GPCR / proteína G
Los inhibidores de GPCR/proteínas G son compuestos que se dirigen a los receptores acoplados a proteínas G (GPCR) y a las proteínas G asociadas, que desempeñan roles cruciales en la transmisión de señales desde el exterior hacia el interior de las células. Estos inhibidores son esenciales para estudiar las vías de señalización mediadas por los GPCR, que están involucradas en numerosos procesos fisiológicos, incluyendo la percepción sensorial, la respuesta inmunitaria y la neurotransmisión. Los inhibidores de GPCR también son importantes en el desarrollo de fármacos, ya que muchos agentes terapéuticos tienen como objetivo estos receptores. En CymitQuimica, ofrecemos una amplia gama de inhibidores de GPCR/proteínas G de alta calidad para apoyar su investigación en farmacología, biología celular y campos relacionados.
Subcategorías de "GPCR / proteína G"
- Receptor 5-HT(1.025 productos)
- Receptor de adenosina(249 productos)
- Receptor adrenérgico(3.002 productos)
- Receptor de bombesina(35 productos)
- Receptor de bradicinina(61 productos)
- CXCR(154 productos)
- CaSR(34 productos)
- Receptor de cannabinoides(216 productos)
- Colecistoquinina(1 productos)
- Receptor de dopamina(445 productos)
- Receptor de endotelina(86 productos)
- Receptor GNRH(84 productos)
- GPCR19(33 productos)
- GRK(33 productos)
- GTPasa(23 productos)
- Receptor de glucagón(192 productos)
- Hedgehog / Smoothened(49 productos)
- Receptor de histamina(385 productos)
- Receptor LPA(21 productos)
- Receptor de melatonina(26 productos)
- Receptor de OX(41 productos)
- Receptor de opioides(325 productos)
- PAFR(14 productos)
- PKA(60 productos)
- Receptor S1P(17 productos)
- SGLT(31 productos)
- Receptor sigma(46 productos)
Mostrar 19 subcategorías más
Se han encontrado 5966 productos de "GPCR / proteína G"
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CP-608039
CAS:CP-608039 is a selective adenosine A3 receptor agonist for both human A3 and human A1 receptors.Fórmula:C23H25ClN8O5Forma y color:SolidPeso molecular:528.95CI-988
CAS:CCK2 (CCK-B) receptor antagonistFórmula:C35H42N4O6Pureza:98%Forma y color:SolidPeso molecular:614.73Histamine H3 antagonist-1
CAS:Compound 10o, a histamine H3 antagonist-1, functions as both a histamine H3 antagonist and a serotonin reuptake inhibitor, making it useful for research in depression [1].
Fórmula:C24H28F3N3O2Forma y color:SolidPeso molecular:447.49CHNQD-01255
CAS:CHNQD-01255 is an orally active inhibitor of Arf-GEFs that is effective against hepatocellular carcinoma (HCC).Fórmula:C23H29NO6Forma y color:SolidPeso molecular:415.48CCR1 antagonist 13
CAS:CCR1 antagonist13 is a selective small molecule antagonist of CCR1.Fórmula:C25H27ClFN3O4Forma y color:SolidPeso molecular:487.95ADORA2A/PDE4D-IN-1
CAS:ADORA2A/PDE4D-IN-1 (Compound 9) is a dual inhibitor of the adenosine A2a receptor (ADORA2A) and phosphodiesterase 4D (PDE4D). This compound is applicable for research in bronchial asthma.Fórmula:C14H11N5Forma y color:SolidPeso molecular:249.271HU-308
CAS:HU-308, a synthetic cannabinoid analogue, is a highly selective agonist of the CB2 receptor. It demonstrates an affinity for the CB2 receptor that is over 440 times greater than its affinity for the CB1 receptor, which are predominantly found in immune cells. This compound plays a crucial role in modulating the immunosuppressive effects of the endocannabinoid system (ECS). Additionally, HU-308 possesses anti-inflammatory and neuroprotective properties, and it regulates the function of microglia. Its potential applications include research into neuroinflammation and retinal diseases.
Fórmula:C27H42O3Forma y color:SolidPeso molecular:414.62Bometolol Hydrochloride
CAS:Bometolol Hydrochloride is a beta-adrenergic blocking compound used for the treatment of cardiovascular disease.Fórmula:C25H33ClN2O7Pureza:98%Forma y color:SolidPeso molecular:508.99Enprostil
CAS:Enprostil: synthetic PGE2 analog, reduces gastric acid, protects mucosa, lowers post-meal gastrin, treats ulcers effectively and safely.Fórmula:C23H28O6Pureza:98%Forma y color:SolidPeso molecular:400.46EP-3945
CAS:EP-3945 is an agonist of Mas-related G protein-coupled receptors (MRGPR), exhibiting greater potency than the small molecule agonist β-Alanine targeting MRGPRD. MRGPRs play a crucial role in inflammatory itch and pain perception. These receptors interact with Gq (MRGPRX2, MRGPRX4, and MRGPRX1 are coupled with Gq; MRGPRX2 and MRGPRD couple with Gi), with EP-3945 having an EC50 value of 211.6 nM for Gq.Fórmula:C24H26N4O3Forma y color:SolidPeso molecular:418.488RGH-122
CAS:RGH-122 (compound 43), characterized as an orally active, potent, and selective hV1a receptor antagonist, demonstrates significant affinity with a K i value of 0.3 nM and an IC 50 of 0.9 nM. It exhibits microsomal stability, indicated by a CL int value of 13/28/25 μL/min/mg [1].Fórmula:C24H25ClN4O3Forma y color:SolidPeso molecular:452.93BRD50837
CAS:BRD50837 is a potent and selective inhibitor of Sonic Hedgehog (Shh).Fórmula:C26H32ClN3O6SPureza:98%Forma y color:SolidPeso molecular:550.07SAR-114137
CAS:SAR-114137 is a histone sphingomyelin kinase inhibitor used in the study of molluscum arteriosum and peripheral neuropathic pain.Fórmula:C25H34N4O7SPureza:99.09% - 99.91%Forma y color:SolidPeso molecular:534.63Aplaviroc
CAS:Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.Fórmula:C33H43N3O6Pureza:97.98% - 98.26%Forma y color:SolidPeso molecular:577.71CCR5 antagonist 1
CAS:CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.Fórmula:C39H46ClF2N5O3SPureza:98%Forma y color:SolidPeso molecular:738.33BI 639667
CAS:BI 639667, an azaindazole-class compound, potently inhibits CCR1 (IC50=1.8 nM in calcium flux assays).Fórmula:C22H18FN5O3SPureza:99.86%Forma y color:SolidPeso molecular:451.47Setomagpran
CAS:Setomagpran is an antagonist of the mas-related G protein-coupled receptor (MRGPR) and possesses anti-inflammatory properties.Fórmula:C22H19Cl2F6N5OForma y color:SolidPeso molecular:554.316PAR-2-IN-2
CAS:PAR-2-IN-2 (compound P-596) is an inhibitor of protease-activated receptor 2 (PAR-2), with an IC50 of 10.79 μM for SLIGKV and an IC50 greater than 200 μM for trypsin.Fórmula:C25H20F3N5O2Forma y color:SolidPeso molecular:479.454Mrgx2 antagonist-3
CAS:Mrgx2 antagonist-3 (Compound B-40) is a highly selective antagonist of the MrgX2 receptor, with an IC50 range of 0.042-2.5 nM. It blocks downstream G protein signaling and β-arrestin recruitment, inhibiting Mrgx2 receptor-mediated calcium influx and cell degranulation. Mrgx2 antagonist-3 shows potential for research in inflammation-associated diseases and pruritus, such as chronic urticaria and allergic asthma.Fórmula:C15H15F2N3OForma y color:SolidPeso molecular:291.30Treprostinil diethanolamine
CAS:Treprostinil diethanolamine (UT-15C) is a potent agonist of EP2, DP1 and IP, with values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1,Fórmula:C27H45NO7Pureza:99.86%Forma y color:SolidPeso molecular:495.65
