GPCR / proteína G
Los inhibidores de GPCR/proteínas G son compuestos que se dirigen a los receptores acoplados a proteínas G (GPCR) y a las proteínas G asociadas, que desempeñan roles cruciales en la transmisión de señales desde el exterior hacia el interior de las células. Estos inhibidores son esenciales para estudiar las vías de señalización mediadas por los GPCR, que están involucradas en numerosos procesos fisiológicos, incluyendo la percepción sensorial, la respuesta inmunitaria y la neurotransmisión. Los inhibidores de GPCR también son importantes en el desarrollo de fármacos, ya que muchos agentes terapéuticos tienen como objetivo estos receptores. En CymitQuimica, ofrecemos una amplia gama de inhibidores de GPCR/proteínas G de alta calidad para apoyar su investigación en farmacología, biología celular y campos relacionados.
Subcategorías de "GPCR / proteína G"
- Receptor 5-HT(1.025 productos)
- Receptor de adenosina(249 productos)
- Receptor adrenérgico(3.018 productos)
- Receptor de bombesina(35 productos)
- Receptor de bradicinina(61 productos)
- CXCR(158 productos)
- CaSR(34 productos)
- Receptor de cannabinoides(217 productos)
- Colecistoquinina(1 productos)
- Receptor de dopamina(445 productos)
- Receptor de endotelina(86 productos)
- Receptor GNRH(84 productos)
- GPCR19(33 productos)
- GRK(33 productos)
- GTPasa(23 productos)
- Receptor de glucagón(194 productos)
- Hedgehog / Smoothened(49 productos)
- Receptor de histamina(385 productos)
- Receptor LPA(21 productos)
- Receptor de melatonina(26 productos)
- Receptor de OX(41 productos)
- Receptor de opioides(327 productos)
- PAFR(14 productos)
- PKA(60 productos)
- Receptor S1P(18 productos)
- SGLT(31 productos)
- Receptor sigma(46 productos)
Mostrar 19 subcategorías más
Se han encontrado 5983 productos de "GPCR / proteína G"
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L 668750
CAS:L 668750 is an inhibitor of platelet-activating factor.Fórmula:C25H34O9SPureza:98%Forma y color:SolidPeso molecular:510.6IMP-1575
CAS:IMP-1575 is a highly effective inhibitor of hedgehog acyltransferase (HHAT), with an IC50 of 0.75 μM when inhibiting purified HHAT. IMP-1575 has potential applications in cancer research.Fórmula:C19H25N3OSPeso molecular:343.49Dersimelagon phosphate
CAS:Dersimelagon phosphate: MC1R agonist, boosts melanin, enhances light tolerance in EPP/XLP without sun.Fórmula:C36H48F4N3O9PForma y color:SolidPeso molecular:773.75(R)-MrgprX2 antagonist-3
CAS:(R)-MrgprX2 antagonist-3 is an antagonist of MrgprX2. It is applicable in the study of inflammatory skin diseases. For more detailed information, please refer to compound E118 in patent document WO2021092240A1.Fórmula:C16H20FN3O2SPeso molecular:337.41Burapitant
CAS:Burapitant (SSR 240600) is a novel non-peptide tachykinin neurokinin 1 (NK) receptor antagonist with anti-coke oven and antidepressant activity.
Fórmula:C31H35Cl2F6N3O3Pureza:>99.99% - >99.99%Forma y color:SolidPeso molecular:682.52Neladenoson
CAS:Neladenoson is an effective and selective agonist of the Adenosine A1 Receptor (A1R). EGFR-IN-162 shows potential for research in heart failure.Fórmula:C29H24ClN5O2S2Forma y color:SolidPeso molecular:574.12CCR1 antagonist 13
CAS:CCR1 antagonist13 is a selective small molecule antagonist of CCR1.Fórmula:C25H27ClFN3O4Forma y color:SolidPeso molecular:487.95HU 433
CAS:HU 433, a synthetic cannabinoid, acts as a CB2 receptor agonist and is an enantiomer of HU 308. It provides anti-inflammatory and neuroprotective effects by binding to the CB2 receptor, primarily found on immune cells, thereby modulating immune responses and inflammation. Additionally, HU 433 influences microglial signaling pathways, particularly LPS and IFNγ-mediated routes, affecting the phosphorylation of MAPKs, including ERK1/2, JNK, p38, and Akt. This compound is valuable in researching neuroinflammation and retinal diseases.
Fórmula:C27H42O3Forma y color:SolidPeso molecular:414.62CVN766
CAS:CVN766 is an orally active orexin 1 receptor antagonist with blood-brain permeability, demonstrating IC50 values of 8 nM for OX1R and >10 μM for OX2R. CVN766 can be used to study schizophrenia [1].Fórmula:C20H21F3N8OForma y color:SolidPeso molecular:446.43NBI 35965 hydrochloride
CAS:NBI 35965 hydrochloride is a selective CRF1 (corticotropin-releasing factor receptor 1) antagonist that is both orally active and capable of penetrating the brain. It possesses a K i value of 4 nM and a pK i of 8.5, and does not affect CRF2. This compound effectively diminishes CRF or stress-triggered ACTH (adrenocorticotropic hormone) production in vivo, demonstrating pIC 50 values of 7.1 and 6.9. Additionally, NBI 35965 hydrochloride exhibits anxiolytic properties [1] [2].Fórmula:C21H23Cl3N4Forma y color:SolidPeso molecular:437.79GPR183 inverse agonist-1
CAS:GPR183 inverse agonist-1 (Compound 78) is an inverse agonist of GPR183. It inhibits GPR183-mediated Gi activation and β-arrestin2 recruitment while blocking PBMC migration. This compound is utilized in research concerning inflammation, autoimmune, and cancer-related diseases.Fórmula:C20H20BrN5O2Forma y color:SolidPeso molecular:442.31SSTR5 antagonist 6
CAS:SSTR5 antagonist 6, an orally active antagonist specific to the somatostatin receptor subtype 5 (SSTR5), exhibits an IC50 value of 24 nM. This compound is utilized in researching type 2 diabetes [1].Fórmula:C22H28ClN3O4Forma y color:SolidPeso molecular:433.93SJPYT-310
CAS:SJPYT-310 is a selective PXR antagonist, exhibiting no noticeable cytotoxicity.Fórmula:C27H36N4O3Forma y color:SolidPeso molecular:464.6Acyline
CAS:Acyline, a GnRH antagonist, suppresses gonadotropins and testosterone in animals and maintains the effect for 2 weeks in men with one dose.Fórmula:C80H102ClN15O14Forma y color:SolidPeso molecular:1533.21GLP-1 receptor agonist 11
CAS:GLP-1 Receptor Agonist 11 (compound 3) acts as an effective agonist for the GLP Receptor, finding use in research related to conditions like diabetes and non-alc. fatty liver disease [1].Fórmula:C31H31ClFN3O4Forma y color:SolidPeso molecular:564.05CB2R/5-HT1AR agonist 1
CAS:Compound 2o, also known as CB2R/5-HT1AR agonist 1, serves as a partial orally active agonist for the CB2 receptor (EC50 = 479.6 nM) and a full agonist for the 5-HT1A receptor (EC50 = 2.7 μM). This compound demonstrates both anti-anxiety and anti-depressive effects and has favorable pharmacokinetic properties [1].Fórmula:C24H33NO3Forma y color:SolidPeso molecular:383.52EP-3945
CAS:EP-3945 is an agonist of Mas-related G protein-coupled receptors (MRGPR), exhibiting greater potency than the small molecule agonist β-Alanine targeting MRGPRD. MRGPRs play a crucial role in inflammatory itch and pain perception. These receptors interact with Gq (MRGPRX2, MRGPRX4, and MRGPRX1 are coupled with Gq; MRGPRX2 and MRGPRD couple with Gi), with EP-3945 having an EC50 value of 211.6 nM for Gq.Fórmula:C24H26N4O3Forma y color:SolidPeso molecular:418.488RGH-122
CAS:RGH-122 (compound 43), characterized as an orally active, potent, and selective hV1a receptor antagonist, demonstrates significant affinity with a K i value of 0.3 nM and an IC 50 of 0.9 nM. It exhibits microsomal stability, indicated by a CL int value of 13/28/25 μL/min/mg [1].Fórmula:C24H25ClN4O3Forma y color:SolidPeso molecular:452.93Tebideutorexant
CAS:Tebideutorexant, an orexin-1 receptor antagonist, shows anti-panic effects in rodents and humans, providing a tool for stress response and psychiatric research.Fórmula:C23H16D2F4N4O2Pureza:98.89%Forma y color:SolidPeso molecular:460.42Mrgx2 antagonist-3
CAS:Mrgx2 antagonist-3 (Compound B-40) is a highly selective antagonist of the MrgX2 receptor, with an IC50 range of 0.042-2.5 nM. It blocks downstream G protein signaling and β-arrestin recruitment, inhibiting Mrgx2 receptor-mediated calcium influx and cell degranulation. Mrgx2 antagonist-3 shows potential for research in inflammation-associated diseases and pruritus, such as chronic urticaria and allergic asthma.Fórmula:C15H15F2N3OForma y color:SolidPeso molecular:291.30
