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Ciclo cellulare/Checkpoint

Ciclo cellulare/Checkpoint

Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.

Sottocategorie di "Ciclo cellulare/Checkpoint"

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Trovati 3749 prodotti di "Ciclo cellulare/Checkpoint"

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  • Antiviral agent 67
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    Antiviral agent 67

    CAS:
    Antiviralagent 67 (compound PC6) is an inhibitor of DENVNS5 (RNA-dependent RNA polymerase) with a Ki value of 1.12 nM.
    Formula:C19H19N3O
    Colore e forma:Solid
    Peso molecolare:305.374

    Ref: TM-T206310

  • Aurora A inhibitor 1
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    Aurora A inhibitor 1

    CAS:
    Aurora A inhibitor 1: potent, selective, targets cancer-linked Aurora A overexpression, potential for cancer research. (WO2021147974A1, 49)
    Formula:C25H28ClF2N5O2
    Colore e forma:Solid
    Peso molecolare:503.97

    Ref: TM-T63436

  • AR-13324 M1 metabolite
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    AR-13324 M1 metabolite

    CAS:
    <p>AR-13324 M1 metabolite is a hydrolysis metabolite of AR-13324 mesylate.</p>
    Formula:C19H19N3O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:321.37

    Ref: TM-T10358L

  • UMPK ligand 1
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    UMPK ligand 1

    CAS:
    <p>UMPK ligand 1 (ZINC07785412) serves as a ligand for uridine monophosphate kinase (UMPK).</p>
    Formula:C15H22N4O5S
    Colore e forma:Solid
    Peso molecolare:370.424

    Ref: TM-T204579

  • Dencatistat
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    Dencatistat

    CAS:
    <p>Dencatistat is a highly selective and oral cytidine triphosphate synthase 1 CTPS1 inhibitor specific.CTPS1-IN-2 for B-cell, T-cell lymphomas and solid tumors.</p>
    Formula:C24H27N7O5S
    Purezza:98.85%
    Colore e forma:Solid
    Peso molecolare:525.58

    Ref: TM-T86106

  • L-I-OddU
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    L-I-OddU

    CAS:
    L-I-OddU: Selective anti-EBV, halts virus DNA/protein synthesis. EC50: 0.03 µM, low toxicity (CC50: 1000 nM).
    Formula:C8H9IN2O5
    Colore e forma:Solid
    Peso molecolare:340.07

    Ref: TM-T61080

  • PPA-037
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    PPA-037

    CAS:
    <p>PPA-037 is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 (CDK12). It induces the degradation of Cyclin K, thereby enhancing antiproliferative effects on tumor cells. PPA-037 holds potential for use in cancer research.</p>
    Formula:C25H27N7
    Colore e forma:Solid
    Peso molecolare:425.53

    Ref: TM-T207610

  • Bersiporocin
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    Bersiporocin

    CAS:
    <p>Bersiporocin is a novel prolyl-tRNA synthetase (PRS) inhibitor that exerts antifibrotic effects through downregulation of collagen synthesis in IPF.</p>
    Formula:C15H19Cl2N3O
    Purezza:98.88% - 99.79%
    Colore e forma:Solid
    Peso molecolare:328.24

    Ref: TM-T39739

  • VPC-80051
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    VPC-80051

    CAS:
    <p>VPC-80051 is an hnRNP A1 splicing activity inhibitor that directly interacts with the hnRNP A1 RBD and reduces AR-V7 messenger levels in the 22Rv1 CRPC cell line. VPC-80051 is applicable in prostate cancer research.</p>
    Formula:C16H13F2N3O
    Colore e forma:Solid
    Peso molecolare:301.291

    Ref: TM-T204737

  • Logo CymitQuimica
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    CDK8-IN-9

    <p>CDK8-IN-9, potent CDK8 inhibitor (IC50: 48.6 nM), curbs tumor growth, useful for colorectal cancer research.</p>
    Colore e forma:Solid

    Ref: TM-T64245

  • PT109
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    PT109

    CAS:
    PT109 is a multikinase inhibitor that targets JNK and other kinases, playing a crucial role in anti-inflammatory, antioxidative, neurogenic, and synaptogenic processes. Specifically, PT109 inhibits JNK isoforms with the following IC50 values: JNK1 at 0.143 μM, JNK2 at 0.831 μM, and JNK3 at 0.285 μM. It also inhibits SGK isoforms (SGK1: IC50=1.34 μM; SGK2: IC50=5.6 μM; SGK3: IC50=26.4 μM) and ROCK2 (IC50=34 μM). Additionally, PT109 reprograms polymorphic glioblastoma multiforme (GBM) into oligodendroglia via the PTBP1/PKM1/2 pathway and alters the metabolic pattern of GBM to exhibit antiglioma activity.
    Formula:C23H31N3OS2
    Colore e forma:Solid
    Peso molecolare:429.64

    Ref: TM-T201273

  • LNA-AMP
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    LNA-AMP

    CAS:
    LNA-AMP is a nucleotide analog used in the synthesis of oligonucleotides.
    Formula:C11H14N5O7P
    Colore e forma:Solid
    Peso molecolare:359.23

    Ref: TM-TSW-00964

  • CHK-IN-1
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    CHK-IN-1

    CAS:
    CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.
    Formula:C18H19ClFN5OS
    Purezza:>99.99%
    Colore e forma:Solid
    Peso molecolare:407.89

    Ref: TM-T13148

  • CDK1-IN-7
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    CDK1-IN-7

    CAS:
    <p>CDK1-IN-7 (compound M7) is a potent CDK1 inhibitor. It effectively suppresses the proliferation and migration of HCT116 and Lovo cells, making it a valuable tool for colorectal cancer research.</p>
    Formula:C23H19ClN4O3
    Colore e forma:Solid
    Peso molecolare:434.88

    Ref: TM-T207488

  • CB 30900
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    CB 30900

    CAS:
    CB30900 is a novel and effective thymidylate synthase inhibitor.
    Formula:C31H32FN5O9
    Colore e forma:Solid
    Peso molecolare:637.61

    Ref: TM-T30760

  • CHK1 inhibitor
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    CHK1 inhibitor

    CAS:
    CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.
    Formula:C17H21BrN4O
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:377.28

    Ref: TM-T10793

  • CIB-L43
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    CIB-L43

    CAS:
    <p>CIB-L43 is a oral TRBP inhibitor, inhibit miR-21, increase PTEN and Smad7, and block the AKT and TGF-β，inhibit proliferation and migration.</p>
    Formula:C15H16N2O3S
    Purezza:99.64%
    Colore e forma:Solid
    Peso molecolare:304.36

    Ref: TM-T205607

  • Methyl 3-oxodecanoate
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    Methyl 3-oxodecanoate

    CAS:
    <p>Methyl 3-oxodecanoate exhibits virulence factor activity against human pathogens and shows effects on Synechococcus elongatus (a species of fluorescent algae) as well as on culture supernatant. Additionally, Methyl 3-oxodecanoate inhibits DNA synthesis by suppressing protein synthesis at the translation initiation level.</p>
    Formula:C11H20O3
    Colore e forma:Solid
    Peso molecolare:200.275

    Ref: TM-T206384

  • CDK4/6-IN-13
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    CDK4/6-IN-13

    CAS:
    Compounds 10B and 10C: potent cdk4/6 inhibitors with low nM activity, great antiproliferative effects, excellent metabolism, and good pharmacokinetics.
    Formula:C25H29N7O
    Colore e forma:Solid
    Peso molecolare:443.54

    Ref: TM-T62605

  • GSK3-IN-10
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    GSK3-IN-10

    CAS:
    GSK3-IN-10 (Compound 4) is a multi-target inhibitor primarily affecting GSK3α and GSK3β with IC50 values of 1.0 nM and 2.0 nM, respectively. It inhibits the activation of β-catenin, enhances neuronal survival, and provides protective effects against endoplasmic reticulum stress.
    Formula:C17H18F2N4O3
    Colore e forma:Solid
    Peso molecolare:364.347

    Ref: TM-T206481