a neurokinin-1 receptor antagonist.Fórmula:C43H50Cl2N2O5SForma y color:SolidPeso molecular:777.84MK-8318
CAS:MK-8318 is an effective and selective antagonist of the CRTh2 receptor (Ki: 5.0 nM).Fórmula:C27H26F4N2O5Pureza:98%Forma y color:SolidPeso molecular:534.5Tipelukast
CAS:Tipelukast (KCA 757), an oral drug for asthma research, blocks leukotrienes and fights inflammation and fibrosis.Fórmula:C29H38O7SPureza:>99.99%Forma y color:SolidPeso molecular:530.67MRS2179 tetrasodium hydrate
MRS2179 blocks turkey P2Y1 receptor (Kb 102 nM, pA2 6.99), affects platelet aggregation, and has varying IC50s on P2 receptors.Fórmula:C11H15N5Na4O10P2Forma y color:SolidPeso molecular:576.21Protease-Activated Receptor-1 antagonist 2
Selective, orally active PAR-1 antagonist with an IC50 of 7 nM, potential for cardiovascular disease studies.Forma y color:SolidTAK-024
CAS:TAK-024 is an inhibitor of platelet(IC50s of 31, 79 and 51 nM in human, monkey and guinea pig, respectively).Fórmula:C27H34N10O6Pureza:98%Forma y color:SolidPeso molecular:594.62PSB-KK1415
CAS:PSB-KK1415 is a selective agonist for the human orphan G protein-coupled receptor GPR18, with an EC50 of 19.1 nM.Fórmula:C24H23ClN6O2Peso molecular:462.93Lythrine
CAS:Lythrine ((+)-Lythrine) is an alkaloid first isolated from H. salicifolia, known to inhibit prostaglandin synthase with an IC50 of 469 μM.Fórmula:C26H29NO5Peso molecular:435.51Leukotriene B4 dimethyl amide
CAS:LTB4 dimethyl amide: inhibits human neutrophil degranulation and rat lysozyme release; antagonizes LTB4 receptor on guinea pig lung membranes (Ki = 130 nM).Fórmula:C22H37NO3Forma y color:SolidPeso molecular:363.53Leukotriene F4
CAS:LTF4, made in vitro from LTE4 with enzymes, contracts vascular muscle weakly; potency is LTD4 > LTC4 > LTE4 >> LTF4.Fórmula:C28H44N2O8SForma y color:SolidPeso molecular:568.72HU-308
CAS:HU-308, a synthetic cannabinoid analogue, is a highly selective agonist of the CB2 receptor. It demonstrates an affinity for the CB2 receptor that is over 440 times greater than its affinity for the CB1 receptor, which are predominantly found in immune cells. This compound plays a crucial role in modulating the immunosuppressive effects of the endocannabinoid system (ECS). Additionally, HU-308 possesses anti-inflammatory and neuroprotective properties, and it regulates the function of microglia. Its potential applications include research into neuroinflammation and retinal diseases.
Fórmula:C27H42O3Forma y color:SolidPeso molecular:414.62SB-423557
CAS:SB-423557 is an orally active antagonist of calcium-sensing receptor (CaR) with IC50 of 520 nMFórmula:C28H36N2O4Pureza:98%Forma y color:SolidPeso molecular:464.60VA012
CAS:VA012 (compound 11) acts as a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. It has been shown to reduce food intake and prevent weight gain during subchronic administration without causing central nervous system-related discomfort. VA012 is applicable in obesity research.Fórmula:C21H19N3Forma y color:SolidPeso molecular:313.40Merigolix
CAS:Merigolix is a potent gonadotrophin releasing hormone (GnRH) antagonist .Fórmula:C36H35F7N4O6Forma y color:SolidPeso molecular:752.68AM8936
AM8936: potent CB1 agonist, EC50 rCB1=8.6nM/hCB1=1.4nM, Ki rat CB1=0.55nM; potential for CNS, metabolic, pain, glaucoma research.Fórmula:C25H33NO3Forma y color:SolidPeso molecular:395.535-HT2A receptor agonist-7
CAS:5-HT2A receptor agonist-7 (517) functions as a modulator of the 5-HT2A receptor, with an EC50 value of less than 100 nM.Fórmula:C12H11F2N3Forma y color:SolidPeso molecular:235.233LPA receptor antagonist-1
CAS:LPA receptor antagonist-1 (example 52) serves as an antagonist for the lysophosphatidic acid (LPA) receptor and is applicable in various types of studies [1].Fórmula:C30H26ClNO5SForma y color:SolidPeso molecular:548.05U75302
CAS:U75302 is an antagonist of thymosin beta-4 (TB4) receptor with a Ki value of 159 nM on guinea pig lung membranes.Fórmula:C22H35NO3Pureza:98%Forma y color:Light Yellow OilPeso molecular:361.52Sp-UTP-α-S
CAS:Sp-UTP-α-S serves as an activator of P2Y2 and P2Y4 receptors and is applicable in cancer research.Fórmula:C9H15N2O14P3SPeso molecular:500.21
