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Ciclo cellulare/Checkpoint

Ciclo cellulare/Checkpoint

Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.

Sottocategorie di "Ciclo cellulare/Checkpoint"

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Trovati 3739 prodotti di "Ciclo cellulare/Checkpoint"

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  • KI-CDK9d-32
    Targetmol
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    KI-CDK9d-32

    CAS:
    <p>KI-CDK9d-32 is a CDK9 PROTAC degrader with a DC50 of 0.89 nM. It facilitates the ubiquitination and degradation of CDK9, inhibits the MYC pathway, and disrupts nucleolar homeostasis. KI-CDK9d-32 demonstrates anticancer activity.</p>
    Formula:C39H45N9O4
    Colore e forma:Solid
    Peso molecolare:703.83

    Ref: TM-T207184

  • CDK9/PARP-IN-1
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    CDK9/PARP-IN-1

    CAS:
    CDK9/PARP-IN-1 (compound 37) is an inhibitor of CDK9 and PARP. It demonstrates IC50 values of 118 nM for CDK9 and 107 nM for PARP1. This compound exhibits a broad-spectrum anti-proliferative effect across various cancer cell lines.
    Formula:C38H34F2N8O3
    Colore e forma:Solid
    Peso molecolare:688.725

    Ref: TM-T205731

  • 2'-O-MOE-GMP
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    2'-O-MOE-GMP

    CAS:
    <p>2'-O-MOE-GMP is a nucleotide analogue that can be utilized in the synthesis of oligonucleotides.</p>
    Formula:C13H20N5O9P
    Colore e forma:Solid
    Peso molecolare:421.30

    Ref: TM-TSW-00967

  • N-Isobutyryl-2', 3'-acetyl-guanosine
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    N-Isobutyryl-2', 3'-acetyl-guanosine

    CAS:
    N-Isobutyryl-2', 3'-acetyl-guanosine is a derivative of guanosine.
    Formula:C18H23N5O8
    Colore e forma:Solid
    Peso molecolare:437.404

    Ref: TM-T206416

  • Logo CymitQuimica
    Targetmol
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    Hesperadin hydrochloride

    Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.
    Formula:C29H33ClN4O3S
    Colore e forma:Solid
    Peso molecolare:553.12

    Ref: TM-T63905

  • CHK1-IN-2
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    CHK1-IN-2

    CAS:
    CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).
    Formula:C20H22N4OS
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:366.48

    Ref: TM-T10790

  • RNAP-σ interaction inhibitor-2
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    RNAP-σ interaction inhibitor-2

    CAS:
    RNAP-σ interaction inhibitor-2 (compound 7d) is an inhibitor targeting the interaction between RNA polymerase and the sigma factor. It demonstrates inhibitory activity against S. aureus with a minimum inhibitory concentration (MIC) of 2 µg/mL.
    Formula:C27H19Cl3N2O6S2
    Colore e forma:Solid
    Peso molecolare:637.939

    Ref: TM-T206884

  • 2′-OMe-ADP
    Targetmol
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    2′-OMe-ADP

    CAS:
    <p>2′-OMe-ADP is a nucleotide analogue used in oligonucleotide synthesis.</p>
    Formula:C11H17N5O10P2
    Colore e forma:Solid
    Peso molecolare:441.23

    Ref: TM-TSW-00949

  • PKMYT1-IN-7
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    PKMYT1-IN-7

    CAS:
    PKMYT1-IN-7 (compound 7) is an orally active PKMYT1 inhibitor with IC50 values of 1.6 nM for PKMYT1 and 0.06 μM for pCDK1. It inhibits the phosphorylation of CDK1 at T14 and Y15 sites and exhibits anticancer activity both in vitro and in vivo.
    Formula:C17H18FN5O3
    Colore e forma:Solid
    Peso molecolare:359.355

    Ref: TM-T206777

  • Plevitrexed
    Targetmol
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    Plevitrexed

    CAS:
    Plevitrexed, an oral TS inhibitor (Ki: 0.44 nM), targets α-folate receptor & reduced folate carrier, treats gastric cancer.
    Formula:C26H25FN8O4
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:532.53

    Ref: TM-T12635L

  • Logo CymitQuimica
    Targetmol
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    RAD51-IN-8

    RAD51-IN-8 inhibits RAD51-BRCA2 interaction and H4A4 with EC50 of 19 μM; a micromolar PPI inhibitor.
    Formula:C16H14Cl2FN3O2
    Colore e forma:Solid
    Peso molecolare:370.21

    Ref: TM-T61469

  • LNA-GMP
    Targetmol
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    LNA-GMP

    CAS:
    LNA-GMP, a nucleotide analogue, is utilized in the synthesis of oligonucleotides.
    Formula:C11H14N5O8P
    Colore e forma:Solid
    Peso molecolare:375.23

    Ref: TM-TSW-00965

  • 6-B345TTQ
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    6-B345TTQ

    CAS:
    6-B345TTQ is an α4 integrin inhibitor that can impede the interaction between α4 and Leupaxin. This compound is applicable for studies focused on inflammation research.
    Formula:C22H20BrNO4
    Colore e forma:Solid
    Peso molecolare:442.303

    Ref: TM-T204244

  • SGC-CLK-1
    Targetmol
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    SGC-CLK-1

    CAS:
    SGC-CLK-1 is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. It effectively inhibits the growth of melanoma and glioblastoma cells.
    Formula:C19H15F3N6O2
    Colore e forma:Solid
    Peso molecolare:416.36

    Ref: TM-T201181

  • FR-β ligand 1
    Targetmol
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    FR-β ligand 1

    CAS:
    FR-β ligand 1 (III) is a ligand that specifically targets folate receptors, exhibiting antitumor activity, high selectivity, and strong affinity.
    Formula:C22H25N5O6
    Colore e forma:Solid
    Peso molecolare:455.46

    Ref: TM-T207453

  • Polθ-IN-5
    Targetmol
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    Polθ-IN-5

    CAS:
    Polθ-IN-5 (Compound 139) is an inhibitor of DNA polymerase theta (Polθ) that exhibits antitumor activity.
    Formula:C23H18ClF2N7O3S
    Colore e forma:Solid
    Peso molecolare:545.95

    Ref: TM-T200913

  • GSK3-IN-10
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    GSK3-IN-10

    CAS:
    GSK3-IN-10 (Compound 4) is a multi-target inhibitor primarily affecting GSK3α and GSK3β with IC50 values of 1.0 nM and 2.0 nM, respectively. It inhibits the activation of β-catenin, enhances neuronal survival, and provides protective effects against endoplasmic reticulum stress.
    Formula:C17H18F2N4O3
    Colore e forma:Solid
    Peso molecolare:364.347

    Ref: TM-T206481

  • Logo CymitQuimica
    Targetmol
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    CYP2C19-IN-1

    CYP2C19-IN-1: potent CYP2C19 inhibitor, non-genotoxic, non-hepatotoxic, blocks RdRP (Ki: 6.16 μM), useful for ZIKV research.
    Formula:C26H26N2O6S
    Colore e forma:Solid
    Peso molecolare:494.56

    Ref: TM-T63337

  • CDK4/6-IN-13
    Targetmol
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    CDK4/6-IN-13

    CAS:
    Compounds 10B and 10C: potent cdk4/6 inhibitors with low nM activity, great antiproliferative effects, excellent metabolism, and good pharmacokinetics.
    Formula:C25H29N7O
    Colore e forma:Solid
    Peso molecolare:443.54

    Ref: TM-T62605

  • Des-ethyl-carafiban
    Targetmol
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    Des-ethyl-carafiban

    CAS:
    Des-ethyl-carafiban (Compound 44) is an antagonist of the fibrinogen receptor, effectively inhibiting platelet aggregation induced by various agonists. It is useful for research in thrombotic diseases.
    Formula:C22H23N5O5
    Colore e forma:Solid
    Peso molecolare:437.448

    Ref: TM-T206156