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Ciclo cellulare/Checkpoint

Ciclo cellulare/Checkpoint

Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.

Sottocategorie di "Ciclo cellulare/Checkpoint"

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Trovati 3739 prodotti di "Ciclo cellulare/Checkpoint"

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  • TREX1-IN-3
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    TREX1-IN-3

    CAS:
    <p>TREX1-IN-3 (Compound 95) is an inhibitor of TREX1 and TREX2, with an IC50 of less than 0.1 μM for TREX1 and less than 1 μM for TREX2, as well as an EC50 of less than 1 μM for HCT116 cells. It is applicable for research in the field of cancer.</p>
    Formula:C24H19ClN6O4
    Colore e forma:Solid
    Peso molecolare:490.898

    Ref: TM-T205254

  • HPH-15
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    HPH-15

    CAS:
    <p>HPH-15 is an anti-cell migration compound that inhibits cell movement by binding to hnRNP U or suppressing TGF-β. Additionally, it prevents epithelial-to-mesenchymal transition (EMT). HPH-15 holds potential for research in areas such as anti-tumor metastasis and anti-fibrosis.</p>
    Formula:C19H31N3S4
    Colore e forma:Solid
    Peso molecolare:429.73

    Ref: TM-T205327

  • INX-315
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    INX-315

    CAS:
    INX-315 is an orally active, selective CDK2 inhibitor that induces cell cycle arrest and senescence in solid tumours, suppresses E2F target gene expression.
    Formula:C19H21N7O3S
    Purezza:99.88%
    Colore e forma:Solid
    Peso molecolare:427.48

    Ref: TM-T86723

  • Zeltociclib
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    Zeltociclib

    CAS:
    Zeltociclib is an inhibitor of cyclin-dependent kinases (CDKs) with anti-tumor properties.
    Formula:C18H20F3N4O2P
    Colore e forma:Solid
    Peso molecolare:412.346

    Ref: TM-T205641

  • DL-Alanosine
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    DL-Alanosine

    CAS:
    <p>DL-Alanosine is an amino acid analog with antitumor activity.</p>
    Formula:C3H7N3O4
    Colore e forma:Solid
    Peso molecolare:149.105

    Ref: TM-T205451

  • TREX1-IN-4
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    TREX1-IN-4

    CAS:
    <p>TREX1-IN-4 (Compound 96) is an inhibitor of TREX1 and TREX2, exhibiting an IC50 of less than 0.1 μM for TREX1 and an IC50 of less than 1 μM for TREX2. It has an EC50 ranging from 0.1 to 10 μM in HCT116 cells. TREX1-IN-4 is applicable for research in the field of cancer.</p>
    Formula:C24H19ClN6O4
    Colore e forma:Solid
    Peso molecolare:490.898

    Ref: TM-T205208

  • MU1409
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    MU1409

    CAS:
    <p>MU1409 is an MRE11 nuclease inhibitor with an IC50 of 12.1 μM. It also inhibits FEN1 and EXO1, with IC50 values of 24.2 μM and 176.4 μM, respectively. MU1409 impacts cellular DNA repair and prevents the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for studying BRCA2 mutation-induced cancers.</p>
    Formula:C20H14BrN3O3S
    Colore e forma:Solid
    Peso molecolare:456.312

    Ref: TM-T205338

  • CDK4/6-IN-24
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    CDK4/6-IN-24

    CAS:
    CDK4/6-IN-24 (Compound A) is an inhibitor of CDK4/6 with broad-spectrum antitumor activity. It can effectively inhibit various cancer cells, exhibiting an IC50 in the submicromolar range.
    Formula:C32H41N7O3
    Colore e forma:Solid
    Peso molecolare:571.713

    Ref: TM-T205628

  • LY309887
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    LY309887

    CAS:
    LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.
    Formula:C19H23N5O6S
    Colore e forma:Solid
    Peso molecolare:449.48

    Ref: TM-T15813

  • KWR095
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    KWR095

    CAS:
    <p>KWR095 is an orally active inhibitor of WRN, demonstrating an IC50 of 0.032 μM against WRN ATPase. It disrupts the double-stranded helicase activity of WRN and inhibits tumor cell proliferation, exhibiting antitumor properties.</p>
    Formula:C33H31ClF3N9O4
    Colore e forma:Solid
    Peso molecolare:710.105

    Ref: TM-T205595

  • OPN expression inhibitor 1
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    OPN expression inhibitor 1

    CAS:
    OPN expression inhibitor 1 is an osteopontin expression inhibitor used in the study of breast cancer metastasis.
    Formula:C25H33N3O5
    Purezza:99.78%
    Colore e forma:Solid
    Peso molecolare:455.55

    Ref: TM-T62820

  • 3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite
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    3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite

    CAS:
    3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite serves as a precursor of adenosine nucleotide monomers used in the solid-phase synthesis of oligonucleotides, particularly for modifying oligonucleotides such as terminally modified DNA strands. It features Trityl (Tr), Cyanoethyl (CE), and Dimethylformamidine (DMF) protective groups, classifying it as a ddNTP adenosine nucleoside suitable for applications like oligonucleotide solid-phase synthesis, probe design, and chain termination sequencing.
    Formula:C41H50N9O3P
    Colore e forma:Solid
    Peso molecolare:747.87

    Ref: TM-TSW-01106

  • 2'-O-MOE-GTP
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    2'-O-MOE-GTP

    CAS:
    2'-O-MOE-GTP is a nucleotide analog utilized in the synthesis of oligonucleotides.
    Formula:C13H22N5O15P3
    Colore e forma:Solid
    Peso molecolare:581.26

    Ref: TM-TSW-00970

  • N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine
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    N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine

    CAS:
    N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine is a nucleoside analog that resembles the natural nucleotide adenosine in structure. It acts as an activator of ribonucleotide reductase, facilitating the conversion of ribonucleotides into deoxyribonucleotides.
    Formula:C38H35N5O6
    Colore e forma:Solid
    Peso molecolare:657.714

    Ref: TM-T206424

  • (Rac)-Plevitrexed
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    (Rac)-Plevitrexed

    CAS:
    (Rac)-Plevitrexed is a racemate of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).
    Formula:C26H25FN8O4
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:532.53

    Ref: TM-T12674

  • RNAP-σ interaction inhibitor-1
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    RNAP-σ interaction inhibitor-1

    CAS:
    RNAP-σ interaction inhibitor-1 (compound 5d) acts as an inhibitor of the interaction between RNA polymerase and the sigma factor. It exhibits activity against Streptococci with a minimum inhibitory concentration (MIC) ranging from 1-2 µg/mL.
    Formula:C19H11Cl3N2O6S2
    Colore e forma:Solid
    Peso molecolare:533.79

    Ref: TM-T207529

  • 6K465
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    6K465

    CAS:
    6K465 is a potent Aurora A kinase inhibitor that reduces c-MYC and N-MYC oncoproteins, showing antiproliferative effects in SCLC and breast cancer cell lines.
    Formula:C26H33ClFN9O
    Purezza:99.78%
    Colore e forma:Solid
    Peso molecolare:542.05

    Ref: TM-T85508

  • PKMYT1-IN-9
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    PKMYT1-IN-9

    CAS:
    PKMYT1-IN-9 is a highly selective, orally active inhibitor of PKMYT1 with an IC50 of 4.4 nM. It exhibits greater selectivity for PKMYT1 compared to WEE1, for which the IC50 is 32.4 μM. Additionally, PKMYT1-IN-9 demonstrates antitumor activity.
    Formula:C17H14FN5O
    Colore e forma:Solid
    Peso molecolare:323.324

    Ref: TM-T206301

  • CDK9-IN-38
    Targetmol
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    CDK9-IN-38

    CAS:
    <p>CDK9-IN-38 (compound 14) is a CDK9 inhibitor with IC50 values of 1.2 nM for wild-type CDK9 and 3.3 nM for the L156F mutant. It effectively inhibits tumor growth both in vitro and in vivo.</p>
    Formula:C22H23N5O3S
    Colore e forma:Solid
    Peso molecolare:437.515

    Ref: TM-T206913

  • Chk1-IN-5
    Targetmol
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    Chk1-IN-5

    CAS:
    Chk1-IN-5 inhibits Chk1, blocking phosphorylation and suppressing colon cancer growth.
    Formula:C18H18FN7O2
    Colore e forma:Solid
    Peso molecolare:383.38

    Ref: TM-T37098