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Ciclo cellulare/Checkpoint

Ciclo cellulare/Checkpoint

Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.

Sottocategorie di "Ciclo cellulare/Checkpoint"

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Trovati 3749 prodotti di "Ciclo cellulare/Checkpoint"

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  • SR121566A
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    SR121566A

    CAS:
    SR121566A is a novel non-peptide antagonist of Glycoprotein IIb/IIIa (GP IIb-IIIa).
    Formula:C20H25N5O4S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:431.51

    Ref: TM-T12999

  • LN-439A
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    LN-439A

    CAS:
    LN-439A (compound LN-439A) is a novel BAP1 inhibitor that suppresses the growth of basal-like breast cancer by degrading KLF5.
    Formula:C24H26FN3O4
    Colore e forma:Solid
    Peso molecolare:439.48

    Ref: TM-T200435

  • And1 degrader 1
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    And1 degrader 1

    CAS:
    And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.
    Formula:C26H27Cl2N3O
    Colore e forma:Solid
    Peso molecolare:468.42

    Ref: TM-T200443

  • 3-IN-PP1
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    3-IN-PP1

    CAS:
    3-IN-PP1: PKD inhibitor (IC50: 94-108 nM for PKD1/2/3), broad anticancer agent for research.
    Formula:C17H18N6
    Colore e forma:Solid
    Peso molecolare:306.36

    Ref: TM-T60718

  • RECTAS-2.0
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    RECTAS-2.0

    CAS:
    <p>RECTAS-2.0 is a small molecule designed to correct RNA mis-splicing caused by the GLA c.639+919G&gt;A mutation, intended for research in Fabry disease.</p>
    Formula:C18H17ClN4O4
    Colore e forma:Solid
    Peso molecolare:388.805

    Ref: TM-T206725

  • GR 83895
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    GR 83895

    CAS:
    GR 83895 is an antagonist of prototype fibrinogen receptor.
    Formula:C29H39N9O8S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:673.74

    Ref: TM-T25460

  • KL-50
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    KL-50

    CAS:
    KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.
    Formula:C7H7FN6O2
    Colore e forma:Solid
    Peso molecolare:226.17

    Ref: TM-T200136

  • Terpendole E
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    Terpendole E

    CAS:
    Terpendole E is an atypical L5 site inhibitor.
    Formula:C28H39NO3
    Colore e forma:Solid
    Peso molecolare:437.61

    Ref: TM-T70289

  • 2-Amino-2'-fluoro-2'-deoxyadenosine
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    2-Amino-2'-fluoro-2'-deoxyadenosine

    CAS:
    <p>2-Amino-2'-fluoro-2'-deoxyadenosine is a component of nucleic acids.</p>
    Formula:C10H13FN6O3
    Colore e forma:Solid
    Peso molecolare:284.25

    Ref: TM-TSW-00955

  • AB25583
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    AB25583

    CAS:
    AB25583 is a small molecule inhibitor of Polθ helicase (Polθ-hel) with an IC50 of 6 nM. It selectively kills cells deficient in BRCA1/2 and synergizes with Olaparib in cancer cells harboring pathogenic BRCA1/2 mutations. AB25583 can be utilized in tumor research.
    Formula:C22H17ClN4O3S
    Colore e forma:Solid
    Peso molecolare:452.91

    Ref: TM-T200101

  • 5-Methylcytosine hydrochloride
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    5-Methylcytosine hydrochloride

    CAS:
    5-Methylcytosine hydrochloride plays a critical role in regulating gene expression, promoting genomic imprinting, and inhibiting transposon factors. It is also closely associated with translation fidelity and tRNA recognition.
    Formula:C5H8ClN3O
    Colore e forma:Solid
    Peso molecolare:161.59

    Ref: TM-T201054

  • DENV-IN-6
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    DENV-IN-6

    CAS:
    DENV-IN-6, a potent anti-DENV (I-IV) and HIV-1 IIIB inhibitor with EC50 ranging 6.8-17.5 μM for DENV and EC50 0.0181 μM for HIV-1.
    Formula:C23H26ClFN4OS
    Colore e forma:Solid
    Peso molecolare:461

    Ref: TM-T62908

  • Norharmine
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    Norharmine

    CAS:
    Norharmine is an analogue of harman and functions as an alkaloid. It serves as an inhibitor of both monoamine oxidase A (MAO-A) and DYRK1A. While it exhibits weak inhibitory activity against MAO-A, it has certain inhibitory effects on DYRK1A.
    Formula:C12H10N2O
    Colore e forma:Solid
    Peso molecolare:198.221

    Ref: TM-T204194

  • 5-Fluorouridine 5'-phosphate
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    5-Fluorouridine 5'-phosphate

    CAS:
    5-Fluorouridine 5'-phosphate acts as an ODCase (uridine 5'-monophosphate decarboxylase) inhibitor, exhibiting a Ki value of 98 µM for human ODCase and 645 µM for Methanococcus jannaschii ODCase. This compound also shows inhibitory activity on leukemia and lymphoma cell lines, making it useful for cancer research studies.
    Formula:C9H12FN2O9P
    Colore e forma:Solid
    Peso molecolare:342.172

    Ref: TM-T205644

  • CDK7-IN-33
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    CDK7-IN-33

    CAS:
    CDK7-IN-33 (Compound 148) is a CDK7 inhibitor with a Ki value of 21.75 nM. It suppresses the proliferation of A549 cells expressing CDK7WT, with a pIC50 of 7.37.
    Formula:C29H36N6O4S
    Colore e forma:Solid
    Peso molecolare:564.699

    Ref: TM-T206088

  • Polθ-IN-8
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    Polθ-IN-8

    CAS:
    Polθ-IN-8 (example 77) is a DNA polymerase θ (Polθ) inhibitor with an IC50 for Polθ ATPase activity of less than 100 nM. Polθ-IN-8 is useful for researching diseases related to Polθ activity, such as cancer.
    Formula:C22H22ClN7O3S
    Colore e forma:Solid
    Peso molecolare:499.97

    Ref: TM-T207723

  • Logo CymitQuimica
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    Pol I-IN-1

    Pol I-IN-1 is a powerful inhibitor of RNA polymerase I (Pol I), specifically targeting the large catalytic subunit RPA194, demonstrating an inhibition
    Formula:C23H22N4O2
    Colore e forma:Solid
    Peso molecolare:386.45

    Ref: TM-T61720

  • L-2'-Fd4C
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    L-2'-Fd4C

    CAS:
    L-2'-Fd4C is an L-nucleoside analogue with both anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity [1].
    Formula:C9H10FN3O3
    Colore e forma:Solid
    Peso molecolare:227.19

    Ref: TM-T60285

  • (R)-CSN5i-3
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    (R)-CSN5i-3

    CAS:
    (R)-CSN5i-3 is CSN5i-3 of the R configuration.
    Formula:C28H29F2N5O2
    Purezza:99.76% - 99.97%
    Colore e forma:Solid
    Peso molecolare:505.56

    Ref: TM-T12620

  • 5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine
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    5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine

    CAS:
    5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine is a nucleoside synthesized through oxime ring-opening at the 5' position and methylation at the 2' position. In chemotaxis assays, 5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine demonstrates tissue affinity.
    Formula:C36H39N5O8
    Colore e forma:Solid
    Peso molecolare:669.724

    Ref: TM-T206273