GPCR / proteína G
Los inhibidores de GPCR/proteínas G son compuestos que se dirigen a los receptores acoplados a proteínas G (GPCR) y a las proteínas G asociadas, que desempeñan roles cruciales en la transmisión de señales desde el exterior hacia el interior de las células. Estos inhibidores son esenciales para estudiar las vías de señalización mediadas por los GPCR, que están involucradas en numerosos procesos fisiológicos, incluyendo la percepción sensorial, la respuesta inmunitaria y la neurotransmisión. Los inhibidores de GPCR también son importantes en el desarrollo de fármacos, ya que muchos agentes terapéuticos tienen como objetivo estos receptores. En CymitQuimica, ofrecemos una amplia gama de inhibidores de GPCR/proteínas G de alta calidad para apoyar su investigación en farmacología, biología celular y campos relacionados.
Subcategorías de "GPCR / proteína G"
- Receptor 5-HT(1.025 productos)
- Receptor de adenosina(249 productos)
- Receptor adrenérgico(3.022 productos)
- Receptor de bombesina(35 productos)
- Receptor de bradicinina(61 productos)
- CXCR(158 productos)
- CaSR(34 productos)
- Receptor de cannabinoides(217 productos)
- Colecistoquinina(1 productos)
- Receptor de dopamina(445 productos)
- Receptor de endotelina(86 productos)
- Receptor GNRH(84 productos)
- GPCR19(33 productos)
- GRK(33 productos)
- GTPasa(23 productos)
- Receptor de glucagón(194 productos)
- Hedgehog / Smoothened(49 productos)
- Receptor de histamina(385 productos)
- Receptor LPA(21 productos)
- Receptor de melatonina(26 productos)
- Receptor de OX(41 productos)
- Receptor de opioides(327 productos)
- PAFR(14 productos)
- PKA(60 productos)
- Receptor S1P(18 productos)
- SGLT(31 productos)
- Receptor sigma(46 productos)
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Se han encontrado 5983 productos de "GPCR / proteína G"
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Nedocromil sodium
CAS:Nedocromil sodium is a pharmacologic stabilizer of mast cells, has been shown to normalize cytokine levels and attenuate cardiac remodeling.Fórmula:C19H17NNaO7Pureza:98%Forma y color:SolidPeso molecular:394.335Edonentan hydrate
CAS:Edonentan (BMS 207940) hydrate effectively blocks the endothelin A (ETA) receptor as a potent and selective antagonist, featuring a K i of 10 pM. It exhibits complete (100%) oral bioavailability in rats [1].Fórmula:C28H34N4O6SForma y color:SolidPeso molecular:554.66DMPX
CAS:DMPX (3,7-Dimethyl-1-propargylxanthine) is a caffeine-like compound capable of crossing the blood-brain barrier. It serves as an A2-selective adenosine receptor (AR) antagonist, effectively and selectively blocking the hypothermia and behavioral inhibition induced by A2 adenosine receptor agonists, such as NECA. DMPX is utilized in research on diseases like Parkinson's disease.Fórmula:C10H10N4O2Forma y color:SolidPeso molecular:218.212Anti-MRSA agent 19
CAS:Anti-MRSA agent 19 (Compound 1) is an antibiotic that exhibits activity against Staphylococcus aureus. It is active against 40 clinical isolates from the CDC, representing diverse bacterial species with various resistance factors, including resistance to vancomycin, aminoglycoside/tetracycline, and oxazolidinone (median MIC=4 μg/mL).Fórmula:C15H10Cl3NO4Forma y color:SolidPeso molecular:374.6SSR 146977 hydrochloride
CAS:SSR 146977 hydrochloride is a potent, selective antagonist of the tachykinin NK 3 receptor, and it can be utilized in research on psychiatric disorders and airway inflammation [1].Fórmula:C35H43Cl3N4O2Peso molecular:658.1LPA5 antagonist 2
LPA5 antagonist 2, compound 65, water-soluble, reduces nociception, for inflammatory/neuropathic pain study.Fórmula:C26H25FN2O4SForma y color:SolidPeso molecular:480.55CI-936
CAS:CI-936 (MRS-3310) is an orally active A2 agonist with a binding affinity of 25 nM. In preclinical studies, it has demonstrated potent and selective effects, indicating potential antipsychotic efficacy. Additionally, CI-936 inhibits exploratory behavior in mice.Fórmula:C24H25N5O4Forma y color:SolidPeso molecular:447.49Cannabigerovarin
CAS:Cannabigerovarin (CBGV) is a compound categorized as a phytocannabinoid.Fórmula:C19H28O2Peso molecular:288.42LAS195319
CAS:LAS195319 is a potent and selective inhaled PI3Kδ Inhibitor (IC50 = 0.5 nM) for the Treatment of Respiratory Diseases.Fórmula:C29H26N10O3SForma y color:SolidPeso molecular:594.65MCTR1
CAS:MCTR1, a pro-resolving mediator derived from DHA, promotes tissue repair and reduces inflammation by enhancing phagocytosis and decreasing eicosanoids.Fórmula:C32H47N3O9SForma y color:SolidPeso molecular:649.8Pexacerfont
CAS:Pexacerfont (BMS-562086) is a selective antagonist of the corticotropin-releasing factor receptor (IC50: 6.1±0.6 nM for the human CRF1 receptor).Fórmula:C18H24N6OPureza:99.77%Forma y color:SolidPeso molecular:340.42CCR3 antagonist 2
CAS:CCR3 antagonist2 (example 66) is a CCR3 antagonist useful for researching inflammatory or allergic diseases, particularly those affecting the respiratory tract, such as inflammatory or obstructive airway conditions.Fórmula:C21H28ClN5O3Forma y color:SolidPeso molecular:433.93Butopamine hydrochloride
CAS:Butopamine hydrochloride is an orally active inotropic compound that is more effective at increasing heart rate compared to Dobutamine.Fórmula:C18H24ClNO3Forma y color:SolidPeso molecular:337.8412(S)-HEPE
CAS:12(S)-HEPE, made from EPA by 12-LO, is an anti-inflammatory ω-3 derivative affecting leukotriene formation.Fórmula:C20H30O3Forma y color:SolidPeso molecular:318.45LY210073
CAS:LY210073 is an antagonist of the Leukotriene B4 (LTB4) receptor (IC50: 6.2 nM).Fórmula:C30H28O8Pureza:98%Forma y color:SolidPeso molecular:516.54CHNQD-01255
CAS:CHNQD-01255 is an orally active inhibitor of Arf-GEFs that is effective against hepatocellular carcinoma (HCC).Fórmula:C23H29NO6Forma y color:SolidPeso molecular:415.48L-796778 acetate
CAS:L-796778 acetate is a selective sst3 receptor agonist. In CHO-K1 cells expressing hsst3 receptors, it acts as a partial agonist that inhibits Forskolin-induced cAMP production, with an IC50 value of 18 nM. Additionally, L-796778 acetate exhibits anticonvulsant properties.Fórmula:C31H44N6O9Forma y color:SolidPeso molecular:644.716M1069
M1069 is an oral A2A/A2B receptor antagonist, 100x more selective over A1/A3, with antitumor properties by blocking adenosine's immunosuppressive effects.Fórmula:C25H30N4O8SForma y color:SolidPeso molecular:546.59MRS2279
CAS:Selective, high affinity competitive antagonist of the P2Y1 receptorFórmula:C13H18ClN5O8P2Pureza:98%Forma y color:SolidPeso molecular:469.71KARI 201 hydrochloride
CAS:KARI 201 hydrochloride is a selective, brain-penetrant, competitive inhibitor of acid sphingomyelinase (ASM) with an IC50 of 338.3 nM. It also acts as an agonist for the growth hormone-releasing peptide receptor (ghrelin receptor). Additionally, KARI 201 hydrochloride can enhance the neuropathological features of Alzheimer's disease.Fórmula:C14H29ClN4O2Forma y color:SolidPeso molecular:320.86
