Métabolisme

NCGC00249987 is a highly selective and allosteric Tyr phosphatase activity of inhibitor of Eya2(Eya2 ED and MBP-Eya2 FL with IC50s of 3 μM and 6.9 μM ).

BMS-566419: Acridinone-based IMPDH inhibitor for studying graft rejection.

L-Homocysteine thiolactone hydrochloride is neurotoxic and can induce epilepsy and Alzheimer's disease.

H-Tyr-OMe.HCl is an endogenous metabolite and tyrosine derivative. H-Tyr-OMe.HCl encapsulates carbon-dot fluorescent probes for metal-free detection of thiols.

N-Desbutyl Dronedarone-d6 HCl is a deuterated compound of N-Desbutyl Dronedarone HCl. N-Desbutyl Dronedarone HCl has a CAS number of 197431-02-0.

Fmoc-Lys(Boc)-Thr(psi(Me,Me)pro)-OH is a dipeptide.

N-Deschlorobenzoyl indomethacin is the primary metabolite of indomethacin, exhibiting very weak inhibitory activity against AKR1C2 and AKR1C3.

N,S-Bis-Fmoc-Glutathione TFA is a potent inhibitor of glyoxalase II, exhibiting a Ki value of 0.75 μM and an IC50 value of 2.5 μM.

Boc-Glu-OBzl, a peptide precursor, aids in synthesizing inhibitors for human caspases and HRV 3C protease.

Fmoc-Cys(Trt)-OH, with catalog number T67555 and CAS number 103213-32-7, is a valuable organic compound for life sciences research.

(R)-Desmethyl Venlafaxine-d6 is a deuterated compound of (R)-Desmethyl Venlafaxine.

Methyl acetyl-L-cysteinate (N-Acetyl-L-cysteine methyl ester) is a cysteine derivative that is used in biosynthesis and is associated with body metabolism and

Debrisoquine is an antihypertensive drug similar to guanethidine.

17α-Hydroxyprogesterone-d8 is a deuterated compound of 17α-Hydroxyprogesterone.

Fmoc-Glu(OtBu)-Ser(psi(Me,Me)pro)-OH is a dipeptide.

Acetaminophen metabolite 3-hydroxy-acetaminophen is an antioxidant and a non-toxic microsomal metabolite of acetaminophen, suitable for metabolic studies.

Fmoc-Tyr(tBu)-Ser(psi(Me,Me)pro)-OH is a dipeptide.

Fmoc-Glu(OtBu)-Thr(psi(Me,Me)pro)-OH is a dipeptide.

alpha-Amyl cinnamaldehyde is a common additive in the perfume and cosmetic industry as an aroma substance.

Malondialdehyde tetrabutylammonium serves as a biomarker with antioxidant properties, and is extensively used in both the food and cosmetics industries primarily for monitoring and assessing product stability and safety. It acts as an indicator of lipid peroxidation, aiding in the evaluation of oxidative stress levels. Additionally, this compound has significant implications for indicating cellular damage and is investigated as a potential biomarker for various diseases.

Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor (IC50: 91 nM) for the study of atherosclerosis.

Methyl 2-amino-3-chloropropanoate hydrochloride is a useful organic compound for research related to life sciences.

2-Furoic Acid-d3 is a deuterated compound of 2-Furoic Acid.

H-4-Nitro-Phe-OEt . HCl is an alanine derivative.

Bz-Arg-OEt.HCl is an amino acid derivative of L-arginine exhibiting binding activity towards Protein-arginine deiminase type-4 (Km=475.2 µM).

2-Amino-3-(2-chlorophenyl)propanoic acid (2-Chloro-DL-Phenylalanine) is a phenylalanine derivative involved in biometabolism.

CD3254 is a selective and potent retinoid X receptor-like (RXR) agonist that inhibits neuronal cell death with OGD/reoxygenation.

N'-Nitrosonornicotine is a tobacco-specific N-nitrosamine and carcinogen that has been found in unburned tobacco and cigarette smoke.1It induces the formation of DNA adducts in isolated rat nasal mucosa and esophagus. N'-Nitrosonornicotine induces tumor formation in rat esophagus and nasal cavity, mouse lung, forestomach, and trachea, and hamster trachea and forebrain. Urinary levels of N'-nitrosonornicotine are positively correlated with the risk of esophageal cancer in smokers.2 1.Hecht, S.S.Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosaminesChem. Res. Toxicol.11(6)559-603(1998) 2.Yuan, J.-M., Knezevich, A.D., Wang, R., et al.Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokersCarcinogenesis32(9)1366-1371(2011)

Pre-vitamin D3 decanoate, a derivative of vitamin D3, can be transformed into the active form of vitamin D in the body. Initially, it is converted to 25-hydroxyvitamin D3 in the liver and then to 1,25-dihydroxyvitamin D3 in the kidneys. During preparation, vitamin D3 might react with triglycerides in the formulation, forming ester compounds that impact the stability and bioavailability of vitamin D3. This compound is utilized in the study of diseases related to vitamin D, including osteoporosis, autoimmune diseases, and certain cancers.

Atrial natriuretic factor (1-28) (human, porcine) TFA exhibits antihypertensive activity by promoting sodium and urine excretion. It inhibits the release of adrenocorticotropic hormone (ACTH) and β-endorphin by suppressing pro-opiomelanocortin (POMC) expression. Additionally, it elevates cGMP levels in RMIC cells, with an IC50 of 1.2 nM.

Fmoc-Asn(Trt)-Ser(psi(Me,Me)pro)-OH is a dipeptide.

Fmoc-D-Met-OH is a useful organic compound for research related to life sciences. The catalog number is T67557 and the CAS number is 112883-40-6.

Fmoc-Gln(Trt)-Thr(psi(Me,Me)pro)-OH is a dipeptide.

2-Amino-3-mercaptopropanoic acid hydrochloride hydrate is a cysteine derivative, widely used in biochemical experiments and drug synthesis research.

Vitamin D3-d3 is a deuterated compound of Vitamin D3.

2F-Peracetyl-Fucose (1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucopyranos), a fucosyltransferase inhibitor, inhibits salivary acidification in an inflammatory mode

Fmoc-Ser(Ac)-OH is an amino acid derivative and has a wide range of applications in life science related research.

Fmoc-β-HoGlu(OtBu)-OH is an amino acid derivative and has a wide range of applications in life science related research.

Hippuryl-His-Leu-OH tests for angiotensin I enzyme activity, allowing His-Leu detection by fluorescence.

Gefitinib Impurity 1: EGFR inhibitor, oral, targets EGF-stimulated tumor growth (IC50=54 nM), induces autophagy & antitumor effects.

Fmoc-Lys-OH is a lysine derivative commonly used in the synthesis of active compounds.

Desvaleryl valsartan is a degradation impurity of valsartan, formed in acidic conditions.

(R)-(-)-1,2-Propanediol, (R)-enantiomer from glucose via E. coli NADH-linked glycerol dehydrogenase.

Trandolapril D5 is a deuterated ACE inhibitor used to treat hypertension and CHF.

PPD 10558, a HMG-CoA reductase inhibitor, is used potentially for treatment of primary hypercholesterolemia.

3α-Aminocholestane (5α-Cholestan-3α-amine) is a SHIP1 inhibitor, (IC50 : 2.5 μM), which can be used for research and immune-related diseases.

Nucleoside Derivatives - Other modified nucleosides; Drugs and Inhibitors; Ribavirin related compound A; metabolite of Ribavirin

MLS-0437605: DUSP3 inhibitor, IC50 3.7 μM, preferential over DUSP22/other PTPs.

Fmoc-Met-OH (Fmoc-L-Met-OH) is an fmoc-based programmed synthesis of methionine derivatives.

Fmoc-Phe(4-NH2)-OH (Fmoc-4-Amino-L-phenylalanine) is a phenylalanine derivative used in research on supramolecular hydrogels.